pulses Search Results


pre pulse inhibition ppi  (Med Associates Inc)
96
Med Associates Inc pre pulse inhibition ppi
Behavioral deficits induced by YFP-difopein expression in WT mice. a Compared with WT mice injected with AAV-YFP in both the HP and PFC ( n = 14), bilateral injections of AAV-YFP-difopein to the HP alone significantly reduce freezing behavior in contextual fear conditioning test 24 h after training ( n = 6; F (1, 18) = 6.994; p = 0.016). However, injections of AAV-YFP-difopein to PFC alone does not affect freezing behavior when compared with WT controls ( n = 6; F (1, 18) = 1.505; p = 0.236). b Bilateral injections of AAV-YFP-difopein into the HP, either alone ( n = 8; F (1, 7.34) = 27.826; p = 0.001) or together with injection to the PFC ( n = 9; F (1, 9.668) = 17.64; p = 0.002), significantly increase travel distances in open field test, compared with WT mice injected with AAV-YFP (HP: n = 9, HP + PFC: n = 6). However, injections of AAV-YFP-difopein to the PFC alone ( n = 7; F (1, 10) = 1.953; p = 0.192) did not affect locomotive behavior of WT mice. c Bilateral injections of AAV-YFP-difopein to the HP of WT mice causes a decrease in pre-pulse <t>inhibition</t> <t>(PPI)</t> at all pre-pulse levels tested, while PPI is significantly lower at the pre-pulse level of 67 dB ( n = 5; F (1, 8) = 6.746; p = 0.032), compared with WT mice with AAV-YFP injected to the HP of ( n = 5). Data are presented as mean ± S.E.M. with statistical significance denoted as: * p < 0.05; ** p < 0.01; one-way ANOVA
Pre Pulse Inhibition Ppi, supplied by Med Associates Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pulses/pmc06386769-141-3-18?v=Med+Associates+Inc
Average 96 stars, based on 1 article reviews
pre pulse inhibition ppi - by Bioz Stars, 2026-07
96/100 stars
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sysa310 accupulser signal generator  (World Precision Instruments)
93
World Precision Instruments sysa310 accupulser signal generator
Behavioral deficits induced by YFP-difopein expression in WT mice. a Compared with WT mice injected with AAV-YFP in both the HP and PFC ( n = 14), bilateral injections of AAV-YFP-difopein to the HP alone significantly reduce freezing behavior in contextual fear conditioning test 24 h after training ( n = 6; F (1, 18) = 6.994; p = 0.016). However, injections of AAV-YFP-difopein to PFC alone does not affect freezing behavior when compared with WT controls ( n = 6; F (1, 18) = 1.505; p = 0.236). b Bilateral injections of AAV-YFP-difopein into the HP, either alone ( n = 8; F (1, 7.34) = 27.826; p = 0.001) or together with injection to the PFC ( n = 9; F (1, 9.668) = 17.64; p = 0.002), significantly increase travel distances in open field test, compared with WT mice injected with AAV-YFP (HP: n = 9, HP + PFC: n = 6). However, injections of AAV-YFP-difopein to the PFC alone ( n = 7; F (1, 10) = 1.953; p = 0.192) did not affect locomotive behavior of WT mice. c Bilateral injections of AAV-YFP-difopein to the HP of WT mice causes a decrease in pre-pulse <t>inhibition</t> <t>(PPI)</t> at all pre-pulse levels tested, while PPI is significantly lower at the pre-pulse level of 67 dB ( n = 5; F (1, 8) = 6.746; p = 0.032), compared with WT mice with AAV-YFP injected to the HP of ( n = 5). Data are presented as mean ± S.E.M. with statistical significance denoted as: * p < 0.05; ** p < 0.01; one-way ANOVA
Sysa310 Accupulser Signal Generator, supplied by World Precision Instruments, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pulses/pm37027294-380-14-18?v=World+Precision+Instruments
