methionine Search Results


l methionine dl sulfoximine  (MedChemExpress)
94
MedChemExpress l methionine dl sulfoximine
L Methionine Dl Sulfoximine, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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l methionine sangon biotech cat  (Sangon Biotech)
86
Sangon Biotech l methionine sangon biotech cat
L Methionine Sangon Biotech Cat, supplied by Sangon Biotech, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rpmi 1640 medium  (Beyotime)
99
Beyotime rpmi 1640 medium
Rpmi 1640 Medium, supplied by Beyotime, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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methyl ester assay kit  (Thermo Fisher)
93
Thermo Fisher methyl ester assay kit
Figure 7. Extracellular lumican increases gemcitabine-induced mitochondrial damage, leading to ROS accumulation, depolarization of mitochondrial membrane potential and Cyto C release. (a) MDA-PATC53 and PANC-1 cells were treated with 1 μM gemcitabine in the absence or presence of 2 μg/ml lumican for 24 h and then were analyzed by western blot. (b) Tumor tissue lysates from wild-type and lumican knockout mice were subjected to western blot. (c) The indicated cells were treated as described in a, and ROS production was identified in live cells by using flow cytometry. (d) MDA-PATC53 cells were treated with 1 μM gemcitabine or/and 2 μg/ml lumican for 24 h. Mitochondria were isolated from the cells using the Mitochondria Isolation <t>Kit</t> (Thermo Scientific, Rockford, lL, USA) and subjected to western blot. The bar graphs in the upper panel are the densitometric values of cytochrome c (Cyto C) in each lane. (e) MDA-PATC53 cells were treated as described in d, and isolated cell cytosol lysates were subjected to immunoblot analyses (left) and immunoprecipitated by Cyto C, followed by immunoblot analysis (right). (f) In MDA-PATC53 cells treated as described in d, depolarization of mitochondrial membrane potential in live cells was shown with Tetramethylrhodamine, <t>methyl</t> <t>ester</t> (TMRM) staining. (g) This schematic model depicts that lumican reduces chemotherapy-induced autophagy through inhibition of AMPK, augmenting cytotoxicity of chemotherapy in PDAC cells.
Methyl Ester Assay Kit, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/methionine/L-Methionine+methyl+ester+hydrochloride%2C+99%25/pm26876211-147-16-20
Average 93 stars, based on 1 article reviews
methyl ester assay kit - by Bioz Stars, 2026-10
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l methionine  (Thermo Fisher)
94
Thermo Fisher l methionine
Figure 7. Extracellular lumican increases gemcitabine-induced mitochondrial damage, leading to ROS accumulation, depolarization of mitochondrial membrane potential and Cyto C release. (a) MDA-PATC53 and PANC-1 cells were treated with 1 μM gemcitabine in the absence or presence of 2 μg/ml lumican for 24 h and then were analyzed by western blot. (b) Tumor tissue lysates from wild-type and lumican knockout mice were subjected to western blot. (c) The indicated cells were treated as described in a, and ROS production was identified in live cells by using flow cytometry. (d) MDA-PATC53 cells were treated with 1 μM gemcitabine or/and 2 μg/ml lumican for 24 h. Mitochondria were isolated from the cells using the Mitochondria Isolation <t>Kit</t> (Thermo Scientific, Rockford, lL, USA) and subjected to western blot. The bar graphs in the upper panel are the densitometric values of cytochrome c (Cyto C) in each lane. (e) MDA-PATC53 cells were treated as described in d, and isolated cell cytosol lysates were subjected to immunoblot analyses (left) and immunoprecipitated by Cyto C, followed by immunoblot analysis (right). (f) In MDA-PATC53 cells treated as described in d, depolarization of mitochondrial membrane potential in live cells was shown with Tetramethylrhodamine, <t>methyl</t> <t>ester</t> (TMRM) staining. (g) This schematic model depicts that lumican reduces chemotherapy-induced autophagy through inhibition of AMPK, augmenting cytotoxicity of chemotherapy in PDAC cells.
