hy-p1119 Search Results


wrw4  (MedChemExpress)
94
MedChemExpress wrw4
Figure 10. Overexpression of ANXA1 in HUVECs indicates that ANXA1 may exert an anti-inflammaging effect through its receptor: A,C) Representative photographs of SA-𝛽-gal staining and quantification of the positive area indicated that overexpression of ANXA1 in HUVECs reversed TNF-𝛼-induced senescence, while treatment with an inhibitor of its receptor FPR2 <t>(WRW4)</t> abolished this beneficial effect (n = 3). Bars = 200 μm. B,D) Alleviation of cell cycle arrest was observed in the ANXA1 overexpression group by flow cytometry (n = 3). F–J) Representative western blot images showing that the expression levels of P21, P16, VCAM-1, ICAM-1, and ANXA1 were significantly decreased in the ANXA1 overexpression treating with TNF-𝛼group (n = 3). The data are presented as the means ±SEMs. One-way ANOVA followed by the Bonferroni post hoc test (C,D,F–J) was used for the analyses. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. ns, p > 0.05.
Wrw4, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p1119/WRW4/pm38358087-401-0-1
Average 94 stars, based on 1 article reviews
wrw4 - by Bioz Stars, 2026-10
94/100 stars
  Buy from Supplier

Image Search Results


Figure 10. Overexpression of ANXA1 in HUVECs indicates that ANXA1 may exert an anti-inflammaging effect through its receptor: A,C) Representative photographs of SA-𝛽-gal staining and quantification of the positive area indicated that overexpression of ANXA1 in HUVECs reversed TNF-𝛼-induced senescence, while treatment with an inhibitor of its receptor FPR2 (WRW4) abolished this beneficial effect (n = 3). Bars = 200 μm. B,D) Alleviation of cell cycle arrest was observed in the ANXA1 overexpression group by flow cytometry (n = 3). F–J) Representative western blot images showing that the expression levels of P21, P16, VCAM-1, ICAM-1, and ANXA1 were significantly decreased in the ANXA1 overexpression treating with TNF-𝛼group (n = 3). The data are presented as the means ±SEMs. One-way ANOVA followed by the Bonferroni post hoc test (C,D,F–J) was used for the analyses. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. ns, p > 0.05.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Article Title: Loss of Endothelial Annexin A1 Aggravates Inflammation-Induched Vascular Aging.

doi: 10.1002/advs.202307040

Figure Lengend Snippet: Figure 10. Overexpression of ANXA1 in HUVECs indicates that ANXA1 may exert an anti-inflammaging effect through its receptor: A,C) Representative photographs of SA-𝛽-gal staining and quantification of the positive area indicated that overexpression of ANXA1 in HUVECs reversed TNF-𝛼-induced senescence, while treatment with an inhibitor of its receptor FPR2 (WRW4) abolished this beneficial effect (n = 3). Bars = 200 μm. B,D) Alleviation of cell cycle arrest was observed in the ANXA1 overexpression group by flow cytometry (n = 3). F–J) Representative western blot images showing that the expression levels of P21, P16, VCAM-1, ICAM-1, and ANXA1 were significantly decreased in the ANXA1 overexpression treating with TNF-𝛼group (n = 3). The data are presented as the means ±SEMs. One-way ANOVA followed by the Bonferroni post hoc test (C,D,F–J) was used for the analyses. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. ns, p > 0.05.

Article Snippet: WRW4 (MCE, USA) was used at 2.5 μm for FPR2 inhibition.

Techniques: Over Expression, Staining, Cytometry, Western Blot, Expressing