interleukin Search Results


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  • 94
    RayBiotech interleukin
    Interleukin, supplied by RayBiotech, used in various techniques. Bioz Stars score: 94/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    99
    Thermo Fisher interleukin 1beta
    Interleukin 1beta, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 32 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Endogen Inc interleukin
    Interleukin, supplied by Endogen Inc, used in various techniques. Bioz Stars score: 92/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    94
    R&D Systems interleukin
    The effects of recombinant tissue type plasminogen activator (rtPA), anti–PA1–1 monoclonal antibodies (anti–PAI–1), or placebo (normal saline (P)) on levels of tumor necrosis factor α (TNF), <t>interleukin</t> (IL)–6, and cytokine–induced neutrophil chemoattractant (CINC)–3 in lung homogenates, 16 hours after intratracheal bacterial challenge ( Pseudomonas aeruginosa , PAO1, 10 8 colony forming units (CFU)) or 16 h after intravenous injection of lipopolysaccharide (LPS, Escherichia coli O111:B4). The horizontal line within the graph represents the median.
    Interleukin, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 452 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Becton Dickinson interleukin
    Immune responses. (A, B) CpG induction of immunogenic phenotype in patient tumor cells. Histograms represent coculture with PF-3512676 (green line) or media alone (red line). (C) Induction of tumor-reactive memory CD8 T cells per upregulation of CD137; data are gated on live CD8+ cells, statistics are percentages of CD45RO+CD137+ cells among that gate. (D) Induction of tumor-reactive CD8 T cells per interferon-γ (IFNg), <t>interleukin-2</t> (IL2), and tumor necrosis factor (TNF) upregulation; data are gated on live CD8+ cells, statistics are percentages of cytokine(+) cells among that gate.
    Interleukin, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 93/100, based on 250 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Novartis interleukin
    Immune responses. (A, B) CpG induction of immunogenic phenotype in patient tumor cells. Histograms represent coculture with PF-3512676 (green line) or media alone (red line). (C) Induction of tumor-reactive memory CD8 T cells per upregulation of CD137; data are gated on live CD8+ cells, statistics are percentages of CD45RO+CD137+ cells among that gate. (D) Induction of tumor-reactive CD8 T cells per interferon-γ (IFNg), <t>interleukin-2</t> (IL2), and tumor necrosis factor (TNF) upregulation; data are gated on live CD8+ cells, statistics are percentages of cytokine(+) cells among that gate.
    Interleukin, supplied by Novartis, used in various techniques. Bioz Stars score: 93/100, based on 65 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    94
    Thermo Fisher interleukin
    TPR-FGFR1 transforms Baf3 cells into IL-3-independent cells. The TPR-FGFR1- or empty vector-transfected Baf3 cells were cultured with or without IL-3 for 4 days. The number of live cells in each group was counted every day. Data are expressed as the mean ± standard error of the mean of three independent experiments. TPR, translocated promoter region; FGFR1, fibroblast growth factor receptor 1; IL3, <t>interleukin</t> 3.
    Interleukin, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 323 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    4Gene interleukin
    TPR-FGFR1 transforms Baf3 cells into IL-3-independent cells. The TPR-FGFR1- or empty vector-transfected Baf3 cells were cultured with or without IL-3 for 4 days. The number of live cells in each group was counted every day. Data are expressed as the mean ± standard error of the mean of three independent experiments. TPR, translocated promoter region; FGFR1, fibroblast growth factor receptor 1; IL3, <t>interleukin</t> 3.
    Interleukin, supplied by 4Gene, used in various techniques. Bioz Stars score: 92/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    BioLegend interleukin
