krt5creert2 Search Results


krt5creert2  (Technology Development Co)
86
Technology Development Co krt5creert2
Krt5creert2, supplied by Technology Development Co, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/krt5creert2/pm42115607-421-35-26?v=Technology+Development+Co
Average 86 stars, based on 1 article reviews
krt5creert2 - by Bioz Stars, 2026-06
86/100 stars
  Buy from Supplier
female krt5 creert2 mice  (Jackson Laboratory)
86
Jackson Laboratory female krt5 creert2 mice
Immunization with salivary gland proteins induces hyposalivation, accompanied by elevated P16 expression in the submandibular glands (SMGs) of <t>KRT5</t> <t>CreERT2</t> ; R26 tdTomato mice. Eight-week-old female KRT5 CreERT2 ; R26 tdTomato mice were immunized with total salivary gland proteins following tamoxifen treatment. ( A ) Experimental timeline of tamoxifen induction, immunizations and analyses. ( B ) Measurement of salivary flow rate (n = 6–8). ( C ) Representative images of immunohistochemical staining of the SMG sections for P16 (scale bar = 100 μm, 400× magnification). The bar graph shows the average percentage of positively stained areas (n = 4–5). Error bars indicate the standard error of the mean (SEM).
Female Krt5 Creert2 Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/krt5creert2/pmc13163249-85-0-20?v=Jackson+Laboratory
Average 86 stars, based on 1 article reviews
female krt5 creert2 mice - by Bioz Stars, 2026-06
86/100 stars
  Buy from Supplier

Image Search Results


Immunization with salivary gland proteins induces hyposalivation, accompanied by elevated P16 expression in the submandibular glands (SMGs) of KRT5 CreERT2 ; R26 tdTomato mice. Eight-week-old female KRT5 CreERT2 ; R26 tdTomato mice were immunized with total salivary gland proteins following tamoxifen treatment. ( A ) Experimental timeline of tamoxifen induction, immunizations and analyses. ( B ) Measurement of salivary flow rate (n = 6–8). ( C ) Representative images of immunohistochemical staining of the SMG sections for P16 (scale bar = 100 μm, 400× magnification). The bar graph shows the average percentage of positively stained areas (n = 4–5). Error bars indicate the standard error of the mean (SEM).

Journal: International Journal of Molecular Sciences

Article Title: The Impact of Alternate-Day Fasting on the Salivary Gland Ductal Compartments and the Differentiation Potential of Keratin 5 + Salivary Gland Progenitor Cells in an Induced Mouse Model of Sjögren’s-like Hyposalivation

doi: 10.3390/ijms27094080

Figure Lengend Snippet: Immunization with salivary gland proteins induces hyposalivation, accompanied by elevated P16 expression in the submandibular glands (SMGs) of KRT5 CreERT2 ; R26 tdTomato mice. Eight-week-old female KRT5 CreERT2 ; R26 tdTomato mice were immunized with total salivary gland proteins following tamoxifen treatment. ( A ) Experimental timeline of tamoxifen induction, immunizations and analyses. ( B ) Measurement of salivary flow rate (n = 6–8). ( C ) Representative images of immunohistochemical staining of the SMG sections for P16 (scale bar = 100 μm, 400× magnification). The bar graph shows the average percentage of positively stained areas (n = 4–5). Error bars indicate the standard error of the mean (SEM).

Article Snippet: Female KRT5 CreERT2 mice (Cat# 029155), R26 tdTomato reporter mice (Cat# 007914) and C57BL/6 mice (Cat# 000664) were obtained from the Jackson Laboratory (Bar Harbor, ME, USA) and maintained under specific pathogen-free conditions at the ADA Forsyth Institute.

Techniques: Expressing, Immunohistochemical staining, Staining

ADF increases salivary flow rate and reduces cellular senescence in the SMGs of KRT5 CreERT2 ; R26 tdtomato mice with induced hyposalivation. Eight-week-old female KRT5 CreERT2 ; R26 tdTomato mice were immunized with SMG proteins following tamoxifen treatment and then subjected to alternate-day fasting (ADF) or fed with standard chow ad libitum (AL), as shown in ( A ) experimental timeline. ( B ) Measurement of salivary flow rate (n = 6–8). ( C ) Representative images of immunohistochemical staining of the SMG sections for P16 (scale bar = 100 μm, 400× magnification). The bar graph shows the average percentage of positively stained areas (n = 5–6). Error bars indicate the standard error of the mean (SEM).

Journal: International Journal of Molecular Sciences

Article Title: The Impact of Alternate-Day Fasting on the Salivary Gland Ductal Compartments and the Differentiation Potential of Keratin 5 + Salivary Gland Progenitor Cells in an Induced Mouse Model of Sjögren’s-like Hyposalivation

doi: 10.3390/ijms27094080

Figure Lengend Snippet: ADF increases salivary flow rate and reduces cellular senescence in the SMGs of KRT5 CreERT2 ; R26 tdtomato mice with induced hyposalivation. Eight-week-old female KRT5 CreERT2 ; R26 tdTomato mice were immunized with SMG proteins following tamoxifen treatment and then subjected to alternate-day fasting (ADF) or fed with standard chow ad libitum (AL), as shown in ( A ) experimental timeline. ( B ) Measurement of salivary flow rate (n = 6–8). ( C ) Representative images of immunohistochemical staining of the SMG sections for P16 (scale bar = 100 μm, 400× magnification). The bar graph shows the average percentage of positively stained areas (n = 5–6). Error bars indicate the standard error of the mean (SEM).

Article Snippet: Female KRT5 CreERT2 mice (Cat# 029155), R26 tdTomato reporter mice (Cat# 007914) and C57BL/6 mice (Cat# 000664) were obtained from the Jackson Laboratory (Bar Harbor, ME, USA) and maintained under specific pathogen-free conditions at the ADA Forsyth Institute.

Techniques: Immunohistochemical staining, Staining

ADF reduces the expression of anti-apoptotic proteins BCL-2, BCL-XL and MCL-1 in the SMGs of KRT5 CreERT2 ; R26 tdtomato mice with induced hyposalivation. Eight-week-old female KRT5 CreERT2 ; R26 tdTomato mice were immunized with SMG proteins following tamoxifen treatment and then subjected to ADF or fed with standard chow AL , as outlined in A. Representative images of immunohistochemical staining of the SMG sections for BCL-2, BCL-XL or MCL-1 (scale bar = 100 µm, 400× magnification). The bar graphs display the average percentage of positively stained areas (n = 5–6). Error bars indicate the standard error of the mean (SEM).

Journal: International Journal of Molecular Sciences

Article Title: The Impact of Alternate-Day Fasting on the Salivary Gland Ductal Compartments and the Differentiation Potential of Keratin 5 + Salivary Gland Progenitor Cells in an Induced Mouse Model of Sjögren’s-like Hyposalivation

doi: 10.3390/ijms27094080

Figure Lengend Snippet: ADF reduces the expression of anti-apoptotic proteins BCL-2, BCL-XL and MCL-1 in the SMGs of KRT5 CreERT2 ; R26 tdtomato mice with induced hyposalivation. Eight-week-old female KRT5 CreERT2 ; R26 tdTomato mice were immunized with SMG proteins following tamoxifen treatment and then subjected to ADF or fed with standard chow AL , as outlined in A. Representative images of immunohistochemical staining of the SMG sections for BCL-2, BCL-XL or MCL-1 (scale bar = 100 µm, 400× magnification). The bar graphs display the average percentage of positively stained areas (n = 5–6). Error bars indicate the standard error of the mean (SEM).

Article Snippet: Female KRT5 CreERT2 mice (Cat# 029155), R26 tdTomato reporter mice (Cat# 007914) and C57BL/6 mice (Cat# 000664) were obtained from the Jackson Laboratory (Bar Harbor, ME, USA) and maintained under specific pathogen-free conditions at the ADA Forsyth Institute.

Techniques: Expressing, Immunohistochemical staining, Staining

ADF reduces the expression levels of NLRP3 and their downstream products IL-1β and IL-18 in the SMGs of KRT5 CreERT2 ; R26 tdTomato mice with induced hyposalivation. Eight-week-old female KRT5 CreERT2 ; R26 tdTomato mice were immunized with SMG proteins following tamoxifen treatment and then subjected to ADF or fed with standard chow AL , as outlined in A. Representative images of immunohistochemical staining of the SMG protein sections for NLRP3, IL-1β and IL-18 are shown (scale bar = 100 µm, 400× magnification). The bar graphs display the average percentage of positively stained areas (n = 5–6). Error bars indicate the standard error of the mean (SEM).

