mlt Search Results


vitro kinase assay  (Carna Inc)
94
Carna Inc vitro kinase assay
Vitro Kinase Assay, supplied by Carna Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/vitro kinase assay/product/Carna Inc
Average 94 stars, based on 1 article reviews
vitro kinase assay - by Bioz Stars, 2026-04
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mlt 748  (MedChemExpress)
92
MedChemExpress mlt 748
Mlt 748, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 92 stars, based on 1 article reviews
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lymphoid tissue lymphoma translocation protein 1  (Proteintech)
93
Proteintech lymphoid tissue lymphoma translocation protein 1
Lymphoid Tissue Lymphoma Translocation Protein 1, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
lymphoid tissue lymphoma translocation protein 1 - by Bioz Stars, 2026-04
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rabbit polyclonal anti zak  (Proteintech)
93
Proteintech rabbit polyclonal anti zak

Rabbit Polyclonal Anti Zak, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
rabbit polyclonal anti zak - by Bioz Stars, 2026-04
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mtor  (Carna Inc)
94
Carna Inc mtor

Mtor, supplied by Carna Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
mtor - by Bioz Stars, 2026-04
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gst  (Carna Inc)
96
Carna Inc gst

Gst, supplied by Carna Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 96 stars, based on 1 article reviews
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melatonin  (Chem Impex International)
95
Chem Impex International melatonin

Melatonin, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 95 stars, based on 1 article reviews
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cas  (Selleck Chemicals)
92
Selleck Chemicals cas

Cas, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 92 stars, based on 1 article reviews
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kinases alk  (Carna Inc)
95
Carna Inc kinases alk
Experimental validation of designed peptides shows improved kinase activity. ( A ) ADP-Glo assay baseline measurements showing kinase activity with parental substrates and background controls for all five tested kinases. ( B–F ) Relative percentage change in kinase activity for designed peptides compared to parental substrates for <t>ALK</t> ( B <t>),</t> <t>MET</t> ( C ), ROS1 ( D ), EGFR L858R ( E ), and SRC ( F ). Designed peptides are color-coded with sequence information provided. Phosphosite residues that were fixed during design are highlighted in green. Four out of five kinases showed substantial activity improvements with at least one designed peptide.
Kinases Alk, supplied by Carna Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 95 stars, based on 1 article reviews
kinases alk - by Bioz Stars, 2026-04
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gene exp mlt 10 ce02426995 m1  (Thermo Fisher)
91
Thermo Fisher gene exp mlt 10 ce02426995 m1
Experimental validation of designed peptides shows improved kinase activity. ( A ) ADP-Glo assay baseline measurements showing kinase activity with parental substrates and background controls for all five tested kinases. ( B–F ) Relative percentage change in kinase activity for designed peptides compared to parental substrates for <t>ALK</t> ( B <t>),</t> <t>MET</t> ( C ), ROS1 ( D ), EGFR L858R ( E ), and SRC ( F ). Designed peptides are color-coded with sequence information provided. Phosphosite residues that were fixed during design are highlighted in green. Four out of five kinases showed substantial activity improvements with at least one designed peptide.
Gene Exp Mlt 10 Ce02426995 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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amino acids  (Chem Impex International)
95
Chem Impex International amino acids
Experimental validation of designed peptides shows improved kinase activity. ( A ) ADP-Glo assay baseline measurements showing kinase activity with parental substrates and background controls for all five tested kinases. ( B–F ) Relative percentage change in kinase activity for designed peptides compared to parental substrates for <t>ALK</t> ( B <t>),</t> <t>MET</t> ( C ), ROS1 ( D ), EGFR L858R ( E ), and SRC ( F ). Designed peptides are color-coded with sequence information provided. Phosphosite residues that were fixed during design are highlighted in green. Four out of five kinases showed substantial activity improvements with at least one designed peptide.
Amino Acids, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/amino acids/product/Chem Impex International
Average 95 stars, based on 1 article reviews
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mlt tube  (Mallinckrodt)
90
Mallinckrodt mlt tube
Experimental validation of designed peptides shows improved kinase activity. ( A ) ADP-Glo assay baseline measurements showing kinase activity with parental substrates and background controls for all five tested kinases. ( B–F ) Relative percentage change in kinase activity for designed peptides compared to parental substrates for <t>ALK</t> ( B <t>),</t> <t>MET</t> ( C ), ROS1 ( D ), EGFR L858R ( E ), and SRC ( F ). Designed peptides are color-coded with sequence information provided. Phosphosite residues that were fixed during design are highlighted in green. Four out of five kinases showed substantial activity improvements with at least one designed peptide.
Mlt Tube, supplied by Mallinckrodt, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Journal: Molecular Cell

Article Title: The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

doi: 10.1016/j.molcel.2024.10.044

Figure Lengend Snippet:

Article Snippet: Rabbit polyclonal anti-ZAK , Proteintech , Cat#14945-1-AP; RRID: AB_1064269.