L Methionine, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/methionine/L-Methionine%2C+98%2B%25/norris_michael_h__2014__identifying_virulence_factors_and_regulators_contributing_to_pathogenesis_by_the_select_agent_bacterium-3167-45-51
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selenomethionine semet carbosynth fs09881 substituted protein complex  (Biosynth Carbosynth)
93
Biosynth Carbosynth selenomethionine semet carbosynth fs09881 substituted protein complex
Figure 7. Extracellular lumican increases gemcitabine-induced mitochondrial damage, leading to ROS accumulation, depolarization of mitochondrial membrane potential and Cyto C release. (a) MDA-PATC53 and PANC-1 cells were treated with 1 μM gemcitabine in the absence or presence of 2 μg/ml lumican for 24 h and then were analyzed by western blot. (b) Tumor tissue lysates from wild-type and lumican knockout mice were subjected to western blot. (c) The indicated cells were treated as described in a, and ROS production was identified in live cells by using flow cytometry. (d) MDA-PATC53 cells were treated with 1 μM gemcitabine or/and 2 μg/ml lumican for 24 h. Mitochondria were isolated from the cells using the Mitochondria Isolation <t>Kit</t> (Thermo Scientific, Rockford, lL, USA) and subjected to western blot. The bar graphs in the upper panel are the densitometric values of cytochrome c (Cyto C) in each lane. (e) MDA-PATC53 cells were treated as described in d, and isolated cell cytosol lysates were subjected to immunoblot analyses (left) and immunoprecipitated by Cyto C, followed by immunoblot analysis (right). (f) In MDA-PATC53 cells treated as described in d, depolarization of mitochondrial membrane potential in live cells was shown with Tetramethylrhodamine, <t>methyl</t> <t>ester</t> (TMRM) staining. (g) This schematic model depicts that lumican reduces chemotherapy-induced autophagy through inhibition of AMPK, augmenting cytotoxicity of chemotherapy in PDAC cells.
Selenomethionine Semet Carbosynth Fs09881 Substituted Protein Complex, supplied by Biosynth Carbosynth, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
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radioactive s adenosyl l  (Revvity)
91
Revvity radioactive s adenosyl l
Figure 7. Extracellular lumican increases gemcitabine-induced mitochondrial damage, leading to ROS accumulation, depolarization of mitochondrial membrane potential and Cyto C release. (a) MDA-PATC53 and PANC-1 cells were treated with 1 μM gemcitabine in the absence or presence of 2 μg/ml lumican for 24 h and then were analyzed by western blot. (b) Tumor tissue lysates from wild-type and lumican knockout mice were subjected to western blot. (c) The indicated cells were treated as described in a, and ROS production was identified in live cells by using flow cytometry. (d) MDA-PATC53 cells were treated with 1 μM gemcitabine or/and 2 μg/ml lumican for 24 h. Mitochondria were isolated from the cells using the Mitochondria Isolation <t>Kit</t> (Thermo Scientific, Rockford, lL, USA) and subjected to western blot. The bar graphs in the upper panel are the densitometric values of cytochrome c (Cyto C) in each lane. (e) MDA-PATC53 cells were treated as described in d, and isolated cell cytosol lysates were subjected to immunoblot analyses (left) and immunoprecipitated by Cyto C, followed by immunoblot analysis (right). (f) In MDA-PATC53 cells treated as described in d, depolarization of mitochondrial membrane potential in live cells was shown with Tetramethylrhodamine, <t>methyl</t> <t>ester</t> (TMRM) staining. (g) This schematic model depicts that lumican reduces chemotherapy-induced autophagy through inhibition of AMPK, augmenting cytotoxicity of chemotherapy in PDAC cells.