Journal: International Journal of Molecular Sciences

Article Title: The Impact of Alternate-Day Fasting on the Salivary Gland Ductal Compartments and the Differentiation Potential of Keratin 5 + Salivary Gland Progenitor Cells in an Induced Mouse Model of Sjögren’s-like Hyposalivation

doi: 10.3390/ijms27094080

Figure Lengend Snippet: ADF reduces the expression levels of NLRP3 and their downstream products IL-1β and IL-18 in the SMGs of KRT5 CreERT2 ; R26 tdTomato mice with induced hyposalivation. Eight-week-old female KRT5 CreERT2 ; R26 tdTomato mice were immunized with SMG proteins following tamoxifen treatment and then subjected to ADF or fed with standard chow AL , as outlined in A. Representative images of immunohistochemical staining of the SMG protein sections for NLRP3, IL-1β and IL-18 are shown (scale bar = 100 µm, 400× magnification). The bar graphs display the average percentage of positively stained areas (n = 5–6). Error bars indicate the standard error of the mean (SEM).

Article Snippet: Female KRT5 CreERT2 mice (Cat# 029155), R26 tdTomato reporter mice (Cat# 007914) and C57BL/6 mice (Cat# 000664) were obtained from the Jackson Laboratory (Bar Harbor, ME, USA) and maintained under specific pathogen-free conditions at the ADA Forsyth Institute.

Techniques: Expressing, Immunohistochemical staining, Staining

ADF moderately promotes acinar cell differentiation from KRT5 + cells in the SMGs of KRT5 CreERT2 ; R26 tdTomato mice with induced hyposalivation. ( A ) Flow cytometric analysis of KRT5 and tdTomato expression in SMG cells from KRT5 CreERT2 ; R26 tdTomato mice 2 weeks after corn oil or tamoxifen treatment. ( B ) Eight-week-old female KRT5 CreERT2 ; R26 tdTomato mice were immunized with SMG proteins following tamoxifen treatment and then subjected to ADF or fed with standard chow AL , as outlined in A. Representative images of immunofluorescence staining of the SMG sections for tdTomato (red) and AQP5 (acinar cell marker, green) are shown. DAPI: blue. Scale bar = 100 µm, 400× magnification (n = 9). The arrow indicates cell aggregates co-expressing tdTomato and AQP5.

Journal: International Journal of Molecular Sciences

Article Title: The Impact of Alternate-Day Fasting on the Salivary Gland Ductal Compartments and the Differentiation Potential of Keratin 5 + Salivary Gland Progenitor Cells in an Induced Mouse Model of Sjögren’s-like Hyposalivation

doi: 10.3390/ijms27094080

Figure Lengend Snippet: ADF moderately promotes acinar cell differentiation from KRT5 + cells in the SMGs of KRT5 CreERT2 ; R26 tdTomato mice with induced hyposalivation. ( A ) Flow cytometric analysis of KRT5 and tdTomato expression in SMG cells from KRT5 CreERT2 ; R26 tdTomato mice 2 weeks after corn oil or tamoxifen treatment. ( B ) Eight-week-old female KRT5 CreERT2 ; R26 tdTomato mice were immunized with SMG proteins following tamoxifen treatment and then subjected to ADF or fed with standard chow AL , as outlined in A. Representative images of immunofluorescence staining of the SMG sections for tdTomato (red) and AQP5 (acinar cell marker, green) are shown. DAPI: blue. Scale bar = 100 µm, 400× magnification (n = 9). The arrow indicates cell aggregates co-expressing tdTomato and AQP5.

Article Snippet: Female KRT5 CreERT2 mice (Cat# 029155), R26 tdTomato reporter mice (Cat# 007914) and C57BL/6 mice (Cat# 000664) were obtained from the Jackson Laboratory (Bar Harbor, ME, USA) and maintained under specific pathogen-free conditions at the ADA Forsyth Institute.

Techniques: Cell Differentiation, Expressing, Immunofluorescence, Staining, Marker