Average 93 stars, based on 1 article reviews
sysa310 accupulser signal generator - by Bioz Stars, 2026-07
93/100 stars
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pippin pulse  (Sage Science)
96
Sage Science pippin pulse
Behavioral deficits induced by YFP-difopein expression in WT mice. a Compared with WT mice injected with AAV-YFP in both the HP and PFC ( n = 14), bilateral injections of AAV-YFP-difopein to the HP alone significantly reduce freezing behavior in contextual fear conditioning test 24 h after training ( n = 6; F (1, 18) = 6.994; p = 0.016). However, injections of AAV-YFP-difopein to PFC alone does not affect freezing behavior when compared with WT controls ( n = 6; F (1, 18) = 1.505; p = 0.236). b Bilateral injections of AAV-YFP-difopein into the HP, either alone ( n = 8; F (1, 7.34) = 27.826; p = 0.001) or together with injection to the PFC ( n = 9; F (1, 9.668) = 17.64; p = 0.002), significantly increase travel distances in open field test, compared with WT mice injected with AAV-YFP (HP: n = 9, HP + PFC: n = 6). However, injections of AAV-YFP-difopein to the PFC alone ( n = 7; F (1, 10) = 1.953; p = 0.192) did not affect locomotive behavior of WT mice. c Bilateral injections of AAV-YFP-difopein to the HP of WT mice causes a decrease in pre-pulse <t>inhibition</t> <t>(PPI)</t> at all pre-pulse levels tested, while PPI is significantly lower at the pre-pulse level of 67 dB ( n = 5; F (1, 8) = 6.746; p = 0.032), compared with WT mice with AAV-YFP injected to the HP of ( n = 5). Data are presented as mean ± S.E.M. with statistical significance denoted as: * p < 0.05; ** p < 0.01; one-way ANOVA
Pippin Pulse, supplied by Sage Science, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pulses/pmc08327913__supp_gr__265058__120_Supplemental_Materials-127-14-16?v=Sage+Science
Average 96 stars, based on 1 article reviews
pippin pulse - by Bioz Stars, 2026-07
96/100 stars
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pulse booster 316s  (UGO Basile S.R.L)
93
UGO Basile S.R.L pulse booster 316s
Behavioral deficits induced by YFP-difopein expression in WT mice. a Compared with WT mice injected with AAV-YFP in both the HP and PFC ( n = 14), bilateral injections of AAV-YFP-difopein to the HP alone significantly reduce freezing behavior in contextual fear conditioning test 24 h after training ( n = 6; F (1, 18) = 6.994; p = 0.016). However, injections of AAV-YFP-difopein to PFC alone does not affect freezing behavior when compared with WT controls ( n = 6; F (1, 18) = 1.505; p = 0.236). b Bilateral injections of AAV-YFP-difopein into the HP, either alone ( n = 8; F (1, 7.34) = 27.826; p = 0.001) or together with injection to the PFC ( n = 9; F (1, 9.668) = 17.64; p = 0.002), significantly increase travel distances in open field test, compared with WT mice injected with AAV-YFP (HP: n = 9, HP + PFC: n = 6). However, injections of AAV-YFP-difopein to the PFC alone ( n = 7; F (1, 10) = 1.953; p = 0.192) did not affect locomotive behavior of WT mice. c Bilateral injections of AAV-YFP-difopein to the HP of WT mice causes a decrease in pre-pulse <t>inhibition</t> <t>(PPI)</t> at all pre-pulse levels tested, while PPI is significantly lower at the pre-pulse level of 67 dB ( n = 5; F (1, 8) = 6.746; p = 0.032), compared with WT mice with AAV-YFP injected to the HP of ( n = 5). Data are presented as mean ± S.E.M. with statistical significance denoted as: * p < 0.05; ** p < 0.01; one-way ANOVA
