neuronal activity blockers Search Results


ion channel targeted library  (TargetMol)
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ttx  (Tocris)
98
Tocris ttx
(A) Bar graph represents a significantly increased 5-HT release from RIN14B cells after stimulation with 100 μM of 5-HI. Data were analyzed using the 2-tailed unpaired t test (**** p < 0.0001). Error bars represent SEM. ( B) Bar graph and illustrative recording in the rat colon represents the enhanced response of the 5-HI on the gut contractility. ( C) The dose response curve and EC 50 value of 5-HI in the rat colonic tissue. (D–G) Bar graphs and illustrative recordings in the rat colon represent the enhanced response of the 5-HT-induced contractility by ( D) 100 μM 5-HI, which was not inhibited after adding ( E) 1 μM ondansetron, ( F) 1 <t>μM</t> <t>SB-207266,</t> or ( G) 1 μM <t>TTX.</t> ( H–J) Bar graphs and illustrative recordings in the rat colon represent enhanced response of the ACh-induced contractility by ( H) 100 μM 5-HI, which was significantly increased after adding ( I) 100 nM DAU 5884 hydrochloride and was not inhibited after the addition of ( J) 1 μM AQ-RA 741. ( K) Addition of 1 μM nifedipine significantly inhibited 5-HI-induced response. (L) Illustrative recording in the rat colon represents enhanced response by 100 μM 5-HI after colonic tissue contractile apparatus is altered by nifedipine. Data represent 3–9 biological replicates. Data were analyzed using the Wilcoxon matched-pairs (before/after) signed rank test (* p < 0.05; ** p < 0.01). Error bars represent SEM. Quantitative analysis of the organ bath data is described in Materials and method section. The raw data used for quantification of A–K can be found in . 5-HI, 5-hydroxyindole; ACh, acetylcholine; n.s., not significant; TTX, tetrodotoxin.
Ttx, supplied by Tocris, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/neuronal+activity+blockers/Tetrodotoxin/pmc07857600-306-33-44
Average 98 stars, based on 1 article reviews
ttx - by Bioz Stars, 2026-09
98/100 stars
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voltage gated sodium channel blocker tetrodotoxin  (Alomone Labs)
95
Alomone Labs voltage gated sodium channel blocker tetrodotoxin
(A) Bar graph represents a significantly increased 5-HT release from RIN14B cells after stimulation with 100 μM of 5-HI. Data were analyzed using the 2-tailed unpaired t test (**** p < 0.0001). Error bars represent SEM. ( B) Bar graph and illustrative recording in the rat colon represents the enhanced response of the 5-HI on the gut contractility. ( C) The dose response curve and EC 50 value of 5-HI in the rat colonic tissue. (D–G) Bar graphs and illustrative recordings in the rat colon represent the enhanced response of the 5-HT-induced contractility by ( D) 100 μM 5-HI, which was not inhibited after adding ( E) 1 μM ondansetron, ( F) 1 <t>μM</t> <t>SB-207266,</t> or ( G) 1 μM <t>TTX.</t> ( H–J) Bar graphs and illustrative recordings in the rat colon represent enhanced response of the ACh-induced contractility by ( H) 100 μM 5-HI, which was significantly increased after adding ( I) 100 nM DAU 5884 hydrochloride and was not inhibited after the addition of ( J) 1 μM AQ-RA 741. ( K) Addition of 1 μM nifedipine significantly inhibited 5-HI-induced response. (L) Illustrative recording in the rat colon represents enhanced response by 100 μM 5-HI after colonic tissue contractile apparatus is altered by nifedipine. Data represent 3–9 biological replicates. Data were analyzed using the Wilcoxon matched-pairs (before/after) signed rank test (* p < 0.05; ** p < 0.01). Error bars represent SEM. Quantitative analysis of the organ bath data is described in Materials and method section. The raw data used for quantification of A–K can be found in . 5-HI, 5-hydroxyindole; ACh, acetylcholine; n.s., not significant; TTX, tetrodotoxin.
Voltage Gated Sodium Channel Blocker Tetrodotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/neuronal+activity+blockers/Tetrodotoxin+citrate/pmc04682123__mmc1-34-16-22
Average 95 stars, based on 1 article reviews
voltage gated sodium channel blocker tetrodotoxin - by Bioz Stars, 2026-09
95/100 stars
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sodium channel blocker ttx  (Tocris)
96
Tocris sodium channel blocker ttx

Sodium Channel Blocker Ttx, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/neuronal+activity+blockers/Tetrodotoxin/pmc07068654-325-10-16
Average 96 stars, based on 1 article reviews
sodium channel blocker ttx - by Bioz Stars, 2026-09
96/100 stars
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neuronal activity blockers  (Tocris)
96
Tocris neuronal activity blockers

Neuronal Activity Blockers, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/neuronal+activity+blockers/NBQX/10__7554_slash_elife__96496__3-395-26-50
Average 96 stars, based on 1 article reviews
neuronal activity blockers - by Bioz Stars, 2026-09
96/100 stars
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Image Search Results


