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Lsmean Procedure, supplied by SAS institute, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Lsmean Option, supplied by SAS institute, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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lsmean ± 95% ci  (GraphPad Software Inc)
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Trazodone reduces total tau but not phosphorylated tau levels in the cortices of rTg4510 mice. A , Total tau (tau5) and p-tau (AT100) immunoblots of cortical rTg4510 samples collected after 9 weeks of treatment. B , Total tau protein levels in cortical extracts after 9 weeks of treatment (WT vs vehicle: U = 0, p = 0.0040; vehicle vs trazodone: U = 2, p = 0.0027). C , Phospho-tau protein levels in cortical extracts after 9 weeks of treatment (WT vs vehicle: U = 0, p = 0.0040; vehicle vs trazodone: U = 17, p = 0.4136). n (WT) = 4, n (vehicle) = 8–9, or n (trazodone) = 6; three to eight technical replicates per sample. Immunoblot data were analyzed using the Mann–Whitney test (two tailed). Values shown in graphs are the band intensity of each protein divided by the intensity of GAPDH, with the results expressed as the respective median relative protein expression level ± minimum/maximum. D , Representative cortical sections of trazodone- or vehicle-treated rTg4510 mice immunostained with AT8 antibody (p-tau). Scale bar, 50 µm. E , AT8 p-tau burden in the cortex of trazodone-treated rTg4510 mice after 9 and 16 weeks of treatment. n (vehicle) = 8–9, n (trazodone) = 6–10. Data are represented as <t>LSMean</t> ± 95% CI. Data analyzed using a general linear mixed model with repeated measures (SAS version 9.4). F–J , Positive Spearman's correlation between p-p38 protein levels and total tau ( F ), pro-caspase-1 ( G ), cleaved caspase-1 ( H ), and ATF4 ( I ), as well as between ATF4 and cleaved caspase-1 ( J ) in the cortex of trazodone-treated rTg4510 mice. Correlations performed by comparing the effect after 9 weeks ( n = 6, filled circles) and after 16 weeks of treatment ( n = 7, inverted triangles). Simple linear regression was computed <t>using</t> <t>GraphPad</t> Prism (version 9.2.0). n.s. p > 0.05, * p < 0.05, # p < 0.01, $ p < 0.001.
Lsmean ± 95% Ci, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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lsmean, sas version 6.12  (SAS institute)
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SAS institute lsmean, sas version 6.12
Trazodone reduces total tau but not phosphorylated tau levels in the cortices of rTg4510 mice. A , Total tau (tau5) and p-tau (AT100) immunoblots of cortical rTg4510 samples collected after 9 weeks of treatment. B , Total tau protein levels in cortical extracts after 9 weeks of treatment (WT vs vehicle: U = 0, p = 0.0040; vehicle vs trazodone: U = 2, p = 0.0027). C , Phospho-tau protein levels in cortical extracts after 9 weeks of treatment (WT vs vehicle: U = 0, p = 0.0040; vehicle vs trazodone: U = 17, p = 0.4136). n (WT) = 4, n (vehicle) = 8–9, or n (trazodone) = 6; three to eight technical replicates per sample. Immunoblot data were analyzed using the Mann–Whitney test (two tailed). Values shown in graphs are the band intensity of each protein divided by the intensity of GAPDH, with the results expressed as the respective median relative protein expression level ± minimum/maximum. D , Representative cortical sections of trazodone- or vehicle-treated rTg4510 mice immunostained with AT8 antibody (p-tau). Scale bar, 50 µm. E , AT8 p-tau burden in the cortex of trazodone-treated rTg4510 mice after 9 and 16 weeks of treatment. n (vehicle) = 8–9, n (trazodone) = 6–10. Data are represented as <t>LSMean</t> ± 95% CI. Data analyzed using a general linear mixed model with repeated measures (SAS version 9.4). F–J , Positive Spearman's correlation between p-p38 protein levels and total tau ( F ), pro-caspase-1 ( G ), cleaved caspase-1 ( H ), and ATF4 ( I ), as well as between ATF4 and cleaved caspase-1 ( J ) in the cortex of trazodone-treated rTg4510 mice. Correlations performed by comparing the effect after 9 weeks ( n = 6, filled circles) and after 16 weeks of treatment ( n = 7, inverted triangles). Simple linear regression was computed <t>using</t> <t>GraphPad</t> Prism (version 9.2.0). n.s. p > 0.05, * p < 0.05, # p < 0.01, $ p < 0.001.
Lsmean, Sas Version 6.12, supplied by SAS institute, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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lsmean option in sas proc glm  (SAS institute)
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SAS institute lsmean option in sas proc glm
Trazodone reduces total tau but not phosphorylated tau levels in the cortices of rTg4510 mice. A , Total tau (tau5) and p-tau (AT100) immunoblots of cortical rTg4510 samples collected after 9 weeks of treatment. B , Total tau protein levels in cortical extracts after 9 weeks of treatment (WT vs vehicle: U = 0, p = 0.0040; vehicle vs trazodone: U = 2, p = 0.0027). C , Phospho-tau protein levels in cortical extracts after 9 weeks of treatment (WT vs vehicle: U = 0, p = 0.0040; vehicle vs trazodone: U = 17, p = 0.4136). n (WT) = 4, n (vehicle) = 8–9, or n (trazodone) = 6; three to eight technical replicates per sample. Immunoblot data were analyzed using the Mann–Whitney test (two tailed). Values shown in graphs are the band intensity of each protein divided by the intensity of GAPDH, with the results expressed as the respective median relative protein expression level ± minimum/maximum. D , Representative cortical sections of trazodone- or vehicle-treated rTg4510 mice immunostained with AT8 antibody (p-tau). Scale bar, 50 µm. E , AT8 p-tau burden in the cortex of trazodone-treated rTg4510 mice after 9 and 16 weeks of treatment. n (vehicle) = 8–9, n (trazodone) = 6–10. Data are represented as <t>LSMean</t> ± 95% CI. Data analyzed using a general linear mixed model with repeated measures (SAS version 9.4). F–J , Positive Spearman's correlation between p-p38 protein levels and total tau ( F ), pro-caspase-1 ( G ), cleaved caspase-1 ( H ), and ATF4 ( I ), as well as between ATF4 and cleaved caspase-1 ( J ) in the cortex of trazodone-treated rTg4510 mice. Correlations performed by comparing the effect after 9 weeks ( n = 6, filled circles) and after 16 weeks of treatment ( n = 7, inverted triangles). Simple linear regression was computed <t>using</t> <t>GraphPad</t> Prism (version 9.2.0). n.s. p > 0.05, * p < 0.05, # p < 0.01, $ p < 0.001.
Lsmean Option In Sas Proc Glm, supplied by SAS institute, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Trazodone reduces total tau but not phosphorylated tau levels in the cortices of rTg4510 mice. A , Total tau (tau5) and p-tau (AT100) immunoblots of cortical rTg4510 samples collected after 9 weeks of treatment. B , Total tau protein levels in cortical extracts after 9 weeks of treatment (WT vs vehicle: U = 0, p = 0.0040; vehicle vs trazodone: U = 2, p = 0.0027). C , Phospho-tau protein levels in cortical extracts after 9 weeks of treatment (WT vs vehicle: U = 0, p = 0.0040; vehicle vs trazodone: U = 17, p = 0.4136). n (WT) = 4, n (vehicle) = 8–9, or n (trazodone) = 6; three to eight technical replicates per sample. Immunoblot data were analyzed using the Mann–Whitney test (two tailed). Values shown in graphs are the band intensity of each protein divided by the intensity of GAPDH, with the results expressed as the respective median relative protein expression level ± minimum/maximum. D , Representative cortical sections of trazodone- or vehicle-treated rTg4510 mice immunostained with AT8 antibody (p-tau). Scale bar, 50 µm. E , AT8 p-tau burden in the cortex of trazodone-treated rTg4510 mice after 9 and 16 weeks of treatment. n (vehicle) = 8–9, n (trazodone) = 6–10. Data are represented as LSMean ± 95% CI. Data analyzed using a general linear mixed model with repeated measures (SAS version 9.4). F–J , Positive Spearman's correlation between p-p38 protein levels and total tau ( F ), pro-caspase-1 ( G ), cleaved caspase-1 ( H ), and ATF4 ( I ), as well as between ATF4 and cleaved caspase-1 ( J ) in the cortex of trazodone-treated rTg4510 mice. Correlations performed by comparing the effect after 9 weeks ( n = 6, filled circles) and after 16 weeks of treatment ( n = 7, inverted triangles). Simple linear regression was computed using GraphPad Prism (version 9.2.0). n.s. p > 0.05, * p < 0.05, # p < 0.01, $ p < 0.001.

