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Selleck Chemicals
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Amcor Flexibles
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Biosynth Carbosynth
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Kyfora Bio
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Johnson & Johnson
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AstraZeneca ltd
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BASF
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Chemdyes Corporation
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Molecular Dimensions LTD
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Chemie GmbH
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Image Search Results
Journal: PLoS ONE
Article Title: In Situ Mass Spectrometry Imaging and Ex Vivo Characterization of Renal Crystalline Deposits Induced in Multiple Preclinical Drug Toxicology Studies
doi: 10.1371/journal.pone.0047353
Figure Lengend Snippet: A) Total ion chromatogram of kidney extract from the LC-MS analysis of vehicle control (upper) and animal dosed with compound 1 (low crystal load) (lower), run on an HILIC column. B) Mass spectrum from the peak marked in red on panel A, showing a PEG distribution with m/z 44 distance between peaks. C) The distribution of PEG on the tissue is represented by the ion distribution image of m/z 437. This distribution pattern is overlaid on the tissue sections from (i) vehicle control, (ii) animal dosed with compound 1 (low crystal load), (iii) animal dosed with compound 1 (high crystal load), and (iv) animal dosed with compound 2 (not formulated in PEG400). The MSI samples were coated with CHCA and analyzed in positive mode on the UltraFlex II. The data was normalized by total ion count.
Article Snippet: The drugs (compound 1; 4-(phenylethynyl)-N-[(2-sulfamoylphenyl)sulfonyl]benzamide; compound 2; 4-(cyclobutylethynyl)-N-[(2-sulfamoylphenyl)sulfonyl] benzamide; ), bisulphonamide ,
Techniques: Liquid Chromatography with Mass Spectroscopy, Control, Hydrophilic Interaction Liquid Chromatography