lc-ms Search Results


  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 96
    Thermo Fisher orbitrap liquid chromatography mass spectrometry lc ms
    Orbitrap Liquid Chromatography Mass Spectrometry Lc Ms, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 96/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/orbitrap liquid chromatography mass spectrometry lc ms/product/Thermo Fisher
    Average 96 stars, based on 5 article reviews
    Price from $9.99 to $1999.99
    orbitrap liquid chromatography mass spectrometry lc ms - by Bioz Stars, 2020-08
    96/100 stars
      Buy from Supplier

    98
    Millipore liquid chromatography mass spectrometry lc ms
    BIRB 796 detected in SM vitreous and attenuated activation of p38 MAPK pathway members in SM retinas. ( a ) Relative abundance of BIRB 796 and reference standard ML-297 in vitreous samples measured by <t>liquid</t> <t>chromatography–mass</t> <t>spectrometry</t> <t>(LC-MS).</t> ( b ) Scatter plot showing LC-MS measurements of BIRB 796 concentration (μM) in SM vitreous samples with known concentrations of BIRB 796 added. ( b’ ) shows nM range of BIRB 796 concentrations applied. ( c ) Bar graph showing LC-MS measurement of BIRB 796 in SM vitreous following topical delivery of 3% BIRB 796 (40 μl/day) to cornea for one week, or two intravitreal injections of 0.75% BIRB 796 (40 μl) one week apart. Last topical dose and last intraviteal injection given just prior to vitreous sampling. ( d ) Scatter plot showing LC-MS measurements of BIRB 796 concentration (μM) in SM vitreous samples following topical delivery of 3% BIRB 796 (40 μl/day) to cornea for 9 weeks. Vitreous sampled every 3 weeks. ( e ) Confocal images from vehicle- and BIRB 796-treated SM retina showing immunolabeling for phosphorylated p38 MAPK (pp38; red). CTB uptake (green) by RGCs is shown. Dotted lines indicate region where label was quantified. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. Scale bars: 30 μm. ( f ) Confocal images from vehicle- and BIRB 796-treated SM retina showing immunolabeling for phosphorylated MK2 (pMK2; red). CTB uptake (green) by RGCs is shown. Dotted lines indicate region where label was quantified. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. ( g ) Confocal images from vehicle- and BIRB 796-treated SM retina showing immunolabeling for phosphorylated heat shock protein 27 (pHSP27; red). CTB uptake (green) by RGCs is shown. Dotted lines indicate region where label was quantified. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. ( h ) Scatter plot showing percent area of vehicle- and BIRB 796-treated SM retinas immunolabeled for phosphorylated p38 MAPK (pp38). Thin black lines indicate mean ± SEM. ( i ) Scatter plot showing percent area of vehicle- and BIRB 796-treated SM retinas immunolabeled for phosphorylated MK2 (pMK2). Thin black lines indicate mean ± SEM. *p = 0.04. ( j ) Scatter plot showing percent area of vehicle- and BIRB 796-treated SM retinas immunolabeled for phosphorylated heat shock protein 27 (pHSP27). Thin black lines indicate mean ± SEM. *p = 0.03. Data expressed as mean ± SEM. Statistical comparisons made using two-sided t-tests. n = 6 SM eyes for naïve, 1 SM eye for topical and 1 SM eye for intravitreal ( c ); n = 2 SM eyes ( d ); n = 4 eyes for vehicle-treated and 4 eyes for BIRB 796-treated groups ( e–j ).
    Liquid Chromatography Mass Spectrometry Lc Ms, supplied by Millipore, used in various techniques. Bioz Stars score: 98/100, based on 17 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/liquid chromatography mass spectrometry lc ms/product/Millipore
    Average 98 stars, based on 17 article reviews
    Price from $9.99 to $1999.99
    liquid chromatography mass spectrometry lc ms - by Bioz Stars, 2020-08
    98/100 stars
      Buy from Supplier

