mtfr Search Results


immobilized mtfr setup  (Biacore)
90
Biacore immobilized mtfr setup
Schematic illustration of methods. <t>a</t> <t>Affinity</t> to <t>mTfR</t> of 8D3 alanine point mutation variants (12 monovalent Fab fragments and 29 bivalent IgGs) were screened in Biacore. b Six monovalent and six bivalent variants were selected from the initial screen and were redesigned as full-length, symmetrical KIH antibodies. The affinities of the reformatted variants to mTfR were further characterized in a cell assay. c A monovalent Bapi-8D3 and bivalent 8D3 with an apparent affinity of 10 nM (10 nM apparent affinity set) and the bivalent wild-type 8D3 (8D3 WT ) were radiolabelled and injected into WT mice for ex vivo biodistribution analysis
Immobilized Mtfr Setup, supplied by Biacore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/immobilized mtfr setup/product/Biacore
Average 90 stars, based on 1 article reviews
immobilized mtfr setup - by Bioz Stars, 2026-03
90/100 stars
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mtfr-his6  (Sino Biological)
90
Sino Biological mtfr-his6
Schematic illustration of methods. <t>a</t> <t>Affinity</t> to <t>mTfR</t> of 8D3 alanine point mutation variants (12 monovalent Fab fragments and 29 bivalent IgGs) were screened in Biacore. b Six monovalent and six bivalent variants were selected from the initial screen and were redesigned as full-length, symmetrical KIH antibodies. The affinities of the reformatted variants to mTfR were further characterized in a cell assay. c A monovalent Bapi-8D3 and bivalent 8D3 with an apparent affinity of 10 nM (10 nM apparent affinity set) and the bivalent wild-type 8D3 (8D3 WT ) were radiolabelled and injected into WT mice for ex vivo biodistribution analysis
Mtfr His6, supplied by Sino Biological, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mtfr-his6/product/Sino Biological
Average 90 stars, based on 1 article reviews
mtfr-his6 - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
synthetic mtfr-glb1 enzyme  (Tanabe)
90
Tanabe synthetic mtfr-glb1 enzyme
Schematic illustration of methods. <t>a</t> <t>Affinity</t> to <t>mTfR</t> of 8D3 alanine point mutation variants (12 monovalent Fab fragments and 29 bivalent IgGs) were screened in Biacore. b Six monovalent and six bivalent variants were selected from the initial screen and were redesigned as full-length, symmetrical KIH antibodies. The affinities of the reformatted variants to mTfR were further characterized in a cell assay. c A monovalent Bapi-8D3 and bivalent 8D3 with an apparent affinity of 10 nM (10 nM apparent affinity set) and the bivalent wild-type 8D3 (8D3 WT ) were radiolabelled and injected into WT mice for ex vivo biodistribution analysis
Synthetic Mtfr Glb1 Enzyme, supplied by Tanabe, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/synthetic mtfr-glb1 enzyme/product/Tanabe
Average 90 stars, based on 1 article reviews
synthetic mtfr-glb1 enzyme - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
purified extracellular domain of mtfr  (Evotec Inc)
90
Evotec Inc purified extracellular domain of mtfr
Schematic illustration of methods. <t>a</t> <t>Affinity</t> to <t>mTfR</t> of 8D3 alanine point mutation variants (12 monovalent Fab fragments and 29 bivalent IgGs) were screened in Biacore. b Six monovalent and six bivalent variants were selected from the initial screen and were redesigned as full-length, symmetrical KIH antibodies. The affinities of the reformatted variants to mTfR were further characterized in a cell assay. c A monovalent Bapi-8D3 and bivalent 8D3 with an apparent affinity of 10 nM (10 nM apparent affinity set) and the bivalent wild-type 8D3 (8D3 WT ) were radiolabelled and injected into WT mice for ex vivo biodistribution analysis
Purified Extracellular Domain Of Mtfr, supplied by Evotec Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/purified extracellular domain of mtfr/product/Evotec Inc
Average 90 stars, based on 1 article reviews
purified extracellular domain of mtfr - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
mtfr-his 6  (Sino Biological)
90
Sino Biological mtfr-his 6
Schematic illustration of methods. <t>a</t> <t>Affinity</t> to <t>mTfR</t> of 8D3 alanine point mutation variants (12 monovalent Fab fragments and 29 bivalent IgGs) were screened in Biacore. b Six monovalent and six bivalent variants were selected from the initial screen and were redesigned as full-length, symmetrical KIH antibodies. The affinities of the reformatted variants to mTfR were further characterized in a cell assay. c A monovalent Bapi-8D3 and bivalent 8D3 with an apparent affinity of 10 nM (10 nM apparent affinity set) and the bivalent wild-type 8D3 (8D3 WT ) were radiolabelled and injected into WT mice for ex vivo biodistribution analysis
Mtfr His 6, supplied by Sino Biological, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mtfr-his 6/product/Sino Biological
Average 90 stars, based on 1 article reviews
mtfr-his 6 - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
bispecific mtfr-aβ antibodies  (Rudbeck Laboratory)
90
Rudbeck Laboratory bispecific mtfr-aβ antibodies
Schematic illustration of methods. <t>a</t> <t>Affinity</t> to <t>mTfR</t> of 8D3 alanine point mutation variants (12 monovalent Fab fragments and 29 bivalent IgGs) were screened in Biacore. b Six monovalent and six bivalent variants were selected from the initial screen and were redesigned as full-length, symmetrical KIH antibodies. The affinities of the reformatted variants to mTfR were further characterized in a cell assay. c A monovalent Bapi-8D3 and bivalent 8D3 with an apparent affinity of 10 nM (10 nM apparent affinity set) and the bivalent wild-type 8D3 (8D3 WT ) were radiolabelled and injected into WT mice for ex vivo biodistribution analysis
Bispecific Mtfr Aβ Antibodies, supplied by Rudbeck Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/bispecific mtfr-aβ antibodies/product/Rudbeck Laboratory
Average 90 stars, based on 1 article reviews
bispecific mtfr-aβ antibodies - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
anti-mtfr antibodies  (Genentech inc)
90
Genentech inc anti-mtfr antibodies
Schematic illustration of methods. <t>a</t> <t>Affinity</t> to <t>mTfR</t> of 8D3 alanine point mutation variants (12 monovalent Fab fragments and 29 bivalent IgGs) were screened in Biacore. b Six monovalent and six bivalent variants were selected from the initial screen and were redesigned as full-length, symmetrical KIH antibodies. The affinities of the reformatted variants to mTfR were further characterized in a cell assay. c A monovalent Bapi-8D3 and bivalent 8D3 with an apparent affinity of 10 nM (10 nM apparent affinity set) and the bivalent wild-type 8D3 (8D3 WT ) were radiolabelled and injected into WT mice for ex vivo biodistribution analysis
Anti Mtfr Antibodies, supplied by Genentech inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/anti-mtfr antibodies/product/Genentech inc
Average 90 stars, based on 1 article reviews
anti-mtfr antibodies - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier

Image Search Results


Schematic illustration of methods. a Affinity to mTfR of 8D3 alanine point mutation variants (12 monovalent Fab fragments and 29 bivalent IgGs) were screened in Biacore. b Six monovalent and six bivalent variants were selected from the initial screen and were redesigned as full-length, symmetrical KIH antibodies. The affinities of the reformatted variants to mTfR were further characterized in a cell assay. c A monovalent Bapi-8D3 and bivalent 8D3 with an apparent affinity of 10 nM (10 nM apparent affinity set) and the bivalent wild-type 8D3 (8D3 WT ) were radiolabelled and injected into WT mice for ex vivo biodistribution analysis

Journal: Fluids and Barriers of the CNS

Article Title: The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo

doi: 10.1186/s12987-025-00643-y

Figure Lengend Snippet: Schematic illustration of methods. a Affinity to mTfR of 8D3 alanine point mutation variants (12 monovalent Fab fragments and 29 bivalent IgGs) were screened in Biacore. b Six monovalent and six bivalent variants were selected from the initial screen and were redesigned as full-length, symmetrical KIH antibodies. The affinities of the reformatted variants to mTfR were further characterized in a cell assay. c A monovalent Bapi-8D3 and bivalent 8D3 with an apparent affinity of 10 nM (10 nM apparent affinity set) and the bivalent wild-type 8D3 (8D3 WT ) were radiolabelled and injected into WT mice for ex vivo biodistribution analysis

Article Snippet: To screen the affinity of the variants in vitro, an immobilized mTfR setup in Biacore was used as this setup allows for a comparison of apparent affinities between monovalent and bivalent binders [ ].

Techniques: Mutagenesis, Injection, Ex Vivo

Apparent affinity determination on Sp2/0-Ag14 cells. Mean fluorescent intensity (MFI) from cell mTfR affinity assay with a monovalent and b bivalent KiH antibodies. c Overlap of the two apparent affinity sets and 8D3 WT

Journal: Fluids and Barriers of the CNS

Article Title: The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo

doi: 10.1186/s12987-025-00643-y

Figure Lengend Snippet: Apparent affinity determination on Sp2/0-Ag14 cells. Mean fluorescent intensity (MFI) from cell mTfR affinity assay with a monovalent and b bivalent KiH antibodies. c Overlap of the two apparent affinity sets and 8D3 WT

Article Snippet: To screen the affinity of the variants in vitro, an immobilized mTfR setup in Biacore was used as this setup allows for a comparison of apparent affinities between monovalent and bivalent binders [ ].

Techniques:

Affinity to mTfR on Sp2/0-Ag14 cells for monovalent and bivalent antibodies

Journal: Fluids and Barriers of the CNS

Article Title: The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo

doi: 10.1186/s12987-025-00643-y

Figure Lengend Snippet: Affinity to mTfR on Sp2/0-Ag14 cells for monovalent and bivalent antibodies

Article Snippet: To screen the affinity of the variants in vitro, an immobilized mTfR setup in Biacore was used as this setup allows for a comparison of apparent affinities between monovalent and bivalent binders [ ].

Techniques: