lbq657 Search Results


medchemexpress llc  (MedChemExpress)
93
MedChemExpress medchemexpress llc
Medchemexpress Llc, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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lbq657 cayman chemical 19829  (Cayman Chemical)
90
Cayman Chemical lbq657 cayman chemical 19829
Lbq657 Cayman Chemical 19829, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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lbq657  (Toronto Research Chemicals)
90
Toronto Research Chemicals lbq657
Combined Effects of Valsartan With <t>LBQ657</t> in In Vitro Assay Using Peritoneal Macrophages (A) Gelatin zymography on the supernatants of peritoneal macrophages stimulated with LPS (10 ng/ml) for 48 h. (B) Semi-quantitative analysis of gelatinolytic activity showed significantly lower activity in VAL + LBQ compared to the VAL-alone and LBQ-alone groups. n = 6 per group. Quantification of (C) IL-1β, and (D) IL-6 concentrations in the supernatants of peritoneal macrophages stimulated with LPS (10 ng/ml) for 48 h. n = 6 per group. (E to G) Real-time reverse transcriptase PCR result for (E) MMP-9, (F) IL-1β, and (G) IL-6 mRNA level in peritoneal macrophages stimulated with LPS (10 ng/ml) for 48 h. The mRNA level was normalized by the level of endogenous control beta-2-microglobulin RNA. n = 8 per group. Results were mean ± SD. Ctrl = control; LBQ = LBQ657; LPS = lipopolysaccharide; VAL = valsartan; other abbreviations as in <xref ref-type=Figure 4 . " width="250" height="auto" />
Lbq657, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sacubitrilat lbq657  (Biomol GmbH)
90
Biomol GmbH sacubitrilat lbq657
Combined Effects of Valsartan With <t>LBQ657</t> in In Vitro Assay Using Peritoneal Macrophages (A) Gelatin zymography on the supernatants of peritoneal macrophages stimulated with LPS (10 ng/ml) for 48 h. (B) Semi-quantitative analysis of gelatinolytic activity showed significantly lower activity in VAL + LBQ compared to the VAL-alone and LBQ-alone groups. n = 6 per group. Quantification of (C) IL-1β, and (D) IL-6 concentrations in the supernatants of peritoneal macrophages stimulated with LPS (10 ng/ml) for 48 h. n = 6 per group. (E to G) Real-time reverse transcriptase PCR result for (E) MMP-9, (F) IL-1β, and (G) IL-6 mRNA level in peritoneal macrophages stimulated with LPS (10 ng/ml) for 48 h. The mRNA level was normalized by the level of endogenous control beta-2-microglobulin RNA. n = 8 per group. Results were mean ± SD. Ctrl = control; LBQ = LBQ657; LPS = lipopolysaccharide; VAL = valsartan; other abbreviations as in <xref ref-type=Figure 4 . " width="250" height="auto" />
Sacubitrilat Lbq657, supplied by Biomol GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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lbq657  (Novartis)
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Novartis lbq657
A , Soluble collagen content in supernatant from hAoSMCs treated with TGF‐β±BNP or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. B , Soluble collagen content in supernatant from TGF‐β+BNP‐stimulated hAoSMCs cotreated with Val, neprilysin inhibitor <t>LBQ657</t> (LBQ; active metabolite of sacubitril), valsartan+LBQ657 (Val+LBQ), or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. hAoSMCs from corresponding experiments were stained for collagen I (red) ( C ), and mean fluorescence (normalized to cell number) was quantified in 3 high‐power fields of 5 independent experiments. Values are individual data points, presented as mean±SEM ( D ). Nuclei are Hoechst stained (blue), and scale bar indicates 100 μm ( C ). ARNI indicates angiotensin receptor–neprilysin inhibitor; BNP, brain natriuretic peptide; ctrl, control; hAoSMCs, human aortic smooth muscle cells; n.s., not significant; TGF‐β, transforming growth factor‐β; and Val, valsartan.
Lbq657, supplied by Novartis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sacubitril lbq657  (Holzel Diagnostika)
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Holzel Diagnostika sacubitril lbq657
A , Soluble collagen content in supernatant from hAoSMCs treated with TGF‐β±BNP or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. B , Soluble collagen content in supernatant from TGF‐β+BNP‐stimulated hAoSMCs cotreated with Val, neprilysin inhibitor <t>LBQ657</t> (LBQ; active metabolite of sacubitril), valsartan+LBQ657 (Val+LBQ), or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. hAoSMCs from corresponding experiments were stained for collagen I (red) ( C ), and mean fluorescence (normalized to cell number) was quantified in 3 high‐power fields of 5 independent experiments. Values are individual data points, presented as mean±SEM ( D ). Nuclei are Hoechst stained (blue), and scale bar indicates 100 μm ( C ). ARNI indicates angiotensin receptor–neprilysin inhibitor; BNP, brain natriuretic peptide; ctrl, control; hAoSMCs, human aortic smooth muscle cells; n.s., not significant; TGF‐β, transforming growth factor‐β; and Val, valsartan.
Sacubitril Lbq657, supplied by Holzel Diagnostika, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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lbq657  (Aobious Inc)
90
Aobious Inc lbq657