Radioactive S Adenosyl L, supplied by Revvity, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/methionine/Adenosyl-L-methionine%2C+S/pmc10726702-172-14-20
Average 91 stars, based on 1 article reviews
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methionine  (Revvity)
91
Revvity methionine
Figure 7. Extracellular lumican increases gemcitabine-induced mitochondrial damage, leading to ROS accumulation, depolarization of mitochondrial membrane potential and Cyto C release. (a) MDA-PATC53 and PANC-1 cells were treated with 1 μM gemcitabine in the absence or presence of 2 μg/ml lumican for 24 h and then were analyzed by western blot. (b) Tumor tissue lysates from wild-type and lumican knockout mice were subjected to western blot. (c) The indicated cells were treated as described in a, and ROS production was identified in live cells by using flow cytometry. (d) MDA-PATC53 cells were treated with 1 μM gemcitabine or/and 2 μg/ml lumican for 24 h. Mitochondria were isolated from the cells using the Mitochondria Isolation <t>Kit</t> (Thermo Scientific, Rockford, lL, USA) and subjected to western blot. The bar graphs in the upper panel are the densitometric values of cytochrome c (Cyto C) in each lane. (e) MDA-PATC53 cells were treated as described in d, and isolated cell cytosol lysates were subjected to immunoblot analyses (left) and immunoprecipitated by Cyto C, followed by immunoblot analysis (right). (f) In MDA-PATC53 cells treated as described in d, depolarization of mitochondrial membrane potential in live cells was shown with Tetramethylrhodamine, <t>methyl</t> <t>ester</t> (TMRM) staining. (g) This schematic model depicts that lumican reduces chemotherapy-induced autophagy through inhibition of AMPK, augmenting cytotoxicity of chemotherapy in PDAC cells.
Methionine, supplied by Revvity, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/methionine/EasyTag+L-%5B35S%5D-Methionine%2C+(18%2E5MBq)%2C+Stabilized+Aqueous+Solution/pmc07797078-89-2-4
Average 91 stars, based on 1 article reviews
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s methionine  (Revvity)
90
Revvity s methionine
Figure 7. Extracellular lumican increases gemcitabine-induced mitochondrial damage, leading to ROS accumulation, depolarization of mitochondrial membrane potential and Cyto C release. (a) MDA-PATC53 and PANC-1 cells were treated with 1 μM gemcitabine in the absence or presence of 2 μg/ml lumican for 24 h and then were analyzed by western blot. (b) Tumor tissue lysates from wild-type and lumican knockout mice were subjected to western blot. (c) The indicated cells were treated as described in a, and ROS production was identified in live cells by using flow cytometry. (d) MDA-PATC53 cells were treated with 1 μM gemcitabine or/and 2 μg/ml lumican for 24 h. Mitochondria were isolated from the cells using the Mitochondria Isolation <t>Kit</t> (Thermo Scientific, Rockford, lL, USA) and subjected to western blot. The bar graphs in the upper panel are the densitometric values of cytochrome c (Cyto C) in each lane. (e) MDA-PATC53 cells were treated as described in d, and isolated cell cytosol lysates were subjected to immunoblot analyses (left) and immunoprecipitated by Cyto C, followed by immunoblot analysis (right). (f) In MDA-PATC53 cells treated as described in d, depolarization of mitochondrial membrane potential in live cells was shown with Tetramethylrhodamine, <t>methyl</t> <t>ester</t> (TMRM) staining. (g) This schematic model depicts that lumican reduces chemotherapy-induced autophagy through inhibition of AMPK, augmenting cytotoxicity of chemotherapy in PDAC cells.