(A) Bar graph represents a significantly increased 5-HT release from RIN14B cells after stimulation with 100 μM of 5-HI. Data were analyzed using the 2-tailed unpaired t test (**** p < 0.0001). Error bars represent SEM. ( B) Bar graph and illustrative recording in the rat colon represents the enhanced response of the 5-HI on the gut contractility. ( C) The dose response curve and EC 50 value of 5-HI in the rat colonic tissue. (D–G) Bar graphs and illustrative recordings in the rat colon represent the enhanced response of the 5-HT-induced contractility by ( D) 100 μM 5-HI, which was not inhibited after adding ( E) 1 μM ondansetron, ( F) 1 μM SB-207266, or ( G) 1 μM TTX. ( H–J) Bar graphs and illustrative recordings in the rat colon represent enhanced response of the ACh-induced contractility by ( H) 100 μM 5-HI, which was significantly increased after adding ( I) 100 nM DAU 5884 hydrochloride and was not inhibited after the addition of ( J) 1 μM AQ-RA 741. ( K) Addition of 1 μM nifedipine significantly inhibited 5-HI-induced response. (L) Illustrative recording in the rat colon represents enhanced response by 100 μM 5-HI after colonic tissue contractile apparatus is altered by nifedipine. Data represent 3–9 biological replicates. Data were analyzed using the Wilcoxon matched-pairs (before/after) signed rank test (* p < 0.05; ** p < 0.01). Error bars represent SEM. Quantitative analysis of the organ bath data is described in Materials and method section. The raw data used for quantification of A–K can be found in . 5-HI, 5-hydroxyindole; ACh, acetylcholine; n.s., not significant; TTX, tetrodotoxin.

Journal: PLoS Biology

Article Title: Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels

doi: 10.1371/journal.pbio.3001070

Figure Lengend Snippet: (A) Bar graph represents a significantly increased 5-HT release from RIN14B cells after stimulation with 100 μM of 5-HI. Data were analyzed using the 2-tailed unpaired t test (**** p < 0.0001). Error bars represent SEM. ( B) Bar graph and illustrative recording in the rat colon represents the enhanced response of the 5-HI on the gut contractility. ( C) The dose response curve and EC 50 value of 5-HI in the rat colonic tissue. (D–G) Bar graphs and illustrative recordings in the rat colon represent the enhanced response of the 5-HT-induced contractility by ( D) 100 μM 5-HI, which was not inhibited after adding ( E) 1 μM ondansetron, ( F) 1 μM SB-207266, or ( G) 1 μM TTX. ( H–J) Bar graphs and illustrative recordings in the rat colon represent enhanced response of the ACh-induced contractility by ( H) 100 μM 5-HI, which was significantly increased after adding ( I) 100 nM DAU 5884 hydrochloride and was not inhibited after the addition of ( J) 1 μM AQ-RA 741. ( K) Addition of 1 μM nifedipine significantly inhibited 5-HI-induced response. (L) Illustrative recording in the rat colon represents enhanced response by 100 μM 5-HI after colonic tissue contractile apparatus is altered by nifedipine. Data represent 3–9 biological replicates. Data were analyzed using the Wilcoxon matched-pairs (before/after) signed rank test (* p < 0.05; ** p < 0.01). Error bars represent SEM. Quantitative analysis of the organ bath data is described in Materials and method section. The raw data used for quantification of A–K can be found in . 5-HI, 5-hydroxyindole; ACh, acetylcholine; n.s., not significant; TTX, tetrodotoxin.

Article Snippet: To perform the tests with antagonists for the receptors involved in the gut motility, either 1 μM ondansetron (5-HT 3 antagonist; O3639, Sigma), 1 μM SB-207266 (5-HT 4 antagonist; SML1349, Sigma), 1 μM TTX (sodium ion transport blocker on the enteric neurons; TTX; 1078/1, Tocris Bioscience), 1 μM hexamethonium bromide (a nicotinic cholinergic antagonist; 4111, Tocris Bioscience), 1 μM AQ-RA 741 (muscarinic receptor 2 antagonist (M2R); 2292, Tocris Bioscience), 100 nM DAU 5884 hydrochloride (M3R antagonist; 2096; Tocris Bioscience), 1 μM ML204 (TRPC4 antagonist; 4732, Tocris Bioscience), 1 μM SAR 7334 (TRPC6 antagonist; 5831; Tocris Bioscience), 100 μM ATP (A1335; Duchefa Bioscience), or 1 μM nifedipine (L-type Ca 2+ channels antagonist; 1075; Tocris Bioscience) was applied sequentially with either ACh, 5-HT, or 5-HI.

Techniques:

Journal: Cell Reports

Article Title: Local Resting Ca 2+ Controls the Scale of Astroglial Ca 2+ Signals

doi: 10.1016/j.celrep.2020.02.043

Figure Lengend Snippet:

Article Snippet: In these experiments, neuronal activity was inhibited by adding the sodium channel blocker TTX (1 μM, Tocris Bioscience) to the extracellular solution.

Techniques: Recombinant, Software