    TPR-FGFR1 transforms Baf3 cells into IL-3-independent cells. The TPR-FGFR1- or empty vector-transfected Baf3 cells were cultured with or without IL-3 for 4 days. The number of live cells in each group was counted every day. Data are expressed as the mean ± standard error of the mean of three independent experiments. TPR, translocated promoter region; FGFR1, fibroblast growth factor receptor 1; IL3, <t>interleukin</t> 3.
    Interleukin, supplied by BioLegend, used in various techniques. Bioz Stars score: 92/100, based on 24 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Bio-Techne interleukin
    TPR-FGFR1 transforms Baf3 cells into IL-3-independent cells. The TPR-FGFR1- or empty vector-transfected Baf3 cells were cultured with or without IL-3 for 4 days. The number of live cells in each group was counted every day. Data are expressed as the mean ± standard error of the mean of three independent experiments. TPR, translocated promoter region; FGFR1, fibroblast growth factor receptor 1; IL3, <t>interleukin</t> 3.
    Interleukin, supplied by Bio-Techne, used in various techniques. Bioz Stars score: 93/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    ImmunoKontact interleukin
    TPR-FGFR1 transforms Baf3 cells into IL-3-independent cells. The TPR-FGFR1- or empty vector-transfected Baf3 cells were cultured with or without IL-3 for 4 days. The number of live cells in each group was counted every day. Data are expressed as the mean ± standard error of the mean of three independent experiments. TPR, translocated promoter region; FGFR1, fibroblast growth factor receptor 1; IL3, <t>interleukin</t> 3.
    Interleukin, supplied by ImmunoKontact, used in various techniques. Bioz Stars score: 92/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Meso Scale Diagnostics LLC interleukin
    Longitudinal expression levels of <t>interleukin</t> (IL)–6 for patients with amyotrophic lateral sclerosis (ALS) The scatterplots show IL-6 plasma levels (black dots) obtained at each follow-up time point from the 59 patients with ALS included in the longitudinal cohort. Median and quartile ranges at each visit are presented with red bars. Patients were subgrouped according to (A.a, A.b) progression rate calculated at baseline (with a cutoff value of 0.5); (B.a, B.b) sex; (C.a, C.b) site of disease onset; (D.a, D.b) ALS Functional Rating Scale–Revised (ALSFRS-R) score at V1 (cutoff value of 40); and (E.a, E.b) whether they were on riluzole or not. * p Value for Kruskal-Wallis test examining difference between all visits; ** p value adjusted for multiple comparison between V1 and V6; *** p value adjusted for multiple comparison between V2 (D only) and V6.
    Interleukin, supplied by Meso Scale Diagnostics LLC, used in various techniques. Bioz Stars score: 92/100, based on 51 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    97
    Millipore interleukin
    Effect of Moringa oleifera on ( a ) tumour necrosis factor-alpha (TNF-α) and ( b ) <t>interleukin-6</t> (IL-6) in the kidneys. NC (Normal control), NC + MO ( Moringa oleifera -treated control rats), DM (Diabetic rats) and DM + MO ( Moringa oleifera -treated diabetic rats). Values are presented as mean (SD). a p
    Interleukin, supplied by Millipore, used in various techniques. Bioz Stars score: 97/100, based on 220 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    PeproTech interleukin
    Human leucocyte antigen (HLA)‐I T cell receptor (TCR)‐transduced CD4 + T cells exhibit a polyfunctional effector profile upon peptide stimulation. Stimulation of HLA A2 + CD8 + and CD4 + T cells transduced with NY‐ESO‐1 (a) and gp100 (b) TCRs with or without the indicated concentrations of SLLMWITQC (SLL) and YLEPGPVTV (YLE) peptide, respectively, pulsed on HLA A2 + T2 target cells. Pie charts reflect proportion of cells exhibiting effector functions measured by intracellular staining with the area of each segment representing the proportion of cells displaying between 0 (grey) to 4 (red) functions. Cells are gated as described in Supporting information, Fig. S1. Effector functions measured were macrophage inflammatory protein (MIP)‐1β, interferon (IFN)‐γ, tumour necrosis factor (TNF)‐α and <t>interleukin</t> (IL)‐2 production. The biophysical data relating to the TCRs are described in Table 1. Values reflected here are from a single representative experiment of two independently performed experiments. UNT = non‐transduced cells.
