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  • 98
    Millipore omeprazole
    Effects of lansoprazole and <t>omeprazole</t> on feedback from horizontal cells to cone I Ca . ( A ) Voltage shifts in cone I Ca were quantified by determining the voltage at which the current was half-maximal (V 50 ). Data are plotted relative to V 50 measured when the horizontal cell was voltage clamped at 0 mV. The hatched bars on the left show control data; data from the same cell pairs measured after bath application of lansoprazole (100 μM) are shown by the open bars on the right ( N = 10 pairs). Lansoprazole significantly reduced the change in V 50 induced by voltage clamping the horizontal cell at −40 ( P
    Omeprazole, supplied by Millipore, used in various techniques. Bioz Stars score: 98/100, based on 501 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    90
    AstraZeneca prilosec omeprazole
    Fraction of the neutral form of <t>omeprazole,</t> α , and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {}_{\text{w}}^{\text{s}} {\text{pH}} $$\end{document} w s pH versus the concentration of omeprazole in the mobile phase with a 25/75, v/v, acetonitrile/phosphate buffer ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {}_{\text{w}}^{\text{w}} {\text{pH}} $$\end{document} w w pH = 9.0) and b 45/55, v/v, methanol/phosphate buffer ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {}_{\text{w}}^{\text{w}} {\text{pH}} $$\end{document} w w pH = 9.0)
    Prilosec Omeprazole, supplied by AstraZeneca, used in various techniques. Bioz Stars score: 90/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    90
    Tocris omeprazole
    High‐performance liquid chromatography‐mass spectrometer ( HPLC ‐ MS ) chromatograms of oxidation metabolites of <t>Omeprazole</t> in suspension cultures of fresh (A = 0 min and B = 30 min) and recovered cryopreserved (C = 0 min and D = 30 min) equine hepatocytes. The ratio between the peak areas of M1, M2, and M3 was 2:1:1, respectively, in both fresh and cryopreserved hepatocytes.
    Omeprazole, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Bracco Diagnostics omeprazole
    Effect of cimetidine, ranitidine, famotidine and <t>omeprazole</t> on DNA synthesis of hepatocytes in primary culture. Hepatocyte isolation has been described under ‘Materials and Methods’. Cells were plated in MEM supplemented with 5% FCS and insulin (10 −7 M). After 3 h, the medium and floating cells were discarded and serum-free medium plus insulin (10 −7 M), EGF (10 ng/ml) and proline (0.26 mM) were added. H 2 blocking agents were added at different concentrations on the basis of their blood level after administration of a therapeutic dose; cimetidine, ranitidine, famotidine (0.62–30 μ g/ml ) and omeprazole (0.06–1.8 μ g/ml). Cultures were exposed to 7.5 μ Ci [ 3 H] thymidine for the last 24 h and processed after 48 h for determination of DNA synthesis. For each medium, triplicate culture dishes from 5 different animals were used. Results (mean ± S.D.) are expressed as cpm × 10 −2 / μ g DNA.
    Omeprazole, supplied by Bracco Diagnostics, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/omeprazole/product/Bracco Diagnostics
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    92
    Merck & Co omeprazole
    Time-kill curves for norfloxacin alone or combined with reserpine (N+R), lansoprazole (N+L), or <t>omeprazole</t> (N+O) (A) and for ciprofloxacin alone or combined with reserpine (C+R), lansoprazole (C+L), or omeprazole (C+O) (B) versus SA 1199B. The fluoroquinolones were tested at 0.25× MICs, and inhibitor concentrations were 100 μg/ml for omeprazole and lansoprazole and 20 μg/ml for reserpine.
    Omeprazole, supplied by Merck & Co, used in various techniques. Bioz Stars score: 92/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Millipore omeprazole slurry
    Inhibition of gastric acid alters the topographic, but not the glandular, distribution of H pylori in vivo . (A–C) A representative experiment showing the mean (±SD) bacterial densities from distinct anatomic regions of mice treated with saline or <t>omeprazole.</t> Each data point represents a biological replicate. The dotted line represents the limit of detection. (D–E) Representative images showing that H pylori (green) are restricted to the pits in infected, omeprazole-treated mice (D) and that inhibition of gastric acid secretion with omeprazole does not expand sLe x (red) expression. The onset of SPEM following HD-Tam treatment allows H pylori to penetrate deep within SPEM glands demonstrating expanded sLe x expression (E). Blue, nuclei. Scale bars, 50 µm. (F) Magnified, representative image shows H pylori (green) co-localizing with sLe x (red) within the pit of an omeprazole-treated mouse. Blue, nuclei. Scale bar, 5 µm. (G) The distance of H pylori along the gland axis was expressed as a percentage of total gland length. Data represent the mean (±SD) distribution from three infected littermates/cagemates for each treatment condition. Each data point represents a gland colonized with H pylori , with total numbers of scored glands indicated in parentheses. Hp, H pylori .
    Omeprazole Slurry, supplied by Millipore, used in various techniques. Bioz Stars score: 93/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    FUJIFILM omeprazole
    Influence of VRC treatment on CYP3A4 , CYP2B6 , and CYP1A2 mRNA levels in primary human hepatocytes. Human hepatocytes (Hu4205, Hu4228, and Hu8114) were treated with vehicle (0.1% DMSO), VRC (1 to 300 μM), or positive control rifampin, phenobarbital, or <t>omeprazole.</t> CYP mRNA levels were determined by real-time PCR and normalized to those of β- ACTIN . Relative mRNA levels are shown as the means from triplicate experiments.
    Omeprazole, supplied by FUJIFILM, used in various techniques. Bioz Stars score: 92/100, based on 21 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    New Era Enterprises omeprazole
    The ACP (A) and NAG (B) levels in mouse serum and spleen. In both the non-MNNG-treated and MNNG-treated subgroups, <t>omeprazole</t> treatment (especially at high dose) decreased both enzyme levels in both serum and spleen. ACP, acid phosphatase; NAG, N-acetyl-β-D-glucosaminidase; MNNG, N-methyl-N’-nitro-N-nitrosoguanidine. *, P
    Omeprazole, supplied by New Era Enterprises, used in various techniques. Bioz Stars score: 91/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Youcare Pharmaceutical Group Co Ltd omeprazole
    Gastric tissue immunohistochemistry after specific IgY treated the Hp infected mice (100 × 10). A: PBS group; B: sucralfate group; C: IgY-CPV group; D: IgY-CPV + sucralfate group; E: IgY-IB group; F: IgY-Hp group; G: <t>omeprazole</t> + clarithromycin group; H: IgY-IB + sucralfate group; I: IgY-Hp + sucralfate group.
    Omeprazole, supplied by Youcare Pharmaceutical Group Co Ltd, used in various techniques. Bioz Stars score: 92/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Effects of lansoprazole and omeprazole on feedback from horizontal cells to cone I Ca . ( A ) Voltage shifts in cone I Ca were quantified by determining the voltage at which the current was half-maximal (V 50 ). Data are plotted relative to V 50 measured when the horizontal cell was voltage clamped at 0 mV. The hatched bars on the left show control data; data from the same cell pairs measured after bath application of lansoprazole (100 μM) are shown by the open bars on the right ( N = 10 pairs). Lansoprazole significantly reduced the change in V 50 induced by voltage clamping the horizontal cell at −40 ( P

    Journal: Investigative Ophthalmology & Visual Science

    Article Title: Oral Proton Pump Inhibitors Disrupt Horizontal Cell-Cone Feedback and Enhance Visual Hallucinations in Macular Degeneration Patients

    doi: 10.1167/iovs.12-11091

    Figure Lengend Snippet: Effects of lansoprazole and omeprazole on feedback from horizontal cells to cone I Ca . ( A ) Voltage shifts in cone I Ca were quantified by determining the voltage at which the current was half-maximal (V 50 ). Data are plotted relative to V 50 measured when the horizontal cell was voltage clamped at 0 mV. The hatched bars on the left show control data; data from the same cell pairs measured after bath application of lansoprazole (100 μM) are shown by the open bars on the right ( N = 10 pairs). Lansoprazole significantly reduced the change in V 50 induced by voltage clamping the horizontal cell at −40 ( P

    Article Snippet: It is notable that the effect of omeprazole (Sigma-Aldrich) was weaker than lansoprazole (Sigma-Aldrich), consistent with its slower rate of inhibition.

