p6 Search Results


  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 85
    ATCC b stearothermophilus pv72 p6
    B Stearothermophilus Pv72 P6, supplied by ATCC, used in various techniques. Bioz Stars score: 85/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/b stearothermophilus pv72 p6/product/ATCC
    Average 85 stars, based on 11 article reviews
    Price from $9.99 to $1999.99
    b stearothermophilus pv72 p6 - by Bioz Stars, 2020-11
    85/100 stars
      Buy from Supplier

    94
    Thermo Fisher calpain 1
    Increased mt ROS and impaired mitochondrial function result in increased calpain‐2, cleaved caspase‐3, and MMP 2 levels in VSMC from middle‐aged Sod2 +/− mice. A, Western blot analysis and densitometric quantification of <t>calpain‐1</t> and calpain‐2 expression in VSMC treated with 100 ng/mL TNF α and 200 ng/mL IFN γ (mean± SEM , n=4). B, Western blot analysis and densitometric quantification of calpain‐2 and cleaved caspase‐3 levels in VSMC treated with TNF α+ IFN γ and nontargeting control or Capn2 si RNA (mean± SEM , n=4). C, Western blot analysis and densitometric quantification of MMP 2 and phospho‐H2 AX levels in VSMC treated with TNF α+ IFN γ and 100 μmol/L PD 150606 (mean± SEM , n=4). N represents a number of independent experiments. * P
    Calpain 1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 158 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/calpain 1/product/Thermo Fisher
    Average 94 stars, based on 158 article reviews
    Price from $9.99 to $1999.99
    calpain 1 - by Bioz Stars, 2020-11
    94/100 stars
      Buy from Supplier

    90
    Pacific Biosciences p6 c4 chemistry
    Increased mt ROS and impaired mitochondrial function result in increased calpain‐2, cleaved caspase‐3, and MMP 2 levels in VSMC from middle‐aged Sod2 +/− mice. A, Western blot analysis and densitometric quantification of <t>calpain‐1</t> and calpain‐2 expression in VSMC treated with 100 ng/mL TNF α and 200 ng/mL IFN γ (mean± SEM , n=4). B, Western blot analysis and densitometric quantification of calpain‐2 and cleaved caspase‐3 levels in VSMC treated with TNF α+ IFN γ and nontargeting control or Capn2 si RNA (mean± SEM , n=4). C, Western blot analysis and densitometric quantification of MMP 2 and phospho‐H2 AX levels in VSMC treated with TNF α+ IFN γ and 100 μmol/L PD 150606 (mean± SEM , n=4). N represents a number of independent experiments. * P
    P6 C4 Chemistry, supplied by Pacific Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 648 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/p6 c4 chemistry/product/Pacific Biosciences
    Average 90 stars, based on 648 article reviews
    Price from $9.99 to $1999.99
    p6 c4 chemistry - by Bioz Stars, 2020-11
    90/100 stars
      Buy from Supplier

    90
    Pacific Biosciences dna polymerase binding kit p6
    Increased mt ROS and impaired mitochondrial function result in increased calpain‐2, cleaved caspase‐3, and MMP 2 levels in VSMC from middle‐aged Sod2 +/− mice. A, Western blot analysis and densitometric quantification of <t>calpain‐1</t> and calpain‐2 expression in VSMC treated with 100 ng/mL TNF α and 200 ng/mL IFN γ (mean± SEM , n=4). B, Western blot analysis and densitometric quantification of calpain‐2 and cleaved caspase‐3 levels in VSMC treated with TNF α+ IFN γ and nontargeting control or Capn2 si RNA (mean± SEM , n=4). C, Western blot analysis and densitometric quantification of MMP 2 and phospho‐H2 AX levels in VSMC treated with TNF α+ IFN γ and 100 μmol/L PD 150606 (mean± SEM , n=4). N represents a number of independent experiments. * P
    Dna Polymerase Binding Kit P6, supplied by Pacific Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 316 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dna polymerase binding kit p6/product/Pacific Biosciences
    Average 90 stars, based on 316 article reviews
    Price from $9.99 to $1999.99
    dna polymerase binding kit p6 - by Bioz Stars, 2020-11
    90/100 stars
      Buy from Supplier

