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indinavir sulfate idv  (US Biological Life Sciences)
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indinavir (idv)  (Glaxo Smith)
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indinavir (idv  (Merck & Co)
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FDA-approved ART drugs and some of their reported mutations.
Indinavir (Idv, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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indinavir (idv)-ritonavir (rtv) 800/100 bid  (Merck & Co)
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FDA-approved ART drugs and some of their reported mutations.
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indinavir (idv, cas no.180686-37-8  (Macklin Inc)
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Nelfinavir inhibits the proteolysis activity of recombinant Emu Ddi1 . Emu Ddi1 was expressed in an E. coli system. Based on the amino acid compositions, this molecular weight of the recombinant protein was predicted to be appropriately 45 KD in the monomer (left) and 90 KD in the dimer (right) (a). At an optimum pH of 7.2, the recombinant Emu Ddi1 was able to hydrolyze the retro-pepsin substrate with a Km = 1.28 (95% CI: 0.80 to 2.02) μM and a Kcat = 0.36 s –1 (b). The HIVPIs, including lopinavir (LPV), <t>indinavir</t> (IDV), darunavir (DRV), fosamprenavir (FAPV), ritonavir (RTV), tipranavir (TPV), atazanavir (ATV), amprenavir (APV), nelfinavir (NFV) and saquinavir (SQV) were tested (n = 3). The enzyme activity of this recombinant protein (at 0.5 μM) could be apparently blocked by nelfinavir (NFV) and saquinavir (SQV) (40 μM) (c). The half-maximal inhibitory concentration (IC 50 ) of nelfinavir on the recombinant Emu Ddi1 was 45.95 μM (d). The results shown are representative of two or more independent experiments. Data shown are represented as mean ± SD.
Indinavir (Idv, Cas No.180686 37 8, supplied by Macklin Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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chemicals indinavir idv  (Vertex Pharmaceuticals)
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Nelfinavir inhibits the proteolysis activity of recombinant Emu Ddi1 . Emu Ddi1 was expressed in an E. coli system. Based on the amino acid compositions, this molecular weight of the recombinant protein was predicted to be appropriately 45 KD in the monomer (left) and 90 KD in the dimer (right) (a). At an optimum pH of 7.2, the recombinant Emu Ddi1 was able to hydrolyze the retro-pepsin substrate with a Km = 1.28 (95% CI: 0.80 to 2.02) μM and a Kcat = 0.36 s –1 (b). The HIVPIs, including lopinavir (LPV), <t>indinavir</t> (IDV), darunavir (DRV), fosamprenavir (FAPV), ritonavir (RTV), tipranavir (TPV), atazanavir (ATV), amprenavir (APV), nelfinavir (NFV) and saquinavir (SQV) were tested (n = 3). The enzyme activity of this recombinant protein (at 0.5 μM) could be apparently blocked by nelfinavir (NFV) and saquinavir (SQV) (40 μM) (c). The half-maximal inhibitory concentration (IC 50 ) of nelfinavir on the recombinant Emu Ddi1 was 45.95 μM (d). The results shown are representative of two or more independent experiments. Data shown are represented as mean ± SD.
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indinavir (idv) nanoparticles  (Baxter Healthcare)
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Nelfinavir inhibits the proteolysis activity of recombinant Emu Ddi1 . Emu Ddi1 was expressed in an E. coli system. Based on the amino acid compositions, this molecular weight of the recombinant protein was predicted to be appropriately 45 KD in the monomer (left) and 90 KD in the dimer (right) (a). At an optimum pH of 7.2, the recombinant Emu Ddi1 was able to hydrolyze the retro-pepsin substrate with a Km = 1.28 (95% CI: 0.80 to 2.02) μM and a Kcat = 0.36 s –1 (b). The HIVPIs, including lopinavir (LPV), <t>indinavir</t> (IDV), darunavir (DRV), fosamprenavir (FAPV), ritonavir (RTV), tipranavir (TPV), atazanavir (ATV), amprenavir (APV), nelfinavir (NFV) and saquinavir (SQV) were tested (n = 3). The enzyme activity of this recombinant protein (at 0.5 μM) could be apparently blocked by nelfinavir (NFV) and saquinavir (SQV) (40 μM) (c). The half-maximal inhibitory concentration (IC 50 ) of nelfinavir on the recombinant Emu Ddi1 was 45.95 μM (d). The results shown are representative of two or more independent experiments. Data shown are represented as mean ± SD.
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indinavir (idv)  (Bristol Myers)
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Nelfinavir inhibits the proteolysis activity of recombinant Emu Ddi1 . Emu Ddi1 was expressed in an E. coli system. Based on the amino acid compositions, this molecular weight of the recombinant protein was predicted to be appropriately 45 KD in the monomer (left) and 90 KD in the dimer (right) (a). At an optimum pH of 7.2, the recombinant Emu Ddi1 was able to hydrolyze the retro-pepsin substrate with a Km = 1.28 (95% CI: 0.80 to 2.02) μM and a Kcat = 0.36 s –1 (b). The HIVPIs, including lopinavir (LPV), <t>indinavir</t> (IDV), darunavir (DRV), fosamprenavir (FAPV), ritonavir (RTV), tipranavir (TPV), atazanavir (ATV), amprenavir (APV), nelfinavir (NFV) and saquinavir (SQV) were tested (n = 3). The enzyme activity of this recombinant protein (at 0.5 μM) could be apparently blocked by nelfinavir (NFV) and saquinavir (SQV) (40 μM) (c). The half-maximal inhibitory concentration (IC 50 ) of nelfinavir on the recombinant Emu Ddi1 was 45.95 μM (d). The results shown are representative of two or more independent experiments. Data shown are represented as mean ± SD.
Indinavir (Idv), supplied by Bristol Myers, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