    Techniques:

    Gut microbiota is changed in rats with long-term omeprazole treatment. Linear discriminant analysis (LDA) effect size (LEfSe) analysis of gut microbiota changes in rats with long-term omeprazole treatment. Significant biomarkers were defined as taxa with a LDA score (log10) ≥ 2. ( b ) Significant taxa were highlighted on the cladogram. P: Phylum; C: Class; O: Order; F: Family; G: Genus. Bacteria at ( c ) family level and ( d ) genus-level with significant changes in abundance with omeprazole treatment (LDA ≥2).

    Journal: Scientific Reports

    Article Title: Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats

    doi: 10.1038/s41598-020-57612-8

    Figure Lengend Snippet: Gut microbiota is changed in rats with long-term omeprazole treatment. Linear discriminant analysis (LDA) effect size (LEfSe) analysis of gut microbiota changes in rats with long-term omeprazole treatment. Significant biomarkers were defined as taxa with a LDA score (log10) ≥ 2. ( b ) Significant taxa were highlighted on the cladogram. P: Phylum; C: Class; O: Order; F: Family; G: Genus. Bacteria at ( c ) family level and ( d ) genus-level with significant changes in abundance with omeprazole treatment (LDA ≥2).

    Article Snippet: At six weeks of age, rats were randomly assigned to one of four exposure groups: (1) oral omeprazole (40 mg/kg) (SIGMA-ALDRICH, St Louis, MO) (2) saline as negative control group; or (3) caerulein (20 μg/kg) as a positive control group.

    Techniques:

    Comparison of metabolites between omeprazole-treated and control Wistar rats. Rats were sacrificed at the end of the experiment (day 30) and serum and stool were collected. The serum and stool metabolites were analyzed by GC-TOFMS. ( a ) Heatmap showing the abundance of the identified metabolites ( b ) Statistical comparison between treated and control rats was performed with exact Wilcoxon-Mann-Whitney test at α = 0.05. Three and five metabolites were found to show significant differences in serum and stool samples respectively.

    Journal: Scientific Reports

    Article Title: Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats

    doi: 10.1038/s41598-020-57612-8

    Figure Lengend Snippet: Comparison of metabolites between omeprazole-treated and control Wistar rats. Rats were sacrificed at the end of the experiment (day 30) and serum and stool were collected. The serum and stool metabolites were analyzed by GC-TOFMS. ( a ) Heatmap showing the abundance of the identified metabolites ( b ) Statistical comparison between treated and control rats was performed with exact Wilcoxon-Mann-Whitney test at α = 0.05. Three and five metabolites were found to show significant differences in serum and stool samples respectively.

    Article Snippet: At six weeks of age, rats were randomly assigned to one of four exposure groups: (1) oral omeprazole (40 mg/kg) (SIGMA-ALDRICH, St Louis, MO) (2) saline as negative control group; or (3) caerulein (20 μg/kg) as a positive control group.

    Techniques: MANN-WHITNEY

    Animal model of long-term omeprazole treatment. Schedule of drug administration in Wistar rats in 30 days. Rats were treated with caerulein (positive control) 5 times per week (total 20 doses), omeprazole was administered orally 3 times per week (total 12 doses). Saline (negative control) was administered as a negative control.

    Journal: Scientific Reports

    Article Title: Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats

    doi: 10.1038/s41598-020-57612-8

    Figure Lengend Snippet: Animal model of long-term omeprazole treatment. Schedule of drug administration in Wistar rats in 30 days. Rats were treated with caerulein (positive control) 5 times per week (total 20 doses), omeprazole was administered orally 3 times per week (total 12 doses). Saline (negative control) was administered as a negative control.

    Article Snippet: At six weeks of age, rats were randomly assigned to one of four exposure groups: (1) oral omeprazole (40 mg/kg) (SIGMA-ALDRICH, St Louis, MO) (2) saline as negative control group; or (3) caerulein (20 μg/kg) as a positive control group.

    Techniques: Animal Model, Positive Control, Negative Control

    Omeprazole induced lesions in the bile duct. The animals were sacrificed after 30 days. Bile ducts were removed and washed with iced phosphate buffer solutions. The tissues were embedded in paraffin wax ( a ) HE stain and ( b ) stained with anti-CK-19 antibody and examined. The bile ducts of rat treated with PPIs display morphological distortion and thickening of the bile duct epithelium. ( c ) Stained with anti-FXR and RXRα antibodies. ( d ) RNA expression levels of FXR and RXRα in cholangiocarcinoma and normal liver obtained from the TCGA database. ( e ) The Oncomine™ (Compendia Bioscience, Ann Arbor, MI) database ( http://www.oncomine.org/ ) was used to compare relative gene expression levels of FXR and RXRα in (1) cholangiocarcinoma, (2) combined cholangiocarcinoma and hepatocellular carcinoma, and (3) hepatocellular carcinoma.

    Journal: Scientific Reports

    Article Title: Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats

    doi: 10.1038/s41598-020-57612-8

    Figure Lengend Snippet: Omeprazole induced lesions in the bile duct. The animals were sacrificed after 30 days. Bile ducts were removed and washed with iced phosphate buffer solutions. The tissues were embedded in paraffin wax ( a ) HE stain and ( b ) stained with anti-CK-19 antibody and examined. The bile ducts of rat treated with PPIs display morphological distortion and thickening of the bile duct epithelium. ( c ) Stained with anti-FXR and RXRα antibodies. ( d ) RNA expression levels of FXR and RXRα in cholangiocarcinoma and normal liver obtained from the TCGA database. ( e ) The Oncomine™ (Compendia Bioscience, Ann Arbor, MI) database ( http://www.oncomine.org/ ) was used to compare relative gene expression levels of FXR and RXRα in (1) cholangiocarcinoma, (2) combined cholangiocarcinoma and hepatocellular carcinoma, and (3) hepatocellular carcinoma.

    Article Snippet: At six weeks of age, rats were randomly assigned to one of four exposure groups: (1) oral omeprazole (40 mg/kg) (SIGMA-ALDRICH, St Louis, MO) (2) saline as negative control group; or (3) caerulein (20 μg/kg) as a positive control group.

    Techniques: H&E Stain, Staining, RNA Expression, Expressing

    Fecal microbiome distribution in rats with long-term omeprazole treatment. The feces of rats treated with and without omeprazole for 30 days were prepared for fecal microbiome profiling by high-throughput sequencing of the 16s rRNA gene with the Illumina MiSeq system. ( a ) Alpha-diversity of omeprazole treated samples and untreated controls. Statistical comparison between two groups was performed with exact Wilcoxon-Mann-Whitney test and significant differences were obtained for all four indices (at α = 0.05) ( b ) Principal coordinate analysis (PCoA) plot based on Unweighted or Weight UniFrac distance of omeprazole treated samples and untreated controls. Significant difference in beta-diversity was evaluated with permutational multivariate analysis of variance (vegan::adonis, 1000 permutations) and beta-dispersion was quantified with betadisper (vegan::betadisper, 1000 permutations). Both indices achieved adonis P

    Journal: Scientific Reports

    Article Title: Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats

    doi: 10.1038/s41598-020-57612-8

    Figure Lengend Snippet: Fecal microbiome distribution in rats with long-term omeprazole treatment. The feces of rats treated with and without omeprazole for 30 days were prepared for fecal microbiome profiling by high-throughput sequencing of the 16s rRNA gene with the Illumina MiSeq system. ( a ) Alpha-diversity of omeprazole treated samples and untreated controls. Statistical comparison between two groups was performed with exact Wilcoxon-Mann-Whitney test and significant differences were obtained for all four indices (at α = 0.05) ( b ) Principal coordinate analysis (PCoA) plot based on Unweighted or Weight UniFrac distance of omeprazole treated samples and untreated controls. Significant difference in beta-diversity was evaluated with permutational multivariate analysis of variance (vegan::adonis, 1000 permutations) and beta-dispersion was quantified with betadisper (vegan::betadisper, 1000 permutations). Both indices achieved adonis P

    Article Snippet: At six weeks of age, rats were randomly assigned to one of four exposure groups: (1) oral omeprazole (40 mg/kg) (SIGMA-ALDRICH, St Louis, MO) (2) saline as negative control group; or (3) caerulein (20 μg/kg) as a positive control group.

