Journal: Talanta

Article Title: Development and validation of chromatographic methods for screening and subsequent quantification of suspected illegal antimicrobial drugs encountered on the Belgian market.

doi: 10.1016/j.talanta.2018.10.078

Figure Lengend Snippet: Fig. 2. Overlay of LC-MS2 total ion chromatograms of 35 antimicrobials and 1 beta-lactamase inhibitor (1 = cefepime, 2 = clavulanic acid, 3 = amoxicillin, 4 =cefadroxil, 5 = lincomycin, 6 = ceftazidime, 7 = cefaclor and trimethoprim, 8 = cefalexin and ampicillin, 9 = cefradine and polymyxin B1, 10 = ofloxacin, 11 = norfloxacin, 12 = tetracycline and ciprofloxacin, 13 = azithromycin, 14 = ceftriaxone and cefotaxime, 15 = clindamycin and nitrofurantoin, 16 = bacitracin, 17 = doxycycline, 18 = erythromycin and cefazolin, 19 = clarithromycin, 20 = roxithromycin, 21 = sulfamethoxazole, 22 = penicillin G, rifampicin and cefur- oxime axetil, 22(2) = benzathine (of benzathine penicillin G), 23 =penicillin V, 24 = griseofulvin, 25 = cloxacillin, 26 = gentamicin and neomycin).

Article Snippet: The reference standards of amoxicillin trihydrate, azithromycin, cefaclor, ceftazidime, cefazolin, cefuroxime axetil, clavulanate lithium, clindamycin and cloxacillin sodium were purchased from the European Directorate for the Quality of Medicines (EDQM) (Strasbourg, France).

Techniques:

Journal: Talanta

Article Title: Development and validation of chromatographic methods for screening and subsequent quantification of suspected illegal antimicrobial drugs encountered on the Belgian market.

doi: 10.1016/j.talanta.2018.10.078

Figure Lengend Snippet: Fig. 3. Overlay of UHPLC-MS2 total ion chromatograms in the positive mode of antimicrobials in their corresponding solvent. A: the group of compounds dissolved in methanol, B in methanol/H2O mixture (50:50, v/v), C in methanol/H2O with 1% HCOOH mixture (20:80, v/v) (1 = trimethoprim, 2 = azithromycin, 3 = ery- thromycin, 4 = sulfamethoxazole, 5 = penicillin G, cefuroxime axetil and rifampicin, 5(2) = benzathine (of benzathine penicillin G), 6 = cefepime, 7 = amoxicillin, 8 = cefadroxil, 9 = lincomycin, 10 = ceftazidime, 11 = cefaclor, 12 = cefalexin and ampicillin, 13 = cefradine and polymyxin B1, 14 = tetracycline, 15 = cef- triaxone, 16 = cefotaxime, 17 = clindamycin, 18 = doxycycline, 19 = cefazolin, 20 = roxithromycin, 21 = penicillin V, 22 = cloxacillin, 23 = gentamicin and neomycin, 24 = ofloxacin, 25 = ciprofloxacin, 26 = bacitracin, 27 = clarithromycin, clavulanic acid was monitored in the negative mode).

Article Snippet: The reference standards of amoxicillin trihydrate, azithromycin, cefaclor, ceftazidime, cefazolin, cefuroxime axetil, clavulanate lithium, clindamycin and cloxacillin sodium were purchased from the European Directorate for the Quality of Medicines (EDQM) (Strasbourg, France).

Techniques: Solvent