Journal: PLoS ONE

Article Title: Screening for Decreased Glomerular Filtration Rate and Associated Risk Factors in a Cohort of HIV-Infected Patients in a Middle-Income Country

doi: 10.1371/journal.pone.0093748

Figure Lengend Snippet: Demographic and clinical characteristics of the study patients.

Article Snippet: Of the patients, 807 (41.0%) had been exposed to tenofovir (MCE 25.0±19.3 months), 305 (15.5%) had been exposed to indinavir (MCE 31.8±26.5 months), 490 (24.9%) had been exposed to atazanavir (MCE: 25.7±18.8 months), and 516 (26.2%) had been exposed to lopinavir (MCE: 27.4±21.3 months).

Techniques:

Journal: PLoS ONE

Article Title: Screening for Decreased Glomerular Filtration Rate and Associated Risk Factors in a Cohort of HIV-Infected Patients in a Middle-Income Country

doi: 10.1371/journal.pone.0093748

Figure Lengend Snippet: Factors associated with decreased GFR ( <60 mL/min per 1.73 m 2 ) in HIV-infected patients of the IPEC/FIOCRUZ Cohort.

Article Snippet: Of the patients, 807 (41.0%) had been exposed to tenofovir (MCE 25.0±19.3 months), 305 (15.5%) had been exposed to indinavir (MCE 31.8±26.5 months), 490 (24.9%) had been exposed to atazanavir (MCE: 25.7±18.8 months), and 516 (26.2%) had been exposed to lopinavir (MCE: 27.4±21.3 months).

Techniques:

Journal: Molecular Diversity

Article Title: Therapeutics for COVID-19: from computation to practices—where we are, where we are heading to

doi: 10.1007/s11030-020-10134-x

Figure Lengend Snippet: A comprehensive list of in silico studies in search of drug molecule to fight COVID-19 [ 95 – 119 ]

Article Snippet: VS through docking (PLANTS) followed by MD (AMBER, MOE2019) , Selleckchem and TargetMol (3118 FDA-approved drug) , 6LU7, 4MDS , VS of two databases on two targets (M pro in complex with peptidomimetic inhibitor and SARS-CoV 3C-Like proteinase 3CL pro ) , 4 (Indinavir, lopinavir, atazanavir, cobicistat) [ ] .

Techniques: In Silico, Binding Assay, Derivative Assay, Activity Assay, Sequencing

Journal: Antiviral Research

Article Title: Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus

doi: 10.1016/j.antiviral.2010.06.010

Figure Lengend Snippet: Activity of compounds against FCoV in fcwf-4 cells.

Article Snippet: Indinavir , Merck (Whitehouse station, USA) , 70.237 μM , ≥70.237 μM , − , NA.

Techniques: Activity Assay, Concentration Assay, Inhibition

Journal: Journal of acquired immune deficiency syndromes (1999)

Article Title: Insulin Resistance in HIV Protease Inhibitor-Associated Diabetes

doi:

Figure Lengend Snippet: Rat islets were incubated for 48 hours in the presence and absence of indinavir (20 μM) at basal (5 mM) and hyperglycemic (22 mM) concentrations of glucose. (A, B) Islets incubated in the absence of indinavir (dark bars) and when carbachol was added to the incubation media. Islets treated with indinavir (light bars) secreted insulin and C-peptide in amounts that were not significantly different from amounts secreted by control islets when glucose concentrations were 5 and 22 mM. (C) Rat islet iPLA2 activity was not suppressed in [beta]-cells treated with indinavir when compared with iPLA2 activity in control [beta]-cells incubated in the absence of indinavir.

Article Snippet: Indinavir for in vitro experiments was obtained from Merck Research Laboratories.

Techniques: Incubation, Activity Assay

Journal: International Journal of Pharmaceutics: X

Article Title: The Dynamic Intestinal Absorption Model (Diamod®), an in vitro tool to study the interconnected kinetics of gastrointestinal solubility, supersaturation, precipitation, and intestinal permeation processes of oral drugs

doi: 10.1016/j.ijpx.2023.100177

Figure Lengend Snippet: Average ± stdev (n = 3) concentration (μM) of total (black squares) and solute (grey circles) indinavir in the stomach (A) and duodenum (B) of the Diamod®, thermodynamic solubility (white diamonds) of indinavir in the duodenum (B) and degree of supersaturation (black diamonds) of indinavir in the duodenum (C) upon administration of indinavir sulfate under fasted state conditions. The pH value of the stomach (A) is represented by a black line whereas the total concentration of bile salts in the duodenum (B) is represented by a grey line.