    Techniques: Next-Generation Sequencing, MANN-WHITNEY

    The pharmacokinetic profiles of bupropion (A), metroprolol (B), omeprazole (C), phenacetin (D), testosterone (E), tolbutamide (F) in control group and diphenoxylate group (low, medium, high) rats (n=8).

    Journal: International Journal of Clinical and Experimental Medicine

    Article Title: Effect of diphenoxylate on CYP450 isoforms activity in rats

    doi:

    Figure Lengend Snippet: The pharmacokinetic profiles of bupropion (A), metroprolol (B), omeprazole (C), phenacetin (D), testosterone (E), tolbutamide (F) in control group and diphenoxylate group (low, medium, high) rats (n=8).

    Article Snippet: Bupropion, metroprolol omeprazole, phenacetin, testosterone and tolbutamide (all > 98%) and the internal standard diazepam (IS) were obtained from Sigma-Aldrich Company (St. Louis, USA).

    Techniques:

    H E staining of rat gastric mucosa in ethanol-induced gastric ulcers (magnification at 20× and 40×). ( A , a ) Vehicle control; ( B , b ) ulcer control; ( C , c ) omeprazole (40 mg/kg); ( D , d ) ExPhy (400 mg/kg).

    Journal: Nutrients

    Article Title: Amelioration of Ethanol-Induced Gastric Ulcers in Rats Pretreated with Phycobiliproteins of Arthrospira (Spirulina) Maxima

    doi: 10.3390/nu10060763

    Figure Lengend Snippet: H E staining of rat gastric mucosa in ethanol-induced gastric ulcers (magnification at 20× and 40×). ( A , a ) Vehicle control; ( B , b ) ulcer control; ( C , c ) omeprazole (40 mg/kg); ( D , d ) ExPhy (400 mg/kg).

    Article Snippet: Drugs and Chemicals Omeprazole was acquired from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: Staining

    ExPhy and omeprazole pretreatments, followed by ethanol-induced gastric ulcers, produced protective effects on the gastric mucosal activity of GPx, SOD and CAT, as well as lowering the levels of MDA compared to the ulcer control. * Indicates p

    Journal: Nutrients

    Article Title: Amelioration of Ethanol-Induced Gastric Ulcers in Rats Pretreated with Phycobiliproteins of Arthrospira (Spirulina) Maxima

    doi: 10.3390/nu10060763

    Figure Lengend Snippet: ExPhy and omeprazole pretreatments, followed by ethanol-induced gastric ulcers, produced protective effects on the gastric mucosal activity of GPx, SOD and CAT, as well as lowering the levels of MDA compared to the ulcer control. * Indicates p

    Article Snippet: Drugs and Chemicals Omeprazole was acquired from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: Produced, Activity Assay, Multiple Displacement Amplification

    Gastric ulcer area of ethanol-induced ulceration in rats. ( A ) Vehicle control; ( B ) ulcer control; ( C ) ExPhy (100 mg/kg); ( D ) ExPhy (200 mg/kg); ( E ) ExPhy (400 mg/kg); ( F ) omeprazole (40 mg/kg).

    Journal: Nutrients

    Article Title: Amelioration of Ethanol-Induced Gastric Ulcers in Rats Pretreated with Phycobiliproteins of Arthrospira (Spirulina) Maxima

    doi: 10.3390/nu10060763

    Figure Lengend Snippet: Gastric ulcer area of ethanol-induced ulceration in rats. ( A ) Vehicle control; ( B ) ulcer control; ( C ) ExPhy (100 mg/kg); ( D ) ExPhy (200 mg/kg); ( E ) ExPhy (400 mg/kg); ( F ) omeprazole (40 mg/kg).

    Article Snippet: Drugs and Chemicals Omeprazole was acquired from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques:

    Effects of platycodin D on levels of plasma histamine. Values are expressed as mean ± SD of eight rats. PD: platycodin D, OMP: omeprazole. # P

    Journal: Evidence-based Complementary and Alternative Medicine : eCAM

    Article Title: Effects of Platycodin D on Reflux Esophagitis due to Modulation of Antioxidant Defense Systems

    doi: 10.1155/2018/7918034

    Figure Lengend Snippet: Effects of platycodin D on levels of plasma histamine. Values are expressed as mean ± SD of eight rats. PD: platycodin D, OMP: omeprazole. # P

    Article Snippet: Omeprazole (OMP) (Sigma, MO, USA) was dissolved in distilled water and used at a dose of 10 mg/kg as a reference drug [ ].

    Techniques:

    Macroscopic appearance of esophageal and gastric mucosa in pretreatment groups. Panels: (a) sham, (b) control, (c) OMP, (d) PD 200, (e) PD 100, and (f): PD50. Compared to sham (a), severe focal lesions with hemorrhage and ulcer exhibited in the esophageal and gastric mucosa of control (b). However, the macroscopic lesions were dose-dependently reduced by treatment with OMP (c) or PD (d, e, f). PD: platycodin D, OMP: omeprazole.

    Journal: Evidence-based Complementary and Alternative Medicine : eCAM

    Article Title: Effects of Platycodin D on Reflux Esophagitis due to Modulation of Antioxidant Defense Systems

    doi: 10.1155/2018/7918034

    Figure Lengend Snippet: Macroscopic appearance of esophageal and gastric mucosa in pretreatment groups. Panels: (a) sham, (b) control, (c) OMP, (d) PD 200, (e) PD 100, and (f): PD50. Compared to sham (a), severe focal lesions with hemorrhage and ulcer exhibited in the esophageal and gastric mucosa of control (b). However, the macroscopic lesions were dose-dependently reduced by treatment with OMP (c) or PD (d, e, f). PD: platycodin D, OMP: omeprazole.

    Article Snippet: Omeprazole (OMP) (Sigma, MO, USA) was dissolved in distilled water and used at a dose of 10 mg/kg as a reference drug [ ].

    Techniques:

    Effects of platycodin D on lesion area in the esophageal and gastric mucosa. Values are expressed as mean ± SD of eight rats; PD: platycodin D, OMP: omeprazole. # P

    Journal: Evidence-based Complementary and Alternative Medicine : eCAM

    Article Title: Effects of Platycodin D on Reflux Esophagitis due to Modulation of Antioxidant Defense Systems

    doi: 10.1155/2018/7918034

    Figure Lengend Snippet: Effects of platycodin D on lesion area in the esophageal and gastric mucosa. Values are expressed as mean ± SD of eight rats; PD: platycodin D, OMP: omeprazole. # P

    Article Snippet: Omeprazole (OMP) (Sigma, MO, USA) was dissolved in distilled water and used at a dose of 10 mg/kg as a reference drug [ ].

    Techniques:

    Histopathological analyses of invasive lesions and total organ wall thickness. The panels show representative histopathological profiles of a hematoxylin-eosin stain of the esophagus and gastric fundus in sham or RE induced rats. Panels: (a) sham, (b) control, (c) OMP, (d) PD 200, (e) PD 100, and (f) PD50. Histopathological analysis showed severe focal lesions with hemorrhage (black arrow), ulcer (circle), and edematous changes (dashed line circle) in the esophagus and gastric fundus of control compared with sham. However, the lesions were notably reduced by treatment with each of the 3 doses of PD compared with control; PD: platycodin D; OMP: omeprazole; LU: lumen; EP: epithelium; MU: mucosa; MS: muscular layer; Scale bars = 80 μ m.

    Journal: Evidence-based Complementary and Alternative Medicine : eCAM

    Article Title: Effects of Platycodin D on Reflux Esophagitis due to Modulation of Antioxidant Defense Systems

    doi: 10.1155/2018/7918034

    Figure Lengend Snippet: Histopathological analyses of invasive lesions and total organ wall thickness. The panels show representative histopathological profiles of a hematoxylin-eosin stain of the esophagus and gastric fundus in sham or RE induced rats. Panels: (a) sham, (b) control, (c) OMP, (d) PD 200, (e) PD 100, and (f) PD50. Histopathological analysis showed severe focal lesions with hemorrhage (black arrow), ulcer (circle), and edematous changes (dashed line circle) in the esophagus and gastric fundus of control compared with sham. However, the lesions were notably reduced by treatment with each of the 3 doses of PD compared with control; PD: platycodin D; OMP: omeprazole; LU: lumen; EP: epithelium; MU: mucosa; MS: muscular layer; Scale bars = 80 μ m.