    Interleukin, supplied by PeproTech, used in various techniques. Bioz Stars score: 93/100, based on 193 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Thermo Fisher murine interleukin
    Human leucocyte antigen (HLA)‐I T cell receptor (TCR)‐transduced CD4 + T cells exhibit a polyfunctional effector profile upon peptide stimulation. Stimulation of HLA A2 + CD8 + and CD4 + T cells transduced with NY‐ESO‐1 (a) and gp100 (b) TCRs with or without the indicated concentrations of SLLMWITQC (SLL) and YLEPGPVTV (YLE) peptide, respectively, pulsed on HLA A2 + T2 target cells. Pie charts reflect proportion of cells exhibiting effector functions measured by intracellular staining with the area of each segment representing the proportion of cells displaying between 0 (grey) to 4 (red) functions. Cells are gated as described in Supporting information, Fig. S1. Effector functions measured were macrophage inflammatory protein (MIP)‐1β, interferon (IFN)‐γ, tumour necrosis factor (TNF)‐α and <t>interleukin</t> (IL)‐2 production. The biophysical data relating to the TCRs are described in Table 1. Values reflected here are from a single representative experiment of two independently performed experiments. UNT = non‐transduced cells.
    Murine Interleukin, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 92/100, based on 9 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    96
    Millipore interleukin 1beta
    Human leucocyte antigen (HLA)‐I T cell receptor (TCR)‐transduced CD4 + T cells exhibit a polyfunctional effector profile upon peptide stimulation. Stimulation of HLA A2 + CD8 + and CD4 + T cells transduced with NY‐ESO‐1 (a) and gp100 (b) TCRs with or without the indicated concentrations of SLLMWITQC (SLL) and YLEPGPVTV (YLE) peptide, respectively, pulsed on HLA A2 + T2 target cells. Pie charts reflect proportion of cells exhibiting effector functions measured by intracellular staining with the area of each segment representing the proportion of cells displaying between 0 (grey) to 4 (red) functions. Cells are gated as described in Supporting information, Fig. S1. Effector functions measured were macrophage inflammatory protein (MIP)‐1β, interferon (IFN)‐γ, tumour necrosis factor (TNF)‐α and <t>interleukin</t> (IL)‐2 production. The biophysical data relating to the TCRs are described in Table 1. Values reflected here are from a single representative experiment of two independently performed experiments. UNT = non‐transduced cells.
    Interleukin 1beta, supplied by Millipore, used in various techniques. Bioz Stars score: 96/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    85
    5 PRIME interleukins 4
    Human leucocyte antigen (HLA)‐I T cell receptor (TCR)‐transduced CD4 + T cells exhibit a polyfunctional effector profile upon peptide stimulation. Stimulation of HLA A2 + CD8 + and CD4 + T cells transduced with NY‐ESO‐1 (a) and gp100 (b) TCRs with or without the indicated concentrations of SLLMWITQC (SLL) and YLEPGPVTV (YLE) peptide, respectively, pulsed on HLA A2 + T2 target cells. Pie charts reflect proportion of cells exhibiting effector functions measured by intracellular staining with the area of each segment representing the proportion of cells displaying between 0 (grey) to 4 (red) functions. Cells are gated as described in Supporting information, Fig. S1. Effector functions measured were macrophage inflammatory protein (MIP)‐1β, interferon (IFN)‐γ, tumour necrosis factor (TNF)‐α and <t>interleukin</t> (IL)‐2 production. The biophysical data relating to the TCRs are described in Table 1. Values reflected here are from a single representative experiment of two independently performed experiments. UNT = non‐transduced cells.
    Interleukins 4, supplied by 5 PRIME, used in various techniques. Bioz Stars score: 85/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    86
    DuPont de Nemours interleukin lβ
    Human leucocyte antigen (HLA)‐I T cell receptor (TCR)‐transduced CD4 + T cells exhibit a polyfunctional effector profile upon peptide stimulation. Stimulation of HLA A2 + CD8 + and CD4 + T cells transduced with NY‐ESO‐1 (a) and gp100 (b) TCRs with or without the indicated concentrations of SLLMWITQC (SLL) and YLEPGPVTV (YLE) peptide, respectively, pulsed on HLA A2 + T2 target cells. Pie charts reflect proportion of cells exhibiting effector functions measured by intracellular staining with the area of each segment representing the proportion of cells displaying between 0 (grey) to 4 (red) functions. Cells are gated as described in Supporting information, Fig. S1. Effector functions measured were macrophage inflammatory protein (MIP)‐1β, interferon (IFN)‐γ, tumour necrosis factor (TNF)‐α and <t>interleukin</t> (IL)‐2 production. The biophysical data relating to the TCRs are described in Table 1. Values reflected here are from a single representative experiment of two independently performed experiments. UNT = non‐transduced cells.
    Interleukin Lβ, supplied by DuPont de Nemours, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Thermo Fisher interleukin 12p40
    Effect of galectin-3 (Gal-3) on TLR2/1-induced cytokine profiles. Cytokine expression of ( A ) <t>interleukin</t> 10 (IL-10; n = 9 donors) and ( B ) interleukin <t>12p40</t> (IL-12p40; n = 7 donors) from monocytes treated with medium or 19-kD (a mycobacterial TLR2/1 ligand)
    Interleukin 12p40, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 93/100, based on 19 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    90
    Miltenyi Biotec interleukin 1beta
    Effect of galectin-3 (Gal-3) on TLR2/1-induced cytokine profiles. Cytokine expression of ( A ) <t>interleukin</t> 10 (IL-10; n = 9 donors) and ( B ) interleukin <t>12p40</t> (IL-12p40; n = 7 donors) from monocytes treated with medium or 19-kD (a mycobacterial TLR2/1 ligand)
    Interleukin 1beta, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 90/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Thermo Fisher interleukin 7rα
    Effect of galectin-3 (Gal-3) on TLR2/1-induced cytokine profiles. Cytokine expression of ( A ) <t>interleukin</t> 10 (IL-10; n = 9 donors) and ( B ) interleukin <t>12p40</t> (IL-12p40; n = 7 donors) from monocytes treated with medium or 19-kD (a mycobacterial TLR2/1 ligand)
    Interleukin 7rα, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 91/100, based on 14 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    FUJIFILM human interleukin
    Effect of galectin-3 (Gal-3) on TLR2/1-induced cytokine profiles. Cytokine expression of ( A ) <t>interleukin</t> 10 (IL-10; n = 9 donors) and ( B ) interleukin <t>12p40</t> (IL-12p40; n = 7 donors) from monocytes treated with medium or 19-kD (a mycobacterial TLR2/1 ligand)
    Human Interleukin, supplied by FUJIFILM, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Abcam interleukin
    Dendritic cell‐specific intercellular adhesion molecule 3‐grabbing non‐integrin 1 (DC‐SIGN) regulates inflammatory cytokine expression. Negative control (NC) or DC‐SIGN siRNAs were transfected into human kidney 2 (HK‐2) cells and treated with or without lipopolysaccharide (LPS) (100 ng/ml) for 12 h. Enzyme‐linked immunosorbent assay (ELISA) was utilized to measure the <t>interleukin</t> (IL)‐6 and tumour necrosis factor (TNF)‐α secretion. The data are expressed as the mean ± standard deviation (s.d.) from three independent tests. * P
    Interleukin, supplied by Abcam, used in various techniques. Bioz Stars score: 92/100, based on 33 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    The effects of recombinant tissue type plasminogen activator (rtPA), anti–PA1–1 monoclonal antibodies (anti–PAI–1), or placebo (normal saline (P)) on levels of tumor necrosis factor α (TNF), interleukin (IL)–6, and cytokine–induced neutrophil chemoattractant (CINC)–3 in lung homogenates, 16 hours after intratracheal bacterial challenge ( Pseudomonas aeruginosa , PAO1, 10 8 colony forming units (CFU)) or 16 h after intravenous injection of lipopolysaccharide (LPS, Escherichia coli O111:B4). The horizontal line within the graph represents the median.

    Journal: PLoS ONE

    Article Title: Nebulized Fibrinolytic Agents Improve Pulmonary Fibrinolysis but Not Inflammation in Rat Models of Direct and Indirect Acute Lung Injury

    doi: 10.1371/journal.pone.0055262

    Figure Lengend Snippet: The effects of recombinant tissue type plasminogen activator (rtPA), anti–PA1–1 monoclonal antibodies (anti–PAI–1), or placebo (normal saline (P)) on levels of tumor necrosis factor α (TNF), interleukin (IL)–6, and cytokine–induced neutrophil chemoattractant (CINC)–3 in lung homogenates, 16 hours after intratracheal bacterial challenge ( Pseudomonas aeruginosa , PAO1, 10 8 colony forming units (CFU)) or 16 h after intravenous injection of lipopolysaccharide (LPS, Escherichia coli O111:B4). The horizontal line within the graph represents the median.

    Article Snippet: Levels of tumor necrosis factor–α (TNF, R & D Systems, Abingdon, United Kingdom), interleukin (IL)–6 (R & D Systems, Abingdon, United Kingdom) and cytokine–induced neutrophil chemoattractant (CINC)–3 (R & D Systems, Abingdon, United Kingdom) and myeloperoxidase (MPO, HyCult biotechnology b.v., Uden, The Netherlands) were measured in lungs by means of ELISA.

    Techniques: Recombinant, Injection

    Immune responses. (A, B) CpG induction of immunogenic phenotype in patient tumor cells. Histograms represent coculture with PF-3512676 (green line) or media alone (red line). (C) Induction of tumor-reactive memory CD8 T cells per upregulation of CD137; data are gated on live CD8+ cells, statistics are percentages of CD45RO+CD137+ cells among that gate. (D) Induction of tumor-reactive CD8 T cells per interferon-γ (IFNg), interleukin-2 (IL2), and tumor necrosis factor (TNF) upregulation; data are gated on live CD8+ cells, statistics are percentages of cytokine(+) cells among that gate.

    Journal: Journal of Clinical Oncology

    Article Title: In Situ Vaccination With a TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study

    doi: 10.1200/JCO.2010.28.9793

    Figure Lengend Snippet: Immune responses. (A, B) CpG induction of immunogenic phenotype in patient tumor cells. Histograms represent coculture with PF-3512676 (green line) or media alone (red line). (C) Induction of tumor-reactive memory CD8 T cells per upregulation of CD137; data are gated on live CD8+ cells, statistics are percentages of CD45RO+CD137+ cells among that gate. (D) Induction of tumor-reactive CD8 T cells per interferon-γ (IFNg), interleukin-2 (IL2), and tumor necrosis factor (TNF) upregulation; data are gated on live CD8+ cells, statistics are percentages of cytokine(+) cells among that gate.

    Article Snippet: For intracellular cytokine measurement, cells were treated with Golgi-Plug (BD Biosciences) for the final 5 hours of coincubation, stained for CD4, CD8, interferon-γ, interleukin (IL) -2, tumor necrosis factor α, and tumor necrosis factor β (BD Biosciences).

    Techniques:

    TPR-FGFR1 transforms Baf3 cells into IL-3-independent cells. The TPR-FGFR1- or empty vector-transfected Baf3 cells were cultured with or without IL-3 for 4 days. The number of live cells in each group was counted every day. Data are expressed as the mean ± standard error of the mean of three independent experiments. TPR, translocated promoter region; FGFR1, fibroblast growth factor receptor 1; IL3, interleukin 3.

    Journal: Molecular Medicine Reports

    Article Title: Activity of fibroblast growth factor receptor inhibitors TKI258, ponatinib and AZD4547 against TPR-FGFR1 fusion

    doi: 10.3892/mmr.2017.6140

    Figure Lengend Snippet: TPR-FGFR1 transforms Baf3 cells into IL-3-independent cells. The TPR-FGFR1- or empty vector-transfected Baf3 cells were cultured with or without IL-3 for 4 days. The number of live cells in each group was counted every day. Data are expressed as the mean ± standard error of the mean of three independent experiments. TPR, translocated promoter region; FGFR1, fibroblast growth factor receptor 1; IL3, interleukin 3.

    Article Snippet: Baf3 cells were cultured in RPMI 1640 supplemented with 10% fetal calf serum containing interleukin (IL) 3 (10 ng/ml; eBioscience, Inc., Vienna, Austria).

    Techniques: Plasmid Preparation, Transfection, Cell Culture

    Tyrosine kinase inhibitorsinhibit the proliferation of TPR-FGFR1-expressing Baf3 cells. The TRP-FGFR1-expressing Baf3 cells were treated with increasing concentrations of TKI258, ponatinib or AZD4547 for 48 h. The absorbance of the control group was taken as 100%. Data are of at least three independent experiments. TPR, translocated promoter region; FGFR1, fibroblast growth factor receptor 1; MTT, methylthiazolyldiphenyl-tetrazolium bromide; IL3, interleukin 3.