Pulse Booster 316s, supplied by UGO Basile S.R.L, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pulses/pmc06539809-287-12-15?v=UGO+Basile+S.R.L
Average 93 stars, based on 1 article reviews
pulse booster 316s - by Bioz Stars, 2026-07
93/100 stars
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pulse transducer  (ADInstruments)
93
ADInstruments pulse transducer
Behavioral deficits induced by YFP-difopein expression in WT mice. a Compared with WT mice injected with AAV-YFP in both the HP and PFC ( n = 14), bilateral injections of AAV-YFP-difopein to the HP alone significantly reduce freezing behavior in contextual fear conditioning test 24 h after training ( n = 6; F (1, 18) = 6.994; p = 0.016). However, injections of AAV-YFP-difopein to PFC alone does not affect freezing behavior when compared with WT controls ( n = 6; F (1, 18) = 1.505; p = 0.236). b Bilateral injections of AAV-YFP-difopein into the HP, either alone ( n = 8; F (1, 7.34) = 27.826; p = 0.001) or together with injection to the PFC ( n = 9; F (1, 9.668) = 17.64; p = 0.002), significantly increase travel distances in open field test, compared with WT mice injected with AAV-YFP (HP: n = 9, HP + PFC: n = 6). However, injections of AAV-YFP-difopein to the PFC alone ( n = 7; F (1, 10) = 1.953; p = 0.192) did not affect locomotive behavior of WT mice. c Bilateral injections of AAV-YFP-difopein to the HP of WT mice causes a decrease in pre-pulse <t>inhibition</t> <t>(PPI)</t> at all pre-pulse levels tested, while PPI is significantly lower at the pre-pulse level of 67 dB ( n = 5; F (1, 8) = 6.746; p = 0.032), compared with WT mice with AAV-YFP injected to the HP of ( n = 5). Data are presented as mean ± S.E.M. with statistical significance denoted as: * p < 0.05; ** p < 0.01; one-way ANOVA
Pulse Transducer, supplied by ADInstruments, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pulses/pmc05442094-66-1-4?v=ADInstruments
Average 93 stars, based on 1 article reviews
pulse transducer - by Bioz Stars, 2026-07
93/100 stars
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pulse picker  (Coherent Corp)
90
Coherent Corp pulse picker
Behavioral deficits induced by YFP-difopein expression in WT mice. a Compared with WT mice injected with AAV-YFP in both the HP and PFC ( n = 14), bilateral injections of AAV-YFP-difopein to the HP alone significantly reduce freezing behavior in contextual fear conditioning test 24 h after training ( n = 6; F (1, 18) = 6.994; p = 0.016). However, injections of AAV-YFP-difopein to PFC alone does not affect freezing behavior when compared with WT controls ( n = 6; F (1, 18) = 1.505; p = 0.236). b Bilateral injections of AAV-YFP-difopein into the HP, either alone ( n = 8; F (1, 7.34) = 27.826; p = 0.001) or together with injection to the PFC ( n = 9; F (1, 9.668) = 17.64; p = 0.002), significantly increase travel distances in open field test, compared with WT mice injected with AAV-YFP (HP: n = 9, HP + PFC: n = 6). However, injections of AAV-YFP-difopein to the PFC alone ( n = 7; F (1, 10) = 1.953; p = 0.192) did not affect locomotive behavior of WT mice. c Bilateral injections of AAV-YFP-difopein to the HP of WT mice causes a decrease in pre-pulse <t>inhibition</t> <t>(PPI)</t> at all pre-pulse levels tested, while PPI is significantly lower at the pre-pulse level of 67 dB ( n = 5; F (1, 8) = 6.746; p = 0.032), compared with WT mice with AAV-YFP injected to the HP of ( n = 5). Data are presented as mean ± S.E.M. with statistical significance denoted as: * p < 0.05; ** p < 0.01; one-way ANOVA
Pulse Picker, supplied by Coherent Corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pulses/pm32872963-52-7-15?v=Coherent+Corp