A , Soluble collagen content in supernatant from hAoSMCs treated with TGF‐β±BNP or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. B , Soluble collagen content in supernatant from TGF‐β+BNP‐stimulated hAoSMCs cotreated with Val, neprilysin inhibitor <t>LBQ657</t> (LBQ; active metabolite of sacubitril), valsartan+LBQ657 (Val+LBQ), or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. hAoSMCs from corresponding experiments were stained for collagen I (red) ( C ), and mean fluorescence (normalized to cell number) was quantified in 3 high‐power fields of 5 independent experiments. Values are individual data points, presented as mean±SEM ( D ). Nuclei are Hoechst stained (blue), and scale bar indicates 100 μm ( C ). ARNI indicates angiotensin receptor–neprilysin inhibitor; BNP, brain natriuretic peptide; ctrl, control; hAoSMCs, human aortic smooth muscle cells; n.s., not significant; TGF‐β, transforming growth factor‐β; and Val, valsartan.
Lbq657, supplied by Aobious Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sacubitilat lbq657  (Abblis Inc)
90
Abblis Inc sacubitilat lbq657
A , Soluble collagen content in supernatant from hAoSMCs treated with TGF‐β±BNP or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. B , Soluble collagen content in supernatant from TGF‐β+BNP‐stimulated hAoSMCs cotreated with Val, neprilysin inhibitor <t>LBQ657</t> (LBQ; active metabolite of sacubitril), valsartan+LBQ657 (Val+LBQ), or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. hAoSMCs from corresponding experiments were stained for collagen I (red) ( C ), and mean fluorescence (normalized to cell number) was quantified in 3 high‐power fields of 5 independent experiments. Values are individual data points, presented as mean±SEM ( D ). Nuclei are Hoechst stained (blue), and scale bar indicates 100 μm ( C ). ARNI indicates angiotensin receptor–neprilysin inhibitor; BNP, brain natriuretic peptide; ctrl, control; hAoSMCs, human aortic smooth muscle cells; n.s., not significant; TGF‐β, transforming growth factor‐β; and Val, valsartan.
Sacubitilat Lbq657, supplied by Abblis Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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omapatrilat  (TargetMol)
94
TargetMol omapatrilat
A , Soluble collagen content in supernatant from hAoSMCs treated with TGF‐β±BNP or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. B , Soluble collagen content in supernatant from TGF‐β+BNP‐stimulated hAoSMCs cotreated with Val, neprilysin inhibitor <t>LBQ657</t> (LBQ; active metabolite of sacubitril), valsartan+LBQ657 (Val+LBQ), or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. hAoSMCs from corresponding experiments were stained for collagen I (red) ( C ), and mean fluorescence (normalized to cell number) was quantified in 3 high‐power fields of 5 independent experiments. Values are individual data points, presented as mean±SEM ( D ). Nuclei are Hoechst stained (blue), and scale bar indicates 100 μm ( C ). ARNI indicates angiotensin receptor–neprilysin inhibitor; BNP, brain natriuretic peptide; ctrl, control; hAoSMCs, human aortic smooth muscle cells; n.s., not significant; TGF‐β, transforming growth factor‐β; and Val, valsartan.
Omapatrilat, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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active metabolite lbq657  (Wolters Kluwer Health)
90
Wolters Kluwer Health active metabolite lbq657
A , Soluble collagen content in supernatant from hAoSMCs treated with TGF‐β±BNP or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. B , Soluble collagen content in supernatant from TGF‐β+BNP‐stimulated hAoSMCs cotreated with Val, neprilysin inhibitor <t>LBQ657</t> (LBQ; active metabolite of sacubitril), valsartan+LBQ657 (Val+LBQ), or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. hAoSMCs from corresponding experiments were stained for collagen I (red) ( C ), and mean fluorescence (normalized to cell number) was quantified in 3 high‐power fields of 5 independent experiments. Values are individual data points, presented as mean±SEM ( D ). Nuclei are Hoechst stained (blue), and scale bar indicates 100 μm ( C ). ARNI indicates angiotensin receptor–neprilysin inhibitor; BNP, brain natriuretic peptide; ctrl, control; hAoSMCs, human aortic smooth muscle cells; n.s., not significant; TGF‐β, transforming growth factor‐β; and Val, valsartan.
Active Metabolite Lbq657, supplied by Wolters Kluwer Health, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Combined Effects of Valsartan With LBQ657 in In Vitro Assay Using Peritoneal Macrophages (A) Gelatin zymography on the supernatants of peritoneal macrophages stimulated with LPS (10 ng/ml) for 48 h. (B) Semi-quantitative analysis of gelatinolytic activity showed significantly lower activity in VAL + LBQ compared to the VAL-alone and LBQ-alone groups. n = 6 per group. Quantification of (C) IL-1β, and (D) IL-6 concentrations in the supernatants of peritoneal macrophages stimulated with LPS (10 ng/ml) for 48 h. n = 6 per group. (E to G) Real-time reverse transcriptase PCR result for (E) MMP-9, (F) IL-1β, and (G) IL-6 mRNA level in peritoneal macrophages stimulated with LPS (10 ng/ml) for 48 h. The mRNA level was normalized by the level of endogenous control beta-2-microglobulin RNA. n = 8 per group. Results were mean ± SD. Ctrl = control; LBQ = LBQ657; LPS = lipopolysaccharide; VAL = valsartan; other abbreviations as in <xref ref-type=Figure 4 . " width="100%" height="100%">