    99
    Bio-Rad bio gel p 6
    Increased mt ROS and impaired mitochondrial function result in increased calpain‐2, cleaved caspase‐3, and MMP 2 levels in VSMC from middle‐aged Sod2 +/− mice. A, Western blot analysis and densitometric quantification of <t>calpain‐1</t> and calpain‐2 expression in VSMC treated with 100 ng/mL TNF α and 200 ng/mL IFN γ (mean± SEM , n=4). B, Western blot analysis and densitometric quantification of calpain‐2 and cleaved caspase‐3 levels in VSMC treated with TNF α+ IFN γ and nontargeting control or Capn2 si RNA (mean± SEM , n=4). C, Western blot analysis and densitometric quantification of MMP 2 and phospho‐H2 AX levels in VSMC treated with TNF α+ IFN γ and 100 μmol/L PD 150606 (mean± SEM , n=4). N represents a number of independent experiments. * P
    Bio Gel P 6, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 99/100, based on 365 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bio gel p 6/product/Bio-Rad
    Average 99 stars, based on 365 article reviews
    Price from $9.99 to $1999.99
    bio gel p 6 - by Bioz Stars, 2020-11
    99/100 stars
      Buy from Supplier

    89
    Pacific Biosciences dna polymerase binding kit p6 v2
    Increased mt ROS and impaired mitochondrial function result in increased calpain‐2, cleaved caspase‐3, and MMP 2 levels in VSMC from middle‐aged Sod2 +/− mice. A, Western blot analysis and densitometric quantification of <t>calpain‐1</t> and calpain‐2 expression in VSMC treated with 100 ng/mL TNF α and 200 ng/mL IFN γ (mean± SEM , n=4). B, Western blot analysis and densitometric quantification of calpain‐2 and cleaved caspase‐3 levels in VSMC treated with TNF α+ IFN γ and nontargeting control or Capn2 si RNA (mean± SEM , n=4). C, Western blot analysis and densitometric quantification of MMP 2 and phospho‐H2 AX levels in VSMC treated with TNF α+ IFN γ and 100 μmol/L PD 150606 (mean± SEM , n=4). N represents a number of independent experiments. * P
    Dna Polymerase Binding Kit P6 V2, supplied by Pacific Biosciences, used in various techniques. Bioz Stars score: 89/100, based on 184 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dna polymerase binding kit p6 v2/product/Pacific Biosciences
    Average 89 stars, based on 184 article reviews
    Price from $9.99 to $1999.99
    dna polymerase binding kit p6 v2 - by Bioz Stars, 2020-11
    89/100 stars
      Buy from Supplier

    88
    Bio-Rad p6 column
    Increased mt ROS and impaired mitochondrial function result in increased calpain‐2, cleaved caspase‐3, and MMP 2 levels in VSMC from middle‐aged Sod2 +/− mice. A, Western blot analysis and densitometric quantification of <t>calpain‐1</t> and calpain‐2 expression in VSMC treated with 100 ng/mL TNF α and 200 ng/mL IFN γ (mean± SEM , n=4). B, Western blot analysis and densitometric quantification of calpain‐2 and cleaved caspase‐3 levels in VSMC treated with TNF α+ IFN γ and nontargeting control or Capn2 si RNA (mean± SEM , n=4). C, Western blot analysis and densitometric quantification of MMP 2 and phospho‐H2 AX levels in VSMC treated with TNF α+ IFN γ and 100 μmol/L PD 150606 (mean± SEM , n=4). N represents a number of independent experiments. * P
    P6 Column, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 88/100, based on 119 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/p6 column/product/Bio-Rad
    Average 88 stars, based on 119 article reviews
    Price from $9.99 to $1999.99
    p6 column - by Bioz Stars, 2020-11
    88/100 stars
      Buy from Supplier

    88
    Celltrion ct p6
    Comparison of Tier 2 biological attributes for <t>CT-P6</t> (blue), EU-Herceptin® (orange) and US-Herceptin® (grey). Box plots of relative (A) HER2 binding affinity by ELISA, (B) cell-based HER2 binding affinity by CELISA, (C) FcγRIIIa-V binding affinity by SPR, (D) FcγRIIIa-F binding affinity by SPR, (E) FcγRIIIb binding affinity by SPR , (F) FcγRIIa binding affinity by SPR, (G) FcγRIIb binding affinity by SPR and (H) FcRn binding affinity SPR. Orange and grey broken lines represent quality range of EU-Herceptin® and US-Herceptin®, respectively. Box plot shows the interquartile range (box), median (band inside of box), maximum and minimum values (whiskers).
    Ct P6, supplied by Celltrion, used in various techniques. Bioz Stars score: 88/100, based on 36 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ct p6/product/Celltrion
    Average 88 stars, based on 36 article reviews
    Price from $9.99 to $1999.99
    ct p6 - by Bioz Stars, 2020-11
    88/100 stars
      Buy from Supplier

