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DILIsym Services Inc pbpk submodels
List of parameters varied in the SimPops™ and results of multiple‐regression analysis in SimPops™ administered tolcapone (200 mg t.i.d. for 1 week)
Pbpk Submodels, supplied by DILIsym Services Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pbpk+submodels/pmc04728295-150-4-15?v=DILIsym+Services+Inc
Average 90 stars, based on 1 article reviews
pbpk submodels - by Bioz Stars, 2026-08
90/100 stars
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List of parameters varied in the SimPops™ and results of multiple‐regression analysis in SimPops™ administered tolcapone (200 mg t.i.d. for 1 week)

Journal: CPT: Pharmacometrics & Systems Pharmacology

Article Title: Elucidating Differences in the Hepatotoxic Potential of Tolcapone and Entacapone With DILIsym ® , a Mechanistic Model of Drug‐Induced Liver Injury

doi: 10.1002/psp4.12053

Figure Lengend Snippet: List of parameters varied in the SimPops™ and results of multiple‐regression analysis in SimPops™ administered tolcapone (200 mg t.i.d. for 1 week)

Article Snippet: Via the use of PBPK submodels developed to describe the disposition of tolcapone and entacapone, DILIsym ® predicted lower hepatic exposure for entacapone than for tolcapone for clinically relevant dosing regimens of each compound.

Techniques: