penta Search Results


β d glucose pentaacetate  (MedChemExpress)
93
MedChemExpress β d glucose pentaacetate
a a scheme for harnessing the dynamic thiol exchange to restore anticancer efficacy from albumin-bound gold. TGTA, thioglucose tetraacetate. Created in BioRender. Xiong, X. (2025) https://BioRender.com/zpgjm50 . b HPLC analysis at 214 nm on the thiol exchange reaction in vitro. 1 mM of auranofin was added to 1.0 mL of 4 mM solution of BSA and then reacted at 37 °C for 60 min in a shaker. 5 mM of TGTA (5 equivalents) was used. The peak of auranofin was marked by a dotted red line. c cellular gold uptake of HCT116 cells under indicated conditions of FBS for 1 h. 3 μM of auranofin was used in all groups with or without TGTA (50 μM). The values were normalized by the protein amount extracted. Data are shown as mean ± s. d. of three independent experiments. Significance was calculated by an unpaired, two-tailed t -test. Significance was defined as p < 0.05. d dose-dependent cytotoxicity boosting of auranofin by glucose homologs after 24-hour treatments. GPA, Glucose <t>pentaacetate.</t> e , measuring cellular thioredoxin reductase (TrxR) activity using HCT116 upon indicated treatments. HCT116 cells in RPMI + 30% FBS were incubated with 0.5 μM auranofin and/or 50 μM TGTA for 1 h before cell lysis for TrxR activity detection. For d , e , mean ± s. d., 3 biological replicates. f mouse models to evaluate the in vivo tumor suppression of auranofin. Drugs were injected intraperitoneally 6 times per week, and the initial administration day was marked by black arrows. An HCT116 xenograft and two patient-derived xenografts (non-small cell lung carcinoma and triple-negative breast cancer) were conducted. HCT116 tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 9 mice. NSCLC PDX tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 7 mice. TNBC PDX tumors: Vehicle, n = 9 mice; TGTA, n = 9 mice; AF, n = 8 mice; AF + TGTA, n = 8 mice. Data were shown as mean ± s. e. m. Source data are provided as a Source Data file.
β D Glucose Pentaacetate, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/penta/%CE%B2-D-Glucose+pentaacetate/pmc12335462-265-1-17
Average 93 stars, based on 1 article reviews
β d glucose pentaacetate - by Bioz Stars, 2026-09
93/100 stars
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anti his hrp antibody  (Bio-Rad)
93
Bio-Rad anti his hrp antibody
a a scheme for harnessing the dynamic thiol exchange to restore anticancer efficacy from albumin-bound gold. TGTA, thioglucose tetraacetate. Created in BioRender. Xiong, X. (2025) https://BioRender.com/zpgjm50 . b HPLC analysis at 214 nm on the thiol exchange reaction in vitro. 1 mM of auranofin was added to 1.0 mL of 4 mM solution of BSA and then reacted at 37 °C for 60 min in a shaker. 5 mM of TGTA (5 equivalents) was used. The peak of auranofin was marked by a dotted red line. c cellular gold uptake of HCT116 cells under indicated conditions of FBS for 1 h. 3 μM of auranofin was used in all groups with or without TGTA (50 μM). The values were normalized by the protein amount extracted. Data are shown as mean ± s. d. of three independent experiments. Significance was calculated by an unpaired, two-tailed t -test. Significance was defined as p < 0.05. d dose-dependent cytotoxicity boosting of auranofin by glucose homologs after 24-hour treatments. GPA, Glucose <t>pentaacetate.</t> e , measuring cellular thioredoxin reductase (TrxR) activity using HCT116 upon indicated treatments. HCT116 cells in RPMI + 30% FBS were incubated with 0.5 μM auranofin and/or 50 μM TGTA for 1 h before cell lysis for TrxR activity detection. For d , e , mean ± s. d., 3 biological replicates. f mouse models to evaluate the in vivo tumor suppression of auranofin. Drugs were injected intraperitoneally 6 times per week, and the initial administration day was marked by black arrows. An HCT116 xenograft and two patient-derived xenografts (non-small cell lung carcinoma and triple-negative breast cancer) were conducted. HCT116 tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 9 mice. NSCLC PDX tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 7 mice. TNBC PDX tumors: Vehicle, n = 9 mice; TGTA, n = 9 mice; AF, n = 8 mice; AF + TGTA, n = 8 mice. Data were shown as mean ± s. e. m. Source data are provided as a Source Data file.
