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recombinant human klotho protein rh-klotho  (PeproTech)
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PeproTech recombinant human klotho protein rh-klotho
The effects of <t> exogenous </t> <t> klotho protein </t> supplementation on kidney function
Recombinant Human Klotho Protein Rh Klotho, supplied by PeproTech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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The effects of exogenous klotho protein supplementation on kidney function

Journal: Acta physiologica (Oxford, England)

Article Title: Klotho protein supplementation reduces blood pressure and renal hypertrophy in db/db mice, a model of type 2 diabetes

doi: 10.1111/apha.13190

Figure Lengend Snippet: The effects of exogenous klotho protein supplementation on kidney function

Article Snippet: 40 Exogenous supplementation of recombinant human klotho protein (rh-klotho, 10 μg/kg/d; PeproTech, Rocky Hill, NJ, USA) or vehicle was started on 8-week-old mice (n = 10 for each group) with daily subcutaneous injections.

Techniques: Control, Clinical Proteomics

Impact of exogenous klotho protein supplementation on renal expressions of TGF-β (A), collagen I (B), fibronectin (C), and E-cadherin (D), Smad3 distribution (E), and interstitial fibrosis (F) in db/db mice (db). The * indicates statistically significant differences between the two groups (n = 10 for each)

Journal: Acta physiologica (Oxford, England)

Article Title: Klotho protein supplementation reduces blood pressure and renal hypertrophy in db/db mice, a model of type 2 diabetes

doi: 10.1111/apha.13190

Figure Lengend Snippet: Impact of exogenous klotho protein supplementation on renal expressions of TGF-β (A), collagen I (B), fibronectin (C), and E-cadherin (D), Smad3 distribution (E), and interstitial fibrosis (F) in db/db mice (db). The * indicates statistically significant differences between the two groups (n = 10 for each)

Article Snippet: 40 Exogenous supplementation of recombinant human klotho protein (rh-klotho, 10 μg/kg/d; PeproTech, Rocky Hill, NJ, USA) or vehicle was started on 8-week-old mice (n = 10 for each group) with daily subcutaneous injections.

Techniques:

Influences of exogenous klotho protein supplementation on phosphorylation of Akt (A, 56 kDa), mTOR (B, 289 kDa), and p70-S6k (C, 70 kDa), and phosphorylated mTOR staining (D) in db/db mice (db). The * indicates statistically significant differences between the two groups (n = 10 for each). db + k depicts db/db mice with klotho supplementation

Journal: Acta physiologica (Oxford, England)

Article Title: Klotho protein supplementation reduces blood pressure and renal hypertrophy in db/db mice, a model of type 2 diabetes

doi: 10.1111/apha.13190

Figure Lengend Snippet: Influences of exogenous klotho protein supplementation on phosphorylation of Akt (A, 56 kDa), mTOR (B, 289 kDa), and p70-S6k (C, 70 kDa), and phosphorylated mTOR staining (D) in db/db mice (db). The * indicates statistically significant differences between the two groups (n = 10 for each). db + k depicts db/db mice with klotho supplementation

Article Snippet: 40 Exogenous supplementation of recombinant human klotho protein (rh-klotho, 10 μg/kg/d; PeproTech, Rocky Hill, NJ, USA) or vehicle was started on 8-week-old mice (n = 10 for each group) with daily subcutaneous injections.

Techniques: Phospho-proteomics, Staining

Effects of exogenous klotho protein supplementation on aortic (A) and renal (B) expressions of superoxide dismutase (SOD), renal abundance of hypoxia-inducible factor-1α (C, 110 kDa, HIF-1α), renal expression of tumour necrosis factor-α (D, TNF-α), plasma concentration of TNF-α (E), and phosphorylation of Iκβ (F, 36 kDa) in db/db mice (db). β-actin was observed at 42 kDa. The * indicates statistically significant differences between the two groups (n = 10 for each). db + k depicts db/db mice with klotho supplementation

Journal: Acta physiologica (Oxford, England)