    94
    Olympus urf p6
    USAF 1951 resolution target (A) HF-EH (1.59 line pairs/mm). (B) <t>URF-P6</t> (3.17 line pairs/mm).
    Urf P6, supplied by Olympus, used in various techniques. Bioz Stars score: 94/100, based on 31 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/urf p6/product/Olympus
    Average 94 stars, based on 31 article reviews
    Price from $9.99 to $1999.99
    urf p6 - by Bioz Stars, 2020-11
    94/100 stars
      Buy from Supplier

    89
    Pacific Biosciences pacbio p6 c4 chemistry
    USAF 1951 resolution target (A) HF-EH (1.59 line pairs/mm). (B) <t>URF-P6</t> (3.17 line pairs/mm).
    Pacbio P6 C4 Chemistry, supplied by Pacific Biosciences, used in various techniques. Bioz Stars score: 89/100, based on 129 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pacbio p6 c4 chemistry/product/Pacific Biosciences
    Average 89 stars, based on 129 article reviews
    Price from $9.99 to $1999.99
    pacbio p6 c4 chemistry - by Bioz Stars, 2020-11
    89/100 stars
      Buy from Supplier

    99
    Bio-Rad micro bio spin p 6 gel columns
    USAF 1951 resolution target (A) HF-EH (1.59 line pairs/mm). (B) <t>URF-P6</t> (3.17 line pairs/mm).
    Micro Bio Spin P 6 Gel Columns, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 99/100, based on 49 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/micro bio spin p 6 gel columns/product/Bio-Rad
    Average 99 stars, based on 49 article reviews
    Price from $9.99 to $1999.99
    micro bio spin p 6 gel columns - by Bioz Stars, 2020-11
    99/100 stars
      Buy from Supplier

    99
    Bio-Rad biogel p6
    USAF 1951 resolution target (A) HF-EH (1.59 line pairs/mm). (B) <t>URF-P6</t> (3.17 line pairs/mm).
    Biogel P6, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 99/100, based on 95 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/biogel p6/product/Bio-Rad
    Average 99 stars, based on 95 article reviews
    Price from $9.99 to $1999.99
    biogel p6 - by Bioz Stars, 2020-11
    99/100 stars
      Buy from Supplier

    88
    Bio-Rad biogel p6 column
    USAF 1951 resolution target (A) HF-EH (1.59 line pairs/mm). (B) <t>URF-P6</t> (3.17 line pairs/mm).
    Biogel P6 Column, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 88/100, based on 53 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/biogel p6 column/product/Bio-Rad
    Average 88 stars, based on 53 article reviews
    Price from $9.99 to $1999.99
    biogel p6 column - by Bioz Stars, 2020-11
    88/100 stars
      Buy from Supplier

    94
    Bio-Rad bio gel p 6 desalting cartridge
    USAF 1951 resolution target (A) HF-EH (1.59 line pairs/mm). (B) <t>URF-P6</t> (3.17 line pairs/mm).
    Bio Gel P 6 Desalting Cartridge, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 94/100, based on 69 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bio gel p 6 desalting cartridge/product/Bio-Rad
    Average 94 stars, based on 69 article reviews
    Price from $9.99 to $1999.99
    bio gel p 6 desalting cartridge - by Bioz Stars, 2020-11
    94/100 stars
      Buy from Supplier

    90
    Pacific Biosciences p6 polymerase
    USAF 1951 resolution target (A) HF-EH (1.59 line pairs/mm). (B) <t>URF-P6</t> (3.17 line pairs/mm).
    P6 Polymerase, supplied by Pacific Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 53 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/p6 polymerase/product/Pacific Biosciences
    Average 90 stars, based on 53 article reviews
    Price from $9.99 to $1999.99
    p6 polymerase - by Bioz Stars, 2020-11
    90/100 stars
      Buy from Supplier

    99
    Bio-Rad p6 spin column
    USAF 1951 resolution target (A) HF-EH (1.59 line pairs/mm). (B) <t>URF-P6</t> (3.17 line pairs/mm).
    P6 Spin Column, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 99/100, based on 65 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/p6 spin column/product/Bio-Rad
    Average 99 stars, based on 65 article reviews
    Price from $9.99 to $1999.99
    p6 spin column - by Bioz Stars, 2020-11
    99/100 stars
      Buy from Supplier