Anti His Hrp Antibody, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/penta/Mouse+anti+Penta+Histidine+Tag/pmc12307814-268-14-17
Average 93 stars, based on 1 article reviews
anti his hrp antibody - by Bioz Stars, 2026-09
93/100 stars
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antibody anti penta his  (Qiagen)
97
Qiagen antibody anti penta his
a a scheme for harnessing the dynamic thiol exchange to restore anticancer efficacy from albumin-bound gold. TGTA, thioglucose tetraacetate. Created in BioRender. Xiong, X. (2025) https://BioRender.com/zpgjm50 . b HPLC analysis at 214 nm on the thiol exchange reaction in vitro. 1 mM of auranofin was added to 1.0 mL of 4 mM solution of BSA and then reacted at 37 °C for 60 min in a shaker. 5 mM of TGTA (5 equivalents) was used. The peak of auranofin was marked by a dotted red line. c cellular gold uptake of HCT116 cells under indicated conditions of FBS for 1 h. 3 μM of auranofin was used in all groups with or without TGTA (50 μM). The values were normalized by the protein amount extracted. Data are shown as mean ± s. d. of three independent experiments. Significance was calculated by an unpaired, two-tailed t -test. Significance was defined as p < 0.05. d dose-dependent cytotoxicity boosting of auranofin by glucose homologs after 24-hour treatments. GPA, Glucose <t>pentaacetate.</t> e , measuring cellular thioredoxin reductase (TrxR) activity using HCT116 upon indicated treatments. HCT116 cells in RPMI + 30% FBS were incubated with 0.5 μM auranofin and/or 50 μM TGTA for 1 h before cell lysis for TrxR activity detection. For d , e , mean ± s. d., 3 biological replicates. f mouse models to evaluate the in vivo tumor suppression of auranofin. Drugs were injected intraperitoneally 6 times per week, and the initial administration day was marked by black arrows. An HCT116 xenograft and two patient-derived xenografts (non-small cell lung carcinoma and triple-negative breast cancer) were conducted. HCT116 tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 9 mice. NSCLC PDX tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 7 mice. TNBC PDX tumors: Vehicle, n = 9 mice; TGTA, n = 9 mice; AF, n = 8 mice; AF + TGTA, n = 8 mice. Data were shown as mean ± s. e. m. Source data are provided as a Source Data file.
Antibody Anti Penta His, supplied by Qiagen, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/penta/Penta+His+Antibody%2C+BSA-free/10__1074_slash_jbc__m111__294843-68-11-13
Average 97 stars, based on 1 article reviews
antibody anti penta his - by Bioz Stars, 2026-09
97/100 stars
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pentahis hrp conjugated antibody  (Qiagen)
95
Qiagen pentahis hrp conjugated antibody
a a scheme for harnessing the dynamic thiol exchange to restore anticancer efficacy from albumin-bound gold. TGTA, thioglucose tetraacetate. Created in BioRender. Xiong, X. (2025) https://BioRender.com/zpgjm50 . b HPLC analysis at 214 nm on the thiol exchange reaction in vitro. 1 mM of auranofin was added to 1.0 mL of 4 mM solution of BSA and then reacted at 37 °C for 60 min in a shaker. 5 mM of TGTA (5 equivalents) was used. The peak of auranofin was marked by a dotted red line. c cellular gold uptake of HCT116 cells under indicated conditions of FBS for 1 h. 3 μM of auranofin was used in all groups with or without TGTA (50 μM). The values were normalized by the protein amount extracted. Data are shown as mean ± s. d. of three independent experiments. Significance was calculated by an unpaired, two-tailed t -test. Significance was defined as p < 0.05. d dose-dependent cytotoxicity boosting of auranofin by glucose homologs after 24-hour treatments. GPA, Glucose <t>pentaacetate.</t> e , measuring cellular thioredoxin reductase (TrxR) activity using HCT116 upon indicated treatments. HCT116 cells in RPMI + 30% FBS were incubated with 0.5 μM auranofin and/or 50 μM TGTA for 1 h before cell lysis for TrxR activity detection. For d , e , mean ± s. d., 3 biological replicates. f mouse models to evaluate the in vivo tumor suppression of auranofin. Drugs were injected intraperitoneally 6 times per week, and the initial administration day was marked by black arrows. An HCT116 xenograft and two patient-derived xenografts (non-small cell lung carcinoma and triple-negative breast cancer) were conducted. HCT116 tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 9 mice. NSCLC PDX tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 7 mice. TNBC PDX tumors: Vehicle, n = 9 mice; TGTA, n = 9 mice; AF, n = 8 mice; AF + TGTA, n = 8 mice. Data were shown as mean ± s. e. m. Source data are provided as a Source Data file.
