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  • 93
    Tocris m nimodipine
    Monoamine receptor antagonists that act to reduce the Na PIC increase the overall firing rate but do not affect the F–I slope. A : average minimum firing rates (measured as last interspike interval during current ramps) for motoneurons of chronic and acute spinal rats under control conditions <t>(nimodipine),</t> with any one antagonist (and nimodipine), and with any combination of 2 out of the 3 antagonists. Note significantly higher minimum firing rate in motoneurons of both chronic and acute spinal rats recorded in one or 2 antagonists. B : instantaneous firing frequency (triangles) and corresponding current (circles) recorded during slow triangular current ramp in motoneuron of chronic spinal rat held through antagonist action (full monoamine block, but before loss of repetitive firing). Open symbols, before; solid symbols, after antagonist application. Note increase in initial and final firing rate, but no change in modulation of frequency ( F–I slope) with current input (upward shift in frequency plot but still parallel). Mark at left of frequency plots indicates 10 Hz. C : comparison of F–I plots before and after antagonist application in motoneuron of chronic spinal rat held through drug action (WB 4101). Recruitment threshold current was subtracted from actual injected current in both traces. Open triangles: control; solid triangles: WB 4101. Note parallel F–I slopes, with vertical shift compared with control (shift measured at y -intercept, vertical dotted line).
    M Nimodipine, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/m nimodipine/product/Tocris
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    m nimodipine - by Bioz Stars, 2022-10
    93/100 stars
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    93
    Alomone Labs m nimodipine
    Effects of Ca 2+ channel inhibitors on peak and trough Ca 2+ concentration. ( A and B ) Time course of the change in Ca 2+ concentration (ΔCa 2+ = Ca 2+ – average Ca 2+ from 2-min baseline) before and after the application of vehicle control (Veh) or Ca 2+ channel inhibitors at the peak ( A ) and trough ( B ). Data are mean ± SEM. ( C and D ) Plots of median, 25th and 75th percentile ( boxes ), and minimal and maximal ( whiskers ) changes in Ca 2+ concentration for individual slices quantified from 9 to 10 min after drugs were applied at the peak ( C ) and trough ( D ). Inhibition of L-type Ca 2+ channels with <t>nimodipine</t> (Nim, 10 μ M) or inhibition of N/P/Q/R/T-type Ca 2+ channels with VGC (a mixture of 3 μ M ConoGVIA, 200 nM AgaIVA, 30 μ M nickel, and 1 μ M TTA-P2) did not significantly affect peak or trough Ca 2+ levels compared to Veh. Inhibition of ryanodine receptors with dantrolene (Dan, 10 μ M), inhibition of SERCA-ATPase with cyclopiazonic acid (CPA, 10 μ M) and combined inhibition of voltage-gated Ca 2+ channels and ryanodine receptors with a cocktail containing Dan, Nim, and VGC (cocktail X) significantly decreased Ca 2+ at peak and trough. * p
    M Nimodipine, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/m nimodipine/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    m nimodipine - by Bioz Stars, 2022-10
    93/100 stars
      Buy from Supplier