    Journal: Molecular Medicine Reports

    Article Title: Activity of fibroblast growth factor receptor inhibitors TKI258, ponatinib and AZD4547 against TPR-FGFR1 fusion

    doi: 10.3892/mmr.2017.6140

    Figure Lengend Snippet: Tyrosine kinase inhibitorsinhibit the proliferation of TPR-FGFR1-expressing Baf3 cells. The TRP-FGFR1-expressing Baf3 cells were treated with increasing concentrations of TKI258, ponatinib or AZD4547 for 48 h. The absorbance of the control group was taken as 100%. Data are of at least three independent experiments. TPR, translocated promoter region; FGFR1, fibroblast growth factor receptor 1; MTT, methylthiazolyldiphenyl-tetrazolium bromide; IL3, interleukin 3.

    Article Snippet: Baf3 cells were cultured in RPMI 1640 supplemented with 10% fetal calf serum containing interleukin (IL) 3 (10 ng/ml; eBioscience, Inc., Vienna, Austria).

    Techniques: Expressing, MTT Assay

    Longitudinal expression levels of interleukin (IL)–6 for patients with amyotrophic lateral sclerosis (ALS) The scatterplots show IL-6 plasma levels (black dots) obtained at each follow-up time point from the 59 patients with ALS included in the longitudinal cohort. Median and quartile ranges at each visit are presented with red bars. Patients were subgrouped according to (A.a, A.b) progression rate calculated at baseline (with a cutoff value of 0.5); (B.a, B.b) sex; (C.a, C.b) site of disease onset; (D.a, D.b) ALS Functional Rating Scale–Revised (ALSFRS-R) score at V1 (cutoff value of 40); and (E.a, E.b) whether they were on riluzole or not. * p Value for Kruskal-Wallis test examining difference between all visits; ** p value adjusted for multiple comparison between V1 and V6; *** p value adjusted for multiple comparison between V2 (D only) and V6.

    Journal: Neurology® Neuroimmunology & Neuroinflammation

    Article Title: Systemic inflammatory response and neuromuscular involvement in amyotrophic lateral sclerosis

    doi: 10.1212/NXI.0000000000000244

    Figure Lengend Snippet: Longitudinal expression levels of interleukin (IL)–6 for patients with amyotrophic lateral sclerosis (ALS) The scatterplots show IL-6 plasma levels (black dots) obtained at each follow-up time point from the 59 patients with ALS included in the longitudinal cohort. Median and quartile ranges at each visit are presented with red bars. Patients were subgrouped according to (A.a, A.b) progression rate calculated at baseline (with a cutoff value of 0.5); (B.a, B.b) sex; (C.a, C.b) site of disease onset; (D.a, D.b) ALS Functional Rating Scale–Revised (ALSFRS-R) score at V1 (cutoff value of 40); and (E.a, E.b) whether they were on riluzole or not. * p Value for Kruskal-Wallis test examining difference between all visits; ** p value adjusted for multiple comparison between V1 and V6; *** p value adjusted for multiple comparison between V2 (D only) and V6.

    Article Snippet: A validated multiplex electrochemiluminescence immunoassay was used for the analysis of interferon (IFN)–γ, tumor necrosis factor (TNF)–α, interleukin (IL)–6, IL-1β, IL-2, IL-8, IL-12p70, IL-4, IL-5, IL-10, and IL-13 from patients with ALS and controls in duplicate (Meso Scale Discovery, Rockville, MD).

    Techniques: Expressing, Functional Assay

    Effect of Moringa oleifera on ( a ) tumour necrosis factor-alpha (TNF-α) and ( b ) interleukin-6 (IL-6) in the kidneys. NC (Normal control), NC + MO ( Moringa oleifera -treated control rats), DM (Diabetic rats) and DM + MO ( Moringa oleifera -treated diabetic rats). Values are presented as mean (SD). a p

    Journal: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

    Article Title: Assessment of the Anti-Hyperglycaemic, Anti-Inflammatory and Antioxidant Activities of the Methanol Extract of Moringa Oleifera in Diabetes-Induced Nephrotoxic Male Wistar Rats

    doi: 10.3390/molecules22040439

    Figure Lengend Snippet: Effect of Moringa oleifera on ( a ) tumour necrosis factor-alpha (TNF-α) and ( b ) interleukin-6 (IL-6) in the kidneys. NC (Normal control), NC + MO ( Moringa oleifera -treated control rats), DM (Diabetic rats) and DM + MO ( Moringa oleifera -treated diabetic rats). Values are presented as mean (SD). a p

    Article Snippet: Determination of Tumour Necrotic Factor (TNF-α) and Interleukin (IL-6) in the Kidney Levels of inflammatory biomarkers, tumour necrotic factor (TNF-α) and interleukin (IL-6) in the kidney were determined using Millipore’s MILLIPLEX® MAP rat cytokine magnetic bead panel kit (Millipore Cooperation, Billerica, MA, USA).

