Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Bateman 2010a

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Medications, Clinical Proteomics, Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Bateman 2010b

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Biomarker Discovery, Sequencing, Selection, Generated, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Beeh 2006

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Infection, Medications, Sequencing, Selection, Generated, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Brusasco 2003

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Infection, Medications, Sequencing, Selection, Generated, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Casaburi 2002

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Biomarker Discovery, Sequencing, Selection, Generated, Capsules

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Chan 2007

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Biomarker Discovery, Infection, Sequencing, Selection, Generated, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Cooper 2010

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Biomarker Discovery, Modification, Sequencing, Selection, Generated, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Covelli 2005

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Biomarker Discovery, Infection, Sequencing, Selection, Generated, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Dusser 2006

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Biomarker Discovery, Infection, Medications, Sequencing, Selection, Generated, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Freeman 2007

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Biomarker Discovery, Infection, Sequencing, Selection, Generated

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Johansson 2008

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Biomarker Discovery, Infection, Sequencing, Selection, Generated, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Magnussen 2008

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Biomarker Discovery, Sequencing, Selection, Generated, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Moita 2008

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Biomarker Discovery, Infection, Sequencing, Selection, Generated, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: NCT00144326

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Activity Assay, Plasmid Preparation, Modification, Sequencing, Selection, Generated, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Niewoehner 2005

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Biomarker Discovery, Medications, Sequencing, Selection, Generated

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Powrie 2007

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Biomarker Discovery, Concentration Assay, Sequencing, Selection, Generated, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Tashkin 2008

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Biomarker Discovery, Infection, Medications, Sequencing, Selection, Generated

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Tonnel 2008

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Biomarker Discovery, Infection, Sequencing, Selection, Blocking Assay, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Trooster 2011

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Medications, Activity Assay, Sequencing, Selection, Generated, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Verkinde 2006

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Infection, Modification, Sequencing, Selection, Generated, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Tiotropium versus placebo for chronic obstructive pulmonary disease

doi: 10.1002/14651858.CD009285.pub3

Figure Lengend Snippet: Voshaar 2008

Article Snippet: COPD‐related respiratory symptoms consist of more than one of the following: cough, wheeze, dyspnoea, chest congestion, shortness of breath, chest tightness, or sputum production Risk of bias Bias Authors' judgement Support for judgement Random sequence generation (selection bias) Low risk The randomisation list was generated by Boehringer Ingelheim using a validated system, which involved a pseudo‐random number generator so that the resulting treatment sequence was both reproducible and non‐predictable Allocation concealment (selection bias) Low risk All investigational medication for each patient was identified by a unique medication number.

Techniques: Biomarker Discovery, Sequencing, Selection, Generated