Average 90 stars, based on 1 article reviews
pulse picker - by Bioz Stars, 2026-07
90/100 stars
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pressure cuff  (ADInstruments)
93
ADInstruments pressure cuff
Behavioral deficits induced by YFP-difopein expression in WT mice. a Compared with WT mice injected with AAV-YFP in both the HP and PFC ( n = 14), bilateral injections of AAV-YFP-difopein to the HP alone significantly reduce freezing behavior in contextual fear conditioning test 24 h after training ( n = 6; F (1, 18) = 6.994; p = 0.016). However, injections of AAV-YFP-difopein to PFC alone does not affect freezing behavior when compared with WT controls ( n = 6; F (1, 18) = 1.505; p = 0.236). b Bilateral injections of AAV-YFP-difopein into the HP, either alone ( n = 8; F (1, 7.34) = 27.826; p = 0.001) or together with injection to the PFC ( n = 9; F (1, 9.668) = 17.64; p = 0.002), significantly increase travel distances in open field test, compared with WT mice injected with AAV-YFP (HP: n = 9, HP + PFC: n = 6). However, injections of AAV-YFP-difopein to the PFC alone ( n = 7; F (1, 10) = 1.953; p = 0.192) did not affect locomotive behavior of WT mice. c Bilateral injections of AAV-YFP-difopein to the HP of WT mice causes a decrease in pre-pulse <t>inhibition</t> <t>(PPI)</t> at all pre-pulse levels tested, while PPI is significantly lower at the pre-pulse level of 67 dB ( n = 5; F (1, 8) = 6.746; p = 0.032), compared with WT mice with AAV-YFP injected to the HP of ( n = 5). Data are presented as mean ± S.E.M. with statistical significance denoted as: * p < 0.05; ** p < 0.01; one-way ANOVA
Pressure Cuff, supplied by ADInstruments, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pulses/pmc08065800-81-11-14?v=ADInstruments
Average 93 stars, based on 1 article reviews
pressure cuff - by Bioz Stars, 2026-07
93/100 stars
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tonometer curve  (ADInstruments)
93
ADInstruments tonometer curve
Behavioral deficits induced by YFP-difopein expression in WT mice. a Compared with WT mice injected with AAV-YFP in both the HP and PFC ( n = 14), bilateral injections of AAV-YFP-difopein to the HP alone significantly reduce freezing behavior in contextual fear conditioning test 24 h after training ( n = 6; F (1, 18) = 6.994; p = 0.016). However, injections of AAV-YFP-difopein to PFC alone does not affect freezing behavior when compared with WT controls ( n = 6; F (1, 18) = 1.505; p = 0.236). b Bilateral injections of AAV-YFP-difopein into the HP, either alone ( n = 8; F (1, 7.34) = 27.826; p = 0.001) or together with injection to the PFC ( n = 9; F (1, 9.668) = 17.64; p = 0.002), significantly increase travel distances in open field test, compared with WT mice injected with AAV-YFP (HP: n = 9, HP + PFC: n = 6). However, injections of AAV-YFP-difopein to the PFC alone ( n = 7; F (1, 10) = 1.953; p = 0.192) did not affect locomotive behavior of WT mice. c Bilateral injections of AAV-YFP-difopein to the HP of WT mice causes a decrease in pre-pulse <t>inhibition</t> <t>(PPI)</t> at all pre-pulse levels tested, while PPI is significantly lower at the pre-pulse level of 67 dB ( n = 5; F (1, 8) = 6.746; p = 0.032), compared with WT mice with AAV-YFP injected to the HP of ( n = 5). Data are presented as mean ± S.E.M. with statistical significance denoted as: * p < 0.05; ** p < 0.01; one-way ANOVA
Tonometer Curve, supplied by ADInstruments, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pulses/10__1161_slash_01__cir__0000145157__07881__a3-44-13-40?v=ADInstruments