    88
    Fisher Scientific liquid chromatography mass spectrometry lc ms grade
    BIRB 796 detected in SM vitreous and attenuated activation of p38 MAPK pathway members in SM retinas. ( a ) Relative abundance of BIRB 796 and reference standard ML-297 in vitreous samples measured by <t>liquid</t> <t>chromatography–mass</t> <t>spectrometry</t> <t>(LC-MS).</t> ( b ) Scatter plot showing LC-MS measurements of BIRB 796 concentration (μM) in SM vitreous samples with known concentrations of BIRB 796 added. ( b’ ) shows nM range of BIRB 796 concentrations applied. ( c ) Bar graph showing LC-MS measurement of BIRB 796 in SM vitreous following topical delivery of 3% BIRB 796 (40 μl/day) to cornea for one week, or two intravitreal injections of 0.75% BIRB 796 (40 μl) one week apart. Last topical dose and last intraviteal injection given just prior to vitreous sampling. ( d ) Scatter plot showing LC-MS measurements of BIRB 796 concentration (μM) in SM vitreous samples following topical delivery of 3% BIRB 796 (40 μl/day) to cornea for 9 weeks. Vitreous sampled every 3 weeks. ( e ) Confocal images from vehicle- and BIRB 796-treated SM retina showing immunolabeling for phosphorylated p38 MAPK (pp38; red). CTB uptake (green) by RGCs is shown. Dotted lines indicate region where label was quantified. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. Scale bars: 30 μm. ( f ) Confocal images from vehicle- and BIRB 796-treated SM retina showing immunolabeling for phosphorylated MK2 (pMK2; red). CTB uptake (green) by RGCs is shown. Dotted lines indicate region where label was quantified. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. ( g ) Confocal images from vehicle- and BIRB 796-treated SM retina showing immunolabeling for phosphorylated heat shock protein 27 (pHSP27; red). CTB uptake (green) by RGCs is shown. Dotted lines indicate region where label was quantified. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. ( h ) Scatter plot showing percent area of vehicle- and BIRB 796-treated SM retinas immunolabeled for phosphorylated p38 MAPK (pp38). Thin black lines indicate mean ± SEM. ( i ) Scatter plot showing percent area of vehicle- and BIRB 796-treated SM retinas immunolabeled for phosphorylated MK2 (pMK2). Thin black lines indicate mean ± SEM. *p = 0.04. ( j ) Scatter plot showing percent area of vehicle- and BIRB 796-treated SM retinas immunolabeled for phosphorylated heat shock protein 27 (pHSP27). Thin black lines indicate mean ± SEM. *p = 0.03. Data expressed as mean ± SEM. Statistical comparisons made using two-sided t-tests. n = 6 SM eyes for naïve, 1 SM eye for topical and 1 SM eye for intravitreal ( c ); n = 2 SM eyes ( d ); n = 4 eyes for vehicle-treated and 4 eyes for BIRB 796-treated groups ( e–j ).
    Liquid Chromatography Mass Spectrometry Lc Ms Grade, supplied by Fisher Scientific, used in various techniques. Bioz Stars score: 88/100, based on 16 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/liquid chromatography mass spectrometry lc ms grade/product/Fisher Scientific
    Average 88 stars, based on 16 article reviews
    Price from $9.99 to $1999.99
    liquid chromatography mass spectrometry lc ms grade - by Bioz Stars, 2020-08
    88/100 stars
      Buy from Supplier