    Article Snippet: Omeprazole (OMP) (Sigma, MO, USA) was dissolved in distilled water and used at a dose of 10 mg/kg as a reference drug [ ].

    Techniques: Staining, Mass Spectrometry

    AMHAE (200 mg/kg) alleviates ethanol-induced gastric histological alterations in rats. ( A ) Normal; ( B ) ulcer control; ( C ) omeprazole (30 mg/kg); ( D ) AMHAE (200 mg/kg); and ( E ) microscopic damage score level of different groups. Original magnification 20×. * p

    Journal: International Journal of Molecular Sciences

    Article Title: Aronia melanocarpa (Black Chokeberry) Reduces Ethanol-Induced Gastric Damage via Regulation of HSP-70, NF-κB, and MCP-1 Signaling

    doi: 10.3390/ijms18061195

    Figure Lengend Snippet: AMHAE (200 mg/kg) alleviates ethanol-induced gastric histological alterations in rats. ( A ) Normal; ( B ) ulcer control; ( C ) omeprazole (30 mg/kg); ( D ) AMHAE (200 mg/kg); and ( E ) microscopic damage score level of different groups. Original magnification 20×. * p

    Article Snippet: Chemicals and Drugs Omeprazole, glibenclamide (K+ ATP channel inhibitor) N -G-nitro-l -arginine methyl ester (l -NAME; non-specific nitric oxide synthase inhibitor), carboxymethyl cellulose (CMC), l -arginine, clonidine, morphine, capsaicin, misoprostol, diazoxide, yohimbine, naloxone, capsazepine, indomethacin, cyanidin-3-galactose, cyanidin-3-glucose, and cyanidin-3-arabinose were obtained from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques:

    Gastroprotective activity of Aronia melanocarpa hydro-alcoholic extract (AMHAE) (200 mg/kg) on ethanol-induced gastric injury in rats. ( A ) Normal rats; ( B ) Ulcer control; ( C ) Omeprazole (30 mg/kg) pretreated rats; ( D ) AMHAE (200 mg/kg) pretreated rats. Ethanol-induced severe injuries to the gastric mucosa appear as elongated bands of hemorrhage (yellow arrows).

    Journal: International Journal of Molecular Sciences

    Article Title: Aronia melanocarpa (Black Chokeberry) Reduces Ethanol-Induced Gastric Damage via Regulation of HSP-70, NF-κB, and MCP-1 Signaling

    doi: 10.3390/ijms18061195

    Figure Lengend Snippet: Gastroprotective activity of Aronia melanocarpa hydro-alcoholic extract (AMHAE) (200 mg/kg) on ethanol-induced gastric injury in rats. ( A ) Normal rats; ( B ) Ulcer control; ( C ) Omeprazole (30 mg/kg) pretreated rats; ( D ) AMHAE (200 mg/kg) pretreated rats. Ethanol-induced severe injuries to the gastric mucosa appear as elongated bands of hemorrhage (yellow arrows).

    Article Snippet: Chemicals and Drugs Omeprazole, glibenclamide (K+ ATP channel inhibitor) N -G-nitro-l -arginine methyl ester (l -NAME; non-specific nitric oxide synthase inhibitor), carboxymethyl cellulose (CMC), l -arginine, clonidine, morphine, capsaicin, misoprostol, diazoxide, yohimbine, naloxone, capsazepine, indomethacin, cyanidin-3-galactose, cyanidin-3-glucose, and cyanidin-3-arabinose were obtained from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: Activity Assay

    Scanning electron micrograph images of gastric injuries. Experimental groups: ( A ) normal; ( B ) ulcer control; ( C ) omeprazole (30 mg/kg); and ( D ) AMHAE (200 mg/kg). Note: epithelial desquamation (yellow asterisk); fibrin deposits and hemorrhage with erythrocytes (yellow arrows); and gastric epithelium with slightly widened gastric pits (pound signs).

    Journal: International Journal of Molecular Sciences

    Article Title: Aronia melanocarpa (Black Chokeberry) Reduces Ethanol-Induced Gastric Damage via Regulation of HSP-70, NF-κB, and MCP-1 Signaling

    doi: 10.3390/ijms18061195

    Figure Lengend Snippet: Scanning electron micrograph images of gastric injuries. Experimental groups: ( A ) normal; ( B ) ulcer control; ( C ) omeprazole (30 mg/kg); and ( D ) AMHAE (200 mg/kg). Note: epithelial desquamation (yellow asterisk); fibrin deposits and hemorrhage with erythrocytes (yellow arrows); and gastric epithelium with slightly widened gastric pits (pound signs).

    Article Snippet: Chemicals and Drugs Omeprazole, glibenclamide (K+ ATP channel inhibitor) N -G-nitro-l -arginine methyl ester (l -NAME; non-specific nitric oxide synthase inhibitor), carboxymethyl cellulose (CMC), l -arginine, clonidine, morphine, capsaicin, misoprostol, diazoxide, yohimbine, naloxone, capsazepine, indomethacin, cyanidin-3-galactose, cyanidin-3-glucose, and cyanidin-3-arabinose were obtained from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques:

    Chemical structure of ilaprazole, ilaprazole sulfone, ilaprazole thiol ether and omeprazole.

    Journal: Acta Pharmacologica Sinica

    Article Title: An improved LC-MS/MS method for quantitative determination of ilaprazole and its metabolites in human plasma and its application to a pharmacokinetic study

    doi: 10.1038/aps.2009.120

    Figure Lengend Snippet: Chemical structure of ilaprazole, ilaprazole sulfone, ilaprazole thiol ether and omeprazole.

    Article Snippet: Materials and reagents Ilaprazole, ilaprazole sulfone and ilaprazole thiol ether standards were obtained from the Livzon Pharmaceutical Group Inc (purity: 99.1% Zhuhai, China); omeprazole standards were obtained from Sigma Company (purity: 99.5%, USA).

    Techniques:

    Production mass spectrum of ila prazole, ilaprazole sulfone, ilaprazole thiol ether, and omeprazole.

    Journal: Acta Pharmacologica Sinica

    Article Title: An improved LC-MS/MS method for quantitative determination of ilaprazole and its metabolites in human plasma and its application to a pharmacokinetic study

    doi: 10.1038/aps.2009.120

    Figure Lengend Snippet: Production mass spectrum of ila prazole, ilaprazole sulfone, ilaprazole thiol ether, and omeprazole.

    Article Snippet: Materials and reagents Ilaprazole, ilaprazole sulfone and ilaprazole thiol ether standards were obtained from the Livzon Pharmaceutical Group Inc (purity: 99.1% Zhuhai, China); omeprazole standards were obtained from Sigma Company (purity: 99.5%, USA).

    Techniques:

    Characterization of in vitro formation and depletion of 5OH-omeprazole and omeprazole sulfone in hepatocytes. Formation of 5OH-omeprazole (A) and omeprazole sulfone (C) from omeprazole. The percentage remaining of 5OH-omeprazole (B) and omeprazole sulfone

    Journal: Drug Metabolism and Disposition

    Article Title: Prediction of Relative In Vivo Metabolite Exposure from In Vitro Data Using Two Model Drugs: Dextromethorphan and Omeprazole

    doi: 10.1124/dmd.111.042200

    Figure Lengend Snippet: Characterization of in vitro formation and depletion of 5OH-omeprazole and omeprazole sulfone in hepatocytes. Formation of 5OH-omeprazole (A) and omeprazole sulfone (C) from omeprazole. The percentage remaining of 5OH-omeprazole (B) and omeprazole sulfone

    Article Snippet: Dextromethorphan, dextrorphan, 3-hydroxymorphinan, omeprazole, 5OH-omeprazole, omeprazole sulfone, NADPH, uridine diphosphate glucuronic acid (UDPGA), alamethicin, and saccharolactone were purchased from Sigma-Aldrich (St. Louis, MO).

