Journal: Metabolism Open

Article Title: Non-coding RNAs in neurodegeneration: an axis-based, evidence-tiered mechanistic synthesis

doi: 10.1016/j.metop.2026.100458

Figure Lengend Snippet: Axis Proteostasis/homeostasis and pathological protein accumulation. ( A ) Representative miRNA nodes implicated in proteostasis collapse across neurodegenerative settings, highlighting links to amyloidogenic processing and stress signaling (e.g., miR-29/BACE1 in Aβ plaque burden; miR-146a–NF-κB signaling intersecting with tau-related pathology; and ALS-associated vulnerability aligned with impaired miRNA processing such as miR-218 depletion). ( B ) lncRNA-mediated regulation of proteostasis-related gene axis, emphasizing lncRNAs proposed to modulate amyloidogenic pathways and protein handling (e.g., BACE1-AS, NDM29, and 51A/SORL1-related mechanisms), as well as aggregation-relevant nodes reported in PD contexts (e.g., HOTAIR–miR-221-3p–α-synuclein-related phenotypes). ( C ) circRNA-linked regulatory motifs that converge on neuronal injury and proteostasis-adjacent clearance pathways, primarily via miRNA-coupled axes (e.g., circAXL/miR-328/BACE1; circLPAR1/miR-212-3p/ZNF217; and circBptf/miR-138-5p/p62/SQSTM1).

Article Snippet: Proteostasis/Protein aggregation , AD , miRNA , miR-29 , BACE1 regulation, amyloid burden , Human/Mouse , Expression + perturbation , Tier 2 , Biomarker candidate , [ ] .

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