    95
    Bio-Rad bio scale mini bio gel p 6 desalting cartridge
    USAF 1951 resolution target (A) HF-EH (1.59 line pairs/mm). (B) <t>URF-P6</t> (3.17 line pairs/mm).
    Bio Scale Mini Bio Gel P 6 Desalting Cartridge, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 95/100, based on 64 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bio scale mini bio gel p 6 desalting cartridge/product/Bio-Rad
    Average 95 stars, based on 64 article reviews
    Price from $9.99 to $1999.99
    bio scale mini bio gel p 6 desalting cartridge - by Bioz Stars, 2020-11
    95/100 stars
      Buy from Supplier

    96
    Bio-Rad biospin p6 column
    USAF 1951 resolution target (A) HF-EH (1.59 line pairs/mm). (B) <t>URF-P6</t> (3.17 line pairs/mm).
    Biospin P6 Column, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 96/100, based on 43 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/biospin p6 column/product/Bio-Rad
    Average 96 stars, based on 43 article reviews
    Price from $9.99 to $1999.99
    biospin p6 column - by Bioz Stars, 2020-11
    96/100 stars
      Buy from Supplier

    96
    Bio-Rad p6 resin
    USAF 1951 resolution target (A) HF-EH (1.59 line pairs/mm). (B) <t>URF-P6</t> (3.17 line pairs/mm).
    P6 Resin, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 96/100, based on 65 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/p6 resin/product/Bio-Rad
    Average 96 stars, based on 65 article reviews
    Price from $9.99 to $1999.99
    p6 resin - by Bioz Stars, 2020-11
    96/100 stars
      Buy from Supplier

    85
    Advanced Biotechnologies Inc anti p6 monoclonal antibody
    Gag processing in molecular HIV MDR clones and insert-lacking HIV MDR clones. COS-7 cells producing primary molecular HIV MDR clones and the corresponding insert-lacking HIV MDR clones were harvested at 72 h after transfection, and their cell lysates were subjected to Western blot analysis with anti-p24 antiserum (A) and an <t>anti-p6</t> monoclonal antibody (B). The positions corresponding to the sizes of the fully cleaved mature proteins (p24 and p6) and the immature proteins (p55, p41, p37, and p15) are indicated by arrows.
    Anti P6 Monoclonal Antibody, supplied by Advanced Biotechnologies Inc, used in various techniques. Bioz Stars score: 85/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti p6 monoclonal antibody/product/Advanced Biotechnologies Inc
    Average 85 stars, based on 13 article reviews
    Price from $9.99 to $1999.99
    anti p6 monoclonal antibody - by Bioz Stars, 2020-11
    85/100 stars
      Buy from Supplier

    Image Search Results


    Increased mt ROS and impaired mitochondrial function result in increased calpain‐2, cleaved caspase‐3, and MMP 2 levels in VSMC from middle‐aged Sod2 +/− mice. A, Western blot analysis and densitometric quantification of calpain‐1 and calpain‐2 expression in VSMC treated with 100 ng/mL TNF α and 200 ng/mL IFN γ (mean± SEM , n=4). B, Western blot analysis and densitometric quantification of calpain‐2 and cleaved caspase‐3 levels in VSMC treated with TNF α+ IFN γ and nontargeting control or Capn2 si RNA (mean± SEM , n=4). C, Western blot analysis and densitometric quantification of MMP 2 and phospho‐H2 AX levels in VSMC treated with TNF α+ IFN γ and 100 μmol/L PD 150606 (mean± SEM , n=4). N represents a number of independent experiments. * P

    Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

    Article Title: Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice

    doi: 10.1161/JAHA.117.006775

    Figure Lengend Snippet: Increased mt ROS and impaired mitochondrial function result in increased calpain‐2, cleaved caspase‐3, and MMP 2 levels in VSMC from middle‐aged Sod2 +/− mice. A, Western blot analysis and densitometric quantification of calpain‐1 and calpain‐2 expression in VSMC treated with 100 ng/mL TNF α and 200 ng/mL IFN γ (mean± SEM , n=4). B, Western blot analysis and densitometric quantification of calpain‐2 and cleaved caspase‐3 levels in VSMC treated with TNF α+ IFN γ and nontargeting control or Capn2 si RNA (mean± SEM , n=4). C, Western blot analysis and densitometric quantification of MMP 2 and phospho‐H2 AX levels in VSMC treated with TNF α+ IFN γ and 100 μmol/L PD 150606 (mean± SEM , n=4). N represents a number of independent experiments. * P

    Article Snippet: Primary antibodies used were against calpain‐1 (Thermo Scientific), calpain‐2 large subunit, cleaved caspase‐3 (Asp175), MMP2, phospho‐H2AX (Cell Signaling Technology), and β‐actin (Sigma‐Aldrich).

