pai 1 Search Results


recombinant rat pai 1  (Innovative Research Inc)
90
Innovative Research Inc recombinant rat pai 1
Recombinant Rat Pai 1, supplied by Innovative Research Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hg10296 acg beijing  (Sino Biological)
90
Sino Biological hg10296 acg beijing
Hg10296 Acg Beijing, supplied by Sino Biological, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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active pai 1  (Innovative Research Inc)
93
Innovative Research Inc active pai 1
Plasma levels of cFGF23 (black filled bars) and iFGF23 (gray filled bars) were measured in WT, untreated, and TM5441-treated Pai-1stab mice ( A ) and in WT, kl/kl , TM5441-treated kl/kl , and kl/klpai-1 −/− mice ( B ). As seen in (A), changes in cFGF23 levels due <t>to</t> <t>PAI-1</t> overexpression and TM5441 treatment were both significant in Pai-1stab mice. Similarly, TM5441 treatment <t>and</t> <t>PAI-1</t> deficiency significantly reduced cFGF23 and iFGF23 levels in kl/kl mice. # P = 0.0003, $ P = 0.0001 versus kl/kl cFGF23; * P = 0.03, ** P = 0.001 versus kl/kl iFGF23. Analysis of the measurements by one-way analysis of variance (ANOVA) yielded significant differences ( P < 0.0001) for both Pai-1stab and kl/kl mice groups.
Active Pai 1, supplied by Innovative Research Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/active pai 1/product/Innovative Research Inc
Average 93 stars, based on 1 article reviews
active pai 1 - by Bioz Stars, 2026-02
93/100 stars
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recombinant active monkey pai 1  (Innovative Research Inc)
90
Innovative Research Inc recombinant active monkey pai 1
Plasma levels of cFGF23 (black filled bars) and iFGF23 (gray filled bars) were measured in WT, untreated, and TM5441-treated Pai-1stab mice ( A ) and in WT, kl/kl , TM5441-treated kl/kl , and kl/klpai-1 −/− mice ( B ). As seen in (A), changes in cFGF23 levels due <t>to</t> <t>PAI-1</t> overexpression and TM5441 treatment were both significant in Pai-1stab mice. Similarly, TM5441 treatment <t>and</t> <t>PAI-1</t> deficiency significantly reduced cFGF23 and iFGF23 levels in kl/kl mice. # P = 0.0003, $ P = 0.0001 versus kl/kl cFGF23; * P = 0.03, ** P = 0.001 versus kl/kl iFGF23. Analysis of the measurements by one-way analysis of variance (ANOVA) yielded significant differences ( P < 0.0001) for both Pai-1stab and kl/kl mice groups.
Recombinant Active Monkey Pai 1, supplied by Innovative Research Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/recombinant active monkey pai 1/product/Innovative Research Inc
Average 90 stars, based on 1 article reviews
recombinant active monkey pai 1 - by Bioz Stars, 2026-02
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human pai 1  (Innovative Research Inc)
92
Innovative Research Inc human pai 1
Plasma levels of cFGF23 (black filled bars) and iFGF23 (gray filled bars) were measured in WT, untreated, and TM5441-treated Pai-1stab mice ( A ) and in WT, kl/kl , TM5441-treated kl/kl , and kl/klpai-1 −/− mice ( B ). As seen in (A), changes in cFGF23 levels due <t>to</t> <t>PAI-1</t> overexpression and TM5441 treatment were both significant in Pai-1stab mice. Similarly, TM5441 treatment <t>and</t> <t>PAI-1</t> deficiency significantly reduced cFGF23 and iFGF23 levels in kl/kl mice. # P = 0.0003, $ P = 0.0001 versus kl/kl cFGF23; * P = 0.03, ** P = 0.001 versus kl/kl iFGF23. Analysis of the measurements by one-way analysis of variance (ANOVA) yielded significant differences ( P < 0.0001) for both Pai-1stab and kl/kl mice groups.
