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CELLnTEC Advanced Cell Systems AG
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ScienCell
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CellSystems Biotechnologie Vertrieb GmbH
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Lonza
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Image Search Results
Journal: Journal of Cellular and Molecular Medicine
Article Title: Down‐regulation of exosomal miR‐200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis
doi: 10.1111/jcmm.15864
Figure Lengend Snippet: Exosomes modulate melanin synthesis via miR‐200c. A, The expression level of miR‐200c in keratinocytes transfected with miR‐200c inhibitor. B, The expression level of miR‐200c in exosomes secreted by keratinocytes which down‐regulated miR‐200c. C, MiR‐200c expression level in exosome‐treated melanocytes with down‐regulated Mir‐200c expression. (D and E) Intracellular melanin content, cell pellets and tyrosinase activity in melanocytes treated with corresponding exosomes and plasmids. melanocytes incubated with exosomes from keratinocytes transfected with miR‐200c mimics or miR‐NC. (F and G) qRT‐PCR and Western blot were used to analyse the expression of MITF, TYR, TRP1 and TRP2 in melanocytes treated with corresponding exosomes and plasmids. Results are expressed as mean ± SD (n = 3). * P < 0.05, ** P < 0.01, *** P < 0.005
Article Snippet: The keratinocytes were cultured in
Techniques: Expressing, Transfection, Activity Assay, Incubation, Quantitative RT-PCR, Western Blot
Journal: Journal of Cellular and Molecular Medicine
Article Title: Down‐regulation of exosomal miR‐200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis
doi: 10.1111/jcmm.15864
Figure Lengend Snippet: A model illustrating the role of exosomal miR‐200c derived from keratinocytes in regulating melanogenesis of melanocytes
Article Snippet: The keratinocytes were cultured in
Techniques: Derivative Assay