Average 93 stars, based on 1 article reviews
tonometer curve - by Bioz Stars, 2026-07
93/100 stars
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med asr pro1 med asr fps apparatus  (AutoMate Scientific Inc)
96
AutoMate Scientific Inc med asr pro1 med asr fps apparatus
Behavioral deficits induced by YFP-difopein expression in WT mice. a Compared with WT mice injected with AAV-YFP in both the HP and PFC ( n = 14), bilateral injections of AAV-YFP-difopein to the HP alone significantly reduce freezing behavior in contextual fear conditioning test 24 h after training ( n = 6; F (1, 18) = 6.994; p = 0.016). However, injections of AAV-YFP-difopein to PFC alone does not affect freezing behavior when compared with WT controls ( n = 6; F (1, 18) = 1.505; p = 0.236). b Bilateral injections of AAV-YFP-difopein into the HP, either alone ( n = 8; F (1, 7.34) = 27.826; p = 0.001) or together with injection to the PFC ( n = 9; F (1, 9.668) = 17.64; p = 0.002), significantly increase travel distances in open field test, compared with WT mice injected with AAV-YFP (HP: n = 9, HP + PFC: n = 6). However, injections of AAV-YFP-difopein to the PFC alone ( n = 7; F (1, 10) = 1.953; p = 0.192) did not affect locomotive behavior of WT mice. c Bilateral injections of AAV-YFP-difopein to the HP of WT mice causes a decrease in pre-pulse <t>inhibition</t> <t>(PPI)</t> at all pre-pulse levels tested, while PPI is significantly lower at the pre-pulse level of 67 dB ( n = 5; F (1, 8) = 6.746; p = 0.032), compared with WT mice with AAV-YFP injected to the HP of ( n = 5). Data are presented as mean ± S.E.M. with statistical significance denoted as: * p < 0.05; ** p < 0.01; one-way ANOVA
Med Asr Pro1 Med Asr Fps Apparatus, supplied by AutoMate Scientific Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pulses/pmc03263988-607-9-19?v=AutoMate+Scientific+Inc
Average 96 stars, based on 1 article reviews
med asr pro1 med asr fps apparatus - by Bioz Stars, 2026-07
96/100 stars
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pulse buffer  (AutoMate Scientific Inc)
97
AutoMate Scientific Inc pulse buffer
Behavioral deficits induced by YFP-difopein expression in WT mice. a Compared with WT mice injected with AAV-YFP in both the HP and PFC ( n = 14), bilateral injections of AAV-YFP-difopein to the HP alone significantly reduce freezing behavior in contextual fear conditioning test 24 h after training ( n = 6; F (1, 18) = 6.994; p = 0.016). However, injections of AAV-YFP-difopein to PFC alone does not affect freezing behavior when compared with WT controls ( n = 6; F (1, 18) = 1.505; p = 0.236). b Bilateral injections of AAV-YFP-difopein into the HP, either alone ( n = 8; F (1, 7.34) = 27.826; p = 0.001) or together with injection to the PFC ( n = 9; F (1, 9.668) = 17.64; p = 0.002), significantly increase travel distances in open field test, compared with WT mice injected with AAV-YFP (HP: n = 9, HP + PFC: n = 6). However, injections of AAV-YFP-difopein to the PFC alone ( n = 7; F (1, 10) = 1.953; p = 0.192) did not affect locomotive behavior of WT mice. c Bilateral injections of AAV-YFP-difopein to the HP of WT mice causes a decrease in pre-pulse <t>inhibition</t> <t>(PPI)</t> at all pre-pulse levels tested, while PPI is significantly lower at the pre-pulse level of 67 dB ( n = 5; F (1, 8) = 6.746; p = 0.032), compared with WT mice with AAV-YFP injected to the HP of ( n = 5). Data are presented as mean ± S.E.M. with statistical significance denoted as: * p < 0.05; ** p < 0.01; one-way ANOVA