    Techniques:

    Human leucocyte antigen (HLA)‐I T cell receptor (TCR)‐transduced CD4 + T cells exhibit a polyfunctional effector profile upon peptide stimulation. Stimulation of HLA A2 + CD8 + and CD4 + T cells transduced with NY‐ESO‐1 (a) and gp100 (b) TCRs with or without the indicated concentrations of SLLMWITQC (SLL) and YLEPGPVTV (YLE) peptide, respectively, pulsed on HLA A2 + T2 target cells. Pie charts reflect proportion of cells exhibiting effector functions measured by intracellular staining with the area of each segment representing the proportion of cells displaying between 0 (grey) to 4 (red) functions. Cells are gated as described in Supporting information, Fig. S1. Effector functions measured were macrophage inflammatory protein (MIP)‐1β, interferon (IFN)‐γ, tumour necrosis factor (TNF)‐α and interleukin (IL)‐2 production. The biophysical data relating to the TCRs are described in Table 1. Values reflected here are from a single representative experiment of two independently performed experiments. UNT = non‐transduced cells.

    Journal: Clinical and Experimental Immunology

    Article Title: Human leucocyte antigen class I‐redirected anti‐tumour CD4+ T cells require a higher T cell receptor binding affinity for optimal activity than CD8+ T cells

    doi: 10.1111/cei.12828

    Figure Lengend Snippet: Human leucocyte antigen (HLA)‐I T cell receptor (TCR)‐transduced CD4 + T cells exhibit a polyfunctional effector profile upon peptide stimulation. Stimulation of HLA A2 + CD8 + and CD4 + T cells transduced with NY‐ESO‐1 (a) and gp100 (b) TCRs with or without the indicated concentrations of SLLMWITQC (SLL) and YLEPGPVTV (YLE) peptide, respectively, pulsed on HLA A2 + T2 target cells. Pie charts reflect proportion of cells exhibiting effector functions measured by intracellular staining with the area of each segment representing the proportion of cells displaying between 0 (grey) to 4 (red) functions. Cells are gated as described in Supporting information, Fig. S1. Effector functions measured were macrophage inflammatory protein (MIP)‐1β, interferon (IFN)‐γ, tumour necrosis factor (TNF)‐α and interleukin (IL)‐2 production. The biophysical data relating to the TCRs are described in Table 1. Values reflected here are from a single representative experiment of two independently performed experiments. UNT = non‐transduced cells.

    Article Snippet: T cells were maintained in R10 with 25 ng/ml interleukin (IL)‐15 (PeproTech EC, London, UK), 200 IU/ml IL‐2 (PeproTech EC) and 2.5% Cellkines (Helvetica Healthcare, Geneva, Switzerland).

    Techniques: Transduction, Staining

    Human leucocyte antigen (HLA)‐I‐restricted NY‐ESO‐1 and gp100 T cell receptor (TCR)‐transduced CD4 + T cells exhibit a different cytokine profile compared to CD8 + counterparts in response to cognate antigen stimulation. CD8 + and CD4 + T cells transduced with the NY‐ESO‐1 (a) and gp100 (b) TCRs were stimulated with titrating concentrations of SLLMWITQC (SLL) and YLEPGPVTV (YLE) peptide, respectively, loaded on HLA A2 + T2 target cells. After overnight incubation, the culture supernatant was harvested for measurement of interferon (IFN)‐γ, macrophage inflammatory protein (MIP)‐1β, tumour necrosis factor (TNF)‐α and interleukin (IL)‐2 by enzyme‐linked immunosorbent assay (ELISA). The biophysical data of the higher‐affinity TCRs are described in Table 1. Values reflected here are from a single representative experiment of two independently performed experiments. UNT = non‐transduced cells.

