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Bio-Techne corporation
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Image Search Results
Journal: Scientific Reports
Article Title: 7,8-Dihydroxyflavone improves neuropathological changes in the brain of Tg26 mice, a model for HIV-associated neurocognitive disorder
doi: 10.1038/s41598-021-97220-8
Figure Lengend Snippet: List of primary antibodies.
Article Snippet:
Techniques: Concentration Assay, Marker
Journal: Scientific Reports
Article Title: 7,8-Dihydroxyflavone improves neuropathological changes in the brain of Tg26 mice, a model for HIV-associated neurocognitive disorder
doi: 10.1038/s41598-021-97220-8
Figure Lengend Snippet: DHF treatment downregulates activation of the TLR4 and NFkB. Legend: TLR4 and NFkB expression in the hippocampus and cortex of Wild Type (WT), Tg26, and DHF treated Tg26 mice ( A - P ). Immunohistochemical stained sections show TLR4 and NFkB expressing cells in the hippocampal and cortex regions of the mice brains. 3 and 3 WT mice, respectively, 3 Tg26 mice, and 4 TG + DHF mice were used. A, B, C, E, F, G, I, J, K, M, N, and O are 400 × magnification pictures of the hippocampus and cortex regions of the mice. ( D ) Quantification of TLR4 expressing cells in the hippocampus: p < 0.001, WT versus Tg; p < 0.001 Tg versus Tg + DHF. ( H ) Quantification of TLR4 expressing cells in cortex: p < 0.05, WT versus Tg; p < 0.001, Tg versus Tg + DHF. ( L ) Quantification of NFkB expressing cells in the hippocampus: p < 0.001, WT versus Tg; p < 0.001 Tg versus Tg + DHF. ( P ) Quantification of NFkB expressing cells in cortex: p < 0.001, WT versus Tg; p > 0.05, Tg versus Tg + DHF. The total numbers of hippocampal fields analyzed (WT, Tg26, TG + DHF) for each antibody were TLR4 (55, 87, 104), NFkB (154, 72, 101). The total numbers of cortex fields analyzed (WT, Tg26, TG + DHF) for each antibody were TLR4 (15, 15, 20), NFkB (15, 15, 20). One Way ANOVA with Bonferroni's Multiple Comparison post- test. scale bar, 100 μm.
Article Snippet:
Techniques: Activation Assay, Expressing, Immunohistochemical staining, Staining