    93
    Millipore m nimodipine
    Effects of Ca 2+ channel inhibitors on peak and trough Ca 2+ concentration. ( A and B ) Time course of the change in Ca 2+ concentration (ΔCa 2+ = Ca 2+ – average Ca 2+ from 2-min baseline) before and after the application of vehicle control (Veh) or Ca 2+ channel inhibitors at the peak ( A ) and trough ( B ). Data are mean ± SEM. ( C and D ) Plots of median, 25th and 75th percentile ( boxes ), and minimal and maximal ( whiskers ) changes in Ca 2+ concentration for individual slices quantified from 9 to 10 min after drugs were applied at the peak ( C ) and trough ( D ). Inhibition of L-type Ca 2+ channels with <t>nimodipine</t> (Nim, 10 μ M) or inhibition of N/P/Q/R/T-type Ca 2+ channels with VGC (a mixture of 3 μ M ConoGVIA, 200 nM AgaIVA, 30 μ M nickel, and 1 μ M TTA-P2) did not significantly affect peak or trough Ca 2+ levels compared to Veh. Inhibition of ryanodine receptors with dantrolene (Dan, 10 μ M), inhibition of SERCA-ATPase with cyclopiazonic acid (CPA, 10 μ M) and combined inhibition of voltage-gated Ca 2+ channels and ryanodine receptors with a cocktail containing Dan, Nim, and VGC (cocktail X) significantly decreased Ca 2+ at peak and trough. * p
    M Nimodipine, supplied by Millipore, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/m nimodipine/product/Millipore
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    m nimodipine - by Bioz Stars, 2022-10
    93/100 stars
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    80
    Millipore ãŽâ¼ m nimodipine
    Effects of Ca 2+ channel inhibitors on peak and trough Ca 2+ concentration. ( A and B ) Time course of the change in Ca 2+ concentration (ΔCa 2+ = Ca 2+ – average Ca 2+ from 2-min baseline) before and after the application of vehicle control (Veh) or Ca 2+ channel inhibitors at the peak ( A ) and trough ( B ). Data are mean ± SEM. ( C and D ) Plots of median, 25th and 75th percentile ( boxes ), and minimal and maximal ( whiskers ) changes in Ca 2+ concentration for individual slices quantified from 9 to 10 min after drugs were applied at the peak ( C ) and trough ( D ). Inhibition of L-type Ca 2+ channels with <t>nimodipine</t> (Nim, 10 μ M) or inhibition of N/P/Q/R/T-type Ca 2+ channels with VGC (a mixture of 3 μ M ConoGVIA, 200 nM AgaIVA, 30 μ M nickel, and 1 μ M TTA-P2) did not significantly affect peak or trough Ca 2+ levels compared to Veh. Inhibition of ryanodine receptors with dantrolene (Dan, 10 μ M), inhibition of SERCA-ATPase with cyclopiazonic acid (CPA, 10 μ M) and combined inhibition of voltage-gated Ca 2+ channels and ryanodine receptors with a cocktail containing Dan, Nim, and VGC (cocktail X) significantly decreased Ca 2+ at peak and trough. * p
    ãŽâ¼ M Nimodipine, supplied by Millipore, used in various techniques. Bioz Stars score: 80/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ãŽâ¼ m nimodipine/product/Millipore
    Average 80 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    ãŽâ¼ m nimodipine - by Bioz Stars, 2022-10
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    Image Search Results


    Monoamine receptor antagonists that act to reduce the Na PIC increase the overall firing rate but do not affect the F–I slope. A : average minimum firing rates (measured as last interspike interval during current ramps) for motoneurons of chronic and acute spinal rats under control conditions (nimodipine), with any one antagonist (and nimodipine), and with any combination of 2 out of the 3 antagonists. Note significantly higher minimum firing rate in motoneurons of both chronic and acute spinal rats recorded in one or 2 antagonists. B : instantaneous firing frequency (triangles) and corresponding current (circles) recorded during slow triangular current ramp in motoneuron of chronic spinal rat held through antagonist action (full monoamine block, but before loss of repetitive firing). Open symbols, before; solid symbols, after antagonist application. Note increase in initial and final firing rate, but no change in modulation of frequency ( F–I slope) with current input (upward shift in frequency plot but still parallel). Mark at left of frequency plots indicates 10 Hz. C : comparison of F–I plots before and after antagonist application in motoneuron of chronic spinal rat held through drug action (WB 4101). Recruitment threshold current was subtracted from actual injected current in both traces. Open triangles: control; solid triangles: WB 4101. Note parallel F–I slopes, with vertical shift compared with control (shift measured at y -intercept, vertical dotted line).

    Journal: Journal of neurophysiology

    Article Title: Endogenous Monoamine Receptor Activation Is Essential for Enabling Persistent Sodium Currents and Repetitive Firing in Rat Spinal Motoneurons

    doi: 10.1152/jn.00341.2006

    Figure Lengend Snippet: Monoamine receptor antagonists that act to reduce the Na PIC increase the overall firing rate but do not affect the F–I slope. A : average minimum firing rates (measured as last interspike interval during current ramps) for motoneurons of chronic and acute spinal rats under control conditions (nimodipine), with any one antagonist (and nimodipine), and with any combination of 2 out of the 3 antagonists. Note significantly higher minimum firing rate in motoneurons of both chronic and acute spinal rats recorded in one or 2 antagonists. B : instantaneous firing frequency (triangles) and corresponding current (circles) recorded during slow triangular current ramp in motoneuron of chronic spinal rat held through antagonist action (full monoamine block, but before loss of repetitive firing). Open symbols, before; solid symbols, after antagonist application. Note increase in initial and final firing rate, but no change in modulation of frequency ( F–I slope) with current input (upward shift in frequency plot but still parallel). Mark at left of frequency plots indicates 10 Hz. C : comparison of F–I plots before and after antagonist application in motoneuron of chronic spinal rat held through drug action (WB 4101). Recruitment threshold current was subtracted from actual injected current in both traces. Open triangles: control; solid triangles: WB 4101. Note parallel F–I slopes, with vertical shift compared with control (shift measured at y -intercept, vertical dotted line).

    Article Snippet: Additional drugs were added as required, including 15 µ M nimodipine (Tocris Cookson) to block L-type Ca channels mediating the Ca PIC, 50 µ M 5-hydroxytryptamine (5-HT; Sigma), 30 µ M of the 5-HT2 receptor agonist (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI; Sigma), and 100 µ M of the α 1-NE receptor agonist methoxamine (Sigma).

    Techniques: Activated Clotting Time Assay, Blocking Assay, Western Blot, Injection

    Effects of Ca 2+ channel inhibitors on peak and trough Ca 2+ concentration. ( A and B ) Time course of the change in Ca 2+ concentration (ΔCa 2+ = Ca 2+ – average Ca 2+ from 2-min baseline) before and after the application of vehicle control (Veh) or Ca 2+ channel inhibitors at the peak ( A ) and trough ( B ). Data are mean ± SEM. ( C and D ) Plots of median, 25th and 75th percentile ( boxes ), and minimal and maximal ( whiskers ) changes in Ca 2+ concentration for individual slices quantified from 9 to 10 min after drugs were applied at the peak ( C ) and trough ( D ). Inhibition of L-type Ca 2+ channels with nimodipine (Nim, 10 μ M) or inhibition of N/P/Q/R/T-type Ca 2+ channels with VGC (a mixture of 3 μ M ConoGVIA, 200 nM AgaIVA, 30 μ M nickel, and 1 μ M TTA-P2) did not significantly affect peak or trough Ca 2+ levels compared to Veh. Inhibition of ryanodine receptors with dantrolene (Dan, 10 μ M), inhibition of SERCA-ATPase with cyclopiazonic acid (CPA, 10 μ M) and combined inhibition of voltage-gated Ca 2+ channels and ryanodine receptors with a cocktail containing Dan, Nim, and VGC (cocktail X) significantly decreased Ca 2+ at peak and trough. * p

    Journal: Biophysical reports

    Article Title: Comparative Ca2+ channel contributions to intracellular Ca2+ levels in the circadian clock

    doi: 10.1016/j.bpr.2021.100005

    Figure Lengend Snippet: Effects of Ca 2+ channel inhibitors on peak and trough Ca 2+ concentration. ( A and B ) Time course of the change in Ca 2+ concentration (ΔCa 2+ = Ca 2+ – average Ca 2+ from 2-min baseline) before and after the application of vehicle control (Veh) or Ca 2+ channel inhibitors at the peak ( A ) and trough ( B ). Data are mean ± SEM. ( C and D ) Plots of median, 25th and 75th percentile ( boxes ), and minimal and maximal ( whiskers ) changes in Ca 2+ concentration for individual slices quantified from 9 to 10 min after drugs were applied at the peak ( C ) and trough ( D ). Inhibition of L-type Ca 2+ channels with nimodipine (Nim, 10 μ M) or inhibition of N/P/Q/R/T-type Ca 2+ channels with VGC (a mixture of 3 μ M ConoGVIA, 200 nM AgaIVA, 30 μ M nickel, and 1 μ M TTA-P2) did not significantly affect peak or trough Ca 2+ levels compared to Veh. Inhibition of ryanodine receptors with dantrolene (Dan, 10 μ M), inhibition of SERCA-ATPase with cyclopiazonic acid (CPA, 10 μ M) and combined inhibition of voltage-gated Ca 2+ channels and ryanodine receptors with a cocktail containing Dan, Nim, and VGC (cocktail X) significantly decreased Ca 2+ at peak and trough. * p

    Article Snippet: Pharmacological reagents were used at final concentrations of 10 μ M nimodipine (Nim; N150; Alomone Labs, Jerusalem, Israel), 10 μ M dantrolene (Dan; D9175; Sigma-Aldrich), 30 μ M CPA (C-750; Alomone Labs), 3 μ M ω -conotoxin GVIA (ConoGVIA; C-300; Alomone Labs), 200 nM ω -agatoxin IVA (AgaIVA; STA-500; Alomone Labs), 30 μ M NiCl2 (Ni2+ ; 22387; Sigma-Aldrich), 10 μ M ionomycin (407951; Sigma-Aldrich), 10 μ M rotenone (R8875; Sigma-Aldrich), and 50 mM KCl (P9333; Sigma-Aldrich).

    Techniques: Concentration Assay, Inhibition