pr-1282 Search Results


t cruzi chimeric chagas multi antigen  (Jena Bioscience)
94
Jena Bioscience t cruzi chimeric chagas multi antigen
Phage library displays the proteome of T. <t>cruzi</t> in 47-aa peptides with a 19-aa step size on the capsid of T7 phage. The library includes all coding regions of the proteome and splice variants. We performed the PhIP-seq assay by incubating the phage library with human plasma, followed by immunoprecipitation of antibodies in the sample and enrichment of antibody-bound phage through lysis in E. coli . We performed two rounds of enrichment and then sequenced the enriched phage to obtain the identity of the immunoprecipitated peptides.
T Cruzi Chimeric Chagas Multi Antigen, supplied by Jena Bioscience, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pr122 super magenta r  (DIC Corporation)
90
DIC Corporation pr122 super magenta r
Phage library displays the proteome of T. <t>cruzi</t> in 47-aa peptides with a 19-aa step size on the capsid of T7 phage. The library includes all coding regions of the proteome and splice variants. We performed the PhIP-seq assay by incubating the phage library with human plasma, followed by immunoprecipitation of antibodies in the sample and enrichment of antibody-bound phage through lysis in E. coli . We performed two rounds of enrichment and then sequenced the enriched phage to obtain the identity of the immunoprecipitated peptides.
Pr122 Super Magenta R, supplied by DIC Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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wet 500  (Evonik)
90
Evonik wet 500
Phage library displays the proteome of T. <t>cruzi</t> in 47-aa peptides with a 19-aa step size on the capsid of T7 phage. The library includes all coding regions of the proteome and splice variants. We performed the PhIP-seq assay by incubating the phage library with human plasma, followed by immunoprecipitation of antibodies in the sample and enrichment of antibody-bound phage through lysis in E. coli . We performed two rounds of enrichment and then sequenced the enriched phage to obtain the identity of the immunoprecipitated peptides.
Wet 500, supplied by Evonik, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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magenta pigment (pr122) water mixture containing 9 wt % tayca power surfactant  (Tayca Corporation)
90
Tayca Corporation magenta pigment (pr122) water mixture containing 9 wt % tayca power surfactant
Phage library displays the proteome of T. <t>cruzi</t> in 47-aa peptides with a 19-aa step size on the capsid of T7 phage. The library includes all coding regions of the proteome and splice variants. We performed the PhIP-seq assay by incubating the phage library with human plasma, followed by immunoprecipitation of antibodies in the sample and enrichment of antibody-bound phage through lysis in E. coli . We performed two rounds of enrichment and then sequenced the enriched phage to obtain the identity of the immunoprecipitated peptides.
Magenta Pigment (Pr122) Water Mixture Containing 9 Wt % Tayca Power Surfactant, supplied by Tayca Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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silica/quinacridone pr122 complex pigments  (TODA KOGYO CORP)
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TODA KOGYO CORP silica/quinacridone pr122 complex pigments
Phage library displays the proteome of T. <t>cruzi</t> in 47-aa peptides with a 19-aa step size on the capsid of T7 phage. The library includes all coding regions of the proteome and splice variants. We performed the PhIP-seq assay by incubating the phage library with human plasma, followed by immunoprecipitation of antibodies in the sample and enrichment of antibody-bound phage through lysis in E. coli . We performed two rounds of enrichment and then sequenced the enriched phage to obtain the identity of the immunoprecipitated peptides.
Silica/Quinacridone Pr122 Complex Pigments, supplied by TODA KOGYO CORP, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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quinacridone red e2b  (BASF)
90
BASF quinacridone red e2b
Phage library displays the proteome of T. <t>cruzi</t> in 47-aa peptides with a 19-aa step size on the capsid of T7 phage. The library includes all coding regions of the proteome and splice variants. We performed the PhIP-seq assay by incubating the phage library with human plasma, followed by immunoprecipitation of antibodies in the sample and enrichment of antibody-bound phage through lysis in E. coli . We performed two rounds of enrichment and then sequenced the enriched phage to obtain the identity of the immunoprecipitated peptides.
Quinacridone Red E2b, supplied by BASF, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pigment red 122  (Clariant Inc)
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Clariant Inc pigment red 122
