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Illumina Inc
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Image Search Results
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
Article Title: Molecular characterization of KRAS wild type tumors in patients with pancreatic adenocarcinoma
doi: 10.1158/1078-0432.CCR-21-3581
Figure Lengend Snippet: Molecular alterations seen in KRAS-WT tumors. 1A: Mutation rates detected by NGS. 1B: Alteration rates detected by immunohistochemistry, copy number amplification rates detected by NGS and fusion rates detected by RNA sequencing. Bars are color coded according to the oncogenic pathways of each biomarker. 1C: BRAF mutations seen in the cohort categorized into class 1, 2 and 3 based on mechanism of action.
Article Snippet: Treatment and survival information were available from a total of 5324 pancreatic cancer patients tested as either KRAS WT (N=705) or KRAS MT (N=4619) using
Techniques: Mutagenesis, Immunohistochemistry, Amplification, RNA Sequencing, Biomarker Discovery
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
Article Title: Molecular characterization of KRAS wild type tumors in patients with pancreatic adenocarcinoma
doi: 10.1158/1078-0432.CCR-21-3581
Figure Lengend Snippet: Volcano plot comparing molecular alterations of KRAS MT vs. WT tumors. NGS: Next-Gen Sequencing detected mutations. Only molecular alterations significantly different (adjusted p<0.05) are labeled. Full results can be found in Supplemental table 4.
Article Snippet: Treatment and survival information were available from a total of 5324 pancreatic cancer patients tested as either KRAS WT (N=705) or KRAS MT (N=4619) using
Techniques: Sequencing, Labeling
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
Article Title: Molecular characterization of KRAS wild type tumors in patients with pancreatic adenocarcinoma
doi: 10.1158/1078-0432.CCR-21-3581
Figure Lengend Snippet: An oncoprint displaying the molecular alteration patten of the 233 PDAC tumors. Each row represents a biomarker of either fusion, mutation or copy number amplification, as well as genomic signatures such as TMB or MSI/MMR. Red, blue and green represents TMB-H, MSI-high/MMR-deficient or mutations detected using DNA-sequencing; green represents copy number amplification detected by DNA sequencing, while navy blue represents fusions detected by RNA Sequencing. Grey represents no alteration detected while blanks represent unavailable data (indeterminate results due to low coverage or noisy signals). Bars on the right represents the prevalence of molecular alterations of each row.
Article Snippet: Treatment and survival information were available from a total of 5324 pancreatic cancer patients tested as either KRAS WT (N=705) or KRAS MT (N=4619) using
Techniques: Biomarker Discovery, Mutagenesis, Amplification, DNA Sequencing, RNA Sequencing
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
Article Title: Molecular characterization of KRAS wild type tumors in patients with pancreatic adenocarcinoma
doi: 10.1158/1078-0432.CCR-21-3581
Figure Lengend Snippet: Comparison of Tumor Microenvironment (TME) characteristics in KRAS MT vs. WT tumors. 5A: Lymphocyte cell fractions estimated by RNA sequencing using Quantiseq.5B: Stromal cell populations estimated by RNA sequencing using MCP counter.**: significantly different after correcting for multiple comparison; * trending differences.
Article Snippet: Treatment and survival information were available from a total of 5324 pancreatic cancer patients tested as either KRAS WT (N=705) or KRAS MT (N=4619) using
Techniques: Comparison, RNA Sequencing