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Image Search Results
Journal: Acta neuropathologica communications
Article Title: BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences.
doi: 10.1186/s40478-024-01906-9
Figure Lengend Snippet: Fig. 2 Riluzole treatment restores hippocampal BDNF in the irradiated hippocampus. 10–12 weeks old WT male mice received cranial radiation therapy (RT) followed by riluzole (RZ) treatment (13 mg/kg) in drinking water for 6–7 weeks. An ELISA-based quantification of BDNF from the micro-dissected hippocampus showed RT-induced reductions in the RT + Vehicle group. Importantly, RZ treatment in the cranially irradiated mice showed significant restoration of BDNF levels. Data are presented as mean ± SEM (N = 6–10 mice per group). P values were derived from two-way ANOVA and Bonferroni’s multiple comparisons test
Article Snippet: BDNF levels were quantified using a commercially available
Techniques: Irradiation, Enzyme-linked Immunosorbent Assay, Derivative Assay
Journal: Frontiers in psychiatry
Article Title: Quetiapine Attenuates Schizophrenia-Like Behaviors and Demyelination in a MK-801-Induced Mouse Model of Schizophrenia.
doi: 10.3389/fpsyt.2020.00843
Figure Lengend Snippet: FIGURE 5 | Brain-derived neurotrophic factor (BDNF) protein level in the frontal cortex of mice in control (Con), quetiapine (Que), MK-801 (MK), and MK-801+quetiapine (MK+Que) groups. Quetiapine attenuated the decrease of BDNF level in the frontal cortex of MK-801 mice. n=5 in each group. Mice were treated with chronic quetiapine (10 mg/kg/day, intraperitoneally) for 28 days. From day 22 to 28, 1 h after the administration of quetiapine, the mice were administered MK-801 (2 mg/kg/day, subcutaneously). One day after behavioral testing, the mice were sacrificed for BDNF protein analysis by ELISA. Results are expressed as means ± S.E.M. *P < 0.05 vs. Con, #P < 0.05 vs. MK.
Article Snippet: The level of BDNF was quantified using a commercial
Techniques: Derivative Assay, Control, Enzyme-linked Immunosorbent Assay
Journal: Frontiers in Neuroscience
Article Title: Adiponectin Mediates Running-Restored Hippocampal Neurogenesis in Streptozotocin-Induced Type 1 Diabetes in Mice
doi: 10.3389/fnins.2018.00679
Figure Lengend Snippet: Effects of streptozotocin on corticosterone and neurotrophic factors. Intraperitoneal administration of streptozotocin significantly increased (A) serum levels of corticosterone while significantly reduced (B) hippocampal levels of adiponectin and (C) hippocampal levels of brain-derived neurotrophic factor in wild-type non-runners. Student t -test ∗ P < 0.05, ∗∗ P < 0.005.
Article Snippet: The levels of corticosterone adiponectin and BDNF were determined using commercially available ELISA kits, including mouse CORT ELISA kits (Assay Designs, Enzo Life Sciences, Switzerland), mouse adiponectin ELISA kits (Adipogen Corporation, United States) and
Techniques: Derivative Assay