Human Pai 1, supplied by Innovative Research Inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/human pai 1/product/Innovative Research Inc
Average 92 stars, based on 1 article reviews
human pai 1 - by Bioz Stars, 2026-02
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rat pai 1 elisa kit  (Innovative Research Inc)
92
Innovative Research Inc rat pai 1 elisa kit
Plasma levels of cFGF23 (black filled bars) and iFGF23 (gray filled bars) were measured in WT, untreated, and TM5441-treated Pai-1stab mice ( A ) and in WT, kl/kl , TM5441-treated kl/kl , and kl/klpai-1 −/− mice ( B ). As seen in (A), changes in cFGF23 levels due <t>to</t> <t>PAI-1</t> overexpression and TM5441 treatment were both significant in Pai-1stab mice. Similarly, TM5441 treatment <t>and</t> <t>PAI-1</t> deficiency significantly reduced cFGF23 and iFGF23 levels in kl/kl mice. # P = 0.0003, $ P = 0.0001 versus kl/kl cFGF23; * P = 0.03, ** P = 0.001 versus kl/kl iFGF23. Analysis of the measurements by one-way analysis of variance (ANOVA) yielded significant differences ( P < 0.0001) for both Pai-1stab and kl/kl mice groups.
Rat Pai 1 Elisa Kit, supplied by Innovative Research Inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 92 stars, based on 1 article reviews
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plasminogen activator inhibitor pai 1  (Innovative Research Inc)
94
Innovative Research Inc plasminogen activator inhibitor pai 1
Plasma levels of cFGF23 (black filled bars) and iFGF23 (gray filled bars) were measured in WT, untreated, and TM5441-treated Pai-1stab mice ( A ) and in WT, kl/kl , TM5441-treated kl/kl , and kl/klpai-1 −/− mice ( B ). As seen in (A), changes in cFGF23 levels due <t>to</t> <t>PAI-1</t> overexpression and TM5441 treatment were both significant in Pai-1stab mice. Similarly, TM5441 treatment <t>and</t> <t>PAI-1</t> deficiency significantly reduced cFGF23 and iFGF23 levels in kl/kl mice. # P = 0.0003, $ P = 0.0001 versus kl/kl cFGF23; * P = 0.03, ** P = 0.001 versus kl/kl iFGF23. Analysis of the measurements by one-way analysis of variance (ANOVA) yielded significant differences ( P < 0.0001) for both Pai-1stab and kl/kl mice groups.
Plasminogen Activator Inhibitor Pai 1, supplied by Innovative Research Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human upa  (Innovative Research Inc)
90
Innovative Research Inc human upa
Plasma levels of cFGF23 (black filled bars) and iFGF23 (gray filled bars) were measured in WT, untreated, and TM5441-treated Pai-1stab mice ( A ) and in WT, kl/kl , TM5441-treated kl/kl , and kl/klpai-1 −/− mice ( B ). As seen in (A), changes in cFGF23 levels due <t>to</t> <t>PAI-1</t> overexpression and TM5441 treatment were both significant in Pai-1stab mice. Similarly, TM5441 treatment <t>and</t> <t>PAI-1</t> deficiency significantly reduced cFGF23 and iFGF23 levels in kl/kl mice. # P = 0.0003, $ P = 0.0001 versus kl/kl cFGF23; * P = 0.03, ** P = 0.001 versus kl/kl iFGF23. Analysis of the measurements by one-way analysis of variance (ANOVA) yielded significant differences ( P < 0.0001) for both Pai-1stab and kl/kl mice groups.
Human Upa, supplied by Innovative Research Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/human upa/product/Innovative Research Inc
Average 90 stars, based on 1 article reviews
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pai 1 sirna  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology pai 1 sirna
Plasma levels of cFGF23 (black filled bars) and iFGF23 (gray filled bars) were measured in WT, untreated, and TM5441-treated Pai-1stab mice ( A ) and in WT, kl/kl , TM5441-treated kl/kl , and kl/klpai-1 −/− mice ( B ). As seen in (A), changes in cFGF23 levels due <t>to</t> <t>PAI-1</t> overexpression and TM5441 treatment were both significant in Pai-1stab mice. Similarly, TM5441 treatment <t>and</t> <t>PAI-1</t> deficiency significantly reduced cFGF23 and iFGF23 levels in kl/kl mice. # P = 0.0003, $ P = 0.0001 versus kl/kl cFGF23; * P = 0.03, ** P = 0.001 versus kl/kl iFGF23. Analysis of the measurements by one-way analysis of variance (ANOVA) yielded significant differences ( P < 0.0001) for both Pai-1stab and kl/kl mice groups.
Pai 1 Sirna, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
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dy 1786 kit  (R&D Systems)
93
R&D Systems dy 1786 kit
Plasma levels of cFGF23 (black filled bars) and iFGF23 (gray filled bars) were measured in WT, untreated, and TM5441-treated Pai-1stab mice ( A ) and in WT, kl/kl , TM5441-treated kl/kl , and kl/klpai-1 −/− mice ( B ). As seen in (A), changes in cFGF23 levels due <t>to</t> <t>PAI-1</t> overexpression and TM5441 treatment were both significant in Pai-1stab mice. Similarly, TM5441 treatment <t>and</t> <t>PAI-1</t> deficiency significantly reduced cFGF23 and iFGF23 levels in kl/kl mice. # P = 0.0003, $ P = 0.0001 versus kl/kl cFGF23; * P = 0.03, ** P = 0.001 versus kl/kl iFGF23. Analysis of the measurements by one-way analysis of variance (ANOVA) yielded significant differences ( P < 0.0001) for both Pai-1stab and kl/kl mice groups.
Dy 1786 Kit, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
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plasminogen activator inhibitor 1 pai 1  (Cusabio)
93
Cusabio plasminogen activator inhibitor 1 pai 1
Plasma levels of cFGF23 (black filled bars) and iFGF23 (gray filled bars) were measured in WT, untreated, and TM5441-treated Pai-1stab mice ( A ) and in WT, kl/kl , TM5441-treated kl/kl , and kl/klpai-1 −/− mice ( B ). As seen in (A), changes in cFGF23 levels due <t>to</t> <t>PAI-1</t> overexpression and TM5441 treatment were both significant in Pai-1stab mice. Similarly, TM5441 treatment <t>and</t> <t>PAI-1</t> deficiency significantly reduced cFGF23 and iFGF23 levels in kl/kl mice. # P = 0.0003, $ P = 0.0001 versus kl/kl cFGF23; * P = 0.03, ** P = 0.001 versus kl/kl iFGF23. Analysis of the measurements by one-way analysis of variance (ANOVA) yielded significant differences ( P < 0.0001) for both Pai-1stab and kl/kl mice groups.
Plasminogen Activator Inhibitor 1 Pai 1, supplied by Cusabio, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Plasma levels of cFGF23 (black filled bars) and iFGF23 (gray filled bars) were measured in WT, untreated, and TM5441-treated Pai-1stab mice ( A ) and in WT, kl/kl , TM5441-treated kl/kl , and kl/klpai-1 −/− mice ( B ). As seen in (A), changes in cFGF23 levels due to PAI-1 overexpression and TM5441 treatment were both significant in Pai-1stab mice. Similarly, TM5441 treatment and PAI-1 deficiency significantly reduced cFGF23 and iFGF23 levels in kl/kl mice. # P = 0.0003, $ P = 0.0001 versus kl/kl cFGF23; * P = 0.03, ** P = 0.001 versus kl/kl iFGF23. Analysis of the measurements by one-way analysis of variance (ANOVA) yielded significant differences ( P < 0.0001) for both Pai-1stab and kl/kl mice groups.