    Techniques: Mouse Assay, Western Blot, Expressing

    Comparison of Tier 2 biological attributes for CT-P6 (blue), EU-Herceptin® (orange) and US-Herceptin® (grey). Box plots of relative (A) HER2 binding affinity by ELISA, (B) cell-based HER2 binding affinity by CELISA, (C) FcγRIIIa-V binding affinity by SPR, (D) FcγRIIIa-F binding affinity by SPR, (E) FcγRIIIb binding affinity by SPR , (F) FcγRIIa binding affinity by SPR, (G) FcγRIIb binding affinity by SPR and (H) FcRn binding affinity SPR. Orange and grey broken lines represent quality range of EU-Herceptin® and US-Herceptin®, respectively. Box plot shows the interquartile range (box), median (band inside of box), maximum and minimum values (whiskers).

    Journal: mAbs

    Article Title: Evaluation of analytical similarity between trastuzumab biosimilar CT-P6 and reference product using statistical analyses

    doi: 10.1080/19420862.2018.1440170

    Figure Lengend Snippet: Comparison of Tier 2 biological attributes for CT-P6 (blue), EU-Herceptin® (orange) and US-Herceptin® (grey). Box plots of relative (A) HER2 binding affinity by ELISA, (B) cell-based HER2 binding affinity by CELISA, (C) FcγRIIIa-V binding affinity by SPR, (D) FcγRIIIa-F binding affinity by SPR, (E) FcγRIIIb binding affinity by SPR , (F) FcγRIIa binding affinity by SPR, (G) FcγRIIb binding affinity by SPR and (H) FcRn binding affinity SPR. Orange and grey broken lines represent quality range of EU-Herceptin® and US-Herceptin®, respectively. Box plot shows the interquartile range (box), median (band inside of box), maximum and minimum values (whiskers).

    Article Snippet: CT-P6 was developed as a biosimilar of Herceptin® (trastuzumab) by Celltrion Inc., and recently received a positive opinion for market authorization by the European Medicines Agency (EMA)'s Committee for Medicinal Products for Human Use.

    Techniques: Binding Assay, Enzyme-linked Immunosorbent Assay, SPR Assay

    Comparison of charge variants of CT-P6 (blue), EU-Herceptin® (orange) and US-Herceptin® (grey) analyzed by IEC-HPLC. (A) Representative ion exchange chromatograms are presented for 3 batches of each product. The number and distribution of IEC-HPLC peaks are conserved between CT-P6 and RMPs. (B) Box plots of acidic peaks % (Peak 1 + Peak 2 + Peak 3 + Peak 4) in IEC-HPLC, (C) Box plot of Peak 6 % in IEC-HPLC. Orange and grey broken lines represent quality range of EU-Herceptin® and US-Herceptin®, respectively. Box plot shows the interquartile range (box), median (band inside of box), maximum and minimum values (whiskers).

    Journal: mAbs

    Article Title: Evaluation of analytical similarity between trastuzumab biosimilar CT-P6 and reference product using statistical analyses

    doi: 10.1080/19420862.2018.1440170

    Figure Lengend Snippet: Comparison of charge variants of CT-P6 (blue), EU-Herceptin® (orange) and US-Herceptin® (grey) analyzed by IEC-HPLC. (A) Representative ion exchange chromatograms are presented for 3 batches of each product. The number and distribution of IEC-HPLC peaks are conserved between CT-P6 and RMPs. (B) Box plots of acidic peaks % (Peak 1 + Peak 2 + Peak 3 + Peak 4) in IEC-HPLC, (C) Box plot of Peak 6 % in IEC-HPLC. Orange and grey broken lines represent quality range of EU-Herceptin® and US-Herceptin®, respectively. Box plot shows the interquartile range (box), median (band inside of box), maximum and minimum values (whiskers).

    Article Snippet: CT-P6 was developed as a biosimilar of Herceptin® (trastuzumab) by Celltrion Inc., and recently received a positive opinion for market authorization by the European Medicines Agency (EMA)'s Committee for Medicinal Products for Human Use.

    Techniques: High Performance Liquid Chromatography

    Comparison of monomer and aggregate contents for CT-P6 (blue), EU-Herceptin® (orange) and US-Herceptin® (grey). Box plots of (A) monomer % measured by SEC-HPLC, (B) HMW % measured by SEC-HPLC, (C) monomer % measured by SEC-MALS, (D) HMW % measured by SEC-MALS, (E) monomer % measured by AUC and (F) dimer % measured by AUC. Orange and grey broken lines represent quality range of EU-Herceptin® and US-Herceptin®, respectively. Box plot shows the interquartile range (box), median (band inside of box), maximum and minimum values (whiskers).

    Journal: mAbs

    Article Title: Evaluation of analytical similarity between trastuzumab biosimilar CT-P6 and reference product using statistical analyses

    doi: 10.1080/19420862.2018.1440170

    Figure Lengend Snippet: Comparison of monomer and aggregate contents for CT-P6 (blue), EU-Herceptin® (orange) and US-Herceptin® (grey). Box plots of (A) monomer % measured by SEC-HPLC, (B) HMW % measured by SEC-HPLC, (C) monomer % measured by SEC-MALS, (D) HMW % measured by SEC-MALS, (E) monomer % measured by AUC and (F) dimer % measured by AUC. Orange and grey broken lines represent quality range of EU-Herceptin® and US-Herceptin®, respectively. Box plot shows the interquartile range (box), median (band inside of box), maximum and minimum values (whiskers).

    Article Snippet: CT-P6 was developed as a biosimilar of Herceptin® (trastuzumab) by Celltrion Inc., and recently received a positive opinion for market authorization by the European Medicines Agency (EMA)'s Committee for Medicinal Products for Human Use.

    Techniques: Size-exclusion Chromatography, High Performance Liquid Chromatography

    Comparison of oligosaccharide profiles of CT-P6 (blue), EU-Herceptin® (orange) and US-Herceptin® (grey) analyzed by HILIC-UPLC with 2-AB labeling. (A) Representative oligosaccharide profiles are presented for 3 batches of each product. The types and proportions of the glycans are conserved among the products. (B) Box plot of afucosylated glycans % (G0+G1+G2), (C) Box plot of high mannose glycans % (Man5+Man6+Man8), (D) Box plot of total afucosylated glycans % (G0+G1+G2+Man5+Man6+Man8). Orange and grey broken lines represent quality range of EU-Herceptin® and US-Herceptin®, respectively. Box plot shows the interquartile range (box), median (band inside of box), maximum and minimum values (whiskers).

    Journal: mAbs

    Article Title: Evaluation of analytical similarity between trastuzumab biosimilar CT-P6 and reference product using statistical analyses

    doi: 10.1080/19420862.2018.1440170

    Figure Lengend Snippet: Comparison of oligosaccharide profiles of CT-P6 (blue), EU-Herceptin® (orange) and US-Herceptin® (grey) analyzed by HILIC-UPLC with 2-AB labeling. (A) Representative oligosaccharide profiles are presented for 3 batches of each product. The types and proportions of the glycans are conserved among the products. (B) Box plot of afucosylated glycans % (G0+G1+G2), (C) Box plot of high mannose glycans % (Man5+Man6+Man8), (D) Box plot of total afucosylated glycans % (G0+G1+G2+Man5+Man6+Man8). Orange and grey broken lines represent quality range of EU-Herceptin® and US-Herceptin®, respectively. Box plot shows the interquartile range (box), median (band inside of box), maximum and minimum values (whiskers).

    Article Snippet: CT-P6 was developed as a biosimilar of Herceptin® (trastuzumab) by Celltrion Inc., and recently received a positive opinion for market authorization by the European Medicines Agency (EMA)'s Committee for Medicinal Products for Human Use.

    Techniques: Hydrophilic Interaction Liquid Chromatography, Labeling

    Scatter plots and equivalence test results for Tier 1 quality attributes. Comparisons of “CT-P6 vs . EU-Herceptin®” and “CT-P6 vs . US-Herceptin®” are shown in left and right, respectively. (A) Scatter plots (up) of relative anti-proliferation activity for CT-P6 (blue dot), EU-Herceptin® (orange dot) and US-Herceptin® (grey dot). Equivalence test results (bottom) are shown with 90% CI of mean difference between the 2 products. (B) Scatter plots (up) of relative ADCC activity for CT-P6 (blue dot), EU-Herceptin® (orange dot) and US-Herceptin® (grey dot). Equivalence test results (bottom) are shown with 90% CI of mean difference between the 2 products.