Techniques: Recombinant, Reverse Transcription, In Situ, Knock-Out, Variant Assay, Software, Purification, Blocking Assay

Experimental validation of designed peptides shows improved kinase activity. ( A ) ADP-Glo assay baseline measurements showing kinase activity with parental substrates and background controls for all five tested kinases. ( B–F ) Relative percentage change in kinase activity for designed peptides compared to parental substrates for ALK ( B ), MET ( C ), ROS1 ( D ), EGFR L858R ( E ), and SRC ( F ). Designed peptides are color-coded with sequence information provided. Phosphosite residues that were fixed during design are highlighted in green. Four out of five kinases showed substantial activity improvements with at least one designed peptide.

Journal: bioRxiv

Article Title: A Computational Workflow for Structure-Guided Design of Potent and Selective Kinase Peptide Substrates

doi: 10.1101/2025.07.04.663216

Figure Lengend Snippet: Experimental validation of designed peptides shows improved kinase activity. ( A ) ADP-Glo assay baseline measurements showing kinase activity with parental substrates and background controls for all five tested kinases. ( B–F ) Relative percentage change in kinase activity for designed peptides compared to parental substrates for ALK ( B ), MET ( C ), ROS1 ( D ), EGFR L858R ( E ), and SRC ( F ). Designed peptides are color-coded with sequence information provided. Phosphosite residues that were fixed during design are highlighted in green. Four out of five kinases showed substantial activity improvements with at least one designed peptide.

Article Snippet: The kinases ALK (#08-518), MET (#08-151), ROS1 (#08-163), and EGFR L858R (#08-502) were products of Carna Biosciences.

Techniques: Biomarker Discovery, Activity Assay, Glo Assay, Sequencing, Phospho-proteomics

Kinetic characterization reveals improved binding affinity of designed peptides. ( A ) Schematic of kinase phosphorylation reaction monitored by the LIMS-kinase assay. ( B ) Multiple reaction monitoring (MRM) setup showing the mass spectrometry detection pathway for ADP quantification. ( C–E ) Michaelis-Menten kinetic analysis comparing parental and optimized peptides for ROS1 ( C ), MET ( D ), and ALK ( E ). Left panels show time-course data at varying substrate concentrations; right panels show saturation curves with fitted K m values and 95% confidence intervals. The designed peptides demonstrated lower K m values, indicating improved apparent binding affinity.

Journal: bioRxiv

Article Title: A Computational Workflow for Structure-Guided Design of Potent and Selective Kinase Peptide Substrates

doi: 10.1101/2025.07.04.663216

Figure Lengend Snippet: Kinetic characterization reveals improved binding affinity of designed peptides. ( A ) Schematic of kinase phosphorylation reaction monitored by the LIMS-kinase assay. ( B ) Multiple reaction monitoring (MRM) setup showing the mass spectrometry detection pathway for ADP quantification. ( C–E ) Michaelis-Menten kinetic analysis comparing parental and optimized peptides for ROS1 ( C ), MET ( D ), and ALK ( E ). Left panels show time-course data at varying substrate concentrations; right panels show saturation curves with fitted K m values and 95% confidence intervals. The designed peptides demonstrated lower K m values, indicating improved apparent binding affinity.

Article Snippet: The kinases ALK (#08-518), MET (#08-151), ROS1 (#08-163), and EGFR L858R (#08-502) were products of Carna Biosciences.

Techniques: Binding Assay, Phospho-proteomics, Kinase Assay, Targeted Proteomics, Mass Spectrometry

Structural analysis reveals molecular basis for improved activity. ( A-D ) Comparison of AlphaFold-Multimer predicted structures and hydrogen bonding networks for parental (green) versus designed (yellow) peptides in complex with ALK ( A ), ROS1 ( B ), MET ( C ), and EGFR L858R ( D ). Kinase structures are shown in gray ribbon representation. Green boxes highlight hydrogen bond interactions formed by parental peptides; yellow boxes show interactions formed by designed peptides. Designed peptides generally form additional or optimized hydrogen bonds that correlate with improved experimental activity.

Journal: bioRxiv

Article Title: A Computational Workflow for Structure-Guided Design of Potent and Selective Kinase Peptide Substrates

doi: 10.1101/2025.07.04.663216

Figure Lengend Snippet: Structural analysis reveals molecular basis for improved activity. ( A-D ) Comparison of AlphaFold-Multimer predicted structures and hydrogen bonding networks for parental (green) versus designed (yellow) peptides in complex with ALK ( A ), ROS1 ( B ), MET ( C ), and EGFR L858R ( D ). Kinase structures are shown in gray ribbon representation. Green boxes highlight hydrogen bond interactions formed by parental peptides; yellow boxes show interactions formed by designed peptides. Designed peptides generally form additional or optimized hydrogen bonds that correlate with improved experimental activity.

Article Snippet: The kinases ALK (#08-518), MET (#08-151), ROS1 (#08-163), and EGFR L858R (#08-502) were products of Carna Biosciences.

Techniques: Activity Assay, Comparison