S Methionine, supplied by Revvity, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/methionine/Methionine%2C+Cell+Labeling+Grade%2C+L-%5B35S%5D-%2C%3E600+Ci+(22%2E2+TBq)+mmol%2C+50+mM+Tricine%2C+10+mM+BME%2C+5+mCi/bio_rxiv__2020__10__03__324186-237-31-32
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l methionine  (MedChemExpress)
94
MedChemExpress l methionine
Figure 7. Extracellular lumican increases gemcitabine-induced mitochondrial damage, leading to ROS accumulation, depolarization of mitochondrial membrane potential and Cyto C release. (a) MDA-PATC53 and PANC-1 cells were treated with 1 μM gemcitabine in the absence or presence of 2 μg/ml lumican for 24 h and then were analyzed by western blot. (b) Tumor tissue lysates from wild-type and lumican knockout mice were subjected to western blot. (c) The indicated cells were treated as described in a, and ROS production was identified in live cells by using flow cytometry. (d) MDA-PATC53 cells were treated with 1 μM gemcitabine or/and 2 μg/ml lumican for 24 h. Mitochondria were isolated from the cells using the Mitochondria Isolation <t>Kit</t> (Thermo Scientific, Rockford, lL, USA) and subjected to western blot. The bar graphs in the upper panel are the densitometric values of cytochrome c (Cyto C) in each lane. (e) MDA-PATC53 cells were treated as described in d, and isolated cell cytosol lysates were subjected to immunoblot analyses (left) and immunoprecipitated by Cyto C, followed by immunoblot analysis (right). (f) In MDA-PATC53 cells treated as described in d, depolarization of mitochondrial membrane potential in live cells was shown with Tetramethylrhodamine, <t>methyl</t> <t>ester</t> (TMRM) staining. (g) This schematic model depicts that lumican reduces chemotherapy-induced autophagy through inhibition of AMPK, augmenting cytotoxicity of chemotherapy in PDAC cells.
L Methionine, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/methionine/L-Methionine/pm39745173-42-20-21
Average 94 stars, based on 1 article reviews
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amino acids  (MedChemExpress)
94
MedChemExpress amino acids
Figure 7. Extracellular lumican increases gemcitabine-induced mitochondrial damage, leading to ROS accumulation, depolarization of mitochondrial membrane potential and Cyto C release. (a) MDA-PATC53 and PANC-1 cells were treated with 1 μM gemcitabine in the absence or presence of 2 μg/ml lumican for 24 h and then were analyzed by western blot. (b) Tumor tissue lysates from wild-type and lumican knockout mice were subjected to western blot. (c) The indicated cells were treated as described in a, and ROS production was identified in live cells by using flow cytometry. (d) MDA-PATC53 cells were treated with 1 μM gemcitabine or/and 2 μg/ml lumican for 24 h. Mitochondria were isolated from the cells using the Mitochondria Isolation <t>Kit</t> (Thermo Scientific, Rockford, lL, USA) and subjected to western blot. The bar graphs in the upper panel are the densitometric values of cytochrome c (Cyto C) in each lane. (e) MDA-PATC53 cells were treated as described in d, and isolated cell cytosol lysates were subjected to immunoblot analyses (left) and immunoprecipitated by Cyto C, followed by immunoblot analysis (right). (f) In MDA-PATC53 cells treated as described in d, depolarization of mitochondrial membrane potential in live cells was shown with Tetramethylrhodamine, <t>methyl</t> <t>ester</t> (TMRM) staining. (g) This schematic model depicts that lumican reduces chemotherapy-induced autophagy through inhibition of AMPK, augmenting cytotoxicity of chemotherapy in PDAC cells.
Amino Acids, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/methionine/Methionine/pmc10905913-259-12-37
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amino acids - by Bioz Stars, 2026-10
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sam b0617a  (MedChemExpress)
94
MedChemExpress sam b0617a
Figure 7. Extracellular lumican increases gemcitabine-induced mitochondrial damage, leading to ROS accumulation, depolarization of mitochondrial membrane potential and Cyto C release. (a) MDA-PATC53 and PANC-1 cells were treated with 1 μM gemcitabine in the absence or presence of 2 μg/ml lumican for 24 h and then were analyzed by western blot. (b) Tumor tissue lysates from wild-type and lumican knockout mice were subjected to western blot. (c) The indicated cells were treated as described in a, and ROS production was identified in live cells by using flow cytometry. (d) MDA-PATC53 cells were treated with 1 μM gemcitabine or/and 2 μg/ml lumican for 24 h. Mitochondria were isolated from the cells using the Mitochondria Isolation <t>Kit</t> (Thermo Scientific, Rockford, lL, USA) and subjected to western blot. The bar graphs in the upper panel are the densitometric values of cytochrome c (Cyto C) in each lane. (e) MDA-PATC53 cells were treated as described in d, and isolated cell cytosol lysates were subjected to immunoblot analyses (left) and immunoprecipitated by Cyto C, followed by immunoblot analysis (right). (f) In MDA-PATC53 cells treated as described in d, depolarization of mitochondrial membrane potential in live cells was shown with Tetramethylrhodamine, <t>methyl</t> <t>ester</t> (TMRM) staining. (g) This schematic model depicts that lumican reduces chemotherapy-induced autophagy through inhibition of AMPK, augmenting cytotoxicity of chemotherapy in PDAC cells.
