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Becton Dickinson
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p21 waf (mouse - by Bioz Stars,
2026-02
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Canji Inc
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Cold Spring Harbor Laboratory Meetings
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2026-02
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Eppendorf AG
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Biovation
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Image Search Results
Journal: PLoS ONE
Article Title: Polyomavirus-Associated Trichodysplasia Spinulosa Involves Hyperproliferation, pRB Phosphorylation and Upregulation of p16 and p21
doi: 10.1371/journal.pone.0108947
Figure Lengend Snippet: Sections of healthy epidermis ( A1–A4 ), healthy hair follicle ( B1–B4 ), TS epidermis ( C1–C4 ) and TS follicle ( D1–D4 ) are stained for p16 ink4a (first panel), p21 waf (second panel), pRB (third panel) and TSPyV (fourth panel). Insets in the fourth panel depict the same region with Hoechst DNA staining (blue). Dotted lines indicate the dermoepidermal junction. Bar depicts 100 µm.
Article Snippet:
Techniques: Staining
Journal: PLoS ONE
Article Title: Polyomavirus-Associated Trichodysplasia Spinulosa Involves Hyperproliferation, pRB Phosphorylation and Upregulation of p16 and p21
doi: 10.1371/journal.pone.0108947
Figure Lengend Snippet: An oversimplified cell-cycling scenario is shown that envisions the TSPyV LT-antigen involvement in regulation of pRB pathway activity. In a normal physiological condition, hypophosphorylated pRB is complexed with transcription factor E2F during early G1 (rest) phase of the cell cycle. When pRB is hyperphosphorylated at specific residues by Cyclin-dependent kinases (CDK) coupled to Cyclin-D1, E2F is released that activates expression of growth stimulatory genes needed for the cells to enter the S (DNA synthesis) phase. pRB phosphorylation is under tight regulation of p16 ink4a and p21 waf . Hypothetically, through its conserved LXCXE motif TSPyV LT-antigen interacts with pRB/E2F complex to dissociate these proteins via pRB hyperphosphorylation, resulting into S phase entry and subsequent increased expression of p16 ink4a and p21 waf as a negative cell cycling feedback (red arrows).
Article Snippet:
Techniques: Activity Assay, Expressing, DNA Synthesis