    92
    Hitachi Ltd liquid chromatography mass spectrometry lc ms
    BIRB 796 detected in SM vitreous and attenuated activation of p38 MAPK pathway members in SM retinas. ( a ) Relative abundance of BIRB 796 and reference standard ML-297 in vitreous samples measured by <t>liquid</t> <t>chromatography–mass</t> <t>spectrometry</t> <t>(LC-MS).</t> ( b ) Scatter plot showing LC-MS measurements of BIRB 796 concentration (μM) in SM vitreous samples with known concentrations of BIRB 796 added. ( b’ ) shows nM range of BIRB 796 concentrations applied. ( c ) Bar graph showing LC-MS measurement of BIRB 796 in SM vitreous following topical delivery of 3% BIRB 796 (40 μl/day) to cornea for one week, or two intravitreal injections of 0.75% BIRB 796 (40 μl) one week apart. Last topical dose and last intraviteal injection given just prior to vitreous sampling. ( d ) Scatter plot showing LC-MS measurements of BIRB 796 concentration (μM) in SM vitreous samples following topical delivery of 3% BIRB 796 (40 μl/day) to cornea for 9 weeks. Vitreous sampled every 3 weeks. ( e ) Confocal images from vehicle- and BIRB 796-treated SM retina showing immunolabeling for phosphorylated p38 MAPK (pp38; red). CTB uptake (green) by RGCs is shown. Dotted lines indicate region where label was quantified. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. Scale bars: 30 μm. ( f ) Confocal images from vehicle- and BIRB 796-treated SM retina showing immunolabeling for phosphorylated MK2 (pMK2; red). CTB uptake (green) by RGCs is shown. Dotted lines indicate region where label was quantified. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. ( g ) Confocal images from vehicle- and BIRB 796-treated SM retina showing immunolabeling for phosphorylated heat shock protein 27 (pHSP27; red). CTB uptake (green) by RGCs is shown. Dotted lines indicate region where label was quantified. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. ( h ) Scatter plot showing percent area of vehicle- and BIRB 796-treated SM retinas immunolabeled for phosphorylated p38 MAPK (pp38). Thin black lines indicate mean ± SEM. ( i ) Scatter plot showing percent area of vehicle- and BIRB 796-treated SM retinas immunolabeled for phosphorylated MK2 (pMK2). Thin black lines indicate mean ± SEM. *p = 0.04. ( j ) Scatter plot showing percent area of vehicle- and BIRB 796-treated SM retinas immunolabeled for phosphorylated heat shock protein 27 (pHSP27). Thin black lines indicate mean ± SEM. *p = 0.03. Data expressed as mean ± SEM. Statistical comparisons made using two-sided t-tests. n = 6 SM eyes for naïve, 1 SM eye for topical and 1 SM eye for intravitreal ( c ); n = 2 SM eyes ( d ); n = 4 eyes for vehicle-treated and 4 eyes for BIRB 796-treated groups ( e–j ).
    Liquid Chromatography Mass Spectrometry Lc Ms, supplied by Hitachi Ltd, used in various techniques. Bioz Stars score: 92/100, based on 19 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/liquid chromatography mass spectrometry lc ms/product/Hitachi Ltd
    Average 92 stars, based on 19 article reviews
    Price from $9.99 to $1999.99
    liquid chromatography mass spectrometry lc ms - by Bioz Stars, 2020-08
    92/100 stars
      Buy from Supplier

    91
    Agilent technologies liquid chromatography mass spectrometry lc ms analysis
    <t>Liquid</t> <t>chromatography</t> <t>mass-spectrometry-based</t> <t>analysis</t> of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.
    Liquid Chromatography Mass Spectrometry Lc Ms Analysis, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 91/100, based on 205 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/liquid chromatography mass spectrometry lc ms analysis/product/Agilent technologies
    Average 91 stars, based on 205 article reviews
    Price from $9.99 to $1999.99
    liquid chromatography mass spectrometry lc ms analysis - by Bioz Stars, 2020-08
    91/100 stars
      Buy from Supplier

    92
    Gilson Inc liquid chromatography mass spectrometry lc ms
    <t>Liquid</t> <t>chromatography</t> <t>mass-spectrometry-based</t> <t>analysis</t> of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.
    Liquid Chromatography Mass Spectrometry Lc Ms, supplied by Gilson Inc, used in various techniques. Bioz Stars score: 92/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/liquid chromatography mass spectrometry lc ms/product/Gilson Inc
    Average 92 stars, based on 5 article reviews
    Price from $9.99 to $1999.99
    liquid chromatography mass spectrometry lc ms - by Bioz Stars, 2020-08
    92/100 stars
      Buy from Supplier