    Journal: mAbs

    Article Title: Evaluation of analytical similarity between trastuzumab biosimilar CT-P6 and reference product using statistical analyses

    doi: 10.1080/19420862.2018.1440170

    Figure Lengend Snippet: Scatter plots and equivalence test results for Tier 1 quality attributes. Comparisons of “CT-P6 vs . EU-Herceptin®” and “CT-P6 vs . US-Herceptin®” are shown in left and right, respectively. (A) Scatter plots (up) of relative anti-proliferation activity for CT-P6 (blue dot), EU-Herceptin® (orange dot) and US-Herceptin® (grey dot). Equivalence test results (bottom) are shown with 90% CI of mean difference between the 2 products. (B) Scatter plots (up) of relative ADCC activity for CT-P6 (blue dot), EU-Herceptin® (orange dot) and US-Herceptin® (grey dot). Equivalence test results (bottom) are shown with 90% CI of mean difference between the 2 products.

    Article Snippet: CT-P6 was developed as a biosimilar of Herceptin® (trastuzumab) by Celltrion Inc., and recently received a positive opinion for market authorization by the European Medicines Agency (EMA)'s Committee for Medicinal Products for Human Use.

    Techniques: Activity Assay

    Box plots of (A) HC isoAsp102 and (B) deamidated LC Asn30 levels for CT-P6 (blue), EU-Herceptin® (orange) and USHerceptin® (grey). Orange and grey broken lines represent quality range of EU-Herceptin® and US-Herceptin®, respectively. Box plot shows the interquartile range (box), median (band inside of box), maximum and minimum values (whiskers).

    Journal: mAbs

    Article Title: Evaluation of analytical similarity between trastuzumab biosimilar CT-P6 and reference product using statistical analyses

    doi: 10.1080/19420862.2018.1440170

    Figure Lengend Snippet: Box plots of (A) HC isoAsp102 and (B) deamidated LC Asn30 levels for CT-P6 (blue), EU-Herceptin® (orange) and USHerceptin® (grey). Orange and grey broken lines represent quality range of EU-Herceptin® and US-Herceptin®, respectively. Box plot shows the interquartile range (box), median (band inside of box), maximum and minimum values (whiskers).

    Article Snippet: CT-P6 was developed as a biosimilar of Herceptin® (trastuzumab) by Celltrion Inc., and recently received a positive opinion for market authorization by the European Medicines Agency (EMA)'s Committee for Medicinal Products for Human Use.

    Techniques:

    Comparison of UV chromatograms of trypsin digested CT-P6 (blue), EU-Herceptin® (orange) and US-Herceptin® (grey). Representative tryptic peptide maps detected at 214 nm are presented for 3 batches of each product.

    Journal: mAbs

    Article Title: Evaluation of analytical similarity between trastuzumab biosimilar CT-P6 and reference product using statistical analyses

    doi: 10.1080/19420862.2018.1440170

    Figure Lengend Snippet: Comparison of UV chromatograms of trypsin digested CT-P6 (blue), EU-Herceptin® (orange) and US-Herceptin® (grey). Representative tryptic peptide maps detected at 214 nm are presented for 3 batches of each product.

    Article Snippet: CT-P6 was developed as a biosimilar of Herceptin® (trastuzumab) by Celltrion Inc., and recently received a positive opinion for market authorization by the European Medicines Agency (EMA)'s Committee for Medicinal Products for Human Use.

    Techniques:

    Comparison of fragmentation and non-glycosylation levels determined by CE-SDS for CT-P6 (blue), EU-Herceptin® (orange) and US-Herceptin® (grey). Box plots of (A) sum of fragments % by non-reduced CE-SDS, (B) intact IgG % by non-reduced by CE-SDS, (C) non-glycosylated heavy chain % by reduced CE-SDS and (D) sum of light and heavy chain % by reduced CE-SDS. Orange and grey broken lines represent quality range of EU-Herceptin® and US-Herceptin®, respectively. Box plot shows the interquartile range (box), median (band inside of box), maximum and minimum values (whiskers). Effects of fragmentation and non-glycosylation level on biological activities were examined in (E) and (F), respectively.

