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p52 relb nuclear translocation inhibitor  (MedChemExpress)
94
MedChemExpress p52 relb nuclear translocation inhibitor
a The expression of <t>p52,</t> RelB and IDO in purified human dMDSCs of uninfected and infected groups were examined by qPCR (data represent the mean ± SD from five independent experiments). b The protein levels of IDO, STAT3, p-STAT3 (Y705), IKKα, p-IKKα, p-p100 in purified human dMDSCs, p52 and RelB in nucleus of dMDSCs of uninfected and infected groups were determined by western blot. c The statistical analysis of IDO, p-STAT3 (Y705), p-IKKα, p-p100, p52 and RelB in protein levels from infected groups and uninfected human dMDSCs by western blot. (data represent the mean ± SD from three independent experiments). d The expression levels of p-STAT3 in mouse dMDSCs were examined by flow cytometry in uninfected ( n = 7) and infected groups ( n = 8) and the results were analyzed by statistical analysis. Data are presented as the mean ± SD, * P < 0.05, ** P < 0.01, human samples in each group assayed individually by the paired t -test and mice samples in each group assayed individually by the unpaired t -test. MFI: mean fluorescence intensity.
P52 Relb Nuclear Translocation Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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a The expression of p52, RelB and IDO in purified human dMDSCs of uninfected and infected groups were examined by qPCR (data represent the mean ± SD from five independent experiments). b The protein levels of IDO, STAT3, p-STAT3 (Y705), IKKα, p-IKKα, p-p100 in purified human dMDSCs, p52 and RelB in nucleus of dMDSCs of uninfected and infected groups were determined by western blot. c The statistical analysis of IDO, p-STAT3 (Y705), p-IKKα, p-p100, p52 and RelB in protein levels from infected groups and uninfected human dMDSCs by western blot. (data represent the mean ± SD from three independent experiments). d The expression levels of p-STAT3 in mouse dMDSCs were examined by flow cytometry in uninfected ( n = 7) and infected groups ( n = 8) and the results were analyzed by statistical analysis. Data are presented as the mean ± SD, * P < 0.05, ** P < 0.01, human samples in each group assayed individually by the paired t -test and mice samples in each group assayed individually by the unpaired t -test. MFI: mean fluorescence intensity.

Journal: Communications Biology

Article Title: Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma gondii infection

doi: 10.1038/s42003-024-06365-5

Figure Lengend Snippet: a The expression of p52, RelB and IDO in purified human dMDSCs of uninfected and infected groups were examined by qPCR (data represent the mean ± SD from five independent experiments). b The protein levels of IDO, STAT3, p-STAT3 (Y705), IKKα, p-IKKα, p-p100 in purified human dMDSCs, p52 and RelB in nucleus of dMDSCs of uninfected and infected groups were determined by western blot. c The statistical analysis of IDO, p-STAT3 (Y705), p-IKKα, p-p100, p52 and RelB in protein levels from infected groups and uninfected human dMDSCs by western blot. (data represent the mean ± SD from three independent experiments). d The expression levels of p-STAT3 in mouse dMDSCs were examined by flow cytometry in uninfected ( n = 7) and infected groups ( n = 8) and the results were analyzed by statistical analysis. Data are presented as the mean ± SD, * P < 0.05, ** P < 0.01, human samples in each group assayed individually by the paired t -test and mice samples in each group assayed individually by the unpaired t -test. MFI: mean fluorescence intensity.

Article Snippet: To investigate if IDO expression was regulated by the STAT3/p52-RelB pathway after T. gondii infection, the p-STAT3 inhibitor (stattic; MCE, China) and p52-RelB nuclear translocation inhibitor (SN52; MCE, China) were separately introduced to human dMDSCs.

Techniques: Expressing, Purification, Infection, Western Blot, Flow Cytometry, Fluorescence

a The mRNA levels of IDO in human dMDSCs of infected group, infected with static treated group and infected with SN52 treated group were detected by qPCR (data represent the mean ± SD from three independent experiments by one-way ANOVA). b The expression changes of STAT3, p-STAT3 (Y705), IKKα, p-IKKα, p-p100, IDO and the expression of p52 and RelB of nucleus in purifed human dMDSCs of the uninfected, infected and infected with static treated groups were determined by western blot (data represent the mean ± SD from three independent experiments by one-way ANOVA). c The expression changes of IDO in human dMDSCs and the expression of p52 and RelB in nucleus of dMDSCs from the infected and infected with SN52 treated groups were determined by western blot (data represent the mean ± SD from three independent experiments by the paired t -test). d The IDO expression in mouse dMDSCs of infected and infected with JSI-124 groups were examined by flow cytometry ( n = 6). Data are presented as the mean ± SD, * P < 0.05, ** P < 0.01, unpaired t -test. MFI mean fluorescence intensity.

Journal: Communications Biology

Article Title: Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma gondii infection

doi: 10.1038/s42003-024-06365-5

Figure Lengend Snippet: a The mRNA levels of IDO in human dMDSCs of infected group, infected with static treated group and infected with SN52 treated group were detected by qPCR (data represent the mean ± SD from three independent experiments by one-way ANOVA). b The expression changes of STAT3, p-STAT3 (Y705), IKKα, p-IKKα, p-p100, IDO and the expression of p52 and RelB of nucleus in purifed human dMDSCs of the uninfected, infected and infected with static treated groups were determined by western blot (data represent the mean ± SD from three independent experiments by one-way ANOVA). c The expression changes of IDO in human dMDSCs and the expression of p52 and RelB in nucleus of dMDSCs from the infected and infected with SN52 treated groups were determined by western blot (data represent the mean ± SD from three independent experiments by the paired t -test). d The IDO expression in mouse dMDSCs of infected and infected with JSI-124 groups were examined by flow cytometry ( n = 6). Data are presented as the mean ± SD, * P < 0.05, ** P < 0.01, unpaired t -test. MFI mean fluorescence intensity.

Article Snippet: To investigate if IDO expression was regulated by the STAT3/p52-RelB pathway after T. gondii infection, the p-STAT3 inhibitor (stattic; MCE, China) and p52-RelB nuclear translocation inhibitor (SN52; MCE, China) were separately introduced to human dMDSCs.

Techniques: Infection, Expressing, Western Blot, Flow Cytometry, Fluorescence

T. gondii infection upregulated the transcriptional levels of IDO in dMDSCs through STAT3/p52-RelB pathway. But IDO protein expression was decreased due to the degradation induced by the increase of SOCS3 by infection, which in turn the reduction of IDO metabolite kynurenine further downregulated TGF-β and IL-10 expression in dNK cells through Kyn/AhR/SP1 signaling pathway, ultimately leading to the dysfunction of dNK and the disorders of maternal-fetal tolerance.

Journal: Communications Biology

Article Title: Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma gondii infection

doi: 10.1038/s42003-024-06365-5

Figure Lengend Snippet: T. gondii infection upregulated the transcriptional levels of IDO in dMDSCs through STAT3/p52-RelB pathway. But IDO protein expression was decreased due to the degradation induced by the increase of SOCS3 by infection, which in turn the reduction of IDO metabolite kynurenine further downregulated TGF-β and IL-10 expression in dNK cells through Kyn/AhR/SP1 signaling pathway, ultimately leading to the dysfunction of dNK and the disorders of maternal-fetal tolerance.

Article Snippet: To investigate if IDO expression was regulated by the STAT3/p52-RelB pathway after T. gondii infection, the p-STAT3 inhibitor (stattic; MCE, China) and p52-RelB nuclear translocation inhibitor (SN52; MCE, China) were separately introduced to human dMDSCs.

Techniques: Infection, Expressing