    92
    Waters Corporation liquid chromatography mass spectrometry lc ms
    <t>Liquid</t> <t>chromatography</t> <t>mass-spectrometry-based</t> <t>analysis</t> of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.
    Liquid Chromatography Mass Spectrometry Lc Ms, supplied by Waters Corporation, used in various techniques. Bioz Stars score: 92/100, based on 192 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/liquid chromatography mass spectrometry lc ms/product/Waters Corporation
    Average 92 stars, based on 192 article reviews
    Price from $9.99 to $1999.99
    liquid chromatography mass spectrometry lc ms - by Bioz Stars, 2020-08
    92/100 stars
      Buy from Supplier

    85
    Fisher Scientific liquid chromatography mass spectrometry lc ms grade solvents
    <t>Liquid</t> <t>chromatography</t> <t>mass-spectrometry-based</t> <t>analysis</t> of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.
    Liquid Chromatography Mass Spectrometry Lc Ms Grade Solvents, supplied by Fisher Scientific, used in various techniques. Bioz Stars score: 85/100, based on 27 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/liquid chromatography mass spectrometry lc ms grade solvents/product/Fisher Scientific
    Average 85 stars, based on 27 article reviews
    Price from $9.99 to $1999.99
    liquid chromatography mass spectrometry lc ms grade solvents - by Bioz Stars, 2020-08
    85/100 stars
      Buy from Supplier

    93
    Agilent technologies g6125bw liquid chromatography mass spectrometry lc ms instrument
    <t>Liquid</t> <t>chromatography</t> <t>mass-spectrometry-based</t> <t>analysis</t> of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.
    G6125bw Liquid Chromatography Mass Spectrometry Lc Ms Instrument, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 93/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/g6125bw liquid chromatography mass spectrometry lc ms instrument/product/Agilent technologies
    Average 93 stars, based on 5 article reviews
    Price from $9.99 to $1999.99
    g6125bw liquid chromatography mass spectrometry lc ms instrument - by Bioz Stars, 2020-08
    93/100 stars
      Buy from Supplier

    93
    Merck & Co liquid chromatography mass spectrometry lc ms grade solvents
    <t>Liquid</t> <t>chromatography</t> <t>mass-spectrometry-based</t> <t>analysis</t> of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.
    Liquid Chromatography Mass Spectrometry Lc Ms Grade Solvents, supplied by Merck & Co, used in various techniques. Bioz Stars score: 93/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/liquid chromatography mass spectrometry lc ms grade solvents/product/Merck & Co
    Average 93 stars, based on 5 article reviews
    Price from $9.99 to $1999.99
    liquid chromatography mass spectrometry lc ms grade solvents - by Bioz Stars, 2020-08
    93/100 stars
      Buy from Supplier

    92
    SCIEX liquid chromatography mass spectrometry lc ms
    <t>Liquid</t> <t>chromatography</t> <t>mass-spectrometry-based</t> <t>analysis</t> of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.
    Liquid Chromatography Mass Spectrometry Lc Ms, supplied by SCIEX, used in various techniques. Bioz Stars score: 92/100, based on 78 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/liquid chromatography mass spectrometry lc ms/product/SCIEX
    Average 92 stars, based on 78 article reviews
    Price from $9.99 to $1999.99
    liquid chromatography mass spectrometry lc ms - by Bioz Stars, 2020-08
    92/100 stars
      Buy from Supplier

    92
    Agilent technologies 6130 single quadrupole liquid chromatography mass spectrometry lc ms
    <t>Liquid</t> <t>chromatography</t> <t>mass-spectrometry-based</t> <t>analysis</t> of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.
    6130 Single Quadrupole Liquid Chromatography Mass Spectrometry Lc Ms, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 92/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/6130 single quadrupole liquid chromatography mass spectrometry lc ms/product/Agilent technologies
    Average 92 stars, based on 12 article reviews
    Price from $9.99 to $1999.99
    6130 single quadrupole liquid chromatography mass spectrometry lc ms - by Bioz Stars, 2020-08
    92/100 stars
      Buy from Supplier

