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Image Search Results
Journal: Neural Regeneration Research
Article Title: An innovative treatment for hypoxic-ischemic encephalopathy: Silk fibroin nanomaterials improve neural stem cell axon formation and facilitate cognitive improvement
doi: 10.4103/nrr.nrr-d-24-01178
Figure Lengend Snippet: Figure 6 |Efficacy assessments in the HIE rat model. (A) Animal experiment timeline. (B) Whole-brain and HE-staining images. The infarct area was significantly reduced in both the hNSC direct injection group and the hNSC-loaded SF hydrogel group compared with the HIE group. Scale bars: 1 cm. (C) Representative IHC images of GFAP in the cerebral cortex and hippocampal CA1, DG, and CA3 regions (scale bars: 100 μm). (D) Number of GFAP-positive cells. Data are presented as the mean ± SD (n = 10/group). *P < 0.05, **P < 0.01, ***P < 0.001 (one-way analysis of variance followed by the least significant difference post hoc test or Welch test with Dunnett post hoc test). CTX: Cerebral cortex; DG: dentate gyrus; ELISA: enzyme-linked immunosorbent assay; GFAP: glial fibrillary acidic protein; HE staining: hematoxylin–eosin staining; HIE: hypoxic-ischemic encephalopathy; hNSC: human-derived neural stem cell; IF: immunofluorescence; IHC: immunohistochemistry; ns: not significant; NSC: neural stem cell; SF: silk fibroin; STI: stereotaxic injection.
Article Snippet: NSC differentiation efficiency was evaluated using a human/mouse/rat neural
Techniques: Staining, Injection, Enzyme-linked Immunosorbent Assay, Derivative Assay, Immunofluorescence, Immunohistochemistry