Article Title: Klotho protein supplementation reduces blood pressure and renal hypertrophy in db/db mice, a model of type 2 diabetes

doi: 10.1111/apha.13190

Figure Lengend Snippet: Effects of exogenous klotho protein supplementation on aortic (A) and renal (B) expressions of superoxide dismutase (SOD), renal abundance of hypoxia-inducible factor-1α (C, 110 kDa, HIF-1α), renal expression of tumour necrosis factor-α (D, TNF-α), plasma concentration of TNF-α (E), and phosphorylation of Iκβ (F, 36 kDa) in db/db mice (db). β-actin was observed at 42 kDa. The * indicates statistically significant differences between the two groups (n = 10 for each). db + k depicts db/db mice with klotho supplementation

Article Snippet: 40 Exogenous supplementation of recombinant human klotho protein (rh-klotho, 10 μg/kg/d; PeproTech, Rocky Hill, NJ, USA) or vehicle was started on 8-week-old mice (n = 10 for each group) with daily subcutaneous injections.

Techniques: Expressing, Clinical Proteomics, Concentration Assay, Phospho-proteomics

Summary of in vitro studies in HK-2 cells. Hydrogen peroxide induced angiotensinogen expression (A) and klotho suppressed this response (For time: F = 36, df = 1, P < 0.005; for klotho treatment: F = 14, df = 1, P < 0.001; for interaction: F = 5, df = 1, P < 0.05; for error: df = 20). An interaction between time and klotho treatment may relate to transcytosis of klotho protein by proximal tubular cells.17 Similarly, hydrogen peroxide induced the expression of tumour necrosis factor-α (B, TNF-alpha), and klotho inhibited this (For time: F = 85, df = 1, P < 0.001; for klotho treatment: F = 8, df = 1, P < 0.05; for interaction: F = 13, df = 1, P < 0.01; for error: df = 20). Insulin-like growth factor repressed expression of superoxide dismutase (C, SOD), and klotho opposed this response (For time: F = 96, df = 1, P < 0.001; for klotho treatment: F = 6, df = 1, P < 0.05; for interaction: F = 9, df = 1, P < 0.01; for error: df = 20). Blue and grey bars depict control and klotho-treated groups respectively. The * indicates statistically significant differences between the two groups

Journal: Acta physiologica (Oxford, England)

Article Title: Klotho protein supplementation reduces blood pressure and renal hypertrophy in db/db mice, a model of type 2 diabetes

doi: 10.1111/apha.13190

Figure Lengend Snippet: Summary of in vitro studies in HK-2 cells. Hydrogen peroxide induced angiotensinogen expression (A) and klotho suppressed this response (For time: F = 36, df = 1, P < 0.005; for klotho treatment: F = 14, df = 1, P < 0.001; for interaction: F = 5, df = 1, P < 0.05; for error: df = 20). An interaction between time and klotho treatment may relate to transcytosis of klotho protein by proximal tubular cells.17 Similarly, hydrogen peroxide induced the expression of tumour necrosis factor-α (B, TNF-alpha), and klotho inhibited this (For time: F = 85, df = 1, P < 0.001; for klotho treatment: F = 8, df = 1, P < 0.05; for interaction: F = 13, df = 1, P < 0.01; for error: df = 20). Insulin-like growth factor repressed expression of superoxide dismutase (C, SOD), and klotho opposed this response (For time: F = 96, df = 1, P < 0.001; for klotho treatment: F = 6, df = 1, P < 0.05; for interaction: F = 9, df = 1, P < 0.01; for error: df = 20). Blue and grey bars depict control and klotho-treated groups respectively. The * indicates statistically significant differences between the two groups

Article Snippet: 40 Exogenous supplementation of recombinant human klotho protein (rh-klotho, 10 μg/kg/d; PeproTech, Rocky Hill, NJ, USA) or vehicle was started on 8-week-old mice (n = 10 for each group) with daily subcutaneous injections.

Techniques: In Vitro, Expressing, Control