Pentahis Hrp Conjugated Antibody, supplied by Qiagen, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/penta/Penta+His+HRP+Conjugate+Kit/pmc13054831-90-8-11
Average 95 stars, based on 1 article reviews
pentahis hrp conjugated antibody - by Bioz Stars, 2026-09
95/100 stars
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alexa fluor 488  (Qiagen)
95
Qiagen alexa fluor 488
a a scheme for harnessing the dynamic thiol exchange to restore anticancer efficacy from albumin-bound gold. TGTA, thioglucose tetraacetate. Created in BioRender. Xiong, X. (2025) https://BioRender.com/zpgjm50 . b HPLC analysis at 214 nm on the thiol exchange reaction in vitro. 1 mM of auranofin was added to 1.0 mL of 4 mM solution of BSA and then reacted at 37 °C for 60 min in a shaker. 5 mM of TGTA (5 equivalents) was used. The peak of auranofin was marked by a dotted red line. c cellular gold uptake of HCT116 cells under indicated conditions of FBS for 1 h. 3 μM of auranofin was used in all groups with or without TGTA (50 μM). The values were normalized by the protein amount extracted. Data are shown as mean ± s. d. of three independent experiments. Significance was calculated by an unpaired, two-tailed t -test. Significance was defined as p < 0.05. d dose-dependent cytotoxicity boosting of auranofin by glucose homologs after 24-hour treatments. GPA, Glucose <t>pentaacetate.</t> e , measuring cellular thioredoxin reductase (TrxR) activity using HCT116 upon indicated treatments. HCT116 cells in RPMI + 30% FBS were incubated with 0.5 μM auranofin and/or 50 μM TGTA for 1 h before cell lysis for TrxR activity detection. For d , e , mean ± s. d., 3 biological replicates. f mouse models to evaluate the in vivo tumor suppression of auranofin. Drugs were injected intraperitoneally 6 times per week, and the initial administration day was marked by black arrows. An HCT116 xenograft and two patient-derived xenografts (non-small cell lung carcinoma and triple-negative breast cancer) were conducted. HCT116 tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 9 mice. NSCLC PDX tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 7 mice. TNBC PDX tumors: Vehicle, n = 9 mice; TGTA, n = 9 mice; AF, n = 8 mice; AF + TGTA, n = 8 mice. Data were shown as mean ± s. e. m. Source data are provided as a Source Data file.
Alexa Fluor 488, supplied by Qiagen, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/penta/Penta+His+Alexa+Fluor+488+Conjugate/pmc01563570-167-1-4
Average 95 stars, based on 1 article reviews
alexa fluor 488 - by Bioz Stars, 2026-09
95/100 stars
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1 2 3 4 6 penta o galloyl b d glucose pgg  (Toronto Research Chemicals)
86
Toronto Research Chemicals 1 2 3 4 6 penta o galloyl b d glucose pgg
a a scheme for harnessing the dynamic thiol exchange to restore anticancer efficacy from albumin-bound gold. TGTA, thioglucose tetraacetate. Created in BioRender. Xiong, X. (2025) https://BioRender.com/zpgjm50 . b HPLC analysis at 214 nm on the thiol exchange reaction in vitro. 1 mM of auranofin was added to 1.0 mL of 4 mM solution of BSA and then reacted at 37 °C for 60 min in a shaker. 5 mM of TGTA (5 equivalents) was used. The peak of auranofin was marked by a dotted red line. c cellular gold uptake of HCT116 cells under indicated conditions of FBS for 1 h. 3 μM of auranofin was used in all groups with or without TGTA (50 μM). The values were normalized by the protein amount extracted. Data are shown as mean ± s. d. of three independent experiments. Significance was calculated by an unpaired, two-tailed t -test. Significance was defined as p < 0.05. d dose-dependent cytotoxicity boosting of auranofin by glucose homologs after 24-hour treatments. GPA, Glucose <t>pentaacetate.</t> e , measuring cellular thioredoxin reductase (TrxR) activity using HCT116 upon indicated treatments. HCT116 cells in RPMI + 30% FBS were incubated with 0.5 μM auranofin and/or 50 μM TGTA for 1 h before cell lysis for TrxR activity detection. For d , e , mean ± s. d., 3 biological replicates. f mouse models to evaluate the in vivo tumor suppression of auranofin. Drugs were injected intraperitoneally 6 times per week, and the initial administration day was marked by black arrows. An HCT116 xenograft and two patient-derived xenografts (non-small cell lung carcinoma and triple-negative breast cancer) were conducted. HCT116 tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 9 mice. NSCLC PDX tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 7 mice. TNBC PDX tumors: Vehicle, n = 9 mice; TGTA, n = 9 mice; AF, n = 8 mice; AF + TGTA, n = 8 mice. Data were shown as mean ± s. e. m. Source data are provided as a Source Data file.
1 2 3 4 6 Penta O Galloyl B D Glucose Pgg, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/penta/1%2C2%2C3%2C4%2C6-Penta-O-galloyl-b-D-glucopyranose/pm21048315-52-0-5
Average 86 stars, based on 1 article reviews
1 2 3 4 6 penta o galloyl b d glucose pgg - by Bioz Stars, 2026-09
86/100 stars
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sc 282  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology sc 282
a a scheme for harnessing the dynamic thiol exchange to restore anticancer efficacy from albumin-bound gold. TGTA, thioglucose tetraacetate. Created in BioRender. Xiong, X. (2025) https://BioRender.com/zpgjm50 . b HPLC analysis at 214 nm on the thiol exchange reaction in vitro. 1 mM of auranofin was added to 1.0 mL of 4 mM solution of BSA and then reacted at 37 °C for 60 min in a shaker. 5 mM of TGTA (5 equivalents) was used. The peak of auranofin was marked by a dotted red line. c cellular gold uptake of HCT116 cells under indicated conditions of FBS for 1 h. 3 μM of auranofin was used in all groups with or without TGTA (50 μM). The values were normalized by the protein amount extracted. Data are shown as mean ± s. d. of three independent experiments. Significance was calculated by an unpaired, two-tailed t -test. Significance was defined as p < 0.05. d dose-dependent cytotoxicity boosting of auranofin by glucose homologs after 24-hour treatments. GPA, Glucose <t>pentaacetate.</t> e , measuring cellular thioredoxin reductase (TrxR) activity using HCT116 upon indicated treatments. HCT116 cells in RPMI + 30% FBS were incubated with 0.5 μM auranofin and/or 50 μM TGTA for 1 h before cell lysis for TrxR activity detection. For d , e , mean ± s. d., 3 biological replicates. f mouse models to evaluate the in vivo tumor suppression of auranofin. Drugs were injected intraperitoneally 6 times per week, and the initial administration day was marked by black arrows. An HCT116 xenograft and two patient-derived xenografts (non-small cell lung carcinoma and triple-negative breast cancer) were conducted. HCT116 tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 9 mice. NSCLC PDX tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 7 mice. TNBC PDX tumors: Vehicle, n = 9 mice; TGTA, n = 9 mice; AF, n = 8 mice; AF + TGTA, n = 8 mice. Data were shown as mean ± s. e. m. Source data are provided as a Source Data file.
