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    • hepatocytes ipsc induced pluripotent stem cell jpt japanese  (iCell Gene Therapeutics)
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    iCell Gene Therapeutics hepatocytes ipsc induced pluripotent stem cell jpt japanese
    Population variability assessment of E-Series and P-Series glycol ethers in human lymphoblast cell lines. Panel A provides an overview of the distribution of calculated Point-of-Departure (POD) values for each one selected E-Series (DEGHE) and P-Series (TPGME) glycol ether across all tested cell lines (n=94). Individual concentration response plots and relative frequency distribution of calculated point-of-departure (POD) values (red inserts) are shown in the top part, the POD frequency distribution for all nine tested donor populations is shown on the bottom. Panel B highlights the distribution of POD values for both E-Series and P-Series glycol ethers across all populations. Individual box and whisker plots indicate the median and span across the 5–95 percentile. Statistical outliers are depicted as individual dots. Abbreviations: CEU=Utah residents with European Ancestry (n=13); CHB=Han Chinese from Beijing, China (n=14); CLB=Colombians from Medellin, Colombia (n=11); GBR=British from England and Scotland (n=9); <t>JPT=Japanese</t> from Tokyo, Japan (n=10); LWK=Luhya from Webuye, Kenya (n=8); MXL=Los Angeles residents with Mexican Ancestry (n=10); TSI=Tuscans from Italy (n=12); YRI=Yoruba from Ibadan, Nigeria (n=11).
    Hepatocytes Ipsc Induced Pluripotent Stem Cell Jpt Japanese, supplied by iCell Gene Therapeutics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Population variability assessment of E-Series and P-Series glycol ethers in human lymphoblast cell lines. Panel A provides an overview of the distribution of calculated Point-of-Departure (POD) values for each one selected E-Series (DEGHE) and P-Series (TPGME) glycol ether across all tested cell lines (n=94). Individual concentration response plots and relative frequency distribution of calculated point-of-departure (POD) values (red inserts) are shown in the top part, the POD frequency distribution for all nine tested donor populations is shown on the bottom. Panel B highlights the distribution of POD values for both E-Series and P-Series glycol ethers across all populations. Individual box and whisker plots indicate the median and span across the 5–95 percentile. Statistical outliers are depicted as individual dots. Abbreviations: CEU=Utah residents with European Ancestry (n=13); CHB=Han Chinese from Beijing, China (n=14); CLB=Colombians from Medellin, Colombia (n=11); GBR=British from England and Scotland (n=9); JPT=Japanese from Tokyo, Japan (n=10); LWK=Luhya from Webuye, Kenya (n=8); MXL=Los Angeles residents with Mexican Ancestry (n=10); TSI=Tuscans from Italy (n=12); YRI=Yoruba from Ibadan, Nigeria (n=11).

    Journal: Regulatory toxicology and pharmacology : RTP

    Article Title: Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers

    doi: 10.1016/j.yrtph.2018.11.011

    Figure Lengend Snippet: Population variability assessment of E-Series and P-Series glycol ethers in human lymphoblast cell lines. Panel A provides an overview of the distribution of calculated Point-of-Departure (POD) values for each one selected E-Series (DEGHE) and P-Series (TPGME) glycol ether across all tested cell lines (n=94). Individual concentration response plots and relative frequency distribution of calculated point-of-departure (POD) values (red inserts) are shown in the top part, the POD frequency distribution for all nine tested donor populations is shown on the bottom. Panel B highlights the distribution of POD values for both E-Series and P-Series glycol ethers across all populations. Individual box and whisker plots indicate the median and span across the 5–95 percentile. Statistical outliers are depicted as individual dots. Abbreviations: CEU=Utah residents with European Ancestry (n=13); CHB=Han Chinese from Beijing, China (n=14); CLB=Colombians from Medellin, Colombia (n=11); GBR=British from England and Scotland (n=9); JPT=Japanese from Tokyo, Japan (n=10); LWK=Luhya from Webuye, Kenya (n=8); MXL=Los Angeles residents with Mexican Ancestry (n=10); TSI=Tuscans from Italy (n=12); YRI=Yoruba from Ibadan, Nigeria (n=11).

    Article Snippet: CEU Utah residents with European Ancestry CHB Han Chinese from Beijing, China CLB Colombians from Medellin, Colombia cm.amp Average peak amplitude in iCell cardiomyocytes cm.bpm Beat frequency in iCell cardiomyocytes (bpm = beats per min) cm.mito Mitochondrial integrity in iCell cardiomyocytes cm.pbl Average peak baseline in iCell cardiomyocytes cm.pdt Average peak decay time in iCell cardiomyocytes cm.prt Average peak rise time in iCell cardiomyocytes cm.ps Average peak spacing in iCell cardiomyocytes cm.tc Nuclei based cell count (tc=total cells) of iCell cardiomyocytes cm.w10a Average peak width at 10% amplitude in iCell cardiomyocytes cm.width Average peak width in iCell cardiomyocytes CO 2 Carbon dioxide DEGBE Diethylene glycol monobutyl ether DEGEE Diethylene glycol monoethyl ether DEGHE Diethylene glycol monohexyl ether DEGME Diethylene glycol monomethyl ether DMSO Dimethyl sulfoxide DPGBE Dipropylene glycol n-butylether DPGnPE Dipropylene glycol n-propyl ether DPGME Dipropylene glycol monomethyl ether EG Ethanediol (Ethylene glycol) EGBE Ethylene glycol monobutyl ether EGEE Ethylene glycol monoethyl ether EGHE Ethylene glycol monohexyl ether EGME Ethylene glycol monomethyl ether EGPE Ethylene glycol monopropyl ether FBS Fetal bovine serum GBR British from England and Scotland hep.cyto Cytoskeletal integrity in iCell hepatocytes hep.lipid Lipid accumulation in iCell hepatocytes hep.mito Mitochondrial integrity in iCell hepatocytes hep.ros Reactive oxygen formation in iCell hepatocytes hep.tc Nuclei based cell count (tc=total cells) of iCell hepatocytes iPSC Induced pluripotent stem cell JPT Japanese from Tokyo, Japan LWK Luhya from Webuye, Kenya MXL Los Angeles residents with Mexican ancestry PBS Phosphate-Buffered Saline PG Propane-1,2-diol (propylene glycol) PGBE 1-butoxy-2-propanol (propylene glycol butyl ether) PGME 1-methoxy-2-propanol (propylene glycol methyl ether) PGnPE Propylene glycol n-propyl ether TEGBE Triethylene glycol monobutyl ether TEGEE Triethylene glycol monoethyl ether TEGME Triethylene glycol monomethyl ether TPGBE Tripropylene glycol monobutyl ether TPGME Tripropylene glycol methyl ether TSI Tuscans from Italy YRI Yoruba from Ibadan, Nigeria

    Techniques: Concentration Assay, Whisker Assay