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Image Search Results
Journal: Cardiovascular Diabetology
Article Title: Tirzepatide, a dual GIP/GLP1-receptor co-agonist preserves cardiac function and improves survival in angiotensin II-induced heart failure model in mice: comparison to liraglutide
doi: 10.1186/s12933-025-02806-5
Figure Lengend Snippet: Tirzepatide and liraglutide treatment led to robust weight reduction combined with AngII. Body weight changes during the treatment period in grams A , Mean ± SEM) and in percent B , and on the day of termination C . Two-way ANOVA followed by Holm–Sidak post-hoc test, *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001
Article Snippet: Based on the treatment, AngII-induced and sham-operated animals were separated into 3 groups: (i) vehicle groups (Sham/Veh n = 7 and AngII/Veh n = 15) received physiological saline intraperitoneally (i.p.) on a daily basis in an equivalent volume relative to the body weight. (ii) tirzepatide groups (Sham/TZP n = 8 and AngII/TZP n = 15) received tirzepatide (TZP, dissolved in physiological saline, BOC Sciences, London, UK) subcutaneously (s.c.) with a dose of 48 μg/kg/day [ ] (iii) liraglutide groups (Sham/Lira n = 7 and AngII/Lira n = 15) received
Techniques:
Journal: Cardiovascular Diabetology
Article Title: Tirzepatide, a dual GIP/GLP1-receptor co-agonist preserves cardiac function and improves survival in angiotensin II-induced heart failure model in mice: comparison to liraglutide
doi: 10.1186/s12933-025-02806-5
Figure Lengend Snippet: Tirzepatide and liraglutide preserved cardiac function. Functional parameters of the heart after one A and two weeks B of AngII infusion. Two-way ANOVA followed by Holm–Sidak post-hoc test, *P < 0.05, **P < 0.01, and ****P < 0.0001
Article Snippet: Based on the treatment, AngII-induced and sham-operated animals were separated into 3 groups: (i) vehicle groups (Sham/Veh n = 7 and AngII/Veh n = 15) received physiological saline intraperitoneally (i.p.) on a daily basis in an equivalent volume relative to the body weight. (ii) tirzepatide groups (Sham/TZP n = 8 and AngII/TZP n = 15) received tirzepatide (TZP, dissolved in physiological saline, BOC Sciences, London, UK) subcutaneously (s.c.) with a dose of 48 μg/kg/day [ ] (iii) liraglutide groups (Sham/Lira n = 7 and AngII/Lira n = 15) received
Techniques: Functional Assay
Journal: Cardiovascular Diabetology
Article Title: Tirzepatide, a dual GIP/GLP1-receptor co-agonist preserves cardiac function and improves survival in angiotensin II-induced heart failure model in mice: comparison to liraglutide
doi: 10.1186/s12933-025-02806-5
Figure Lengend Snippet: Angiotensin II produced conduction and repolarization abnormalities, mitigated by tirzepatide and liraglutide. Representative electrocardiograms from lead II A and QRS width measured in lead III B Two-way ANOVA followed by Holm–Sidak post-hoc test, *P < 0.05
Article Snippet: Based on the treatment, AngII-induced and sham-operated animals were separated into 3 groups: (i) vehicle groups (Sham/Veh n = 7 and AngII/Veh n = 15) received physiological saline intraperitoneally (i.p.) on a daily basis in an equivalent volume relative to the body weight. (ii) tirzepatide groups (Sham/TZP n = 8 and AngII/TZP n = 15) received tirzepatide (TZP, dissolved in physiological saline, BOC Sciences, London, UK) subcutaneously (s.c.) with a dose of 48 μg/kg/day [ ] (iii) liraglutide groups (Sham/Lira n = 7 and AngII/Lira n = 15) received
Techniques: Produced
Journal: Cardiovascular Diabetology
Article Title: Tirzepatide, a dual GIP/GLP1-receptor co-agonist preserves cardiac function and improves survival in angiotensin II-induced heart failure model in mice: comparison to liraglutide
doi: 10.1186/s12933-025-02806-5
Figure Lengend Snippet: Tirzepatide and liraglutide alleviate the fibrosis and hypertrophy caused by angiotensin II infusion. Representatives of Sirius red staining in the heart A show that AngII infusion led to higher fibrosis compared to the controls. Markers of fibrosis and hypertrophy B Two-way ANOVA followed by Holm–Sidak post-hoc test, *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001
Article Snippet: Based on the treatment, AngII-induced and sham-operated animals were separated into 3 groups: (i) vehicle groups (Sham/Veh n = 7 and AngII/Veh n = 15) received physiological saline intraperitoneally (i.p.) on a daily basis in an equivalent volume relative to the body weight. (ii) tirzepatide groups (Sham/TZP n = 8 and AngII/TZP n = 15) received tirzepatide (TZP, dissolved in physiological saline, BOC Sciences, London, UK) subcutaneously (s.c.) with a dose of 48 μg/kg/day [ ] (iii) liraglutide groups (Sham/Lira n = 7 and AngII/Lira n = 15) received
Techniques: Staining