Sc 282, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/penta/1%2C2%2C3%2C4%2C6-Penta-O-acetyl-b-D-glucopyranose/pm27297670-78-37-38
Average 93 stars, based on 1 article reviews
sc 282 - by Bioz Stars, 2026-09
93/100 stars
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pgg  (MedChemExpress)
94
MedChemExpress pgg
a a scheme for harnessing the dynamic thiol exchange to restore anticancer efficacy from albumin-bound gold. TGTA, thioglucose tetraacetate. Created in BioRender. Xiong, X. (2025) https://BioRender.com/zpgjm50 . b HPLC analysis at 214 nm on the thiol exchange reaction in vitro. 1 mM of auranofin was added to 1.0 mL of 4 mM solution of BSA and then reacted at 37 °C for 60 min in a shaker. 5 mM of TGTA (5 equivalents) was used. The peak of auranofin was marked by a dotted red line. c cellular gold uptake of HCT116 cells under indicated conditions of FBS for 1 h. 3 μM of auranofin was used in all groups with or without TGTA (50 μM). The values were normalized by the protein amount extracted. Data are shown as mean ± s. d. of three independent experiments. Significance was calculated by an unpaired, two-tailed t -test. Significance was defined as p < 0.05. d dose-dependent cytotoxicity boosting of auranofin by glucose homologs after 24-hour treatments. GPA, Glucose <t>pentaacetate.</t> e , measuring cellular thioredoxin reductase (TrxR) activity using HCT116 upon indicated treatments. HCT116 cells in RPMI + 30% FBS were incubated with 0.5 μM auranofin and/or 50 μM TGTA for 1 h before cell lysis for TrxR activity detection. For d , e , mean ± s. d., 3 biological replicates. f mouse models to evaluate the in vivo tumor suppression of auranofin. Drugs were injected intraperitoneally 6 times per week, and the initial administration day was marked by black arrows. An HCT116 xenograft and two patient-derived xenografts (non-small cell lung carcinoma and triple-negative breast cancer) were conducted. HCT116 tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 9 mice. NSCLC PDX tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 7 mice. TNBC PDX tumors: Vehicle, n = 9 mice; TGTA, n = 9 mice; AF, n = 8 mice; AF + TGTA, n = 8 mice. Data were shown as mean ± s. e. m. Source data are provided as a Source Data file.
Pgg, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/penta/Pentagalloylglucose/pmc13088301-168-0-2
Average 94 stars, based on 1 article reviews
pgg - by Bioz Stars, 2026-09
94/100 stars
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1 2 3 4 6 penta o acetyl a d mannopyranose  (Biosynth Carbosynth)
90
Biosynth Carbosynth 1 2 3 4 6 penta o acetyl a d mannopyranose
a a scheme for harnessing the dynamic thiol exchange to restore anticancer efficacy from albumin-bound gold. TGTA, thioglucose tetraacetate. Created in BioRender. Xiong, X. (2025) https://BioRender.com/zpgjm50 . b HPLC analysis at 214 nm on the thiol exchange reaction in vitro. 1 mM of auranofin was added to 1.0 mL of 4 mM solution of BSA and then reacted at 37 °C for 60 min in a shaker. 5 mM of TGTA (5 equivalents) was used. The peak of auranofin was marked by a dotted red line. c cellular gold uptake of HCT116 cells under indicated conditions of FBS for 1 h. 3 μM of auranofin was used in all groups with or without TGTA (50 μM). The values were normalized by the protein amount extracted. Data are shown as mean ± s. d. of three independent experiments. Significance was calculated by an unpaired, two-tailed t -test. Significance was defined as p < 0.05. d dose-dependent cytotoxicity boosting of auranofin by glucose homologs after 24-hour treatments. GPA, Glucose <t>pentaacetate.</t> e , measuring cellular thioredoxin reductase (TrxR) activity using HCT116 upon indicated treatments. HCT116 cells in RPMI + 30% FBS were incubated with 0.5 μM auranofin and/or 50 μM TGTA for 1 h before cell lysis for TrxR activity detection. For d , e , mean ± s. d., 3 biological replicates. f mouse models to evaluate the in vivo tumor suppression of auranofin. Drugs were injected intraperitoneally 6 times per week, and the initial administration day was marked by black arrows. An HCT116 xenograft and two patient-derived xenografts (non-small cell lung carcinoma and triple-negative breast cancer) were conducted. HCT116 tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 9 mice. NSCLC PDX tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 7 mice. TNBC PDX tumors: Vehicle, n = 9 mice; TGTA, n = 9 mice; AF, n = 8 mice; AF + TGTA, n = 8 mice. Data were shown as mean ± s. e. m. Source data are provided as a Source Data file.