    Techniques: In Vitro

    Characterization of in vitro formation and depletion of 5OH-omeprazole and omeprazole sulfone in pooled HLM. Formation (A) and depletion (B) of 5OH-omeprazole. Formation (C) and depletion (D) of omeprazole sulfone. B, the percentage remaining of 5OH-omeprazole

    Journal: Drug Metabolism and Disposition

    Article Title: Prediction of Relative In Vivo Metabolite Exposure from In Vitro Data Using Two Model Drugs: Dextromethorphan and Omeprazole

    doi: 10.1124/dmd.111.042200

    Figure Lengend Snippet: Characterization of in vitro formation and depletion of 5OH-omeprazole and omeprazole sulfone in pooled HLM. Formation (A) and depletion (B) of 5OH-omeprazole. Formation (C) and depletion (D) of omeprazole sulfone. B, the percentage remaining of 5OH-omeprazole

    Article Snippet: Dextromethorphan, dextrorphan, 3-hydroxymorphinan, omeprazole, 5OH-omeprazole, omeprazole sulfone, NADPH, uridine diphosphate glucuronic acid (UDPGA), alamethicin, and saccharolactone were purchased from Sigma-Aldrich (St. Louis, MO).

    Techniques: In Vitro

    The fold-induction of CYP isozymes after 48 hours treatment with positive inducers (1A2: 25, 50, and 100 μM omeprazole; 2B6: 500, 750, and 1000 μM Phenobarbital; 2C9, 3A4: 10, 25, and 50 μM rifampin) in 3 hepatocyte cell lines. * p

    Journal: Biomolecules & Therapeutics

    Article Title: Measurement of Human Cytochrome P450 Enzyme Induction Based on Mesalazine and Mosapride Citrate Treatments Using a Luminescent Assay

    doi: 10.4062/biomolther.2015.041

    Figure Lengend Snippet: The fold-induction of CYP isozymes after 48 hours treatment with positive inducers (1A2: 25, 50, and 100 μM omeprazole; 2B6: 500, 750, and 1000 μM Phenobarbital; 2C9, 3A4: 10, 25, and 50 μM rifampin) in 3 hepatocyte cell lines. * p

    Article Snippet: Reagents and media Omeprazole, rifampin, Krebs-Henseleit buffer, mesalazine, and mosapride citrate were purchased from Sigma-Aldrich (Saint Louis, MO, USA).

    Techniques:

    Fraction of the neutral form of omeprazole, α , and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {}_{\text{w}}^{\text{s}} {\text{pH}} $$\end{document} w s pH versus the concentration of omeprazole in the mobile phase with a 25/75, v/v, acetonitrile/phosphate buffer ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {}_{\text{w}}^{\text{w}} {\text{pH}} $$\end{document} w w pH = 9.0) and b 45/55, v/v, methanol/phosphate buffer ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {}_{\text{w}}^{\text{w}} {\text{pH}} $$\end{document} w w pH = 9.0)

    Journal: Chromatographia

    Article Title: Combining Chemometric Models with Adsorption Isotherm Measurements to Study Omeprazole in RP-LC

    doi: 10.1007/s10337-016-3151-8

    Figure Lengend Snippet: Fraction of the neutral form of omeprazole, α , and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {}_{\text{w}}^{\text{s}} {\text{pH}} $$\end{document} w s pH versus the concentration of omeprazole in the mobile phase with a 25/75, v/v, acetonitrile/phosphate buffer ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {}_{\text{w}}^{\text{w}} {\text{pH}} $$\end{document} w w pH = 9.0) and b 45/55, v/v, methanol/phosphate buffer ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {}_{\text{w}}^{\text{w}} {\text{pH}} $$\end{document} w w pH = 9.0)

    Article Snippet: The solutes were omeprazole ( > 99 %), methyl-omeprazole (analytical reference standard), and omeprazole sulfone (analytical reference standard) and were gifts from AstraZeneca R & D (Mölndal, Sweden).

    Techniques: Concentration Assay

    Comparison between experimental elution profiles ( blue lines ) and elution profiles calculated using the pH-dependent isotherm model ( red lines ) and the quadratic isotherm model ( green lines ) for omeprazole at different pH levels. In a – c 25/75, v/v, acetonitrile/phosphate buffer is used as mobile phase, and in d – f 45/55, v/v, methanol/phosphate buffer is used as mobile phase. For acetonitrile, the flow rate was 1.0 mL min −1 and injections were 0.5 mL of a 2.5 g L −1 solution. For methanol, the flow rate was 0.7 mL min −1 and injections were 0.5 mL of a 4.0 g L −1 solution. The column temperature was 30 °C in all experiments. Note that for the pH-dependent model, one set of numerical parameters is used at all pH levels, while for the quadratic model, a different parameter set is used at each pH

    Journal: Chromatographia

    Article Title: Combining Chemometric Models with Adsorption Isotherm Measurements to Study Omeprazole in RP-LC

    doi: 10.1007/s10337-016-3151-8

    Figure Lengend Snippet: Comparison between experimental elution profiles ( blue lines ) and elution profiles calculated using the pH-dependent isotherm model ( red lines ) and the quadratic isotherm model ( green lines ) for omeprazole at different pH levels. In a – c 25/75, v/v, acetonitrile/phosphate buffer is used as mobile phase, and in d – f 45/55, v/v, methanol/phosphate buffer is used as mobile phase. For acetonitrile, the flow rate was 1.0 mL min −1 and injections were 0.5 mL of a 2.5 g L −1 solution. For methanol, the flow rate was 0.7 mL min −1 and injections were 0.5 mL of a 4.0 g L −1 solution. The column temperature was 30 °C in all experiments. Note that for the pH-dependent model, one set of numerical parameters is used at all pH levels, while for the quadratic model, a different parameter set is used at each pH

    Article Snippet: The solutes were omeprazole ( > 99 %), methyl-omeprazole (analytical reference standard), and omeprazole sulfone (analytical reference standard) and were gifts from AstraZeneca R & D (Mölndal, Sweden).

    Techniques: Flow Cytometry

    Structure of the omeprazole and the investigated impurities along with the chromatogram obtained at the center point (buffer \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {}_{\text{w}}^{\text{w}} {\text{pH}} $$\end{document} w w pH = 8.0, 30 °C) of the experimental design with acetonitrile as organic modifier. The flow rate was 1.0 mL min −1 , the detection was conducted at 302 nm, and the injection was 10 μL of 0.15 mg mL −1 omeprazole, 0.011 mg mL −1 omeprazole sulfone, and 0.007 mg mL −1 methyl-omeprazole. The hydrogen of the benzimidazole group lost at high pH for omeprazole and omeprazole sulfone is indicated in red

    Journal: Chromatographia

    Article Title: Combining Chemometric Models with Adsorption Isotherm Measurements to Study Omeprazole in RP-LC

    doi: 10.1007/s10337-016-3151-8

    Figure Lengend Snippet: Structure of the omeprazole and the investigated impurities along with the chromatogram obtained at the center point (buffer \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {}_{\text{w}}^{\text{w}} {\text{pH}} $$\end{document} w w pH = 8.0, 30 °C) of the experimental design with acetonitrile as organic modifier. The flow rate was 1.0 mL min −1 , the detection was conducted at 302 nm, and the injection was 10 μL of 0.15 mg mL −1 omeprazole, 0.011 mg mL −1 omeprazole sulfone, and 0.007 mg mL −1 methyl-omeprazole. The hydrogen of the benzimidazole group lost at high pH for omeprazole and omeprazole sulfone is indicated in red

    Article Snippet: The solutes were omeprazole ( > 99 %), methyl-omeprazole (analytical reference standard), and omeprazole sulfone (analytical reference standard) and were gifts from AstraZeneca R & D (Mölndal, Sweden).

    Techniques: Flow Cytometry, Injection

    Response surfaces from the experimental designs with acetonitrile ( a , c , e ) and methanol ( b , d , f ) as organic modifier. a , b Retention factors, k , of omeprazole, c , d resolution factors, R s , between omeprazole and H168/66, and e , f tailing factors, T f , of omeprazole

    Journal: Chromatographia

    Article Title: Combining Chemometric Models with Adsorption Isotherm Measurements to Study Omeprazole in RP-LC

    doi: 10.1007/s10337-016-3151-8

    Figure Lengend Snippet: Response surfaces from the experimental designs with acetonitrile ( a , c , e ) and methanol ( b , d , f ) as organic modifier. a , b Retention factors, k , of omeprazole, c , d resolution factors, R s , between omeprazole and H168/66, and e , f tailing factors, T f , of omeprazole

    Article Snippet: The solutes were omeprazole ( > 99 %), methyl-omeprazole (analytical reference standard), and omeprazole sulfone (analytical reference standard) and were gifts from AstraZeneca R & D (Mölndal, Sweden).

    Techniques:

    Elution profiles of omeprazole using different sample concentrations to illustrate that the fronting is due to thermodynamic overloading. The mobile phase with 25/75, v/v, acetonitrile/phosphate buffer ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {}_{\text{w}}^{\text{w}} {\text{pH}} $$\end{document} w w pH = 9.0) at a temperature of 30 °C and flow rate of 1.0 mL/min

    Journal: Chromatographia

    Article Title: Combining Chemometric Models with Adsorption Isotherm Measurements to Study Omeprazole in RP-LC

    doi: 10.1007/s10337-016-3151-8

    Figure Lengend Snippet: Elution profiles of omeprazole using different sample concentrations to illustrate that the fronting is due to thermodynamic overloading. The mobile phase with 25/75, v/v, acetonitrile/phosphate buffer ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {}_{\text{w}}^{\text{w}} {\text{pH}} $$\end{document} w w pH = 9.0) at a temperature of 30 °C and flow rate of 1.0 mL/min

    Article Snippet: The solutes were omeprazole ( > 99 %), methyl-omeprazole (analytical reference standard), and omeprazole sulfone (analytical reference standard) and were gifts from AstraZeneca R & D (Mölndal, Sweden).

    Techniques: Flow Cytometry

    Estimation of p K a values for omeprazole and omeprazole sulfone in 25/75, v/v, acetonitrile/water and 45/55, v/v methanol/water at 30 °C. Symbols are experimental retention factors at different mobile phase \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {}_{\text{w}}^{\text{s}} {\text{pH}} $$\end{document} w s pH levels and solid lines are the best fit to Eq. ( 4 )

    Journal: Chromatographia

    Article Title: Combining Chemometric Models with Adsorption Isotherm Measurements to Study Omeprazole in RP-LC

    doi: 10.1007/s10337-016-3151-8

    Figure Lengend Snippet: Estimation of p K a values for omeprazole and omeprazole sulfone in 25/75, v/v, acetonitrile/water and 45/55, v/v methanol/water at 30 °C. Symbols are experimental retention factors at different mobile phase \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {}_{\text{w}}^{\text{s}} {\text{pH}} $$\end{document} w s pH levels and solid lines are the best fit to Eq. ( 4 )

    Article Snippet: The solutes were omeprazole ( > 99 %), methyl-omeprazole (analytical reference standard), and omeprazole sulfone (analytical reference standard) and were gifts from AstraZeneca R & D (Mölndal, Sweden).

    Techniques:

    High‐performance liquid chromatography‐mass spectrometer ( HPLC ‐ MS ) chromatograms of oxidation metabolites of Omeprazole in suspension cultures of fresh (A = 0 min and B = 30 min) and recovered cryopreserved (C = 0 min and D = 30 min) equine hepatocytes. The ratio between the peak areas of M1, M2, and M3 was 2:1:1, respectively, in both fresh and cryopreserved hepatocytes.

    Journal: Pharmacology Research & Perspectives

    Article Title: Equine hepatocytes: isolation, cryopreservation, and applications to in vitro drug metabolism studies, Equine hepatocytes: isolation, cryopreservation, and applications to in vitro drug metabolism studies

    doi: 10.1002/prp2.268

    Figure Lengend Snippet: High‐performance liquid chromatography‐mass spectrometer ( HPLC ‐ MS ) chromatograms of oxidation metabolites of Omeprazole in suspension cultures of fresh (A = 0 min and B = 30 min) and recovered cryopreserved (C = 0 min and D = 30 min) equine hepatocytes. The ratio between the peak areas of M1, M2, and M3 was 2:1:1, respectively, in both fresh and cryopreserved hepatocytes.

    Article Snippet: Omeprazole and lanzaprozole were purchased from Tocris Bioscience (Bristol, UK).

    Techniques: High Performance Liquid Chromatography, Mass Spectrometry

    Comparison of intrinsic clearance between fresh and cryopreserved hepatocytes (mean presented by dash line) for omeprazole (A), flunixin (B), and phenylbutazone (C) ( n = 3 horses for each drug). The results show that there is no significant difference between fresh and cryopreserved equine hepatocytes, P > 0.5.

    Journal: Pharmacology Research & Perspectives

    Article Title: Equine hepatocytes: isolation, cryopreservation, and applications to in vitro drug metabolism studies, Equine hepatocytes: isolation, cryopreservation, and applications to in vitro drug metabolism studies

    doi: 10.1002/prp2.268

    Figure Lengend Snippet: Comparison of intrinsic clearance between fresh and cryopreserved hepatocytes (mean presented by dash line) for omeprazole (A), flunixin (B), and phenylbutazone (C) ( n = 3 horses for each drug). The results show that there is no significant difference between fresh and cryopreserved equine hepatocytes, P > 0.5.

    Article Snippet: Omeprazole and lanzaprozole were purchased from Tocris Bioscience (Bristol, UK).

    Techniques:

    Effect of cimetidine, ranitidine, famotidine and omeprazole on DNA synthesis of hepatocytes in primary culture. Hepatocyte isolation has been described under ‘Materials and Methods’. Cells were plated in MEM supplemented with 5% FCS and insulin (10 −7 M). After 3 h, the medium and floating cells were discarded and serum-free medium plus insulin (10 −7 M), EGF (10 ng/ml) and proline (0.26 mM) were added. H 2 blocking agents were added at different concentrations on the basis of their blood level after administration of a therapeutic dose; cimetidine, ranitidine, famotidine (0.62–30 μ g/ml ) and omeprazole (0.06–1.8 μ g/ml). Cultures were exposed to 7.5 μ Ci [ 3 H] thymidine for the last 24 h and processed after 48 h for determination of DNA synthesis. For each medium, triplicate culture dishes from 5 different animals were used. Results (mean ± S.D.) are expressed as cpm × 10 −2 / μ g DNA.

    Journal: Journal of hepatology

    Article Title: Effect of cimetidine, ranitidine, famotidine and omeprazole on hepatocyte proliferation in vitro

    doi:

    Figure Lengend Snippet: Effect of cimetidine, ranitidine, famotidine and omeprazole on DNA synthesis of hepatocytes in primary culture. Hepatocyte isolation has been described under ‘Materials and Methods’. Cells were plated in MEM supplemented with 5% FCS and insulin (10 −7 M). After 3 h, the medium and floating cells were discarded and serum-free medium plus insulin (10 −7 M), EGF (10 ng/ml) and proline (0.26 mM) were added. H 2 blocking agents were added at different concentrations on the basis of their blood level after administration of a therapeutic dose; cimetidine, ranitidine, famotidine (0.62–30 μ g/ml ) and omeprazole (0.06–1.8 μ g/ml). Cultures were exposed to 7.5 μ Ci [ 3 H] thymidine for the last 24 h and processed after 48 h for determination of DNA synthesis. For each medium, triplicate culture dishes from 5 different animals were used. Results (mean ± S.D.) are expressed as cpm × 10 −2 / μ g DNA.

    Article Snippet: Cimetidine was obtained from Smith, Kline and French Lab Co., Caroline, PR, ranitidine from Glaxo, Inc., Research Triangle Park, NC, famotidine from Sigma Tau Co., Rome, Italy, omeprazole from Bracco, Milan, Italy.

    Techniques: DNA Synthesis, Isolation, Blocking Assay

    Time-kill curves for norfloxacin alone or combined with reserpine (N+R), lansoprazole (N+L), or omeprazole (N+O) (A) and for ciprofloxacin alone or combined with reserpine (C+R), lansoprazole (C+L), or omeprazole (C+O) (B) versus SA 1199B. The fluoroquinolones were tested at 0.25× MICs, and inhibitor concentrations were 100 μg/ml for omeprazole and lansoprazole and 20 μg/ml for reserpine.

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Effects of NorA Inhibitors on In Vitro Antibacterial Activities and Postantibiotic Effects of Levofloxacin, Ciprofloxacin, and Norfloxacin in Genetically Related Strains of Staphylococcus aureus

    doi:

    Figure Lengend Snippet: Time-kill curves for norfloxacin alone or combined with reserpine (N+R), lansoprazole (N+L), or omeprazole (N+O) (A) and for ciprofloxacin alone or combined with reserpine (C+R), lansoprazole (C+L), or omeprazole (C+O) (B) versus SA 1199B. The fluoroquinolones were tested at 0.25× MICs, and inhibitor concentrations were 100 μg/ml for omeprazole and lansoprazole and 20 μg/ml for reserpine.

    Article Snippet: Omeprazole (lot E6828) was obtained from Astra Merck (Södertälje, Sweden).

    Techniques:

    Time-kill curves for norfloxacin alone or combined with reserpine (N+R), lansoprazole (N+L), or omeprazole (N+O) (A) and for ciprofloxacin alone or combined with reserpine (C+R), lansoprazole (C+L), or omeprazole (C+O) (B) versus SA 1199. The fluoroquinolones were tested at 0.25× MICs, and inhibitor concentrations were 100 μg/ml for omeprazole and lansoprazole and 20 μg/ml for reserpine.

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Effects of NorA Inhibitors on In Vitro Antibacterial Activities and Postantibiotic Effects of Levofloxacin, Ciprofloxacin, and Norfloxacin in Genetically Related Strains of Staphylococcus aureus

    doi:

    Figure Lengend Snippet: Time-kill curves for norfloxacin alone or combined with reserpine (N+R), lansoprazole (N+L), or omeprazole (N+O) (A) and for ciprofloxacin alone or combined with reserpine (C+R), lansoprazole (C+L), or omeprazole (C+O) (B) versus SA 1199. The fluoroquinolones were tested at 0.25× MICs, and inhibitor concentrations were 100 μg/ml for omeprazole and lansoprazole and 20 μg/ml for reserpine.

    Article Snippet: Omeprazole (lot E6828) was obtained from Astra Merck (Södertälje, Sweden).

    Techniques:

    Inhibition of gastric acid alters the topographic, but not the glandular, distribution of H pylori in vivo . (A–C) A representative experiment showing the mean (±SD) bacterial densities from distinct anatomic regions of mice treated with saline or omeprazole. Each data point represents a biological replicate. The dotted line represents the limit of detection. (D–E) Representative images showing that H pylori (green) are restricted to the pits in infected, omeprazole-treated mice (D) and that inhibition of gastric acid secretion with omeprazole does not expand sLe x (red) expression. The onset of SPEM following HD-Tam treatment allows H pylori to penetrate deep within SPEM glands demonstrating expanded sLe x expression (E). Blue, nuclei. Scale bars, 50 µm. (F) Magnified, representative image shows H pylori (green) co-localizing with sLe x (red) within the pit of an omeprazole-treated mouse. Blue, nuclei. Scale bar, 5 µm. (G) The distance of H pylori along the gland axis was expressed as a percentage of total gland length. Data represent the mean (±SD) distribution from three infected littermates/cagemates for each treatment condition. Each data point represents a gland colonized with H pylori , with total numbers of scored glands indicated in parentheses. Hp, H pylori .

    Journal: Gastroenterology

    Article Title: Tropism for Spasmolytic Polypeptide-Expressing Metaplasia Allows Helicobacter pylori to Expand its Intra-gastric Niche.

    doi: 10.1053/j.gastro.2018.09.050

    Figure Lengend Snippet: Inhibition of gastric acid alters the topographic, but not the glandular, distribution of H pylori in vivo . (A–C) A representative experiment showing the mean (±SD) bacterial densities from distinct anatomic regions of mice treated with saline or omeprazole. Each data point represents a biological replicate. The dotted line represents the limit of detection. (D–E) Representative images showing that H pylori (green) are restricted to the pits in infected, omeprazole-treated mice (D) and that inhibition of gastric acid secretion with omeprazole does not expand sLe x (red) expression. The onset of SPEM following HD-Tam treatment allows H pylori to penetrate deep within SPEM glands demonstrating expanded sLe x expression (E). Blue, nuclei. Scale bars, 50 µm. (F) Magnified, representative image shows H pylori (green) co-localizing with sLe x (red) within the pit of an omeprazole-treated mouse. Blue, nuclei. Scale bar, 5 µm. (G) The distance of H pylori along the gland axis was expressed as a percentage of total gland length. Data represent the mean (±SD) distribution from three infected littermates/cagemates for each treatment condition. Each data point represents a gland colonized with H pylori , with total numbers of scored glands indicated in parentheses. Hp, H pylori .

    Article Snippet: For omeprazole treatment, mice were infected for 6 weeks, then gavaged daily for one week with 200 µL of either saline (Hospira Inc., Lake Forest, IL) or an omeprazole slurry (Sigma; 1.5 mg/20 g body weight resuspended in saline) prior to sacrifice.

    Techniques: Inhibition, In Vivo, Mouse Assay, Infection, Expressing

    Influence of VRC treatment on CYP3A4 , CYP2B6 , and CYP1A2 mRNA levels in primary human hepatocytes. Human hepatocytes (Hu4205, Hu4228, and Hu8114) were treated with vehicle (0.1% DMSO), VRC (1 to 300 μM), or positive control rifampin, phenobarbital, or omeprazole. CYP mRNA levels were determined by real-time PCR and normalized to those of β- ACTIN . Relative mRNA levels are shown as the means from triplicate experiments.

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Coordinated Roles of Pregnane X Receptor and Constitutive Androstane Receptor in Autoinduction of Voriconazole Metabolism in Mice

    doi: 10.1128/AAC.01900-12

    Figure Lengend Snippet: Influence of VRC treatment on CYP3A4 , CYP2B6 , and CYP1A2 mRNA levels in primary human hepatocytes. Human hepatocytes (Hu4205, Hu4228, and Hu8114) were treated with vehicle (0.1% DMSO), VRC (1 to 300 μM), or positive control rifampin, phenobarbital, or omeprazole. CYP mRNA levels were determined by real-time PCR and normalized to those of β- ACTIN . Relative mRNA levels are shown as the means from triplicate experiments.

    Article Snippet: Phenacetin, midazolam, alprazolam, phenobarbital, and omeprazole were purchased from Wako Pure Chemical Industries, Ltd. (Osaka, Japan), and rifampin and EDTA were purchased from Sigma-Aldrich Japan K.K. (Tokyo, Japan).

    Techniques: Positive Control, Real-time Polymerase Chain Reaction

    The ACP (A) and NAG (B) levels in mouse serum and spleen. In both the non-MNNG-treated and MNNG-treated subgroups, omeprazole treatment (especially at high dose) decreased both enzyme levels in both serum and spleen. ACP, acid phosphatase; NAG, N-acetyl-β-D-glucosaminidase; MNNG, N-methyl-N’-nitro-N-nitrosoguanidine. *, P

    Journal: Oncotarget

    Article Title: Omeprazole promotes carcinogenesis of fore-stomach in mice with co-stimulation of nitrosamine

    doi: 10.18632/oncotarget.19696

    Figure Lengend Snippet: The ACP (A) and NAG (B) levels in mouse serum and spleen. In both the non-MNNG-treated and MNNG-treated subgroups, omeprazole treatment (especially at high dose) decreased both enzyme levels in both serum and spleen. ACP, acid phosphatase; NAG, N-acetyl-β-D-glucosaminidase; MNNG, N-methyl-N’-nitro-N-nitrosoguanidine. *, P

    Article Snippet: Omeprazole was from New Era Pharmaceutical Co. Ltd. (Shandong, China).

    Techniques:

    Body weight changes (A) and spleen weight index (B). The body weights in the MNNG-treated subgroups were lower than those in the non-MNNG-treated groups. Omeprazole treatment decreased the spleen weight index in both the non-MNNG-treated and MNNG-treated subgroups. MNNG, N-methyl-N’-nitro-N-nitrosoguanidine.

    Journal: Oncotarget

    Article Title: Omeprazole promotes carcinogenesis of fore-stomach in mice with co-stimulation of nitrosamine

    doi: 10.18632/oncotarget.19696

    Figure Lengend Snippet: Body weight changes (A) and spleen weight index (B). The body weights in the MNNG-treated subgroups were lower than those in the non-MNNG-treated groups. Omeprazole treatment decreased the spleen weight index in both the non-MNNG-treated and MNNG-treated subgroups. MNNG, N-methyl-N’-nitro-N-nitrosoguanidine.