    Journal: Clinical and Experimental Immunology

    Article Title: Human leucocyte antigen class I‐redirected anti‐tumour CD4+ T cells require a higher T cell receptor binding affinity for optimal activity than CD8+ T cells

    doi: 10.1111/cei.12828

    Figure Lengend Snippet: Human leucocyte antigen (HLA)‐I‐restricted NY‐ESO‐1 and gp100 T cell receptor (TCR)‐transduced CD4 + T cells exhibit a different cytokine profile compared to CD8 + counterparts in response to cognate antigen stimulation. CD8 + and CD4 + T cells transduced with the NY‐ESO‐1 (a) and gp100 (b) TCRs were stimulated with titrating concentrations of SLLMWITQC (SLL) and YLEPGPVTV (YLE) peptide, respectively, loaded on HLA A2 + T2 target cells. After overnight incubation, the culture supernatant was harvested for measurement of interferon (IFN)‐γ, macrophage inflammatory protein (MIP)‐1β, tumour necrosis factor (TNF)‐α and interleukin (IL)‐2 by enzyme‐linked immunosorbent assay (ELISA). The biophysical data of the higher‐affinity TCRs are described in Table 1. Values reflected here are from a single representative experiment of two independently performed experiments. UNT = non‐transduced cells.

    Article Snippet: T cells were maintained in R10 with 25 ng/ml interleukin (IL)‐15 (PeproTech EC, London, UK), 200 IU/ml IL‐2 (PeproTech EC) and 2.5% Cellkines (Helvetica Healthcare, Geneva, Switzerland).

    Techniques: Transduction, Incubation, Enzyme-linked Immunosorbent Assay

    Effect of galectin-3 (Gal-3) on TLR2/1-induced cytokine profiles. Cytokine expression of ( A ) interleukin 10 (IL-10; n = 9 donors) and ( B ) interleukin 12p40 (IL-12p40; n = 7 donors) from monocytes treated with medium or 19-kD (a mycobacterial TLR2/1 ligand)

    Journal: The Journal of Infectious Diseases

    Article Title: Galectin-3 Regulates the Innate Immune Response of Human Monocytes

    doi: 10.1093/infdis/jis920

    Figure Lengend Snippet: Effect of galectin-3 (Gal-3) on TLR2/1-induced cytokine profiles. Cytokine expression of ( A ) interleukin 10 (IL-10; n = 9 donors) and ( B ) interleukin 12p40 (IL-12p40; n = 7 donors) from monocytes treated with medium or 19-kD (a mycobacterial TLR2/1 ligand)

    Article Snippet: Supernatants were collected and IL-10 (Invitrogen) and interleukin 12p40 (IL-12p40; Invitrogen) measured by enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's instructions.

    Techniques: Expressing

    Dendritic cell‐specific intercellular adhesion molecule 3‐grabbing non‐integrin 1 (DC‐SIGN) regulates inflammatory cytokine expression. Negative control (NC) or DC‐SIGN siRNAs were transfected into human kidney 2 (HK‐2) cells and treated with or without lipopolysaccharide (LPS) (100 ng/ml) for 12 h. Enzyme‐linked immunosorbent assay (ELISA) was utilized to measure the interleukin (IL)‐6 and tumour necrosis factor (TNF)‐α secretion. The data are expressed as the mean ± standard deviation (s.d.) from three independent tests. * P

    Journal: Clinical and Experimental Immunology

    Article Title: DC‐SIGN reacts with TLR‐4 and regulates inflammatory cytokine expression via NF‐κB activation in renal tubular epithelial cells during acute renal injury

    doi: 10.1111/cei.13048

    Figure Lengend Snippet: Dendritic cell‐specific intercellular adhesion molecule 3‐grabbing non‐integrin 1 (DC‐SIGN) regulates inflammatory cytokine expression. Negative control (NC) or DC‐SIGN siRNAs were transfected into human kidney 2 (HK‐2) cells and treated with or without lipopolysaccharide (LPS) (100 ng/ml) for 12 h. Enzyme‐linked immunosorbent assay (ELISA) was utilized to measure the interleukin (IL)‐6 and tumour necrosis factor (TNF)‐α secretion. The data are expressed as the mean ± standard deviation (s.d.) from three independent tests. * P

    Article Snippet: Interleukin (IL)‐6 and tumour necrosis factor (TNF)‐α enzyme‐linked immunosorbent assay (ELISA) kits were used to detected cytokine secretion (Abcam).

    Techniques: Expressing, Negative Control, Transfection, Enzyme-linked Immunosorbent Assay, Standard Deviation