notch pathway activator Search Results


notch pathway activation  (Deltex Medical)
90
Deltex Medical notch pathway activation
Notch Pathway Activation, supplied by Deltex Medical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/notch pathway activation/product/Deltex Medical
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notch pathway activation - by Bioz Stars, 2026-02
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notch pathway activity signature array  (Qiagen)
90
Qiagen notch pathway activity signature array
Adult T-cell leukemia (ATL) cells have a high <t>notch</t> <t>pathway</t> <t>activity</t> score. ( A ) Gene <t>array</t> analysis of Notch pathway activity <t>signature</t> genes in control, healthy peripheral blood mononuclear cells (PBMCs), two ATL lines (Jurkat, T-ALL and Nalm20, B-ALL), and three ATL lines (MT1, ATLT, and ATL25). Expression is normalized to control PBMCs and is color-coded to represent expression levels, as stated in . ( B ) Notch pathway activity score generated from array data and Qiagen pathway analysis. PBMCs served as a control, with a score of 0.0. ATL and ALL cell scores are in red and represent an elevation compared to PBMCs. p -values are indicated. ( C ) Graphs representing the Log10 normalized gene expression of Notch pathway genes of ATL cells (MT1, ATLT, and ALT25) compared to the Log10 normalized gene expression in PBMCs. Graphs are generated using Qiagen software. ( D ) Real-time PCR analysis of Notch targets in Jurkat, MT1, and ATL25. GAPDH served as a control. Results are from at least two distinct cDNA preparations, from at least two different experiments and real-time PCR runs. Cells were treated with 1 µM GSI for 48 h. Fold change is compared to cells treated with DMSO control. Significant decreases are indicated in pale green with p -values of at least > 0.05. ( E ) Venn diagram representing common GSI-sensitive targets among Jurkat (yellow), MT1 (red), and ATL25 (blue).
Notch Pathway Activity Signature Array, supplied by Qiagen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/notch pathway activity signature array/product/Qiagen
Average 90 stars, based on 1 article reviews
notch pathway activity signature array - by Bioz Stars, 2026-02
90/100 stars
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putative transcriptional activator in the c. elegans notch pathway  (Kimble Inc)
90
Kimble Inc putative transcriptional activator in the c. elegans notch pathway
Adult T-cell leukemia (ATL) cells have a high <t>notch</t> <t>pathway</t> <t>activity</t> score. ( A ) Gene <t>array</t> analysis of Notch pathway activity <t>signature</t> genes in control, healthy peripheral blood mononuclear cells (PBMCs), two ATL lines (Jurkat, T-ALL and Nalm20, B-ALL), and three ATL lines (MT1, ATLT, and ATL25). Expression is normalized to control PBMCs and is color-coded to represent expression levels, as stated in . ( B ) Notch pathway activity score generated from array data and Qiagen pathway analysis. PBMCs served as a control, with a score of 0.0. ATL and ALL cell scores are in red and represent an elevation compared to PBMCs. p -values are indicated. ( C ) Graphs representing the Log10 normalized gene expression of Notch pathway genes of ATL cells (MT1, ATLT, and ALT25) compared to the Log10 normalized gene expression in PBMCs. Graphs are generated using Qiagen software. ( D ) Real-time PCR analysis of Notch targets in Jurkat, MT1, and ATL25. GAPDH served as a control. Results are from at least two distinct cDNA preparations, from at least two different experiments and real-time PCR runs. Cells were treated with 1 µM GSI for 48 h. Fold change is compared to cells treated with DMSO control. Significant decreases are indicated in pale green with p -values of at least > 0.05. ( E ) Venn diagram representing common GSI-sensitive targets among Jurkat (yellow), MT1 (red), and ATL25 (blue).
Putative Transcriptional Activator In The C. Elegans Notch Pathway, supplied by Kimble Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/putative transcriptional activator in the c. elegans notch pathway/product/Kimble Inc
Average 90 stars, based on 1 article reviews
putative transcriptional activator in the c. elegans notch pathway - by Bioz Stars, 2026-02
90/100 stars
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Image Search Results


Adult T-cell leukemia (ATL) cells have a high notch pathway activity score. ( A ) Gene array analysis of Notch pathway activity signature genes in control, healthy peripheral blood mononuclear cells (PBMCs), two ATL lines (Jurkat, T-ALL and Nalm20, B-ALL), and three ATL lines (MT1, ATLT, and ATL25). Expression is normalized to control PBMCs and is color-coded to represent expression levels, as stated in . ( B ) Notch pathway activity score generated from array data and Qiagen pathway analysis. PBMCs served as a control, with a score of 0.0. ATL and ALL cell scores are in red and represent an elevation compared to PBMCs. p -values are indicated. ( C ) Graphs representing the Log10 normalized gene expression of Notch pathway genes of ATL cells (MT1, ATLT, and ALT25) compared to the Log10 normalized gene expression in PBMCs. Graphs are generated using Qiagen software. ( D ) Real-time PCR analysis of Notch targets in Jurkat, MT1, and ATL25. GAPDH served as a control. Results are from at least two distinct cDNA preparations, from at least two different experiments and real-time PCR runs. Cells were treated with 1 µM GSI for 48 h. Fold change is compared to cells treated with DMSO control. Significant decreases are indicated in pale green with p -values of at least > 0.05. ( E ) Venn diagram representing common GSI-sensitive targets among Jurkat (yellow), MT1 (red), and ATL25 (blue).

Journal: International Journal of Molecular Sciences

Article Title: Increased H19 /miR-675 Expression in Adult T-Cell Leukemia Is Associated with a Unique Notch Signature Pathway

doi: 10.3390/ijms25105130

Figure Lengend Snippet: Adult T-cell leukemia (ATL) cells have a high notch pathway activity score. ( A ) Gene array analysis of Notch pathway activity signature genes in control, healthy peripheral blood mononuclear cells (PBMCs), two ATL lines (Jurkat, T-ALL and Nalm20, B-ALL), and three ATL lines (MT1, ATLT, and ATL25). Expression is normalized to control PBMCs and is color-coded to represent expression levels, as stated in . ( B ) Notch pathway activity score generated from array data and Qiagen pathway analysis. PBMCs served as a control, with a score of 0.0. ATL and ALL cell scores are in red and represent an elevation compared to PBMCs. p -values are indicated. ( C ) Graphs representing the Log10 normalized gene expression of Notch pathway genes of ATL cells (MT1, ATLT, and ALT25) compared to the Log10 normalized gene expression in PBMCs. Graphs are generated using Qiagen software. ( D ) Real-time PCR analysis of Notch targets in Jurkat, MT1, and ATL25. GAPDH served as a control. Results are from at least two distinct cDNA preparations, from at least two different experiments and real-time PCR runs. Cells were treated with 1 µM GSI for 48 h. Fold change is compared to cells treated with DMSO control. Significant decreases are indicated in pale green with p -values of at least > 0.05. ( E ) Venn diagram representing common GSI-sensitive targets among Jurkat (yellow), MT1 (red), and ATL25 (blue).

Article Snippet: We performed a Notch pathway activity signature array developed by Qiagen that selects 16 experimentally derived Notch signature biomarker genes, which, along with classification algorithms, acquire a quantitative analysis to determine a Notch activity score for ATL and ALL cells.

Techniques: Activity Assay, Control, Expressing, Generated, Gene Expression, Software, Real-time Polymerase Chain Reaction