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Image Search Results
Journal: Acta Physiologica (Oxford, England)
Article Title: Genetic ablation of carbonic anhydrase IX disrupts gastric barrier function via claudin‐18 downregulation and acid backflux
doi: 10.1111/apha.12923
Figure Lengend Snippet: Acid secretory capacity declines in parallel with the decline in parietal cell number. Time course of acid secretory rates in isolated gastric mucosae of (a) 8‐day‐, (b) 1‐month‐ and (c) 6‐month‐old Car9 −/− and WT mice. (d) Basal and (e) maximal acid secretory rates after stimulation with forskolin ( FSK ) and IBMX were significantly lower in Car9 −/− mice than in WT up from 3 months of age. The decline in acid secretory capacity in the mucosa of Car9 −/− mice is paralleled by the decline in parietal cell numbers (see Fig. ). n = 6–7, * P < 0.05.
Article Snippet: Maximal acid secretory capacity was investigated by serosal application of 10 μ m forskolin (FSK) and 100 μ m
Techniques: Isolation