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Image Search Results
Journal: International Journal of Molecular Sciences
Article Title: The Antitumor Effect of Timosaponin A3 through c-Myc Inhibition in Colorectal Cancer Cells and Combined Treatment Effect with 5-FU or Doxorubicin
doi: 10.3390/ijms231911900
Figure Lengend Snippet: TA3 inhibits c-Myc and induces apoptosis via CNOT2 or MID1IP1. ( A ) HCT116 p53+/+ cells were transfected with CNOT2 siRNA or control siRNA for 48 h and then cells were treated with TA3 (12.5 μM) for 24 h (three independent experiments in HCT116 p53+/+ cells). ( B ) HCT116 p53+/+ cells were transfected with MID1IP1 siRNA or control siRNA for 48 h and then cells were treated with TA3 for 24 h (three independent experiments in HCT116 p53+/+ cells). Statistical significance was analyzed using one-way analysis of variance (ANOVA) followed by Tukey’s test and the unpaired t-test. p -value indicates a significant difference between the groups. Quantification of protein expression is shown in the lower panel. * p < 0.01, ** p < 0.005, *** p < 0.001 vs. control; # p < 0.01, ## p < 0.005, ### p < 0.001 vs. only TA3-treated group. ( C ) HCT116 p53+/+ cells were treated with TA3 for 24 h. Then, cells were harvested for co-immunoprecipitation assay.
Article Snippet: Primary antibodies for CNOT2 (Cat No. 34214) and PARP (Cat No. 9542) were purchased from Cell Signaling Technology (Beverly, MA, USA),
Techniques: Transfection, Control, Expressing, Co-Immunoprecipitation Assay
Journal: International Journal of Molecular Sciences
Article Title: The Antitumor Effect of Timosaponin A3 through c-Myc Inhibition in Colorectal Cancer Cells and Combined Treatment Effect with 5-FU or Doxorubicin
doi: 10.3390/ijms231911900
Figure Lengend Snippet: Mechanism of TA3 to induce apoptosis in colorectal cancer by downregulating c-Myc via CNOT2 or MID1IP1.
Article Snippet: Primary antibodies for CNOT2 (Cat No. 34214) and PARP (Cat No. 9542) were purchased from Cell Signaling Technology (Beverly, MA, USA),
Techniques:
Journal: Physiological Genomics
Article Title: Human gene copy number spectra analysis in congenital heart malformations
doi: 10.1152/physiolgenomics.00013.2012
Figure Lengend Snippet: Known CHD risk genes
Article Snippet: MID1 , MIDLINE 1 , Xp22.2 , 10373595 , 388135 ,
Techniques: Retroviral, Sequencing, Virus, Reverse Transcription
Journal: Physiological Genomics
Article Title: Human gene copy number spectra analysis in congenital heart malformations
doi: 10.1152/physiolgenomics.00013.2012
Figure Lengend Snippet: Case reports of likely causal CNVs
Article Snippet: MID1 , MIDLINE 1 , Xp22.2 , 10373595 , 388135 ,
Techniques:
Journal: Physiological Genomics
Article Title: Human gene copy number spectra analysis in congenital heart malformations
doi: 10.1152/physiolgenomics.00013.2012
Figure Lengend Snippet: CHD-associated gene regions significantly enriched with large, rare CNVs
Article Snippet: MID1 , MIDLINE 1 , Xp22.2 , 10373595 , 388135 ,
Techniques:
Journal: Physiological Genomics
Article Title: Human gene copy number spectra analysis in congenital heart malformations
doi: 10.1152/physiolgenomics.00013.2012
Figure Lengend Snippet: Enriched syndrome genes
Article Snippet: MID1 , MIDLINE 1 , Xp22.2 , 10373595 , 388135 ,
Techniques: