Journal: Aging Clinical and Experimental Research

Article Title: Physical Activity and Nutrition INfluences In ageing (PANINI): consortium mission statement

doi: 10.1007/s40520-017-0823-7

Figure Lengend Snippet: Summary of main projects in the PANINI network

Article Snippet: 10. University of Bologna , Epigenetics of nutrition in ageing , DNA methylation analysis (gene-targeted) by Sequenom ® MassARRAY EpiTYPER platform , NU-AGE samples and new PANINI data , Changes in DNA methylation patterns induced by dietary and physical interventions. Development of a gene-targeted epigenetic clock.

Techniques: Battery, Activity Assay, Modification, DNA Methylation Assay, Variant Assay

Journal: PLoS ONE

Article Title: Methylation of the SLC6a2 Gene Promoter in Major Depression and Panic Disorder

doi: 10.1371/journal.pone.0083223

Figure Lengend Snippet: Bisulphite primer sequences for SLC6a2 .

Article Snippet: Promoter methylation of the SLC6a2 gene was also investigated using EpiTYPER methylation analysis on the MassARRAY® platform (Sequenom).

Techniques: Sequencing, Bisulfite Sequencing

Journal: PLoS ONE

Article Title: Methylation of the SLC6a2 Gene Promoter in Major Depression and Panic Disorder

doi: 10.1371/journal.pone.0083223

Figure Lengend Snippet: Representation of the methylation percentages for CpG sites in Region A of the SLC6a2 gene determined by EpiTYPER analysis. CpG site. CpG sites are numbered 5’- 3’ along the X-axis, with percentage methylation on the Y-axis. Usable data could not be obtained for all CpG sites for all samples. All groups exhibited a similar methylation profile across the region, and no difference between groups for the region as a whole was determined to be significant by two-way ANOVA.

Article Snippet: Promoter methylation of the SLC6a2 gene was also investigated using EpiTYPER methylation analysis on the MassARRAY® platform (Sequenom).

Techniques: Methylation

Journal: PLoS ONE

Article Title: Methylation of the SLC6a2 Gene Promoter in Major Depression and Panic Disorder

doi: 10.1371/journal.pone.0083223

Figure Lengend Snippet: Representation of the methylation percentages for CpG sites in Region B of the SLC6a2 gene determined by EpiTYPER analysis. CpG sites are numbered 5’- 3’ along the X-axis, with percentage methylation on the Y-axis. Usable data could not be obtained for all CpG sites for all samples. The overall methylation of Region B in subjects with MDD was determined to be significantly greater than all other groups (p<0.05).

Article Snippet: Promoter methylation of the SLC6a2 gene was also investigated using EpiTYPER methylation analysis on the MassARRAY® platform (Sequenom).

Techniques: Methylation

Journal: PLoS ONE

Article Title: Methylation of the SLC6a2 Gene Promoter in Major Depression and Panic Disorder

doi: 10.1371/journal.pone.0083223

Figure Lengend Snippet: Representation of the methylation percentages for CpG sites in Region A of the NET gene determined by EpiTYPER analysis in human leukocytes pre- and post-SSRI treatment. CpG sites are numbered 5’- 3’ along the X-axis, with percentage methylation on the Y-axis. Usable data could not be obtained for all CpG sites for all samples. Samples pre- and post-SSRI treatment exhibited a similar methylation profile across the region, and no differences in average methylation of CpG sites in response to SSRI treatment were determined to be significant by paired t-test. *Statistically significant site-specific difference in methylation with SSRI treatment.

Article Snippet: Promoter methylation of the SLC6a2 gene was also investigated using EpiTYPER methylation analysis on the MassARRAY® platform (Sequenom).

Techniques: Methylation