1 2 3 4 6 Penta O Acetyl A D Mannopyranose, supplied by Biosynth Carbosynth, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/penta/1%2C2%2C3%2C4%2C6-Penta-O-acetyl-a-D-mannopyranose/10__1002_slash_app__44947-58-3-5
Average 90 stars, based on 1 article reviews
1 2 3 4 6 penta o acetyl a d mannopyranose - by Bioz Stars, 2026-09
90/100 stars
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gapdh  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology gapdh
a a scheme for harnessing the dynamic thiol exchange to restore anticancer efficacy from albumin-bound gold. TGTA, thioglucose tetraacetate. Created in BioRender. Xiong, X. (2025) https://BioRender.com/zpgjm50 . b HPLC analysis at 214 nm on the thiol exchange reaction in vitro. 1 mM of auranofin was added to 1.0 mL of 4 mM solution of BSA and then reacted at 37 °C for 60 min in a shaker. 5 mM of TGTA (5 equivalents) was used. The peak of auranofin was marked by a dotted red line. c cellular gold uptake of HCT116 cells under indicated conditions of FBS for 1 h. 3 μM of auranofin was used in all groups with or without TGTA (50 μM). The values were normalized by the protein amount extracted. Data are shown as mean ± s. d. of three independent experiments. Significance was calculated by an unpaired, two-tailed t -test. Significance was defined as p < 0.05. d dose-dependent cytotoxicity boosting of auranofin by glucose homologs after 24-hour treatments. GPA, Glucose <t>pentaacetate.</t> e , measuring cellular thioredoxin reductase (TrxR) activity using HCT116 upon indicated treatments. HCT116 cells in RPMI + 30% FBS were incubated with 0.5 μM auranofin and/or 50 μM TGTA for 1 h before cell lysis for TrxR activity detection. For d , e , mean ± s. d., 3 biological replicates. f mouse models to evaluate the in vivo tumor suppression of auranofin. Drugs were injected intraperitoneally 6 times per week, and the initial administration day was marked by black arrows. An HCT116 xenograft and two patient-derived xenografts (non-small cell lung carcinoma and triple-negative breast cancer) were conducted. HCT116 tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 9 mice. NSCLC PDX tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 7 mice. TNBC PDX tumors: Vehicle, n = 9 mice; TGTA, n = 9 mice; AF, n = 8 mice; AF + TGTA, n = 8 mice. Data were shown as mean ± s. e. m. Source data are provided as a Source Data file.
Gapdh, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/penta/cis+Resveratrol+Penta-O-acetyl-4%E2%80%B2-%CE%B2-D-glucuronide+Methyl+Ester/pmc10518564-790-38-39
Average 93 stars, based on 1 article reviews
gapdh - by Bioz Stars, 2026-09
93/100 stars
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flipr tetra cellular screening system  (Danaher Inc)
94
Danaher Inc flipr tetra cellular screening system
a a scheme for harnessing the dynamic thiol exchange to restore anticancer efficacy from albumin-bound gold. TGTA, thioglucose tetraacetate. Created in BioRender. Xiong, X. (2025) https://BioRender.com/zpgjm50 . b HPLC analysis at 214 nm on the thiol exchange reaction in vitro. 1 mM of auranofin was added to 1.0 mL of 4 mM solution of BSA and then reacted at 37 °C for 60 min in a shaker. 5 mM of TGTA (5 equivalents) was used. The peak of auranofin was marked by a dotted red line. c cellular gold uptake of HCT116 cells under indicated conditions of FBS for 1 h. 3 μM of auranofin was used in all groups with or without TGTA (50 μM). The values were normalized by the protein amount extracted. Data are shown as mean ± s. d. of three independent experiments. Significance was calculated by an unpaired, two-tailed t -test. Significance was defined as p < 0.05. d dose-dependent cytotoxicity boosting of auranofin by glucose homologs after 24-hour treatments. GPA, Glucose <t>pentaacetate.</t> e , measuring cellular thioredoxin reductase (TrxR) activity using HCT116 upon indicated treatments. HCT116 cells in RPMI + 30% FBS were incubated with 0.5 μM auranofin and/or 50 μM TGTA for 1 h before cell lysis for TrxR activity detection. For d , e , mean ± s. d., 3 biological replicates. f mouse models to evaluate the in vivo tumor suppression of auranofin. Drugs were injected intraperitoneally 6 times per week, and the initial administration day was marked by black arrows. An HCT116 xenograft and two patient-derived xenografts (non-small cell lung carcinoma and triple-negative breast cancer) were conducted. HCT116 tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 9 mice. NSCLC PDX tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 7 mice. TNBC PDX tumors: Vehicle, n = 9 mice; TGTA, n = 9 mice; AF, n = 8 mice; AF + TGTA, n = 8 mice. Data were shown as mean ± s. e. m. Source data are provided as a Source Data file.
Flipr Tetra Cellular Screening System, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/penta/FLIPR+Penta+High-Throughput+Cellular+Screening+System/pmc06231908-95-35-45
Average 94 stars, based on 1 article reviews
flipr tetra cellular screening system - by Bioz Stars, 2026-09
94/100 stars
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penta o benzoyl  (BOC Sciences)
93
BOC Sciences penta o benzoyl
a a scheme for harnessing the dynamic thiol exchange to restore anticancer efficacy from albumin-bound gold. TGTA, thioglucose tetraacetate. Created in BioRender. Xiong, X. (2025) https://BioRender.com/zpgjm50 . b HPLC analysis at 214 nm on the thiol exchange reaction in vitro. 1 mM of auranofin was added to 1.0 mL of 4 mM solution of BSA and then reacted at 37 °C for 60 min in a shaker. 5 mM of TGTA (5 equivalents) was used. The peak of auranofin was marked by a dotted red line. c cellular gold uptake of HCT116 cells under indicated conditions of FBS for 1 h. 3 μM of auranofin was used in all groups with or without TGTA (50 μM). The values were normalized by the protein amount extracted. Data are shown as mean ± s. d. of three independent experiments. Significance was calculated by an unpaired, two-tailed t -test. Significance was defined as p < 0.05. d dose-dependent cytotoxicity boosting of auranofin by glucose homologs after 24-hour treatments. GPA, Glucose <t>pentaacetate.</t> e , measuring cellular thioredoxin reductase (TrxR) activity using HCT116 upon indicated treatments. HCT116 cells in RPMI + 30% FBS were incubated with 0.5 μM auranofin and/or 50 μM TGTA for 1 h before cell lysis for TrxR activity detection. For d , e , mean ± s. d., 3 biological replicates. f mouse models to evaluate the in vivo tumor suppression of auranofin. Drugs were injected intraperitoneally 6 times per week, and the initial administration day was marked by black arrows. An HCT116 xenograft and two patient-derived xenografts (non-small cell lung carcinoma and triple-negative breast cancer) were conducted. HCT116 tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 9 mice. NSCLC PDX tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 7 mice. TNBC PDX tumors: Vehicle, n = 9 mice; TGTA, n = 9 mice; AF, n = 8 mice; AF + TGTA, n = 8 mice. Data were shown as mean ± s. e. m. Source data are provided as a Source Data file.
