Journal: AAPS PharmSciTech

Article Title: Improved Skin Penetration Using In Situ Nanoparticulate Diclofenac Diethylamine in Hydrogel Systems: In Vitro and In Vivo Studies

doi: 10.1208/s12249-015-0347-4

Figure Lengend Snippet: Composition of Hydrogel

Article Snippet: Hydrogel with the microsize drug particles was observed in an optical microscope (Axiostar Plus, Carl Zeiss, Jena, Germany). . Viscosity Study The viscosity of hydrogels was measured using Viscometer TV-10 (Toki Sangyo Co. Ltd., Tokyo, Japan).

Techniques:

Journal: AAPS PharmSciTech

Article Title: Improved Skin Penetration Using In Situ Nanoparticulate Diclofenac Diethylamine in Hydrogel Systems: In Vitro and In Vivo Studies

doi: 10.1208/s12249-015-0347-4

Figure Lengend Snippet: Analysis of load vs. time profile of hydrogel formulation using texture analyzer (a hydrogel with nanosize particles without enhancer, b hydrogel with microsize particles without enhancer)

Article Snippet: Hydrogel with the microsize drug particles was observed in an optical microscope (Axiostar Plus, Carl Zeiss, Jena, Germany). . Viscosity Study The viscosity of hydrogels was measured using Viscometer TV-10 (Toki Sangyo Co. Ltd., Tokyo, Japan).

Techniques: Formulation

Journal: AAPS PharmSciTech

Article Title: Improved Skin Penetration Using In Situ Nanoparticulate Diclofenac Diethylamine in Hydrogel Systems: In Vitro and In Vivo Studies

doi: 10.1208/s12249-015-0347-4

Figure Lengend Snippet: Drug release from hydrogel formulations of diclofenac diethylamine (white triangle hydrogel with nanosize drug without enhancer, black triangle hydrogel with nanosize drug with enhancer, white circle hydrogel with microsize drug without enhancer, black circle hydrogel with microsize drug with enhancer, black square marketed hydrogel formulation). Data show mean ± SD (n = 5)

Article Snippet: Hydrogel with the microsize drug particles was observed in an optical microscope (Axiostar Plus, Carl Zeiss, Jena, Germany). . Viscosity Study The viscosity of hydrogels was measured using Viscometer TV-10 (Toki Sangyo Co. Ltd., Tokyo, Japan).

Techniques: Formulation

Journal: AAPS PharmSciTech

Article Title: Improved Skin Penetration Using In Situ Nanoparticulate Diclofenac Diethylamine in Hydrogel Systems: In Vitro and In Vivo Studies

doi: 10.1208/s12249-015-0347-4

Figure Lengend Snippet: Permeation of hydrogel formulations of diclofenac diethylamine through cadaver skin (white triangle hydrogel with nanosize drug without enhancer, black triangle hydrogel with nanosize drug with enhancer, white circle hydrogel with microsize drug without enhancer, black circle hydrogel with microsize drug with enhancer, black square marketed hydrogel formulation). Data show mean ± SD (n = 5)

Article Snippet: Hydrogel with the microsize drug particles was observed in an optical microscope (Axiostar Plus, Carl Zeiss, Jena, Germany). . Viscosity Study The viscosity of hydrogels was measured using Viscometer TV-10 (Toki Sangyo Co. Ltd., Tokyo, Japan).

Techniques: Formulation

Journal: AAPS PharmSciTech

Article Title: Improved Skin Penetration Using In Situ Nanoparticulate Diclofenac Diethylamine in Hydrogel Systems: In Vitro and In Vivo Studies

doi: 10.1208/s12249-015-0347-4

Figure Lengend Snippet: Plasma profile of diclofenac diethylamine from hydrogels in rats (white triangle hydrogel with nanosize drug without enhancer, black triangle hydrogel with nanosize drug with enhancer, black circle hydrogel with microsize drug with enhancer, black square marketed hydrogel formulation). Data show mean ± SD (n = 4)

Article Snippet: Hydrogel with the microsize drug particles was observed in an optical microscope (Axiostar Plus, Carl Zeiss, Jena, Germany). . Viscosity Study The viscosity of hydrogels was measured using Viscometer TV-10 (Toki Sangyo Co. Ltd., Tokyo, Japan).

Techniques: Clinical Proteomics, Formulation