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90
BOC Sciences sorafenib related compound 8
Sorafenib Related Compound 8, supplied by BOC Sciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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94
Cayman Chemical compound 3
Oral administration of compound 52 blocked poly(I:C)-induced acute airway inflammation in mice. C57BL/6J mice were pretreated (10 mg/kg, po) with compound 52 before intranasal administration (i.n.) of poly(I:C). <t>Compound</t> <t>3</t> was included as a positive control. (A) Lung histology images of hematoxylin and eosin (H&E) staining were performed on paraffin-embedded lung sections and were shown at magnitude of ×10 and ×20, respectively. (B) Compound 52 blocked the secretion of poly(I:C)-induced inflammatory cells in bronchoalveolar lavage fluid (BALF). (C) Compound 52 blocked poly(I:C)-induced inflammatory cytokines in BALF. (D) Compound 52 blocked poly(I:C)-induced expression of inflammatory genes in lung tissues of mice. #p < 0.01, compared to control, *p < 0.01, compared to poly(I:C) only, n = 5.
Compound 3, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
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86
ChromaDex compound 8
Oral administration of compound 52 blocked poly(I:C)-induced acute airway inflammation in mice. C57BL/6J mice were pretreated (10 mg/kg, po) with compound 52 before intranasal administration (i.n.) of poly(I:C). <t>Compound</t> <t>3</t> was included as a positive control. (A) Lung histology images of hematoxylin and eosin (H&E) staining were performed on paraffin-embedded lung sections and were shown at magnitude of ×10 and ×20, respectively. (B) Compound 52 blocked the secretion of poly(I:C)-induced inflammatory cells in bronchoalveolar lavage fluid (BALF). (C) Compound 52 blocked poly(I:C)-induced inflammatory cytokines in BALF. (D) Compound 52 blocked poly(I:C)-induced expression of inflammatory genes in lung tissues of mice. #p < 0.01, compared to control, *p < 0.01, compared to poly(I:C) only, n = 5.
Compound 8, supplied by ChromaDex, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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86
Megazyme compound 8
Oral administration of compound 52 blocked poly(I:C)-induced acute airway inflammation in mice. C57BL/6J mice were pretreated (10 mg/kg, po) with compound 52 before intranasal administration (i.n.) of poly(I:C). <t>Compound</t> <t>3</t> was included as a positive control. (A) Lung histology images of hematoxylin and eosin (H&E) staining were performed on paraffin-embedded lung sections and were shown at magnitude of ×10 and ×20, respectively. (B) Compound 52 blocked the secretion of poly(I:C)-induced inflammatory cells in bronchoalveolar lavage fluid (BALF). (C) Compound 52 blocked poly(I:C)-induced inflammatory cytokines in BALF. (D) Compound 52 blocked poly(I:C)-induced expression of inflammatory genes in lung tissues of mice. #p < 0.01, compared to control, *p < 0.01, compared to poly(I:C) only, n = 5.
Compound 8, supplied by Megazyme, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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86
ASINEX Inc compound 8
Oral administration of compound 52 blocked poly(I:C)-induced acute airway inflammation in mice. C57BL/6J mice were pretreated (10 mg/kg, po) with compound 52 before intranasal administration (i.n.) of poly(I:C). <t>Compound</t> <t>3</t> was included as a positive control. (A) Lung histology images of hematoxylin and eosin (H&E) staining were performed on paraffin-embedded lung sections and were shown at magnitude of ×10 and ×20, respectively. (B) Compound 52 blocked the secretion of poly(I:C)-induced inflammatory cells in bronchoalveolar lavage fluid (BALF). (C) Compound 52 blocked poly(I:C)-induced inflammatory cytokines in BALF. (D) Compound 52 blocked poly(I:C)-induced expression of inflammatory genes in lung tissues of mice. #p < 0.01, compared to control, *p < 0.01, compared to poly(I:C) only, n = 5.
Compound 8, supplied by ASINEX Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Oral administration of compound 52 blocked poly(I:C)-induced acute airway inflammation in mice. C57BL/6J mice were pretreated (10 mg/kg, po) with compound 52 before intranasal administration (i.n.) of poly(I:C). Compound 3 was included as a positive control. (A) Lung histology images of hematoxylin and eosin (H&E) staining were performed on paraffin-embedded lung sections and were shown at magnitude of ×10 and ×20, respectively. (B) Compound 52 blocked the secretion of poly(I:C)-induced inflammatory cells in bronchoalveolar lavage fluid (BALF). (C) Compound 52 blocked poly(I:C)-induced inflammatory cytokines in BALF. (D) Compound 52 blocked poly(I:C)-induced expression of inflammatory genes in lung tissues of mice. #p < 0.01, compared to control, *p < 0.01, compared to poly(I:C) only, n = 5.

Journal: Journal of medicinal chemistry

Article Title: Discovery, X‑ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site

doi: 10.1021/acs.jmedchem.1c01851

Figure Lengend Snippet: Oral administration of compound 52 blocked poly(I:C)-induced acute airway inflammation in mice. C57BL/6J mice were pretreated (10 mg/kg, po) with compound 52 before intranasal administration (i.n.) of poly(I:C). Compound 3 was included as a positive control. (A) Lung histology images of hematoxylin and eosin (H&E) staining were performed on paraffin-embedded lung sections and were shown at magnitude of ×10 and ×20, respectively. (B) Compound 52 blocked the secretion of poly(I:C)-induced inflammatory cells in bronchoalveolar lavage fluid (BALF). (C) Compound 52 blocked poly(I:C)-induced inflammatory cytokines in BALF. (D) Compound 52 blocked poly(I:C)-induced expression of inflammatory genes in lung tissues of mice. #p < 0.01, compared to control, *p < 0.01, compared to poly(I:C) only, n = 5.

Article Snippet: Compound 1 was purchased from Tocris, and compound 3 was purchased from Cayman Chemical (Ann Arbor, Michigan).

Techniques: Positive Control, Staining, Expressing

BRD4 inhibitors 52 and 53 significantly blocked poly(I:C)-induced H3K122Ac levels in hSAECs (A) and in lung tissue of mice (B). (A) Immunofluorescence staining of H3K122Ac (green color) was performed in hSAECs. (B) Immunofluorescence staining of H3K122Ac (red) was performed on paraffin-embedded lung sections of mice. Right panel, quantification of total fluorescence intensity shown as fold changes on immunofluorescence. #p < 0.01, compared with control; *p < 0.01 compared with poly(I:C) only, n = 5. Compound 3 was included as a positive control.

Journal: Journal of medicinal chemistry

Article Title: Discovery, X‑ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site

doi: 10.1021/acs.jmedchem.1c01851

Figure Lengend Snippet: BRD4 inhibitors 52 and 53 significantly blocked poly(I:C)-induced H3K122Ac levels in hSAECs (A) and in lung tissue of mice (B). (A) Immunofluorescence staining of H3K122Ac (green color) was performed in hSAECs. (B) Immunofluorescence staining of H3K122Ac (red) was performed on paraffin-embedded lung sections of mice. Right panel, quantification of total fluorescence intensity shown as fold changes on immunofluorescence. #p < 0.01, compared with control; *p < 0.01 compared with poly(I:C) only, n = 5. Compound 3 was included as a positive control.

Article Snippet: Compound 1 was purchased from Tocris, and compound 3 was purchased from Cayman Chemical (Ann Arbor, Michigan).

Techniques: Immunofluorescence, Staining, Fluorescence, Positive Control