hy-p1956 Search Results


hsa  (MedChemExpress)
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MedChemExpress hsa
Fig. 1 Schematic representation of the synthesis of SANPs (A) and CNPs (B). C Transmission electron microscopy (TEM) images of SANPs and CNPs. Scale bar, 100 nm. D Nanoparticle tracking analysis of SANPs and CNPs. E FTIR spectra of TAC, TAC-HS, <t>HSA,</t> SANPs, and CNPs. F Drug loading of SANPs and CNPs. G Solubility of fTAC, SANPs, and CNPs in PBS. H TAC release from SANPs and CNPs in vitro. Effects of varying concentrations of SANPs (I) and CNPs (J) on the viability of human podocytes. K,L Hemolysis assays of SANPs and CNPs at different concentrations. ns p > 0.05, * p < 0.05, ** p < 0.01 and *** p < 0.001
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Fig. 1 Schematic representation of the synthesis of SANPs (A) and CNPs (B). C Transmission electron microscopy (TEM) images of SANPs and CNPs. Scale bar, 100 nm. D Nanoparticle tracking analysis of SANPs and CNPs. E FTIR spectra of TAC, TAC-HS, HSA, SANPs, and CNPs. F Drug loading of SANPs and CNPs. G Solubility of fTAC, SANPs, and CNPs in PBS. H TAC release from SANPs and CNPs in vitro. Effects of varying concentrations of SANPs (I) and CNPs (J) on the viability of human podocytes. K,L Hemolysis assays of SANPs and CNPs at different concentrations. ns p > 0.05, * p < 0.05, ** p < 0.01 and *** p < 0.001

Journal: Journal of nanobiotechnology

Article Title: RGD-HSA-TAC nanoparticles targeted delivery of tacrolimus and attenuation of podocyte injury in diabetic kidney disease.

doi: 10.1186/s12951-025-03108-4

Figure Lengend Snippet: Fig. 1 Schematic representation of the synthesis of SANPs (A) and CNPs (B). C Transmission electron microscopy (TEM) images of SANPs and CNPs. Scale bar, 100 nm. D Nanoparticle tracking analysis of SANPs and CNPs. E FTIR spectra of TAC, TAC-HS, HSA, SANPs, and CNPs. F Drug loading of SANPs and CNPs. G Solubility of fTAC, SANPs, and CNPs in PBS. H TAC release from SANPs and CNPs in vitro. Effects of varying concentrations of SANPs (I) and CNPs (J) on the viability of human podocytes. K,L Hemolysis assays of SANPs and CNPs at different concentrations. ns p > 0.05, * p < 0.05, ** p < 0.01 and *** p < 0.001

Article Snippet: In this study, we constructed two RGD-crosslinked tacrolimus (MCE, HY-13756) and HSA (MCE, HY-P1956) compounds, namely self-assembled nanoparticles (RGDHSA-TAC SANPs, hereafter referred to as SANPs) and coupled nanoparticles (RGD-HSA-TAC CNPs, hereafter referred to as CNPs).

Techniques: Transmission Assay, Electron Microscopy, Solubility, In Vitro