Article Snippet: Indinavir (USP reference standard) and itraconazole were purchased from Merck Life Science B.V. (Overijse, Belgium) while indinavir sulfate was acquired from Abcam (Cambridge, United Kingdom).

Techniques: Concentration Assay, Solubility

Journal: International Journal of Pharmaceutics: X

Article Title: The Dynamic Intestinal Absorption Model (Diamod®), an in vitro tool to study the interconnected kinetics of gastrointestinal solubility, supersaturation, precipitation, and intestinal permeation processes of oral drugs

doi: 10.1016/j.ijpx.2023.100177

Figure Lengend Snippet: Stomach, duodenal, and permeated AUC 0–240min of total and solute indinavir in the Diamod® upon administration of indinavir sulfate to the stomach under fasted state conditions, fed state conditions with ingestion of a high protein meal, fed state conditions with ingestion of a carbohydrate solution and high gall bladder activity, and fed state conditions with ingestion of a carbohydrate meal with low gall bladder activity. A comparison was made with the AUC 0-inf values measured in plasma samples of individuals under fasted or fed state conditions during an in vivo food effect study with indinavir sulfate ( Carver et al., 1999 ).

Article Snippet: Indinavir (USP reference standard) and itraconazole were purchased from Merck Life Science B.V. (Overijse, Belgium) while indinavir sulfate was acquired from Abcam (Cambridge, United Kingdom).

Techniques: Activity Assay, In Vivo

Journal: International Journal of Pharmaceutics: X

Article Title: The Dynamic Intestinal Absorption Model (Diamod®), an in vitro tool to study the interconnected kinetics of gastrointestinal solubility, supersaturation, precipitation, and intestinal permeation processes of oral drugs

doi: 10.1016/j.ijpx.2023.100177

Figure Lengend Snippet: Average ± stdev (n = 3) concentration (μM) of permeated indinavir upon administration of indinavir sulfate under fasted state conditions (black squares) under fed state conditions with a high protein meal (grey circles), fed state conditions with a carbohydrate meal and high bile salt concentrations (grey diamonds) and fed state conditions with a carbohydrate meal and low bile salt concentrations (white diamonds).

Article Snippet: Indinavir (USP reference standard) and itraconazole were purchased from Merck Life Science B.V. (Overijse, Belgium) while indinavir sulfate was acquired from Abcam (Cambridge, United Kingdom).

Techniques: Concentration Assay

Journal: International Journal of Pharmaceutics: X

Article Title: The Dynamic Intestinal Absorption Model (Diamod®), an in vitro tool to study the interconnected kinetics of gastrointestinal solubility, supersaturation, precipitation, and intestinal permeation processes of oral drugs

doi: 10.1016/j.ijpx.2023.100177

Figure Lengend Snippet: Average ± stdev (n = 3) concentration (μM) of total (black squares) and solute (grey circles) indinavir in the stomach (A, D, and G) and duodenum (B, E, and H) of the Diamod®, thermodynamic solubility (white diamonds) of indinavir in the duodenum (B, E, and H) and degree of supersaturation (black diamonds) of indinavir in the duodenum (C, F, and I) upon administration of indinavir sulfate under fed state conditions with a high protein meal (A, B, and C), fed state conditions with a carbohydrate meal and high bile salt secretions (D, E, and F) and fed state conditions with a carbohydrate meal and low bile salts concentrations (G, H, and I). The pH value of the stomach (A, D, and G) is represented by a black line whereas the total concentration of bile salts in the duodenum (B, E, and H) is represented by a grey line.

Article Snippet: Indinavir (USP reference standard) and itraconazole were purchased from Merck Life Science B.V. (Overijse, Belgium) while indinavir sulfate was acquired from Abcam (Cambridge, United Kingdom).

Techniques: Concentration Assay, Solubility