    93
    Fisher Scientific liquid chromatography mass spectrometry lc ms grade optima
    <t>Liquid</t> <t>chromatography</t> <t>mass-spectrometry-based</t> <t>analysis</t> of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.
    Liquid Chromatography Mass Spectrometry Lc Ms Grade Optima, supplied by Fisher Scientific, used in various techniques. Bioz Stars score: 93/100, based on 22 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/liquid chromatography mass spectrometry lc ms grade optima/product/Fisher Scientific
    Average 93 stars, based on 22 article reviews
    Price from $9.99 to $1999.99
    liquid chromatography mass spectrometry lc ms grade optima - by Bioz Stars, 2020-08
    93/100 stars
      Buy from Supplier

    89
    Agilent technologies 1100 liquid chromatography mass spectrometry lc ms
    <t>Liquid</t> <t>chromatography</t> <t>mass-spectrometry-based</t> <t>analysis</t> of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.
    1100 Liquid Chromatography Mass Spectrometry Lc Ms, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 89/100, based on 86 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/1100 liquid chromatography mass spectrometry lc ms/product/Agilent technologies
    Average 89 stars, based on 86 article reviews
    Price from $9.99 to $1999.99
    1100 liquid chromatography mass spectrometry lc ms - by Bioz Stars, 2020-08
    89/100 stars
      Buy from Supplier

    91
    Bruker Corporation liquid chromatography mass spectrometry lc ms analysis
    <t>Liquid</t> <t>chromatography</t> <t>mass-spectrometry-based</t> <t>analysis</t> of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.
    Liquid Chromatography Mass Spectrometry Lc Ms Analysis, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 91/100, based on 71 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/liquid chromatography mass spectrometry lc ms analysis/product/Bruker Corporation
    Average 91 stars, based on 71 article reviews
    Price from $9.99 to $1999.99
    liquid chromatography mass spectrometry lc ms analysis - by Bioz Stars, 2020-08
    91/100 stars
      Buy from Supplier

    85
    Agilent technologies 6460 triplequad liquid chromatography mass spectrometry lc ms system
    <t>Liquid</t> <t>chromatography</t> <t>mass-spectrometry-based</t> <t>analysis</t> of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.
    6460 Triplequad Liquid Chromatography Mass Spectrometry Lc Ms System, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 85/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/6460 triplequad liquid chromatography mass spectrometry lc ms system/product/Agilent technologies
    Average 85 stars, based on 5 article reviews
    Price from $9.99 to $1999.99
    6460 triplequad liquid chromatography mass spectrometry lc ms system - by Bioz Stars, 2020-08
    85/100 stars
      Buy from Supplier

    92
    Shimadzu Corporation liquid chromatography mass spectrometry lc ms
    <t>Liquid</t> <t>chromatography</t> <t>mass-spectrometry-based</t> <t>analysis</t> of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.
    Liquid Chromatography Mass Spectrometry Lc Ms, supplied by Shimadzu Corporation, used in various techniques. Bioz Stars score: 92/100, based on 125 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/liquid chromatography mass spectrometry lc ms/product/Shimadzu Corporation
    Average 92 stars, based on 125 article reviews
    Price from $9.99 to $1999.99
    liquid chromatography mass spectrometry lc ms - by Bioz Stars, 2020-08
    92/100 stars
      Buy from Supplier

