nb100-791 Search Results


mat1a  (Novus Biologicals)
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Novus Biologicals mat1a
Methionine, folate and cysteine metabolism in mammals. (A) The transsulfuration and cysteine oxidation pathways and, methionine and folate cycles are shown. Betaine-homocysteine S-methyltransferase (BHMT), cystathionine β-synthase (CBS), cystathionine γ-lyase (CGL), cysteine dioxygenase (CDO), cysteinesulfinate decarboxylase (CSAD), glutamic-oxaloacetic transaminase (GOT), glycine N-methyltransferase (GNMT), methionine adenosyl transferase <t>(MAT1A),</t> methionine synthase (MTR), methylenetetrahydrofolate reductase (MTHFR), S-adenosyl homocysteine hydrolase (SAHH). (B) Cgl null female but not male mice exhibit severely elevated levels of plasma tHcy. Plasma levels of tHcy in wild type (WT) mice plus and minus treatment with the CGL specific inhibitor PPG and untreated male and female Cgl null mice. Values shown represent the mean±s.d., n =6, *** P <0.001.
Mat1a, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Methionine, folate and cysteine metabolism in mammals. (A) The transsulfuration and cysteine oxidation pathways and, methionine and folate cycles are shown. Betaine-homocysteine S-methyltransferase (BHMT), cystathionine β-synthase (CBS), cystathionine γ-lyase (CGL), cysteine dioxygenase (CDO), cysteinesulfinate decarboxylase (CSAD), glutamic-oxaloacetic transaminase (GOT), glycine N-methyltransferase (GNMT), methionine adenosyl transferase (MAT1A), methionine synthase (MTR), methylenetetrahydrofolate reductase (MTHFR), S-adenosyl homocysteine hydrolase (SAHH). (B) Cgl null female but not male mice exhibit severely elevated levels of plasma tHcy. Plasma levels of tHcy in wild type (WT) mice plus and minus treatment with the CGL specific inhibitor PPG and untreated male and female Cgl null mice. Values shown represent the mean±s.d., n =6, *** P <0.001.

Journal: Biology Open

Article Title: Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap

doi: 10.1242/bio.013433

Figure Lengend Snippet: Methionine, folate and cysteine metabolism in mammals. (A) The transsulfuration and cysteine oxidation pathways and, methionine and folate cycles are shown. Betaine-homocysteine S-methyltransferase (BHMT), cystathionine β-synthase (CBS), cystathionine γ-lyase (CGL), cysteine dioxygenase (CDO), cysteinesulfinate decarboxylase (CSAD), glutamic-oxaloacetic transaminase (GOT), glycine N-methyltransferase (GNMT), methionine adenosyl transferase (MAT1A), methionine synthase (MTR), methylenetetrahydrofolate reductase (MTHFR), S-adenosyl homocysteine hydrolase (SAHH). (B) Cgl null female but not male mice exhibit severely elevated levels of plasma tHcy. Plasma levels of tHcy in wild type (WT) mice plus and minus treatment with the CGL specific inhibitor PPG and untreated male and female Cgl null mice. Values shown represent the mean±s.d., n =6, *** P <0.001.

Article Snippet: Antibodies for MTR (#NB100-791) and MAT1A (NBP1-55120) were obtained from Novus biologicals.

Techniques: Clinical Proteomics

MAT1A protein levels are significantly increased in female Cgl null mice with severely elevated plasma tHcy. Western blotting analysis of hepatic GNMT and MAT1A protein expression levels in male and female WT and Cgl null mice. Values shown represent the mean±s.d., * P <0.05, ** P <0.01.

Journal: Biology Open

Article Title: Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap

doi: 10.1242/bio.013433

Figure Lengend Snippet: MAT1A protein levels are significantly increased in female Cgl null mice with severely elevated plasma tHcy. Western blotting analysis of hepatic GNMT and MAT1A protein expression levels in male and female WT and Cgl null mice. Values shown represent the mean±s.d., * P <0.05, ** P <0.01.

Article Snippet: Antibodies for MTR (#NB100-791) and MAT1A (NBP1-55120) were obtained from Novus biologicals.

Techniques: Clinical Proteomics, Western Blot, Expressing