Pulse Buffer, supplied by AutoMate Scientific Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pulses/pmc05220471-51-24-34?v=AutoMate+Scientific+Inc
Average 97 stars, based on 1 article reviews
pulse buffer - by Bioz Stars, 2026-07
97/100 stars
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bitalino plugged kit  (PLUX Biosignals SA)
92
PLUX Biosignals SA bitalino plugged kit
Behavioral deficits induced by YFP-difopein expression in WT mice. a Compared with WT mice injected with AAV-YFP in both the HP and PFC ( n = 14), bilateral injections of AAV-YFP-difopein to the HP alone significantly reduce freezing behavior in contextual fear conditioning test 24 h after training ( n = 6; F (1, 18) = 6.994; p = 0.016). However, injections of AAV-YFP-difopein to PFC alone does not affect freezing behavior when compared with WT controls ( n = 6; F (1, 18) = 1.505; p = 0.236). b Bilateral injections of AAV-YFP-difopein into the HP, either alone ( n = 8; F (1, 7.34) = 27.826; p = 0.001) or together with injection to the PFC ( n = 9; F (1, 9.668) = 17.64; p = 0.002), significantly increase travel distances in open field test, compared with WT mice injected with AAV-YFP (HP: n = 9, HP + PFC: n = 6). However, injections of AAV-YFP-difopein to the PFC alone ( n = 7; F (1, 10) = 1.953; p = 0.192) did not affect locomotive behavior of WT mice. c Bilateral injections of AAV-YFP-difopein to the HP of WT mice causes a decrease in pre-pulse <t>inhibition</t> <t>(PPI)</t> at all pre-pulse levels tested, while PPI is significantly lower at the pre-pulse level of 67 dB ( n = 5; F (1, 8) = 6.746; p = 0.032), compared with WT mice with AAV-YFP injected to the HP of ( n = 5). Data are presented as mean ± S.E.M. with statistical significance denoted as: * p < 0.05; ** p < 0.01; one-way ANOVA
Bitalino Plugged Kit, supplied by PLUX Biosignals SA, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pulses/pm37215174-74-10-13?v=PLUX+Biosignals+SA
Average 92 stars, based on 1 article reviews
bitalino plugged kit - by Bioz Stars, 2026-07
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magnetic field pulses  (Neurostar GmbH)
90
Neurostar GmbH magnetic field pulses
Behavioral deficits induced by YFP-difopein expression in WT mice. a Compared with WT mice injected with AAV-YFP in both the HP and PFC ( n = 14), bilateral injections of AAV-YFP-difopein to the HP alone significantly reduce freezing behavior in contextual fear conditioning test 24 h after training ( n = 6; F (1, 18) = 6.994; p = 0.016). However, injections of AAV-YFP-difopein to PFC alone does not affect freezing behavior when compared with WT controls ( n = 6; F (1, 18) = 1.505; p = 0.236). b Bilateral injections of AAV-YFP-difopein into the HP, either alone ( n = 8; F (1, 7.34) = 27.826; p = 0.001) or together with injection to the PFC ( n = 9; F (1, 9.668) = 17.64; p = 0.002), significantly increase travel distances in open field test, compared with WT mice injected with AAV-YFP (HP: n = 9, HP + PFC: n = 6). However, injections of AAV-YFP-difopein to the PFC alone ( n = 7; F (1, 10) = 1.953; p = 0.192) did not affect locomotive behavior of WT mice. c Bilateral injections of AAV-YFP-difopein to the HP of WT mice causes a decrease in pre-pulse <t>inhibition</t> <t>(PPI)</t> at all pre-pulse levels tested, while PPI is significantly lower at the pre-pulse level of 67 dB ( n = 5; F (1, 8) = 6.746; p = 0.032), compared with WT mice with AAV-YFP injected to the HP of ( n = 5). Data are presented as mean ± S.E.M. with statistical significance denoted as: * p < 0.05; ** p < 0.01; one-way ANOVA