    Image Search Results


    BIRB 796 detected in SM vitreous and attenuated activation of p38 MAPK pathway members in SM retinas. ( a ) Relative abundance of BIRB 796 and reference standard ML-297 in vitreous samples measured by liquid chromatography–mass spectrometry (LC-MS). ( b ) Scatter plot showing LC-MS measurements of BIRB 796 concentration (μM) in SM vitreous samples with known concentrations of BIRB 796 added. ( b’ ) shows nM range of BIRB 796 concentrations applied. ( c ) Bar graph showing LC-MS measurement of BIRB 796 in SM vitreous following topical delivery of 3% BIRB 796 (40 μl/day) to cornea for one week, or two intravitreal injections of 0.75% BIRB 796 (40 μl) one week apart. Last topical dose and last intraviteal injection given just prior to vitreous sampling. ( d ) Scatter plot showing LC-MS measurements of BIRB 796 concentration (μM) in SM vitreous samples following topical delivery of 3% BIRB 796 (40 μl/day) to cornea for 9 weeks. Vitreous sampled every 3 weeks. ( e ) Confocal images from vehicle- and BIRB 796-treated SM retina showing immunolabeling for phosphorylated p38 MAPK (pp38; red). CTB uptake (green) by RGCs is shown. Dotted lines indicate region where label was quantified. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. Scale bars: 30 μm. ( f ) Confocal images from vehicle- and BIRB 796-treated SM retina showing immunolabeling for phosphorylated MK2 (pMK2; red). CTB uptake (green) by RGCs is shown. Dotted lines indicate region where label was quantified. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. ( g ) Confocal images from vehicle- and BIRB 796-treated SM retina showing immunolabeling for phosphorylated heat shock protein 27 (pHSP27; red). CTB uptake (green) by RGCs is shown. Dotted lines indicate region where label was quantified. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. ( h ) Scatter plot showing percent area of vehicle- and BIRB 796-treated SM retinas immunolabeled for phosphorylated p38 MAPK (pp38). Thin black lines indicate mean ± SEM. ( i ) Scatter plot showing percent area of vehicle- and BIRB 796-treated SM retinas immunolabeled for phosphorylated MK2 (pMK2). Thin black lines indicate mean ± SEM. *p = 0.04. ( j ) Scatter plot showing percent area of vehicle- and BIRB 796-treated SM retinas immunolabeled for phosphorylated heat shock protein 27 (pHSP27). Thin black lines indicate mean ± SEM. *p = 0.03. Data expressed as mean ± SEM. Statistical comparisons made using two-sided t-tests. n = 6 SM eyes for naïve, 1 SM eye for topical and 1 SM eye for intravitreal ( c ); n = 2 SM eyes ( d ); n = 4 eyes for vehicle-treated and 4 eyes for BIRB 796-treated groups ( e–j ).

    Journal: Scientific Reports

    Article Title: Of Mice and Monkeys: Neuroprotective Efficacy of the p38 Inhibitor BIRB 796 Depends on Model Duration in Experimental Glaucoma

    doi: 10.1038/s41598-020-65374-6

    Figure Lengend Snippet: BIRB 796 detected in SM vitreous and attenuated activation of p38 MAPK pathway members in SM retinas. ( a ) Relative abundance of BIRB 796 and reference standard ML-297 in vitreous samples measured by liquid chromatography–mass spectrometry (LC-MS). ( b ) Scatter plot showing LC-MS measurements of BIRB 796 concentration (μM) in SM vitreous samples with known concentrations of BIRB 796 added. ( b’ ) shows nM range of BIRB 796 concentrations applied. ( c ) Bar graph showing LC-MS measurement of BIRB 796 in SM vitreous following topical delivery of 3% BIRB 796 (40 μl/day) to cornea for one week, or two intravitreal injections of 0.75% BIRB 796 (40 μl) one week apart. Last topical dose and last intraviteal injection given just prior to vitreous sampling. ( d ) Scatter plot showing LC-MS measurements of BIRB 796 concentration (μM) in SM vitreous samples following topical delivery of 3% BIRB 796 (40 μl/day) to cornea for 9 weeks. Vitreous sampled every 3 weeks. ( e ) Confocal images from vehicle- and BIRB 796-treated SM retina showing immunolabeling for phosphorylated p38 MAPK (pp38; red). CTB uptake (green) by RGCs is shown. Dotted lines indicate region where label was quantified. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. Scale bars: 30 μm. ( f ) Confocal images from vehicle- and BIRB 796-treated SM retina showing immunolabeling for phosphorylated MK2 (pMK2; red). CTB uptake (green) by RGCs is shown. Dotted lines indicate region where label was quantified. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. ( g ) Confocal images from vehicle- and BIRB 796-treated SM retina showing immunolabeling for phosphorylated heat shock protein 27 (pHSP27; red). CTB uptake (green) by RGCs is shown. Dotted lines indicate region where label was quantified. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. ( h ) Scatter plot showing percent area of vehicle- and BIRB 796-treated SM retinas immunolabeled for phosphorylated p38 MAPK (pp38). Thin black lines indicate mean ± SEM. ( i ) Scatter plot showing percent area of vehicle- and BIRB 796-treated SM retinas immunolabeled for phosphorylated MK2 (pMK2). Thin black lines indicate mean ± SEM. *p = 0.04. ( j ) Scatter plot showing percent area of vehicle- and BIRB 796-treated SM retinas immunolabeled for phosphorylated heat shock protein 27 (pHSP27). Thin black lines indicate mean ± SEM. *p = 0.03. Data expressed as mean ± SEM. Statistical comparisons made using two-sided t-tests. n = 6 SM eyes for naïve, 1 SM eye for topical and 1 SM eye for intravitreal ( c ); n = 2 SM eyes ( d ); n = 4 eyes for vehicle-treated and 4 eyes for BIRB 796-treated groups ( e–j ).