Sam B0617a, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/methionine/S-Adenosyl-L-methionine/pm41922101-424-25-18
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Image Search Results


Figure 7. Extracellular lumican increases gemcitabine-induced mitochondrial damage, leading to ROS accumulation, depolarization of mitochondrial membrane potential and Cyto C release. (a) MDA-PATC53 and PANC-1 cells were treated with 1 μM gemcitabine in the absence or presence of 2 μg/ml lumican for 24 h and then were analyzed by western blot. (b) Tumor tissue lysates from wild-type and lumican knockout mice were subjected to western blot. (c) The indicated cells were treated as described in a, and ROS production was identified in live cells by using flow cytometry. (d) MDA-PATC53 cells were treated with 1 μM gemcitabine or/and 2 μg/ml lumican for 24 h. Mitochondria were isolated from the cells using the Mitochondria Isolation Kit (Thermo Scientific, Rockford, lL, USA) and subjected to western blot. The bar graphs in the upper panel are the densitometric values of cytochrome c (Cyto C) in each lane. (e) MDA-PATC53 cells were treated as described in d, and isolated cell cytosol lysates were subjected to immunoblot analyses (left) and immunoprecipitated by Cyto C, followed by immunoblot analysis (right). (f) In MDA-PATC53 cells treated as described in d, depolarization of mitochondrial membrane potential in live cells was shown with Tetramethylrhodamine, methyl ester (TMRM) staining. (g) This schematic model depicts that lumican reduces chemotherapy-induced autophagy through inhibition of AMPK, augmenting cytotoxicity of chemotherapy in PDAC cells.

Journal: Oncogene

Article Title: Extracellular lumican augments cytotoxicity of chemotherapy in pancreatic ductal adenocarcinoma cells via autophagy inhibition.

doi: 10.1038/onc.2016.20

Figure Lengend Snippet: Figure 7. Extracellular lumican increases gemcitabine-induced mitochondrial damage, leading to ROS accumulation, depolarization of mitochondrial membrane potential and Cyto C release. (a) MDA-PATC53 and PANC-1 cells were treated with 1 μM gemcitabine in the absence or presence of 2 μg/ml lumican for 24 h and then were analyzed by western blot. (b) Tumor tissue lysates from wild-type and lumican knockout mice were subjected to western blot. (c) The indicated cells were treated as described in a, and ROS production was identified in live cells by using flow cytometry. (d) MDA-PATC53 cells were treated with 1 μM gemcitabine or/and 2 μg/ml lumican for 24 h. Mitochondria were isolated from the cells using the Mitochondria Isolation Kit (Thermo Scientific, Rockford, lL, USA) and subjected to western blot. The bar graphs in the upper panel are the densitometric values of cytochrome c (Cyto C) in each lane. (e) MDA-PATC53 cells were treated as described in d, and isolated cell cytosol lysates were subjected to immunoblot analyses (left) and immunoprecipitated by Cyto C, followed by immunoblot analysis (right). (f) In MDA-PATC53 cells treated as described in d, depolarization of mitochondrial membrane potential in live cells was shown with Tetramethylrhodamine, methyl ester (TMRM) staining. (g) This schematic model depicts that lumican reduces chemotherapy-induced autophagy through inhibition of AMPK, augmenting cytotoxicity of chemotherapy in PDAC cells.

Article Snippet: Mitochondrial membrane potential assay Depolarization of mitochondrial membrane potential in live cells was measured by Tetramethylrhodamine, methyl ester assay kit (Life Technologies, T-668) according to the manufacturers’ instructions.

Techniques: Membrane, Western Blot, Knock-Out, Cytometry, Isolation, Immunoprecipitation, Staining, Inhibition