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MedChemExpress
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NAPHTHOL AS-E PHOSPHATE(cas# 18228-17-6) is a histochemical substrate for alkaline phosphatases. It blocks cAMP-induction of CREB (cAMP Response Element Binding Protein)-dependent target gene transcription (Ki 10 microM)) through interference in the binding between the KID
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Selleck Chemicals
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IKA Werke GmbH Co KG
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ApexBio
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IKA Werke GmbH Co KG
ks 501 digital shaker (1 hr at 325 rpm; ika werke gmbh & co. kg, germany) Ks 501 Digital Shaker (1 Hr At 325 Rpm; Ika Werke Gmbh & Co. Kg, Germany), supplied by IKA Werke GmbH Co KG, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/product/kg+501/ks+501+digital+shaker++1+hr+at+325+rpm++ika+werke+gmbh+++co++kg++germany+/10__1111_slash_1365___2435__13454-127-22-31 Average 90 stars, based on 1 article reviews
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IKA Werke GmbH Co KG
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medchemexpress
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Georg Thieme Verlag KG
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IKA Werke GmbH Co KG
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InformationKG-501 (2-naphthol-AS-E-phosphate) KG-501 (2-naphthol-AS-E-phosphate) is a cAMP response element-binding protein (CREB) inhibitor that disrupts CREB-dependent transcription (Ki = 10 μM) and CREB:CBP interaction (Ki = 50 μM). It also disrupts phospho (Ser-133) CREB binding to
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Image Search Results
Journal: The Korean Journal of Pain
Article Title: Perampanel ameliorates nitroglycerin-induced migraine through inhibition of the cAMP/PKA/CREB signaling pathway in the trigeminal ganglion in rats
doi: 10.3344/kjp.23039
Figure Lengend Snippet: Effects of perampanel on PKA/CREB and PLC/PKC signaling pathways in NTG-induced migraine. (A) Western blot showing the protein levels of PKA, CREB and p-CREB; (B) Western blot analysis of the expression of PKA in TG. Kruskal–Wallis statistic = 17.20, *** P < 0.001; (C) Western blot analysis of the expression of P-CREB in TG. Kruskal–Wallis statistic = 11.52, ** P = 0.009; (D) Western blot analysis of the expression of CREB in TG. Kruskal–Wallis statistic = 9.125, * P = 0.028; (E) Western blot showing the protein levels of PLC and PKC. (F) Western blot analysis of the expression of PLC in TG. Kruskal–Wallis statistic = 3.631, P = 0.304; (G) Western blot analysis of the expression of PKC in TG. Kruskal–Wallis statistic = 7.030, P = 0.071. Control, n = 4; NTG, n = 6; PER 50 μg/kg + NTG, n = 6; PER 100 μg/kg + NTG, n = 6. Data are presented as mean ± SEM. PKA: protein kinase A, CREB: cAMP-responsive-element-binding protein, PLC: phospholipase C, PKC: protein kinase C, NTG: nitroglycerin, TG: trigeminal ganglion, PER: perampanel. Significant differences: * P < 0.05, ** P < 0.01.
Article Snippet: The cells were seeded in 6-well plates and incubated with different drugs treatment: 100 μM perampanel [ ], 100 μM SQ22536 (HY-100396, MedChemExpress), a adenylate cyclase (AC) inhibitor; 10 μM forskolin (HY-15371, MedChemExpress), a AC agonist; 10 μM H-89 (HY-15979, MedChemExpress), a protein kinase A (PKA) inhibitor; 0.1 mM 8-bromo-cAMP sodium salt (HY-12306, MedChemExpress), a PKA agonist and 25 μM KG501 (HY-103299,
Techniques: Protein-Protein interactions, Western Blot, Expressing, Control, Binding Assay
Journal: The Korean Journal of Pain
Article Title: Perampanel ameliorates nitroglycerin-induced migraine through inhibition of the cAMP/PKA/CREB signaling pathway in the trigeminal ganglion in rats
doi: 10.3344/kjp.23039
Figure Lengend Snippet: Effects of perampanel on cAMP/PKA/CREB signaling pathways in vitro . (A) Western blot showing the protein levels of PACAP in HT-22 cell incubated with forskolin 10 µM for 24 hours; (B) Western blot analysis of the expression of PACAP. Kruskal–Wallis statistic = 7.538, * P = 0.011. Control, n = 4; Forskolin 10 µM, n = 4; PER 100 μM, n = 4; (C) Western blot showing the protein levels of PACAP in HT-22 cell incubated with 8-bromo-cAMP sodium salt 0.1 mM for 24 hours; (D) Western blot analysis of the expression of PACAP. Kruskal–Wallis statistic = 16.33, P = 0.001. Control, n = 4; 8-bromo-cAMP sodium salt 0.1 mM, n = 4; PER 100 μM, n = 4; (E) Western blot showing the protein levels of PACAP in HT-22 cell incubated with SQ22536 100 μM for 24 hours; (F) Western blot analysis of the expression of PACAP. Kruskal–Wallis statistic = 9.269, *** P < 0.001. Control, n = 4; SQ22536 100 μM, n = 4; PER 100 μM, n = 4. (G) Western blot showing the protein levels of PACAP in HT-22 cell incubated with H-89 10 µM for 24 hours; (H) Western blot analysis of the expression of PACAP. Kruskal–Wallis statistic = 9.846, *** P < 0.001. Control, n = 4; H-89 10 µM, n = 4; PER 100 μM, n = 4. (I) Western blot showing the protein levels of PACAP in HT-22 cell incubated with KG501 25 µM for 24 hours; (J) Western blot analysis of the expression of PACAP. Kruskal–Wallis statistic = 8.769, ** P = 0.001. Control, n = 4; KG501 25 µM, n = 4; PER 100 μM, n = 4. Data are presented as mean ± SEM. PKA: protein kinase A, CREB: cAMP-responsive-element-binding protein, PER: perampanel. Significant differences: * P < 0.05, ** P < 0.01.
Article Snippet: The cells were seeded in 6-well plates and incubated with different drugs treatment: 100 μM perampanel [ ], 100 μM SQ22536 (HY-100396, MedChemExpress), a adenylate cyclase (AC) inhibitor; 10 μM forskolin (HY-15371, MedChemExpress), a AC agonist; 10 μM H-89 (HY-15979, MedChemExpress), a protein kinase A (PKA) inhibitor; 0.1 mM 8-bromo-cAMP sodium salt (HY-12306, MedChemExpress), a PKA agonist and 25 μM KG501 (HY-103299,
Techniques: Protein-Protein interactions, In Vitro, Western Blot, Incubation, Expressing, Control, Binding Assay