Journal: Stem cell research

Article Title: Characterization and application of electrically active neuronal networks established from human induced pluripotent stem cell-derived neural progenitor cells for neurotoxicity evaluation.

doi: 10.1016/j.scr.2020.101761

Figure Lengend Snippet: Fig. 5. Modifications of electrical activity by acute pharmacological treatment. Ratio of treatment/control of CINDA-NN and rNN treated with GABA [1 mM], bicuculline [10 μM], glutamate [100 µM], AP5 [20 µM] and NBQX [10 µM]. Results are depicted as A) MFR, B) MBR and C) Spikes/Burst as mean+SEM. hiNPC: n = 7–10, rNN: n = 6–10. D and E Representative 60 s SRP of hNN and rNN of baseline- and GABA (D) or bicuculline treatment (E). *Significant within condition (p < 0.05).

Article Snippet: NBQX disodium salt, DL-AP5 sodium salt and Bicuculline were obtained from Santa Cruz Biotechnologies (Texas, USA).

Techniques: Activity Assay, Control