    Journal: mAbs

    Article Title: Evaluation of analytical similarity between trastuzumab biosimilar CT-P6 and reference product using statistical analyses

    doi: 10.1080/19420862.2018.1440170

    Figure Lengend Snippet: Comparison of fragmentation and non-glycosylation levels determined by CE-SDS for CT-P6 (blue), EU-Herceptin® (orange) and US-Herceptin® (grey). Box plots of (A) sum of fragments % by non-reduced CE-SDS, (B) intact IgG % by non-reduced by CE-SDS, (C) non-glycosylated heavy chain % by reduced CE-SDS and (D) sum of light and heavy chain % by reduced CE-SDS. Orange and grey broken lines represent quality range of EU-Herceptin® and US-Herceptin®, respectively. Box plot shows the interquartile range (box), median (band inside of box), maximum and minimum values (whiskers). Effects of fragmentation and non-glycosylation level on biological activities were examined in (E) and (F), respectively.

    Article Snippet: CT-P6 was developed as a biosimilar of Herceptin® (trastuzumab) by Celltrion Inc., and recently received a positive opinion for market authorization by the European Medicines Agency (EMA)'s Committee for Medicinal Products for Human Use.

    Techniques:

    Higher order structure analyzed by CD and antibody conformational array for CT-P6, EU-Herceptin® and US-Herceptin®. CD spectra for (A) Far-UV region and (B) Near-UV region are overlaid. Histograms of epitope exposure analyzed by antibody conformational array in (C) variable region, and (D) constant region are compared for 3 batches of each product.

    Journal: mAbs

    Article Title: Evaluation of analytical similarity between trastuzumab biosimilar CT-P6 and reference product using statistical analyses

    doi: 10.1080/19420862.2018.1440170

    Figure Lengend Snippet: Higher order structure analyzed by CD and antibody conformational array for CT-P6, EU-Herceptin® and US-Herceptin®. CD spectra for (A) Far-UV region and (B) Near-UV region are overlaid. Histograms of epitope exposure analyzed by antibody conformational array in (C) variable region, and (D) constant region are compared for 3 batches of each product.

    Article Snippet: CT-P6 was developed as a biosimilar of Herceptin® (trastuzumab) by Celltrion Inc., and recently received a positive opinion for market authorization by the European Medicines Agency (EMA)'s Committee for Medicinal Products for Human Use.

    Techniques:

    USAF 1951 resolution target (A) HF-EH (1.59 line pairs/mm). (B) URF-P6 (3.17 line pairs/mm).

    Journal: Investigative and Clinical Urology

    Article Title: In vitro, in vivo, and clinical tests of a novel flexible ureteroscope for the diagnosis and treatment of kidney and ureteral diseases

    doi: 10.4111/icu.2018.59.5.328

    Figure Lengend Snippet: USAF 1951 resolution target (A) HF-EH (1.59 line pairs/mm). (B) URF-P6 (3.17 line pairs/mm).

    Article Snippet: MATERIALS AND METHODS Here, we compared the novel device ‘HF-EH’ (Hyunjoo In-Tech, Seoul, Korea) with the ‘URF-P6’ (Olympus, Tokyo, Japan) and ‘COBRA’ (Richard Wolf, Knittlingen, Germany) ureteroscopes.

    Techniques:

    Gag processing in molecular HIV MDR clones and insert-lacking HIV MDR clones. COS-7 cells producing primary molecular HIV MDR clones and the corresponding insert-lacking HIV MDR clones were harvested at 72 h after transfection, and their cell lysates were subjected to Western blot analysis with anti-p24 antiserum (A) and an anti-p6 monoclonal antibody (B). The positions corresponding to the sizes of the fully cleaved mature proteins (p24 and p6) and the immature proteins (p55, p41, p37, and p15) are indicated by arrows.

    Journal: Journal of Virology

    Article Title: Amino Acid Insertions near Gag Cleavage Sites Restore the Otherwise Compromised Replication of Human Immunodeficiency Virus Type 1 Variants Resistant to Protease Inhibitors

    doi: 10.1128/JVI.78.21.12030-12040.2004

    Figure Lengend Snippet: Gag processing in molecular HIV MDR clones and insert-lacking HIV MDR clones. COS-7 cells producing primary molecular HIV MDR clones and the corresponding insert-lacking HIV MDR clones were harvested at 72 h after transfection, and their cell lysates were subjected to Western blot analysis with anti-p24 antiserum (A) and an anti-p6 monoclonal antibody (B). The positions corresponding to the sizes of the fully cleaved mature proteins (p24 and p6) and the immature proteins (p55, p41, p37, and p15) are indicated by arrows.

    Article Snippet: The HIV-1 Gag proteins were visualized with SuperSignal WestPico (Pierce) by using anti-p24 Gag antiserum or anti-p6 monoclonal antibody (Advanced Biotechnologies, Inc., Columbia, Md.).

    Techniques: Clone Assay, Transfection, Western Blot