Magnetic Field Pulses, supplied by Neurostar GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pulses/us09649501-30-1-1?v=Neurostar+GmbH
Average 90 stars, based on 1 article reviews
magnetic field pulses - by Bioz Stars, 2026-07
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Image Search Results


Behavioral deficits induced by YFP-difopein expression in WT mice. a Compared with WT mice injected with AAV-YFP in both the HP and PFC ( n = 14), bilateral injections of AAV-YFP-difopein to the HP alone significantly reduce freezing behavior in contextual fear conditioning test 24 h after training ( n = 6; F (1, 18) = 6.994; p = 0.016). However, injections of AAV-YFP-difopein to PFC alone does not affect freezing behavior when compared with WT controls ( n = 6; F (1, 18) = 1.505; p = 0.236). b Bilateral injections of AAV-YFP-difopein into the HP, either alone ( n = 8; F (1, 7.34) = 27.826; p = 0.001) or together with injection to the PFC ( n = 9; F (1, 9.668) = 17.64; p = 0.002), significantly increase travel distances in open field test, compared with WT mice injected with AAV-YFP (HP: n = 9, HP + PFC: n = 6). However, injections of AAV-YFP-difopein to the PFC alone ( n = 7; F (1, 10) = 1.953; p = 0.192) did not affect locomotive behavior of WT mice. c Bilateral injections of AAV-YFP-difopein to the HP of WT mice causes a decrease in pre-pulse inhibition (PPI) at all pre-pulse levels tested, while PPI is significantly lower at the pre-pulse level of 67 dB ( n = 5; F (1, 8) = 6.746; p = 0.032), compared with WT mice with AAV-YFP injected to the HP of ( n = 5). Data are presented as mean ± S.E.M. with statistical significance denoted as: * p < 0.05; ** p < 0.01; one-way ANOVA

Journal: NPJ Schizophrenia

Article Title: Region-specific inhibition of 14-3-3 proteins induces psychomotor behaviors in mice

doi: 10.1038/s41537-018-0069-1

Figure Lengend Snippet: Behavioral deficits induced by YFP-difopein expression in WT mice. a Compared with WT mice injected with AAV-YFP in both the HP and PFC ( n = 14), bilateral injections of AAV-YFP-difopein to the HP alone significantly reduce freezing behavior in contextual fear conditioning test 24 h after training ( n = 6; F (1, 18) = 6.994; p = 0.016). However, injections of AAV-YFP-difopein to PFC alone does not affect freezing behavior when compared with WT controls ( n = 6; F (1, 18) = 1.505; p = 0.236). b Bilateral injections of AAV-YFP-difopein into the HP, either alone ( n = 8; F (1, 7.34) = 27.826; p = 0.001) or together with injection to the PFC ( n = 9; F (1, 9.668) = 17.64; p = 0.002), significantly increase travel distances in open field test, compared with WT mice injected with AAV-YFP (HP: n = 9, HP + PFC: n = 6). However, injections of AAV-YFP-difopein to the PFC alone ( n = 7; F (1, 10) = 1.953; p = 0.192) did not affect locomotive behavior of WT mice. c Bilateral injections of AAV-YFP-difopein to the HP of WT mice causes a decrease in pre-pulse inhibition (PPI) at all pre-pulse levels tested, while PPI is significantly lower at the pre-pulse level of 67 dB ( n = 5; F (1, 8) = 6.746; p = 0.032), compared with WT mice with AAV-YFP injected to the HP of ( n = 5). Data are presented as mean ± S.E.M. with statistical significance denoted as: * p < 0.05; ** p < 0.01; one-way ANOVA

Article Snippet: Startle response and pre-pulse inhibition (PPI) of the acoustic startle response were assessed using Acoustic Startle Reflex package (Med Associates).

Techniques: Expressing, Injection, Inhibition