Journal: Science Advances

Article Title: PAI-1 is a critical regulator of FGF23 homeostasis

doi: 10.1126/sciadv.1603259

Figure Lengend Snippet: Plasma levels of cFGF23 (black filled bars) and iFGF23 (gray filled bars) were measured in WT, untreated, and TM5441-treated Pai-1stab mice ( A ) and in WT, kl/kl , TM5441-treated kl/kl , and kl/klpai-1 −/− mice ( B ). As seen in (A), changes in cFGF23 levels due to PAI-1 overexpression and TM5441 treatment were both significant in Pai-1stab mice. Similarly, TM5441 treatment and PAI-1 deficiency significantly reduced cFGF23 and iFGF23 levels in kl/kl mice. # P = 0.0003, $ P = 0.0001 versus kl/kl cFGF23; * P = 0.03, ** P = 0.001 versus kl/kl iFGF23. Analysis of the measurements by one-way analysis of variance (ANOVA) yielded significant differences ( P < 0.0001) for both Pai-1stab and kl/kl mice groups.

Article Snippet: Purified recombinant human two-chain tPA (catalog no. HTPA-TC), uPA (catalog no. UPA-LMW), and active PAI-1 (catalog no. CPAI) were obtained from Molecular Innovations.

Techniques: Over Expression

( A ) AKI induces plasma PAI-1 levels 10-fold higher in FA-treated WT mice ( n = 13) compared to vehicle-treated WT mice ( n = 5). ( B ) Mouse iFGF23 (miFGF23) levels in WT ( n = 7), WT with AKI ( n = 21), TM5441-treated WT with AKI ( n = 15), PAI-1 −/− with AKI ( n = 9), and pai-1 −/− untreated ( n = 6). * P = 0.007, # P = 0.005. ( C ) Effect of PAI-1 inhibition on clearance of rhFGF23 in WT AKI mice ( n = 7) and TM5441 (10 mg/kg per day)–treated WT AKI mice ( n = 7). The rhFGF23 was injected into the tail vein, and human cFGF23 (hcFGF23) levels were measured in plasma samples collected at time points 1, 3, 5, 15, 30, 60, and 120 min. ( D ) The cFGF23 levels at 1 min were considered as 100% to plot percent remaining values of rhFGF23 over the time course of the experiment.

Journal: Science Advances

Article Title: PAI-1 is a critical regulator of FGF23 homeostasis

doi: 10.1126/sciadv.1603259

Figure Lengend Snippet: ( A ) AKI induces plasma PAI-1 levels 10-fold higher in FA-treated WT mice ( n = 13) compared to vehicle-treated WT mice ( n = 5). ( B ) Mouse iFGF23 (miFGF23) levels in WT ( n = 7), WT with AKI ( n = 21), TM5441-treated WT with AKI ( n = 15), PAI-1 −/− with AKI ( n = 9), and pai-1 −/− untreated ( n = 6). * P = 0.007, # P = 0.005. ( C ) Effect of PAI-1 inhibition on clearance of rhFGF23 in WT AKI mice ( n = 7) and TM5441 (10 mg/kg per day)–treated WT AKI mice ( n = 7). The rhFGF23 was injected into the tail vein, and human cFGF23 (hcFGF23) levels were measured in plasma samples collected at time points 1, 3, 5, 15, 30, 60, and 120 min. ( D ) The cFGF23 levels at 1 min were considered as 100% to plot percent remaining values of rhFGF23 over the time course of the experiment.

Article Snippet: Purified recombinant human two-chain tPA (catalog no. HTPA-TC), uPA (catalog no. UPA-LMW), and active PAI-1 (catalog no. CPAI) were obtained from Molecular Innovations.

Techniques: Inhibition, Injection

TM5441 treatment or PAI-1 deficiency did not affect the increased serum phosphate levels ( # P < 0.05 versus WT) ( A ) and elevated plasma levels of PTH (* P < 0.01 versus WT) ( B ) in kl/kl and FA-treated WT and pai-1 −/− mice. mPTH, mouse PTH.

Journal: Science Advances

Article Title: PAI-1 is a critical regulator of FGF23 homeostasis

doi: 10.1126/sciadv.1603259

Figure Lengend Snippet: TM5441 treatment or PAI-1 deficiency did not affect the increased serum phosphate levels ( # P < 0.05 versus WT) ( A ) and elevated plasma levels of PTH (* P < 0.01 versus WT) ( B ) in kl/kl and FA-treated WT and pai-1 −/− mice. mPTH, mouse PTH.

Article Snippet: Purified recombinant human two-chain tPA (catalog no. HTPA-TC), uPA (catalog no. UPA-LMW), and active PAI-1 (catalog no. CPAI) were obtained from Molecular Innovations.

Techniques:

( A ) Silver-stained SDS-PAGE gel of reactions containing purified recombinant human tPA, PAI-1, and FGF23 with and without the PAI-1 antagonist TM5441. ( B ) Model depicting that inhibition of PAI-1 leads to restoration of PA- and furin-mediated FGF23 proteolysis.

Journal: Science Advances

Article Title: PAI-1 is a critical regulator of FGF23 homeostasis

doi: 10.1126/sciadv.1603259

Figure Lengend Snippet: ( A ) Silver-stained SDS-PAGE gel of reactions containing purified recombinant human tPA, PAI-1, and FGF23 with and without the PAI-1 antagonist TM5441. ( B ) Model depicting that inhibition of PAI-1 leads to restoration of PA- and furin-mediated FGF23 proteolysis.

Article Snippet: Purified recombinant human two-chain tPA (catalog no. HTPA-TC), uPA (catalog no. UPA-LMW), and active PAI-1 (catalog no. CPAI) were obtained from Molecular Innovations.

Techniques: Staining, SDS Page, Purification, Recombinant, Inhibition