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Miltenyi Biotec
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Biogems International
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ReproCELL
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FUJIFILM
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STEMCELL Technologies Inc
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ChemScene llc
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Image Search Results
Journal: Oncotarget
Article Title: The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: resistance reversal with WNT inhibitor
doi:
Figure Lengend Snippet: (A) MDA-MB-231 and MCF7 cells were treated with GDC-0941 combined with LGK974. The doses we used for GDC-0941 were 0.8 μM, 1.6 μM and 3.2 μM, and the doses for LGK974 were 0.75 μM, 1.5 μM and 3 μM, respectively. After incubation for 72 hr, proliferation assays were performed, and the synergistic effect was analyzed using CalcuSyn software (Biosoft). The combination index (CI) theorem defined the resulting calculation as an addictive effect, CI=1; synergism, CI<1 or antagonism, CI>1. (B) Schematic model for the potential pathways involved in the effects of GDC-0941 on MDA-MB-231 and HCC1937 cells.
Article Snippet: The compounds used in this study were purchased from the following vendors: Wortmannin (Sigma-Aldrich, St. Louis, MO), GDC-0941 (LC Laboratories, Woburn, MA), Perifosine (LC Laboratories, Woburn, MA), Everolimus (Sigma-Aldrich, St. Louis, MO), NVP-BEZ235 (LC Laboratories, Woburn, MA), BKM120 (Chemie Tek, Indianapolis, IN), XL147 (Chemie Tek, Indianapolis, IN),
Techniques: Incubation, Software