FDA-approved ART drugs and some of their reported mutations.

Journal: Viruses

Article Title: Current ARTs, Virologic Failure, and Implications for AIDS Management: A Systematic Review

doi: 10.3390/v15081732

Figure Lengend Snippet: FDA-approved ART drugs and some of their reported mutations.

Article Snippet: , , Indinavir (IDV) , Crixivan ® , Merck & Co, Inc. New Jersey, USA. , , 32I, 46IL, 47V, 54VTALM, 76V, 82ATFS, 84V, 88S, 90M…etc..

Techniques: Blocking Assay

Nelfinavir inhibits the proteolysis activity of recombinant Emu Ddi1 . Emu Ddi1 was expressed in an E. coli system. Based on the amino acid compositions, this molecular weight of the recombinant protein was predicted to be appropriately 45 KD in the monomer (left) and 90 KD in the dimer (right) (a). At an optimum pH of 7.2, the recombinant Emu Ddi1 was able to hydrolyze the retro-pepsin substrate with a Km = 1.28 (95% CI: 0.80 to 2.02) μM and a Kcat = 0.36 s –1 (b). The HIVPIs, including lopinavir (LPV), indinavir (IDV), darunavir (DRV), fosamprenavir (FAPV), ritonavir (RTV), tipranavir (TPV), atazanavir (ATV), amprenavir (APV), nelfinavir (NFV) and saquinavir (SQV) were tested (n = 3). The enzyme activity of this recombinant protein (at 0.5 μM) could be apparently blocked by nelfinavir (NFV) and saquinavir (SQV) (40 μM) (c). The half-maximal inhibitory concentration (IC 50 ) of nelfinavir on the recombinant Emu Ddi1 was 45.95 μM (d). The results shown are representative of two or more independent experiments. Data shown are represented as mean ± SD.

Journal: eBioMedicine

Article Title: HIV protease inhibitor nelfinavir is a potent drug candidate against echinococcosis by targeting Ddi1-like protein

doi: 10.1016/j.ebiom.2022.104177

Figure Lengend Snippet: Nelfinavir inhibits the proteolysis activity of recombinant Emu Ddi1 . Emu Ddi1 was expressed in an E. coli system. Based on the amino acid compositions, this molecular weight of the recombinant protein was predicted to be appropriately 45 KD in the monomer (left) and 90 KD in the dimer (right) (a). At an optimum pH of 7.2, the recombinant Emu Ddi1 was able to hydrolyze the retro-pepsin substrate with a Km = 1.28 (95% CI: 0.80 to 2.02) μM and a Kcat = 0.36 s –1 (b). The HIVPIs, including lopinavir (LPV), indinavir (IDV), darunavir (DRV), fosamprenavir (FAPV), ritonavir (RTV), tipranavir (TPV), atazanavir (ATV), amprenavir (APV), nelfinavir (NFV) and saquinavir (SQV) were tested (n = 3). The enzyme activity of this recombinant protein (at 0.5 μM) could be apparently blocked by nelfinavir (NFV) and saquinavir (SQV) (40 μM) (c). The half-maximal inhibitory concentration (IC 50 ) of nelfinavir on the recombinant Emu Ddi1 was 45.95 μM (d). The results shown are representative of two or more independent experiments. Data shown are represented as mean ± SD.

Article Snippet: HIV protease inhibitors (HIVPIs), including nelfinavir (NFV, CAS NO. 159989-64-7), lopinavir (LPV, CAS NO. 192725-17-0), indinavir (IDV, CAS NO.180686-37-8), darunavir (DRV, CAS NO. 206361-99-1), fosamprenavir (FAPV, CAS NO. 226700-79-4), ritonavir (RTV, CAS NO. 176655-55-3), tipranavir (TPV, CAS NO. 174484-41-4), atazanavir (ATV, CAS NO. 198904-31-3), saquinavir (SQV, CAS NO. 149845-06-7), and amprenavir (APV, CAS NO. 161814-49-9), were purchased from Macklin (Shanghai, China).

Techniques: Activity Assay, Recombinant, Molecular Weight, Concentration Assay