Journal: The Journal of Neuroscience

Article Title: Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice

doi: 10.1523/JNEUROSCI.2162-21.2022

Figure Lengend Snippet: Trazodone reduces total tau but not phosphorylated tau levels in the cortices of rTg4510 mice. A , Total tau (tau5) and p-tau (AT100) immunoblots of cortical rTg4510 samples collected after 9 weeks of treatment. B , Total tau protein levels in cortical extracts after 9 weeks of treatment (WT vs vehicle: U = 0, p = 0.0040; vehicle vs trazodone: U = 2, p = 0.0027). C , Phospho-tau protein levels in cortical extracts after 9 weeks of treatment (WT vs vehicle: U = 0, p = 0.0040; vehicle vs trazodone: U = 17, p = 0.4136). n (WT) = 4, n (vehicle) = 8–9, or n (trazodone) = 6; three to eight technical replicates per sample. Immunoblot data were analyzed using the Mann–Whitney test (two tailed). Values shown in graphs are the band intensity of each protein divided by the intensity of GAPDH, with the results expressed as the respective median relative protein expression level ± minimum/maximum. D , Representative cortical sections of trazodone- or vehicle-treated rTg4510 mice immunostained with AT8 antibody (p-tau). Scale bar, 50 µm. E , AT8 p-tau burden in the cortex of trazodone-treated rTg4510 mice after 9 and 16 weeks of treatment. n (vehicle) = 8–9, n (trazodone) = 6–10. Data are represented as LSMean ± 95% CI. Data analyzed using a general linear mixed model with repeated measures (SAS version 9.4). F–J , Positive Spearman's correlation between p-p38 protein levels and total tau ( F ), pro-caspase-1 ( G ), cleaved caspase-1 ( H ), and ATF4 ( I ), as well as between ATF4 and cleaved caspase-1 ( J ) in the cortex of trazodone-treated rTg4510 mice. Correlations performed by comparing the effect after 9 weeks ( n = 6, filled circles) and after 16 weeks of treatment ( n = 7, inverted triangles). Simple linear regression was computed using GraphPad Prism (version 9.2.0). n.s. p > 0.05, * p < 0.05, # p < 0.01, $ p < 0.001.