Journal: JACC: Basic to Translational Science

Article Title: Cardioprotective Effects of LCZ696 (Sacubitril/Valsartan) After Experimental Acute Myocardial Infarction

doi: 10.1016/j.jacbts.2017.08.001

Figure Lengend Snippet: Combined Effects of Valsartan With LBQ657 in In Vitro Assay Using Peritoneal Macrophages (A) Gelatin zymography on the supernatants of peritoneal macrophages stimulated with LPS (10 ng/ml) for 48 h. (B) Semi-quantitative analysis of gelatinolytic activity showed significantly lower activity in VAL + LBQ compared to the VAL-alone and LBQ-alone groups. n = 6 per group. Quantification of (C) IL-1β, and (D) IL-6 concentrations in the supernatants of peritoneal macrophages stimulated with LPS (10 ng/ml) for 48 h. n = 6 per group. (E to G) Real-time reverse transcriptase PCR result for (E) MMP-9, (F) IL-1β, and (G) IL-6 mRNA level in peritoneal macrophages stimulated with LPS (10 ng/ml) for 48 h. The mRNA level was normalized by the level of endogenous control beta-2-microglobulin RNA. n = 8 per group. Results were mean ± SD. Ctrl = control; LBQ = LBQ657; LPS = lipopolysaccharide; VAL = valsartan; other abbreviations as in Figure 4 .

Article Snippet: Valsartan was purchased from Sigma-Aldrich (St. Louis, Missouri), and LBQ657 (an active form of sacubitril) was purchased from Toronto Research Chemicals (Toronto, Ontario, Canada), which were used in an in vitro assay.

Techniques: In Vitro, Zymography, Activity Assay, Reverse Transcription, Control

A , Soluble collagen content in supernatant from hAoSMCs treated with TGF‐β±BNP or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. B , Soluble collagen content in supernatant from TGF‐β+BNP‐stimulated hAoSMCs cotreated with Val, neprilysin inhibitor LBQ657 (LBQ; active metabolite of sacubitril), valsartan+LBQ657 (Val+LBQ), or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. hAoSMCs from corresponding experiments were stained for collagen I (red) ( C ), and mean fluorescence (normalized to cell number) was quantified in 3 high‐power fields of 5 independent experiments. Values are individual data points, presented as mean±SEM ( D ). Nuclei are Hoechst stained (blue), and scale bar indicates 100 μm ( C ). ARNI indicates angiotensin receptor–neprilysin inhibitor; BNP, brain natriuretic peptide; ctrl, control; hAoSMCs, human aortic smooth muscle cells; n.s., not significant; TGF‐β, transforming growth factor‐β; and Val, valsartan.

Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Article Title: Angiotensin Receptor–Neprilysin Inhibition (Sacubitril/Valsartan) Reduces Structural Arterial Stiffness in Middle‐Aged Mice

doi: 10.1161/JAHA.123.032641

Figure Lengend Snippet: A , Soluble collagen content in supernatant from hAoSMCs treated with TGF‐β±BNP or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. B , Soluble collagen content in supernatant from TGF‐β+BNP‐stimulated hAoSMCs cotreated with Val, neprilysin inhibitor LBQ657 (LBQ; active metabolite of sacubitril), valsartan+LBQ657 (Val+LBQ), or untreated (ctrl). Data from n=5 independent experiments. Values are individual data points, presented as mean±SEM. hAoSMCs from corresponding experiments were stained for collagen I (red) ( C ), and mean fluorescence (normalized to cell number) was quantified in 3 high‐power fields of 5 independent experiments. Values are individual data points, presented as mean±SEM ( D ). Nuclei are Hoechst stained (blue), and scale bar indicates 100 μm ( C ). ARNI indicates angiotensin receptor–neprilysin inhibitor; BNP, brain natriuretic peptide; ctrl, control; hAoSMCs, human aortic smooth muscle cells; n.s., not significant; TGF‐β, transforming growth factor‐β; and Val, valsartan.

Article Snippet: BNP (10 nM; TOCRIS Bioscience, Bristol, UK), valsartan (1 μM; provided by Novartis), and LBQ657 (10 μM; provided by Novartis) were added as indicated 1 hour before stimulation.

Techniques: Staining, Fluorescence