Journal: Solar physics

Article Title: Solar Terrestrial Relations Observatory (STEREO) Observations of Stream Interaction Regions in 2007 – 2016: Relationship with Heliospheric Current Sheets, Solar Cycle Variations, and Dual Observations

doi: 10.1007/s11207-019-1416-8

Figure Lengend Snippet: The SIR observed by (a) STA and (b) STB on 17 – 19 May 2007. The spacecraft locations in the heliographic inertial (HGI) coordinate (Fränz and Harper, 2002) are listed at the top. From top to bottom, the panels are the pitch-angle distribution of suprathermal-electron flux at 246.6 eV, solar-wind speed, azimuthal-flow angle [φV] defined as arctan 2(Vt, Vr) in blue curve, meridional-flow angles [θV] defined as asin(Vn/V), proton number density, proton temperature, entropy, magnetic-field intensity, and the Parker-spiral angle of the magnetic field [φB] defined as arctan 2(Bt, Br) (the magenta-dotted lines at 135°and −45° mark the nominal spiral angles for the toward and away sectors, respectively) and total pressure. In (a) at STA, the pair of red-dashed lines denotes the start and stop of SIR (T1A and T2A); the pink-shaded region marks the heliospheric plasma sheet (HPS); the red-dotted line indicates the HCS coincident with the sharp discontinuity (SD) of proton number density and temperature; and the red-dash–dotted line marks the SI uniformly defined at the peak of Pt. In (b) at STB, the pair of blue-dashed lines denotes the start and stop of SIR (T1B and T2B); there is a forward shock (FS) at the leading edge; the blue-dotted line indicates the HCS; the blue-dash–dotted line marks the SI, and the cyan-shaded region marks a small transient.

Article Snippet: There are four different couplings of photospheric magnetograms and the MHD-Algorithm-outside-a-Sphere (MAS) coronal and heliospheric model ( e.g . Riley et al ., 2011 ; Lionello et al ., 2014 ) provided for the relevant Carrington rotations by Predictive Science Inc. www.predsci.com/stereo/ .

Techniques: Clinical Proteomics

Journal: Nature Communications

Article Title: Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets

doi: 10.1038/s41467-024-46132-y

Figure Lengend Snippet: A Blood pressure tissue prioritisation. B Kidney GReX derived by Prediction Using Models Informed by Chromatin conformations and Epigenomics (PUMICE) algorithm – discovery analysis. C Kidney GReX – validation analysis. D BP kidney TWAS analysis. E Causality and drug repositioning analyses. The input data sources are coloured in blue, schematic intermediate results are coloured in grey, the primary outputs are coloured in yellow, downstream single-gene analyses are marked in green. GReX – genetically regulated expression, GWAS – genome-wide association study, TWAS – transcriptome-wide association studies, Beta – effect size estimate, SE – standard error of beta, ChIP-seq – chromatin immunoprecipitation sequencing, HiChIP – chromosome conformation capture by sequencing and immunoprecipitation, ENCODE – encyclopaedia of DNA elements consortium, H3K27me3 – histone 3, lysine residue 27, tri-methylation, H3K4me3 – histone 3, lysine residue 4, tri-methylation, DHS – DNase I hypersensitive sites, H3K27ac – histone 3, lysine residue 27, acetylation, HK2 cell line – human kidney 2 cell line, BP – blood pressure, ICBP – International Consortium for Blood Pressure, FDR – false discovery rate, PMR – probabilistic Mendelian randomisation, FOCUS – fine-mapping of causal gene sets. Parts of the figure were drawn by using pictures from Servier Medical Art and some of these pictures were modified. Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License ( https://creativecommons.org/licenses/by/3.0/ . Further parts of the figure were drawn by using pictures from Marcel Tisch ( https://twitter.com/MarcelTisch ) and are licensed under a Creative Commons CC0 License ( https://creativecommons.org/publicdomain/zero/1.0/ ).

Article Snippet: B Kidney GReX derived by Prediction Using Models Informed by Chromatin conformations and Epigenomics (PUMICE) algorithm – discovery analysis.

Techniques: Derivative Assay, Biomarker Discovery, Expressing, GWAS, ChIP-sequencing, HiChIP, Sequencing, Immunoprecipitation, Residue, Methylation, Modification