    Article Snippet: We collaborated with the Vanderbilt Mass Spectrometry Research Center with the goal of using liquid chromatography–mass spectrometry (LC-MS) to measure drug content in SM vitreous samples.

    Techniques: Activation Assay, Liquid Chromatography, Mass Spectrometry, Liquid Chromatography with Mass Spectroscopy, Concentration Assay, Injection, Sampling, Immunolabeling, CtB Assay

    Liquid chromatography mass-spectrometry-based analysis of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.

    Journal: International Journal of Nanomedicine

    Article Title: Identification of mycolic acid forms using surface-enhanced Raman scattering as a fast detection method for tuberculosis

    doi: 10.2147/IJN.S171400

    Figure Lengend Snippet: Liquid chromatography mass-spectrometry-based analysis of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.

    Article Snippet: Liquid chromatography mass-spectrometry (LC-MS) analysis of MA LC-MS/MS analysis was conducted on an Agilent 6490 mass spectrometer coupled to an Agilent 1290 Infinity LC.

    Techniques: Liquid Chromatography, Mass Spectrometry

    Modulatory effect of XanMax ® 2002 oil on Lutein and Zeaxanthin levels in serum and macula portion of the retina from rats. Rats were treated with XanMax® 2002 oil for 42 days and lutein and zeaxanthin values in serum (a and b respectively), and macular homogenates (c and d respectively) were determined by liquid chromatography-mass spectrometry and expressed as ppb concentration. Values are expressed as mean ± standard deviation for each group; *** P

    Journal: Pharmacognosy Magazine

    Article Title: Modulatory Effect of Carotenoid Supplement Constituting Lutein and Zeaxanthin (10:1) on Anti-oxidant Enzymes and Macular Pigments Level in Rats

    doi: 10.4103/pm.pm_340_17

    Figure Lengend Snippet: Modulatory effect of XanMax ® 2002 oil on Lutein and Zeaxanthin levels in serum and macula portion of the retina from rats. Rats were treated with XanMax® 2002 oil for 42 days and lutein and zeaxanthin values in serum (a and b respectively), and macular homogenates (c and d respectively) were determined by liquid chromatography-mass spectrometry and expressed as ppb concentration. Values are expressed as mean ± standard deviation for each group; *** P

    Article Snippet: Equipments All the instruments, Weighing Balance (Citizen, Singapore), Microplate Reader (Biotech, USA), UV-Vis spectrophotometer (Systronics, India), Liquid chromatography-mass spectrometry (LC-MS) (Agilent 6130), and other laboratory equipment used for the experiments were calibrated and validated regularly.

    Techniques: Liquid Chromatography, Mass Spectrometry, Concentration Assay, Standard Deviation