Phage library displays the proteome of T. <t>cruzi</t> in 47-aa peptides with a 19-aa step size on the capsid of T7 phage. The library includes all coding regions of the proteome and splice variants. We performed the PhIP-seq assay by incubating the phage library with human plasma, followed by immunoprecipitation of antibodies in the sample and enrichment of antibody-bound phage through lysis in E. coli . We performed two rounds of enrichment and then sequenced the enriched phage to obtain the identity of the immunoprecipitated peptides.
Pigment Red 122, supplied by Clariant Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mirneasy kit pr1202  (Bioteke Corporation)
90
Bioteke Corporation mirneasy kit pr1202
Phage library displays the proteome of T. <t>cruzi</t> in 47-aa peptides with a 19-aa step size on the capsid of T7 phage. The library includes all coding regions of the proteome and splice variants. We performed the PhIP-seq assay by incubating the phage library with human plasma, followed by immunoprecipitation of antibodies in the sample and enrichment of antibody-bound phage through lysis in E. coli . We performed two rounds of enrichment and then sequenced the enriched phage to obtain the identity of the immunoprecipitated peptides.
Mirneasy Kit Pr1202, supplied by Bioteke Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anionic surfactant high tehnol nf-17  (Seiyaku Corporation)
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Seiyaku Corporation anionic surfactant high tehnol nf-17
Phage library displays the proteome of T. <t>cruzi</t> in 47-aa peptides with a 19-aa step size on the capsid of T7 phage. The library includes all coding regions of the proteome and splice variants. We performed the PhIP-seq assay by incubating the phage library with human plasma, followed by immunoprecipitation of antibodies in the sample and enrichment of antibody-bound phage through lysis in E. coli . We performed two rounds of enrichment and then sequenced the enriched phage to obtain the identity of the immunoprecipitated peptides.
Anionic Surfactant High Tehnol Nf 17, supplied by Seiyaku Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pigment sun chemical pigment blue 15:3bg  (DIC Corporation)
90
DIC Corporation pigment sun chemical pigment blue 15:3bg
Phage library displays the proteome of T. <t>cruzi</t> in 47-aa peptides with a 19-aa step size on the capsid of T7 phage. The library includes all coding regions of the proteome and splice variants. We performed the PhIP-seq assay by incubating the phage library with human plasma, followed by immunoprecipitation of antibodies in the sample and enrichment of antibody-bound phage through lysis in E. coli . We performed two rounds of enrichment and then sequenced the enriched phage to obtain the identity of the immunoprecipitated peptides.
Pigment Sun Chemical Pigment Blue 15:3bg, supplied by DIC Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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oligos pr1271-pr1272  (Oligos Etc)
90
Oligos Etc oligos pr1271-pr1272
Phage library displays the proteome of T. <t>cruzi</t> in 47-aa peptides with a 19-aa step size on the capsid of T7 phage. The library includes all coding regions of the proteome and splice variants. We performed the PhIP-seq assay by incubating the phage library with human plasma, followed by immunoprecipitation of antibodies in the sample and enrichment of antibody-bound phage through lysis in E. coli . We performed two rounds of enrichment and then sequenced the enriched phage to obtain the identity of the immunoprecipitated peptides.
Oligos Pr1271 Pr1272, supplied by Oligos Etc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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c. i. pigment red 122 cromophtal jet magenta dmq  (Ciba Specialty Chemicals Corporation)
90
Ciba Specialty Chemicals Corporation c. i. pigment red 122 cromophtal jet magenta dmq
Phage library displays the proteome of T. <t>cruzi</t> in 47-aa peptides with a 19-aa step size on the capsid of T7 phage. The library includes all coding regions of the proteome and splice variants. We performed the PhIP-seq assay by incubating the phage library with human plasma, followed by immunoprecipitation of antibodies in the sample and enrichment of antibody-bound phage through lysis in E. coli . We performed two rounds of enrichment and then sequenced the enriched phage to obtain the identity of the immunoprecipitated peptides.
C. I. Pigment Red 122 Cromophtal Jet Magenta Dmq, supplied by Ciba Specialty Chemicals Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Phage library displays the proteome of T. cruzi in 47-aa peptides with a 19-aa step size on the capsid of T7 phage. The library includes all coding regions of the proteome and splice variants. We performed the PhIP-seq assay by incubating the phage library with human plasma, followed by immunoprecipitation of antibodies in the sample and enrichment of antibody-bound phage through lysis in E. coli . We performed two rounds of enrichment and then sequenced the enriched phage to obtain the identity of the immunoprecipitated peptides.

Journal: medRxiv

Article Title: A Trypanosoma cruzi Trans-Sialidase Peptide Demonstrates High Serological Prevalence Among Infected Populations Across Endemic Regions of Latin America

doi: 10.1101/2025.01.22.25320967

Figure Lengend Snippet: Phage library displays the proteome of T. cruzi in 47-aa peptides with a 19-aa step size on the capsid of T7 phage. The library includes all coding regions of the proteome and splice variants. We performed the PhIP-seq assay by incubating the phage library with human plasma, followed by immunoprecipitation of antibodies in the sample and enrichment of antibody-bound phage through lysis in E. coli . We performed two rounds of enrichment and then sequenced the enriched phage to obtain the identity of the immunoprecipitated peptides.

Article Snippet: An anti- T. cruzi IgG BLI method was developed using a commercial T. cruzi Chimeric Chagas Multi-Antigen (MACH; Jena Biosciences).

Techniques: Immunoprecipitation, Lysis

( A , B ) Heatmap of z-score enrichment over seronegative controls in the (A) blood donor (BD) specimens (n=64 seropositive, n=26 seronegative) and the (B) cardiac biomarker (CBM) specimens (n=114, seropositive; n=18, seronegative; n=95, healthy controls) for seroreactive peptides (rows) with >15% seropositivity within each cohort. Peptides are sorted by protein name and samples are sorted by patient region of origin (n=10, Central America [yellow]; n=13, Mexico [blue]; n=12, South America [light green]; n=1, USA [pink]; n=28, unknown [green]) (A), or cardiac disease stage (n=14 stage A seronegative [magenta]; n=6 stage B seronegative [orange]; n=38 stage A seropositive [magenta]; n=46 stage B seropositive [orange]; n=7 stage C seropositive [light green]; n=23 stage D seropositive [blue]) (B). Protein groups with well-characterized antigens are indicated by labels (Surface antigen, Surface antigen 2 (CA-2); NSP-like, Nucleoporin NSP1-like C-terminal domain-containing protein; MASP, Mucin-associated surface protein; Mucin, TcMUCII; MAP, Microtubule-associated protein; CCP, Calpain-like cysteine peptidase; 60S, 40S, ribosomal subunit proteins). ( C ) Breadth of antibody reactivity, shown as the number of seroreactive peptides in each person. The dotted red line and number signify the median number of seroreactive peptides in BD and CBM specimen sets. Samples are grouped by geographic region (BD specimens) and heart disease stage (CBM specimens). ( D ) Number of peptides identified as seroreactive in this study that are part of proteins expressed in specific stages of the T. cruzi life cycle (Tryp = trypomastigote; Ama = amastigote; Meta = metacyclic trypomastigote; Epi = epimastigote; Multiple = protein is expressed in trypomastigote, amastigote, and/or metacyclic trypomastigote stages). Stage expression analysis shows seroreactive peptides in every host-interfacing lifecycle stage. Stage-specific expression is based on the ‘Life cycle proteome (Brazil)’ data set from TriTrypDB. Gene IDs for stage-specific proteins were mapped onto the gene IDs that corresponded to seroreactive peptides. ( E , F ) Selected known seroreactive antigens are captured by T. cruzi PhIP-seq. Neg. is seronegative specimens from the respective specimen sets; Pos. is seropositive specimens from the respective cohorts; NYBC is NYBC US controls. Antibody reactivity to two known antigens (E) Ag2, a nucleoporin protein, and (F) TCE, a 60S ribosomal subunit protein are plotted as reads per 100,000 (RPK). The dotted red line signifies the RPK that corresponds to a z-score cutoff of 5 in the seronegative population of each cohort.

Journal: medRxiv

Article Title: A Trypanosoma cruzi Trans-Sialidase Peptide Demonstrates High Serological Prevalence Among Infected Populations Across Endemic Regions of Latin America

doi: 10.1101/2025.01.22.25320967

Figure Lengend Snippet: ( A , B ) Heatmap of z-score enrichment over seronegative controls in the (A) blood donor (BD) specimens (n=64 seropositive, n=26 seronegative) and the (B) cardiac biomarker (CBM) specimens (n=114, seropositive; n=18, seronegative; n=95, healthy controls) for seroreactive peptides (rows) with >15% seropositivity within each cohort. Peptides are sorted by protein name and samples are sorted by patient region of origin (n=10, Central America [yellow]; n=13, Mexico [blue]; n=12, South America [light green]; n=1, USA [pink]; n=28, unknown [green]) (A), or cardiac disease stage (n=14 stage A seronegative [magenta]; n=6 stage B seronegative [orange]; n=38 stage A seropositive [magenta]; n=46 stage B seropositive [orange]; n=7 stage C seropositive [light green]; n=23 stage D seropositive [blue]) (B). Protein groups with well-characterized antigens are indicated by labels (Surface antigen, Surface antigen 2 (CA-2); NSP-like, Nucleoporin NSP1-like C-terminal domain-containing protein; MASP, Mucin-associated surface protein; Mucin, TcMUCII; MAP, Microtubule-associated protein; CCP, Calpain-like cysteine peptidase; 60S, 40S, ribosomal subunit proteins). ( C ) Breadth of antibody reactivity, shown as the number of seroreactive peptides in each person. The dotted red line and number signify the median number of seroreactive peptides in BD and CBM specimen sets. Samples are grouped by geographic region (BD specimens) and heart disease stage (CBM specimens). ( D ) Number of peptides identified as seroreactive in this study that are part of proteins expressed in specific stages of the T. cruzi life cycle (Tryp = trypomastigote; Ama = amastigote; Meta = metacyclic trypomastigote; Epi = epimastigote; Multiple = protein is expressed in trypomastigote, amastigote, and/or metacyclic trypomastigote stages). Stage expression analysis shows seroreactive peptides in every host-interfacing lifecycle stage. Stage-specific expression is based on the ‘Life cycle proteome (Brazil)’ data set from TriTrypDB. Gene IDs for stage-specific proteins were mapped onto the gene IDs that corresponded to seroreactive peptides. ( E , F ) Selected known seroreactive antigens are captured by T. cruzi PhIP-seq. Neg. is seronegative specimens from the respective specimen sets; Pos. is seropositive specimens from the respective cohorts; NYBC is NYBC US controls. Antibody reactivity to two known antigens (E) Ag2, a nucleoporin protein, and (F) TCE, a 60S ribosomal subunit protein are plotted as reads per 100,000 (RPK). The dotted red line signifies the RPK that corresponds to a z-score cutoff of 5 in the seronegative population of each cohort.

Article Snippet: An anti- T. cruzi IgG BLI method was developed using a commercial T. cruzi Chimeric Chagas Multi-Antigen (MACH; Jena Biosciences).

Techniques: Biomarker Assay, Expressing

( A ) Anti-trans-sialidase peptide antibody reactivity is plotted as RPK. The dotted red line signifies the RPK that corresponds to a z-score cutoff of 5 in the seronegative population of each cohort. ( B ) Trans-sialidase reactivity orthogonal validation using a split-luciferase binding assay (SLBA). Reactivity was tested against four seropositive blood donor specimens and five seronegative US healthy control specimens. ( C ) Alanine-scanning mutagenesis in 10-aa windows (highlighted in red) across the entire trans-sialidase antigenic fragment demonstrates the seroreactive epitope in Chagas disease. Values are normalized antibody indices and represent the averages of five seropositive blood donor specimens.

Journal: medRxiv

Article Title: A Trypanosoma cruzi Trans-Sialidase Peptide Demonstrates High Serological Prevalence Among Infected Populations Across Endemic Regions of Latin America

doi: 10.1101/2025.01.22.25320967

Figure Lengend Snippet: ( A ) Anti-trans-sialidase peptide antibody reactivity is plotted as RPK. The dotted red line signifies the RPK that corresponds to a z-score cutoff of 5 in the seronegative population of each cohort. ( B ) Trans-sialidase reactivity orthogonal validation using a split-luciferase binding assay (SLBA). Reactivity was tested against four seropositive blood donor specimens and five seronegative US healthy control specimens. ( C ) Alanine-scanning mutagenesis in 10-aa windows (highlighted in red) across the entire trans-sialidase antigenic fragment demonstrates the seroreactive epitope in Chagas disease. Values are normalized antibody indices and represent the averages of five seropositive blood donor specimens.

Article Snippet: An anti- T. cruzi IgG BLI method was developed using a commercial T. cruzi Chimeric Chagas Multi-Antigen (MACH; Jena Biosciences).

Techniques: Luciferase, Binding Assay, Control, Mutagenesis

Recombinant antigens in current FDA-cleared serology tests include Ag 1, Ag 2, Ag 13, Ag 30, Ag 36 ( , ), shed acute phase antigen (SAPA) , KMP-11 , TcD and TcE ( , ). Note, TcD contains the same antigenic epitope as Ag 13. ( A ) Heatmap of z-score enrichment over seronegative controls in the seropositive blood donor (BD) specimens (n=64). Each antigen motif was derived using Multiple EM for Motif Elicitation (MEME) and then scored against the entire T. cruzi PhIP-seq proteome. The maximum z-score across all peptides with significant sequence matches to a given antigen motif was plotted for each sample and each antigen. ( B ) Percent of samples enriched ( z-score ≥5) for each antigen in BD and cardiac biomarker (CBM) specimen sets.

Journal: medRxiv

Article Title: A Trypanosoma cruzi Trans-Sialidase Peptide Demonstrates High Serological Prevalence Among Infected Populations Across Endemic Regions of Latin America

doi: 10.1101/2025.01.22.25320967

Figure Lengend Snippet: Recombinant antigens in current FDA-cleared serology tests include Ag 1, Ag 2, Ag 13, Ag 30, Ag 36 ( , ), shed acute phase antigen (SAPA) , KMP-11 , TcD and TcE ( , ). Note, TcD contains the same antigenic epitope as Ag 13. ( A ) Heatmap of z-score enrichment over seronegative controls in the seropositive blood donor (BD) specimens (n=64). Each antigen motif was derived using Multiple EM for Motif Elicitation (MEME) and then scored against the entire T. cruzi PhIP-seq proteome. The maximum z-score across all peptides with significant sequence matches to a given antigen motif was plotted for each sample and each antigen. ( B ) Percent of samples enriched ( z-score ≥5) for each antigen in BD and cardiac biomarker (CBM) specimen sets.

Article Snippet: An anti- T. cruzi IgG BLI method was developed using a commercial T. cruzi Chimeric Chagas Multi-Antigen (MACH; Jena Biosciences).

Techniques: Recombinant, Derivative Assay, Sequencing, Biomarker Assay