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Informa UK Limited
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Hamamatsu
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Randstad Inc
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FreeLife LLC
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Pfleger GmbH
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GeneGo Inc
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SAS institute
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TomoTherapy
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Meso Scale Diagnostics LLC
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Meso Scale Diagnostics LLC
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AMODIA Bioservice GmbH
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Nebeker Ranch
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Image Search Results
Journal: Frontiers in Neuroinformatics
Article Title: Revealing the Synaptic Hodology of Mammalian Neural Circuits With Multiscale Neurocartography
doi: 10.3389/fninf.2019.00052
Figure Lengend Snippet: Spatial scales for mammalian neurocartography. (A) The ultimate goal of neurocartography is to create maps of connectivity across the entire brain. Given the immense volume and complexity of the human brain, most neurocartographic efforts have focused on surpassing technical hurdles and obtaining first principles from the mouse brain. We consider maps of long-range neuronal projection systems across the entire brain to be mesoscale neurocartography. (B) We consider maps of connectivity that span entire neural circuits to individual dendrites containing many synapses to be microscale neurocartography. (C) We consider maps that examine the localization of individual proteins or other molecules within synapses or measure the subsynaptic ultrastructural features to be nanoscale neurocartography. Panels are modified with permissions from , and unpublished work.
Article Snippet:
Techniques: Modification
Journal: Frontiers in Neuroinformatics
Article Title: Revealing the Synaptic Hodology of Mammalian Neural Circuits With Multiscale Neurocartography
doi: 10.3389/fninf.2019.00052
Figure Lengend Snippet: A two-photon serial tomography approach for mesoscale neurocartography. (A1–A4) The integration of a two-photon microscope with a vibratome (A1) permits serial imaging of fluorescent signals throughout the entire brain (A2) at resolution high enough to resolve dendrites (A3) and axons (A4) . Scale bars represent 25 μm in (A3,A4) and 5 μm (inset in A3 ). (B) A mesoscale projectome of distinct cortical regions (left) that make topographically organized projections to caudoputamen (center) and to regions of the thalamus (right). (C) Sparse labeling strategies permit the reconstruction of dendrites (left) and entire axonal projections (right) of individual neurons across the whole brain. Panel (A) modified with permissions from ; panel (B) modified with permissions from and panel (C) created courtesy of MouseLight project at Janelia Research Campus: ( http://ml-neuronbrowser.janelia.org/ ).
Article Snippet:
Techniques: Tomography, Microscopy, Imaging, Labeling, Modification