    Article Snippet: Omeprazole was from New Era Pharmaceutical Co. Ltd. (Shandong, China).

    Techniques:

    The gross mouse gastric specimens In the control group (A) , the mouse fore-head gastric mucosa was smooth, and the glandular stomach had intact mucosa, with obvious mucosal folds. In the omeprazole-treated groups (B) , low dose omeprazole; and (C) , high dose omeprazole), there existed papillary eminences in the fore-gastric mucosa, and the mucosal folds of the glandular mucosa were markedly shallower, especially in the high-dose group. In the MNNG-treated group (D) , ulcerative lesions occurred in the fore-stomach, with obvious mucosal hypertension, and the glandular gastric folds became shallower. In the groups treated by MNNG and omeprazole (E) , MNNG + low dose omeprazole; and (F) , MNNG + high dose omeprazole), there existed many eminent lesions in the fore-stomach, and the mucosal folds of the glandular stomach disappeared. The typical lesions in the omeprazole-treated groups were marked with ‘*’. MNNG, N-methyl-N’-nitro-N-nitrosoguanidine.

    Journal: Oncotarget

    Article Title: Omeprazole promotes carcinogenesis of fore-stomach in mice with co-stimulation of nitrosamine

    doi: 10.18632/oncotarget.19696

    Figure Lengend Snippet: The gross mouse gastric specimens In the control group (A) , the mouse fore-head gastric mucosa was smooth, and the glandular stomach had intact mucosa, with obvious mucosal folds. In the omeprazole-treated groups (B) , low dose omeprazole; and (C) , high dose omeprazole), there existed papillary eminences in the fore-gastric mucosa, and the mucosal folds of the glandular mucosa were markedly shallower, especially in the high-dose group. In the MNNG-treated group (D) , ulcerative lesions occurred in the fore-stomach, with obvious mucosal hypertension, and the glandular gastric folds became shallower. In the groups treated by MNNG and omeprazole (E) , MNNG + low dose omeprazole; and (F) , MNNG + high dose omeprazole), there existed many eminent lesions in the fore-stomach, and the mucosal folds of the glandular stomach disappeared. The typical lesions in the omeprazole-treated groups were marked with ‘*’. MNNG, N-methyl-N’-nitro-N-nitrosoguanidine.

    Article Snippet: Omeprazole was from New Era Pharmaceutical Co. Ltd. (Shandong, China).

    Techniques:

    The pathology of mouse fore and glandular stomachs In the omeprazole-treated groups, the fore-stomach squamous epithelial cells underwent hyperkeratosis, and the basement cells were disorderly arranged, invading into the deeper layer in a papillary shape; in the glandular stomach, part of the glands presented atypical hyperplasia. The fore-stomach in the MNNG-treated groups presented a papillary proliferation status with hyperkeratosis and parakeratosis, and malignant cells were occasionally seen; however, the glandular stomach was basically normal. In the glandular stomach of the MNNG plus omeprazole groups, infiltration of inflammatory cells into the mucosal and sub-mucosal layers were prevalent, with more frequent glandular intestinal metaplasia, dysplasia and abnormal hyperplasia, some accompanied with adenocarcinomas. MNNG, N-methyl-N’-nitro-N-nitrosoguanidine.

    Journal: Oncotarget

    Article Title: Omeprazole promotes carcinogenesis of fore-stomach in mice with co-stimulation of nitrosamine

    doi: 10.18632/oncotarget.19696

    Figure Lengend Snippet: The pathology of mouse fore and glandular stomachs In the omeprazole-treated groups, the fore-stomach squamous epithelial cells underwent hyperkeratosis, and the basement cells were disorderly arranged, invading into the deeper layer in a papillary shape; in the glandular stomach, part of the glands presented atypical hyperplasia. The fore-stomach in the MNNG-treated groups presented a papillary proliferation status with hyperkeratosis and parakeratosis, and malignant cells were occasionally seen; however, the glandular stomach was basically normal. In the glandular stomach of the MNNG plus omeprazole groups, infiltration of inflammatory cells into the mucosal and sub-mucosal layers were prevalent, with more frequent glandular intestinal metaplasia, dysplasia and abnormal hyperplasia, some accompanied with adenocarcinomas. MNNG, N-methyl-N’-nitro-N-nitrosoguanidine.

    Article Snippet: Omeprazole was from New Era Pharmaceutical Co. Ltd. (Shandong, China).

    Techniques:

    Western blotting (A) and relative band intensity to β-actin of p21 and mTOR (B) . Both proteins were down-regulated after omeprazole treatment in both the non-MNNG-treated and MNNG-treated subgroups. 1, control; 2, low dose omeprazole; 3, high dose omeprazole; 4, MNNG; 5, MNNG + low dose omeprazole; 6, MNNG + high dose omeprazole. MNNG, N-methyl-N’-nitro-N-nitrosoguanidine.

    Journal: Oncotarget

    Article Title: Omeprazole promotes carcinogenesis of fore-stomach in mice with co-stimulation of nitrosamine

    doi: 10.18632/oncotarget.19696

    Figure Lengend Snippet: Western blotting (A) and relative band intensity to β-actin of p21 and mTOR (B) . Both proteins were down-regulated after omeprazole treatment in both the non-MNNG-treated and MNNG-treated subgroups. 1, control; 2, low dose omeprazole; 3, high dose omeprazole; 4, MNNG; 5, MNNG + low dose omeprazole; 6, MNNG + high dose omeprazole. MNNG, N-methyl-N’-nitro-N-nitrosoguanidine.

    Article Snippet: Omeprazole was from New Era Pharmaceutical Co. Ltd. (Shandong, China).

    Techniques: Western Blot

    Gastric tissue immunohistochemistry after specific IgY treated the Hp infected mice (100 × 10). A: PBS group; B: sucralfate group; C: IgY-CPV group; D: IgY-CPV + sucralfate group; E: IgY-IB group; F: IgY-Hp group; G: omeprazole + clarithromycin group; H: IgY-IB + sucralfate group; I: IgY-Hp + sucralfate group.

    Journal: International Journal of Clinical and Experimental Pathology

    Article Title: Preparation of specific anti-Helicobacter pylori yolk antibodies and their antibacterial effects

    doi:

    Figure Lengend Snippet: Gastric tissue immunohistochemistry after specific IgY treated the Hp infected mice (100 × 10). A: PBS group; B: sucralfate group; C: IgY-CPV group; D: IgY-CPV + sucralfate group; E: IgY-IB group; F: IgY-Hp group; G: omeprazole + clarithromycin group; H: IgY-IB + sucralfate group; I: IgY-Hp + sucralfate group.

    Article Snippet: Hp whole bacterial antigen, IB antigen and CTB adjuvant were provided by Sichuan Vaccine Technology Co., Ltd. Omeprazole was purchased from Youcare Pharmaceutical Group Co., Ltd. Sucralfate was purchased from Huanan Pharmaceutical Group Co., Ltd., Guangdong.

    Techniques: Immunohistochemistry, Infection, Mouse Assay

    Gastric tissue pathology after specific IgY treated the Hp infected mice. (HE staining, 40 × 10). A: PBS group; B: sucralfate group; C: IgY-CPV group; D: IgY-CPV + sucralfate group; E: IgY-IB group; F: IgY-Hp group; G: omeprazole + clarithromycin group; H: IgY-IB + sucralfate group; I: IgY-Hp + sucralfate group.

    Journal: International Journal of Clinical and Experimental Pathology

    Article Title: Preparation of specific anti-Helicobacter pylori yolk antibodies and their antibacterial effects

    doi:

    Figure Lengend Snippet: Gastric tissue pathology after specific IgY treated the Hp infected mice. (HE staining, 40 × 10). A: PBS group; B: sucralfate group; C: IgY-CPV group; D: IgY-CPV + sucralfate group; E: IgY-IB group; F: IgY-Hp group; G: omeprazole + clarithromycin group; H: IgY-IB + sucralfate group; I: IgY-Hp + sucralfate group.

    Article Snippet: Hp whole bacterial antigen, IB antigen and CTB adjuvant were provided by Sichuan Vaccine Technology Co., Ltd. Omeprazole was purchased from Youcare Pharmaceutical Group Co., Ltd. Sucralfate was purchased from Huanan Pharmaceutical Group Co., Ltd., Guangdong.

    Techniques: Infection, Mouse Assay, Staining