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a a scheme for harnessing the dynamic thiol exchange to restore anticancer efficacy from albumin-bound gold. TGTA, thioglucose tetraacetate. Created in BioRender. Xiong, X. (2025) https://BioRender.com/zpgjm50 . b HPLC analysis at 214 nm on the thiol exchange reaction in vitro. 1 mM of auranofin was added to 1.0 mL of 4 mM solution of BSA and then reacted at 37 °C for 60 min in a shaker. 5 mM of TGTA (5 equivalents) was used. The peak of auranofin was marked by a dotted red line. c cellular gold uptake of HCT116 cells under indicated conditions of FBS for 1 h. 3 μM of auranofin was used in all groups with or without TGTA (50 μM). The values were normalized by the protein amount extracted. Data are shown as mean ± s. d. of three independent experiments. Significance was calculated by an unpaired, two-tailed t -test. Significance was defined as p < 0.05. d dose-dependent cytotoxicity boosting of auranofin by glucose homologs after 24-hour treatments. GPA, Glucose pentaacetate. e , measuring cellular thioredoxin reductase (TrxR) activity using HCT116 upon indicated treatments. HCT116 cells in RPMI + 30% FBS were incubated with 0.5 μM auranofin and/or 50 μM TGTA for 1 h before cell lysis for TrxR activity detection. For d , e , mean ± s. d., 3 biological replicates. f mouse models to evaluate the in vivo tumor suppression of auranofin. Drugs were injected intraperitoneally 6 times per week, and the initial administration day was marked by black arrows. An HCT116 xenograft and two patient-derived xenografts (non-small cell lung carcinoma and triple-negative breast cancer) were conducted. HCT116 tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 9 mice. NSCLC PDX tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 7 mice. TNBC PDX tumors: Vehicle, n = 9 mice; TGTA, n = 9 mice; AF, n = 8 mice; AF + TGTA, n = 8 mice. Data were shown as mean ± s. e. m. Source data are provided as a Source Data file.

Journal: Nature Communications

Article Title: Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation

doi: 10.1038/s41467-025-62634-9

Figure Lengend Snippet: a a scheme for harnessing the dynamic thiol exchange to restore anticancer efficacy from albumin-bound gold. TGTA, thioglucose tetraacetate. Created in BioRender. Xiong, X. (2025) https://BioRender.com/zpgjm50 . b HPLC analysis at 214 nm on the thiol exchange reaction in vitro. 1 mM of auranofin was added to 1.0 mL of 4 mM solution of BSA and then reacted at 37 °C for 60 min in a shaker. 5 mM of TGTA (5 equivalents) was used. The peak of auranofin was marked by a dotted red line. c cellular gold uptake of HCT116 cells under indicated conditions of FBS for 1 h. 3 μM of auranofin was used in all groups with or without TGTA (50 μM). The values were normalized by the protein amount extracted. Data are shown as mean ± s. d. of three independent experiments. Significance was calculated by an unpaired, two-tailed t -test. Significance was defined as p < 0.05. d dose-dependent cytotoxicity boosting of auranofin by glucose homologs after 24-hour treatments. GPA, Glucose pentaacetate. e , measuring cellular thioredoxin reductase (TrxR) activity using HCT116 upon indicated treatments. HCT116 cells in RPMI + 30% FBS were incubated with 0.5 μM auranofin and/or 50 μM TGTA for 1 h before cell lysis for TrxR activity detection. For d , e , mean ± s. d., 3 biological replicates. f mouse models to evaluate the in vivo tumor suppression of auranofin. Drugs were injected intraperitoneally 6 times per week, and the initial administration day was marked by black arrows. An HCT116 xenograft and two patient-derived xenografts (non-small cell lung carcinoma and triple-negative breast cancer) were conducted. HCT116 tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 9 mice. NSCLC PDX tumors: Vehicle, n = 7 mice; TGTA, n = 6 mice; AF, n = 6 mice; AF + TGTA, n = 7 mice. TNBC PDX tumors: Vehicle, n = 9 mice; TGTA, n = 9 mice; AF, n = 8 mice; AF + TGTA, n = 8 mice. Data were shown as mean ± s. e. m. Source data are provided as a Source Data file.

Article Snippet: Disulfiram, β-D-glucose pentaacetate, coenzyme A, lipoic acid, dihydrolipoic acid, oltipraz, pyrithioxin dihydrochloride, and cisplatin were purchased from MedChemExpress.

Techniques: In Vitro, Two Tailed Test, Activity Assay, Incubation, Lysis, In Vivo, Injection, Derivative Assay