Journal: Neuron

Article Title: Dynamics of awake hippocampal-prefrontal replay for spatial learning and memory-guided decision making

doi: 10.1016/j.neuron.2019.09.012

Figure Lengend Snippet: KEY RESOURCES TABLE

Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Chemicals Cresyl Violet Acros Organics Cat#: AC229630050 Formaldehyde Fisher Cat#: 50-00-0,67561,7732-18-5 Isoflurane Patterson Veterinary Cat#: 07-806-3204 Ketamine Patterson Veterinary Cat#: 07-803-6637 Xylazine Patterson Veterinary Cat#: 07-808-1947 Atropine Patterson Veterinary Cat#: 07-869-6061 Bupivacaine Patterson Veterinary Cat#: 07-890-4881 Beuthanasia-D Patterson Veterinary Cat#: 07-807-3963 Sucrose Sigma-Aldrich Cat#: S8501-5KG Experimental Models: Organisms/Strains Rat: Long Evans Charles River Cat#: Crl:LE 006;RRID:RGD_2308852 Software and Algorithms MATLAB 2017a Mathworks, MA RRID: SCR_001622 Trodes SpikeGadgets http://www.spikegadgets.com Matclust Mattias P. Karlsson https://www.mathworks.com/matlabcentral/fileexchange/39663-matclust , V1.7 Libsvm Chang and Lin 2011 https://www.csie.ntu.edu.tw/~cjlin/libsvm/ , V3.12 Chronux Partha Mitra http://chronux.org/ , V2.12 Prism 8 GraphPad Software RRID: SCR_002798 Other 128 Channel electrophysiology data acquisition system SpikeGadgets http://www.spikegadgets.com 12.7 μm NiCr tetrode wire Sandvik Cat#: PX000004 Open in a separate window KEY RESOURCES TABLE Continuous hippocampal-prefrontal (CA1-PFC) replay tracking during spatial learning Reverse replay for retrospective evaluation, forward replay for prospective planning Opposing learning gradients for CA1 reverse and forward replay prediction of paths CA1-PFC replay supports past recall and future decisions for spatial working memory

Techniques: Software

Journal: bioRxiv

Article Title: Antidepressant and antipsychotic drugs reduce viral infection by SARS-CoV-2 and fluoxetine show antiviral activity against the novel variants in vitro

doi: 10.1101/2021.03.22.436379

Figure Lengend Snippet: ( a ) Ketamine and ketamine metabolites ( b ) 2R,6R-HNK and ( c ) 2S,6S-HNK did not change the luciferase reporter activity. Other classical antidepressant drugs ( d ) rolipram and ( e ) phenelzine were also found to be ineffective. ( f ) Anticonvulsant carbamazepine did not change the amount of luciferase activity. Data represented as mean ± SEM.

Article Snippet: Fluoxetine (#H6995, Bosche Scientific), citalopram (#C505000, Toronto Research Chemicals), paroxetine (#2141, Tocris), fluvoxamine (#1033), venlafaxine (#2917, Tocris), reboxetine (#1982, Tocris), imipramine (#I7379-5G, Sigma–Aldrich), clomipramine (#C7291, Sigma–Aldrich), desipramine (#3067, Tocris), phenelzine (#P6777, Sigma–Aldrich), rolipram (#R6520, Sigma–Aldrich), ketamine (#3131, Tocris), 2R, 6R-Hydroxynorketamine and 2S, 6S-Hydroxynorketamine (#6094 and #6095, respectively, Tocris), carbamazepine (#4098, Tocris), chlorpromazine (#C8138, Sigma–Aldrich), flupenthixol (#4057, Tocris), and pimozide (#0937, Tocris) were investigated in this study.

Techniques: Luciferase, Activity Assay

Journal: Pharmacognosy Research

Article Title: Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5’-diphospho-glucuronosyltransferase isoforms

doi: 10.4103/0974-8490.159580

Figure Lengend Snippet: Inhibitory effects of mitragynine, 7-hydroxymitragynine, ketamine, buprenorphine, and diclofenac on 4-methylumbelliferone glucuronide formation by rat liver microsomes. Panels to the right show inhibitor concentrations. Each bar represents the mean percentage activity relative to control ± standard error of mean for three independent measurements ( n = 3). Statistical analysis was conducted using one-way ANOVA and Dunnett test. * P < 0.05 versus control (no inhibitor)

Article Snippet: Ketamine hydrochloride and buprenorphine hydrochloride were purchased from Toronto Research Chemicals Inc. (North York, ON, Canada).

Techniques: Activity Assay, Control

Journal: Pharmacognosy Research

Article Title: Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5’-diphospho-glucuronosyltransferase isoforms

doi: 10.4103/0974-8490.159580

Figure Lengend Snippet: Inhibitory effects of mitragynine, 7-hydroxymitragynine, ketamine, buprenorphine, and diclofenac on 4-methylumbelliferone glucuronide formation by recombinant human UGT2B7 isoform. Panels to the right show inhibitor concentrations. Each bar represents the mean percentage activity relative to control ± standard error of mean for three independent measurements ( n = 3). Statistical analysis was conducted using one-way ANOVA and Dunnett test. * P < 0.05 versus control (no inhibitor)

Article Snippet: Ketamine hydrochloride and buprenorphine hydrochloride were purchased from Toronto Research Chemicals Inc. (North York, ON, Canada).

Techniques: Recombinant, Activity Assay, Control

Journal: Pharmacognosy Research

Article Title: Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5’-diphospho-glucuronosyltransferase isoforms

doi: 10.4103/0974-8490.159580

Figure Lengend Snippet: Inhibitory effects of mitragynine, 7-hydroxymitragynine, ketamine, buprenorphine, and diclofenac on 4-methylumbelliferone glucuronide formation by human liver microsomes. Panels to the right show inhibitor concentrations. Each bar represents the mean percentage activity relative to control ± standard error of mean for three independent measurements ( n = 3). Statistical analysis was conducted using one-way ANOVA and Dunnett test. * P < 0.05 versus control (no inhibitor)

Article Snippet: Ketamine hydrochloride and buprenorphine hydrochloride were purchased from Toronto Research Chemicals Inc. (North York, ON, Canada).

Techniques: Activity Assay, Control

Journal: Pharmacognosy Research

Article Title: Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5’-diphospho-glucuronosyltransferase isoforms

doi: 10.4103/0974-8490.159580

Figure Lengend Snippet: Inhibitory effects of mitragynine, 7-hydroxymitragynine, ketamine, buprenorphine, and diclofenac on 4-methylumbelliferone glucuronide formation by recombinant human UGT1A1 isoform. Panels to the right show inhibitor concentrations. Each bar represents the mean percentage activity relative to control ± standard error of mean for three independent measurements ( n = 3). Statistical analysis was conducted using one-way ANOVA and Dunnett test. * P < 0.05 versus control (no inhibitor)

Article Snippet: Ketamine hydrochloride and buprenorphine hydrochloride were purchased from Toronto Research Chemicals Inc. (North York, ON, Canada).

Techniques: Recombinant, Activity Assay, Control