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Image Search Results
Journal: Molecular cancer therapeutics
Article Title: Targeting Aberrant DNA double strand break repair in triple negative breast cancer with alpha particle emitter radiolabeled anti-EGFR antibody
doi: 10.1158/1535-7163.MCT-13-0108
Figure Lengend Snippet: DNA-PKcs inhibitor NU7441 enhances cytotoxicity of 213Bi-Cetuximab in TNBC cells. Cell survival curves of A) MDA-MB-231, B) MDA-MB-436 and C) HCC1937 after treatment by 213Bi-Cetuximab or 213Bi-Cetuximab plus NU7441.
Article Snippet:
Techniques:
Journal: Molecular cancer therapeutics
Article Title: Targeting Aberrant DNA double strand break repair in triple negative breast cancer with alpha particle emitter radiolabeled anti-EGFR antibody
doi: 10.1158/1535-7163.MCT-13-0108
Figure Lengend Snippet: A) Representative images showing immunefluorescently stained γH2AX foci at 1hr and 24hr after treatment with 213Bi-Cetuximab or 213Bi-Cetuximab plus NU7441 in MCF-7 and the four TNBC cell lines studied. B) Quantification of number of γ-H2AX foci at 1hr and 24hr after treatment by 213Bi-Cetuximab or 213Bi-Cetuximab plus NU7441. Two way ANOVA test showed that there was a statistical significant decrease (*) of DSBs foci in MDA-MB-231 (P<0.001), MDA-MB-436 (P<0.001) and MCF-7 (P<0.001) cells from 1hr to 24 hr after treatment with 213Bi-Cetuximab alone, while such decrease was not observed in HCC1937 (P=0.13) and MDA-MB-468 (P=0.63) cells. NU7441 treatment significantly inhibited the decrease of γH2AX foci from 1hr to 24 hr in MDA-MB-231 (P=0.43) and MDA-MB-436 (P=0.68) cells, but did not affect HCC1937 and MDA-MB-468 cells.
Article Snippet:
Techniques: Staining
Journal: Molecular cancer therapeutics
Article Title: Targeting Aberrant DNA double strand break repair in triple negative breast cancer with alpha particle emitter radiolabeled anti-EGFR antibody
doi: 10.1158/1535-7163.MCT-13-0108
Figure Lengend Snippet: Cell cycle analysis showed alpha particle induced cell cycle arrest in G2/M phase in BRCA-1 defective HCC1937 and NU7441 treated MDAMB231 cells.
Article Snippet:
Techniques: Cell Cycle Assay