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Image Search Results
Journal: medRxiv
Article Title: Fine-tuning and pre-training improve the predictive accuracy of large language models for rheumatoid arthritis disease activity
doi: 10.1101/2024.10.14.24315448
Figure Lengend Snippet: The IORRA cohort (n = 15,004) was used for this study, with patients who had a follow-up period of less than two years excluded (n = 3,139). The remaining data were divided into three sets: a training set (n = 9,500), a validation set (n = 102), and a test set (n = 2,263). Llama2 and Meditron served as the large language models (LLMs) for predicting disease activity and physical function. Meditron, pre-trained on medical literature, were fine-tuned using the data of training set. A linear regression was used for comparison. Predictive indicators were DAS28-ESR, DAS28-CRP, and CDAI (high disease activity or remission), and J-HAQ score (high score or remission) after two years.
Article Snippet: For this study, we utilized two LLMs:
Techniques: Biomarker Discovery, Activity Assay, Comparison
Journal: medRxiv
Article Title: Fine-tuning and pre-training improve the predictive accuracy of large language models for rheumatoid arthritis disease activity
doi: 10.1101/2024.10.14.24315448
Figure Lengend Snippet: Receiver operating characteristic (ROC) curves displaying the classification performance of five models in predicting high disease activity and remission across three disease activity indices and high score and remission in J-HAQ in patients with rheumatoid arthritis: DAS28-ESR (A), DAS28-CRP (B), CDAI (C), and J-HAQ (D). The models evaluated include a linear regression model, Llama2 without fine-tuning, Llama2 with fine-tuning, Meditron without fine-tuning, and Meditron with fine-tuning. For DAS28-ESR (A), the ROC curves on the left show the models’ performance in predicting high disease activity (DAS28-ESR >5.1), while the curves on the right assess the models’ performance in predicting remission (DAS28-ESR <2.6). A similar layout is followed for DAS28-CRP (>4.1 for high disease activity and <2.3 for remission) (B), and CDAI (>22 for high disease activity and ≤2.8 for remission) (C). For J-HAQ (D), the left and right panel show the models’ performance in predicting J-HAQ score >2.5 and J-HAQ <0.5, respectively.
Article Snippet: For this study, we utilized two LLMs:
Techniques: Activity Assay