Article Snippet: Data were reported using LSMean ± 95% CI in GraphPad Prism (version 9.2.0) or SigmaPlot version 14.0 (Systat Software).

Techniques: Western Blot, MANN-WHITNEY, Two Tailed Test, Expressing

Olfactory memory was transiently improved in trazodone-treated rTg4510 mice. A , Odor discrimination test protocol. Familiar odor discrimination calculated between first familiar odor presentation and last novel odor trial. B , C , Difference of time ( B ) and frequency ( C ) spent investigating the familiar odor versus the novel cue after 4 and 16 weeks of trazodone treatment ( post hoc analyses: time: 4 weeks, p = 0.0073; 16 weeks, p = 0.2220; frequency: 4 weeks, p = 0.0224; 16 weeks, p = 0.3806). D , T-maze rewarded alternation task protocol. E , F , Averaged number of trials completed ( E ) and percentage of correct choices ( F ) in the T-maze after 4 and 16 weeks of trazodone treatment. n (vehicle) = 4–7 or n (trazodone) = 11–15 from baseline to 16 weeks. Data are represented as LSMean ± 95% CI. Data are analyzed using a general linear mixed model with repeated measures and baseline as the covariate (SAS version 9.4). Post hoc comparisons for significant treatment × week interactions represented as * p < 0.05, # p < 0.01, $ p < 0.001. G , Negative Kendall's tau correlation between relative EEG theta power in REMS during the 12 h light period and familiar odor discrimination duration. H , Positive Kendall's tau correlation between REMS duration in the 12 h light phase and familiar odor discrimination count. I , J , No significant correlation was found between the relative EEG delta power in NREMS during the 12 h light period and familiar odor discrimination duration ( I ) or count (Kendall's tau correlation; J ). Correlations performed comparing effects at baseline (filled circles) and at the end of the treatment (inverted triangles; baseline: n = 7; end: n = 4). Simple linear regression computed using GraphPad Prism (version 9.2.0). * p < 0.05, # p < 0.01, $ p < 0.001.

Journal: The Journal of Neuroscience

Article Title: Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice

doi: 10.1523/JNEUROSCI.2162-21.2022

Figure Lengend Snippet: Olfactory memory was transiently improved in trazodone-treated rTg4510 mice. A , Odor discrimination test protocol. Familiar odor discrimination calculated between first familiar odor presentation and last novel odor trial. B , C , Difference of time ( B ) and frequency ( C ) spent investigating the familiar odor versus the novel cue after 4 and 16 weeks of trazodone treatment ( post hoc analyses: time: 4 weeks, p = 0.0073; 16 weeks, p = 0.2220; frequency: 4 weeks, p = 0.0224; 16 weeks, p = 0.3806). D , T-maze rewarded alternation task protocol. E , F , Averaged number of trials completed ( E ) and percentage of correct choices ( F ) in the T-maze after 4 and 16 weeks of trazodone treatment. n (vehicle) = 4–7 or n (trazodone) = 11–15 from baseline to 16 weeks. Data are represented as LSMean ± 95% CI. Data are analyzed using a general linear mixed model with repeated measures and baseline as the covariate (SAS version 9.4). Post hoc comparisons for significant treatment × week interactions represented as * p < 0.05, # p < 0.01, $ p < 0.001. G , Negative Kendall's tau correlation between relative EEG theta power in REMS during the 12 h light period and familiar odor discrimination duration. H , Positive Kendall's tau correlation between REMS duration in the 12 h light phase and familiar odor discrimination count. I , J , No significant correlation was found between the relative EEG delta power in NREMS during the 12 h light period and familiar odor discrimination duration ( I ) or count (Kendall's tau correlation; J ). Correlations performed comparing effects at baseline (filled circles) and at the end of the treatment (inverted triangles; baseline: n = 7; end: n = 4). Simple linear regression computed using GraphPad Prism (version 9.2.0). * p < 0.05, # p < 0.01, $ p < 0.001.

Article Snippet: Data were reported using LSMean ± 95% CI in GraphPad Prism (version 9.2.0) or SigmaPlot version 14.0 (Systat Software).

Techniques: